Cloning and Characterisation of TPO Autoantibodies Using Combinatorial Phage Display Libraries

References

• Furmaniak J, Rees Smith B. The structure of thyroid autoantigens. Autoimmunity 1990; 7: 63–70
   PubMed Web of Science ®Google Scholar
• Petersen VB, Fukuma N, McLachlan SM, Bradbury J, Beever K, Devey ME, Bleasdale-Barr KM, Phillips DIM, Baylis P, Ryley H, Rees Smith B. A human-mouse hybridoma which secretes monoclonal thyroglobulin autoantibody with properties similar to those of the donor patient's serum. Autoimmunity 1989; 4: 89–102
   PubMed Web of Science ®Google Scholar
• Horimoto M, Petersen VB, Pegg CAS, Fukuma N, Wakaba-Yashi N, Kiso Y. Production and characterisation of a human monoclonal thyroid peroxidase autoantibody. Autoimmunity 1992; 14: 1–7
   PubMedGoogle Scholar
• Hexham JM, Furmaniak J, Pegg C, Burton DR, Rees Smith B. Cloning of a human autoimmune response: preparation and sequencing of a human anti-thyroglobulin autoantibody using a combinatorial approach. Autoimmunity 1992; 12: 135–141
   PubMed Web of Science ®Google Scholar
• Portolano S, Seto P, Chazenbalk GD, Nagayama Y, McLachlan SM, Rapoport B. A human Fab fragment specific for thyroid peroxidase generated by cloning thyroid lymphocyte derived immunoglobulin genes in a bacteriophage library. Biochem Biophys Res Commun 1991; 179: 372–377
   PubMed Web of Science ®Google Scholar
• Portolano S, Chazenbalk GD, Seto P, Scott Hutchison JY, Rapoport B, McLachlan SM. Recognition by recombinant autoimmune thyroid disease derived Fab fragments of a dominant conformational epitope on human thyroid peroxidase. J Clin Invest 1992; 90: 720–726
   PubMed Web of Science ®Google Scholar
• Portolano S, Chazenbalk GD, Scott Hutchison J, McLachlan SM, Rapoport B. Lack of promiscuity in autoantigen specific H and L chain combinations as revealed by human H and L chain roulette. J Immunol 1993; ISO: 880–887
   Google Scholar
• Huse WD, Sastry L, Iverson SA, Kang AS, Alting-Mees M, Burton DR, Benkovic SJ, Lerner RA. Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda. Science 1989; 246: 1275–1281
   PubMed Web of Science ®Google Scholar
• Barbas CF, Kang AS, Lerner RA, Benkovic SJ. Assembly of combinatorial antibody libraries on phage surfaces (Phabs): The gene III site. Proc Natl Acad Sci USA 1991; 88: 7879–7982
   Google Scholar
• Clackson T, Hoogenboom HR, Griffiths AD, Winter G. Making antibody fragments using phage display libraries. Nature 1991; 352: 624–628
   PubMed Web of Science ®Google Scholar
• Chowdury K. One-step miniprep method for the isolation of plasmid DNA. Nucleic Acids Res 1991; 19: 2792
   PubMedGoogle Scholar
• Atherton MC, McLachlan SM, Pegg CAS, Dickinson A, Baylis P, Young ET, Proctor SJ, Rees Smith B. Thyroid autoantibody synthesis by lymphocytes from different lymphoid organs: fractionation of B-cells on density gradients. Immunology 1985; 55: 271–279
   PubMed Web of Science ®Google Scholar
• Hexham JM, Pegg CAS, Burton DR, Petersen VB, Horimoto M, Furmaniak J, Rees Smith B. Variable region sequence of a human monoclonal thyroid peroxidase autoantibody. Autoimmunity 1992; 14: 169–172
   PubMed Web of Science ®Google Scholar
• Schardt CW, McLachlan SM, Matheson J, Rees Smith B. An enzyme-linked immunoassay for thyroid microsomal antibodies. J Immunol Methods 1982; 55: 155–168
   PubMed Web of Science ®Google Scholar
• Sanger F, Nicklen S, Coulson AR. DNA sequencing with chain terminating inhibitors. Proc Natl Acad Sci USA 1977; 74: 5463–5467
   PubMed Web of Science ®Google Scholar
• Devereux J, Heaberli P, Smithies O. A comprehensive set of sequence analysis programmes for the VAX. Nucl Acids Res 1984; 12: 387–395
   PubMed Web of Science ®Google Scholar
• Kabat EA, Perry HM, Gottesman KS, Foeller C. Sequences of proteins of immunological interest (5th edition). US Dept of Health and Human services, Washington, DC 1991
   Google Scholar
• Kiso Y, Petersen VB, Horimoto M, Fukuma N, Pegg CAS. Furmaniak J and Rees Smith B. Analysis of autoantigenic sites on thyroglobulin using human monoclonal antoanti-bodies. J Endocrinol Invest 1992; 15: 108, suppl. 2
   Google Scholar
• Beever K, Bradbury J, Phillips D, McLachlan SM, Pegg CAS, Goral A. Highly sensitive assays of autoantibodies to thyroglobulin and to thyroid peroxidase. Clin Chem 1989; 35: 1949–1954
   PubMed Web of Science ®Google Scholar
• Pargent W, Meindl A, Thiebe R, Mitzel S, Zachau H. The human immunoglobulin kappa locus. Characterisation of duplicated O regions. Eur J Immunol 1991; 21: 1821–1827
   PubMedGoogle Scholar
• Radoux V, Chen PP, Sorge JA, Carson DA. A conserved human germline Vk gene directly encodes rheumatoid factor light chains. J Exp Med 1986; 164: 2119–2124
   PubMed Web of Science ®Google Scholar
• Tomlinson Im, Walter G, Marks JD, Llewelyn MB, Winter G. The repetoire of human VH sequences reveals about fifty groups of VH segments with different hypervariable loops. J Mol Biol 1992; 227: 776–798
   PubMed Web of Science ®Google Scholar
• Chen PP, Liu MF, Sinha S, Carson DA. A 16/6 idiotype positive anti-DNA antibody is encoded by a conserved VH gene with no somatic mutation. Arthritis Rheum 1988; 31: 1429–1431
   PubMed Web of Science ®Google Scholar
• Wang D, Liao J, Mitra D, Akulkar PN, Gruezo F, Kabat EA. The repertoire of antibodies to single antigenic determinant. Mol Immunol 1991; 28: 1387–1397
   PubMedGoogle Scholar
• Kim S, Davis M, Simm E, Patten P, Hood L. Antibody diversity: somatic hypermutation of rearranged VH genes. Cell 1981; 27: 573–581
   PubMed Web of Science ®Google Scholar
• Manser T, Huang SY, Gefter ML. Influence of clonal selection on the expression of immunoglobulin variable region genes. Science 1984; 226: 1283–1288
   PubMed Web of Science ®Google Scholar
• Victor KD, Pascual V, Lefvert AK, Capra JD. Human anti-acetylcholine receptor antibodies use variable gene segments analogous to those used in autoantibodies of various specificities. Mol Immunol 1992; 29: 1501–1506
   PubMedGoogle Scholar
• Stewart AK, Huang C, Long AA, Stollar BD, Schwartz RS. VH-gene representation in autoantibodies reflects the normal human B-cell repertoire. Immunol rev 1992; 128: 101–122
   PubMed Web of Science ®Google Scholar
• Huang C, Stewart AK. Schwartz RS and Stollar BD. Immunoglobulin heavy chain gene expression in peripheral blood lymphocytes. J Clin Invest 1992; 89: 1331–1343
   PubMed Web of Science ®Google Scholar
• Barbas CF, Collett TA. Amberg W, Roben P, Binley JM, Hoekstra D, Molecular profile of an antibody response to HIV-1 as probed by combinatorial libraries. Mol Biol 1993; 230: 812–823
   Google Scholar
• Chothia C, Lesk AM, Gheradi E, Tomlinson IM, Walter G, Marks JD, Llewelyn MB, Winter G. Structural repertoire of the human VH segments. J Mol Biol 1992; 227: 799–817
   PubMed Web of Science ®Google Scholar
• Ichihara Y. Matsuoka H and Kurosawa Y. Organisation of human immunoglobulin heavy chain diversity gene loci. EMBO Journal 1988; 7: 4141–4150
   PubMed Web of Science ®Google Scholar
• Victor KD, Pascual V, Williams CL, Lennon VA, Capra JD. Human monoclonal striational autoantibodies isolated from thymic B lymphocytes of patients with myasthenia gravis use VH and VL gene segments associated with the autoimmune repertoire. Eur J Immunol 1992; 22: 2231–2236
   PubMedGoogle Scholar
• Prentice L, Peterson VB, Grennan F, Fukuma N, Horimoto M, Wedlock N, Pegg C, Rees Smith B. Human anti-thyroglobulin autoantibody variable region genes. J Endocrinol Invest 1993; 16: 123, suppl. 2-6
   PubMedGoogle Scholar
• Victor KD, Randen I, Thompson K, Forre O, Natvig J, Fu SM, Capra JD. Rheumatoid factors isolated from patients with autoimmune disorders are derived from germ-line genes distinct from those encoding the Wa, Po and Bla cross-reactive idiotypes. J Clin Invest 1991; 87: 1603–1613
   PubMed Web of Science ®Google Scholar
• Kipps TF, Tomhave E, Chen PP, Fox RI. Molecular characterisation of a major autoantibody associated cross- reactive idiotype in Sjogrens syndrome. J Immunol 1989; 142: 4261–4268
   PubMed Web of Science ®Google Scholar
• Meindl A, Klobeck HG, Ohnheiser R, Zachau H. The Vk gene repertoire in the human germline. Eur J Immunol 1990; 20: 1855–1863
   PubMedGoogle Scholar
• Adderson EE, Shackelford PG, Insel RA, Quinn A, Wilson PM, Carroll WL. Immunoglobulin light chain variable region gene sequences for human antibodies to Haemophilus influenzae type-B capsular polysaccharide are dominated by a limited number of Vk and VlD segments and VJ combinations. J Clin Invest 1992; 89: 729–738
   PubMedGoogle Scholar
• Andris JS, Ostberg L, Ehrlich PH, Capra JD. Probing the human antibody repertoire to exogeneous antigens. J Immunol 1992; 149: 4053–4059
   PubMedGoogle Scholar
• DeCossio MEF, Ohlin M, Selander B, Cruz S, Delvalle J, Borrebaeck CAK. Human monoclonal antibodies against an epitope on the class 5c outer-membrane protein common to many pathogenic strains of neisseria-meningitidis. J Infect Diseases 1992; 166: 1322–1328
   PubMedGoogle Scholar
• Newkirk MM, Gram H, Heinrich GF, Oestberg L, Capra JD, Wasserman RL. Complete protein sequences of the variable regions of the light chains of a human anti-cytomegalovirus antibody reveal a striking similarity to human monoclonal rheumatoid factors of the Wa idiotypic family. J Clin Invest 1988; 81: 1511–1518
   PubMed Web of Science ®Google Scholar
• Marasco WA, Bagley J, Zani C, Posner M, Cavacini L, Haseltine WA, Sodroski J. Characterisation of the cDNA of a broadly reactive neutralising human anti-gP 120 monoclonal antibody. J Clin Invest 1992; 90: 1467–1478
   PubMed Web of Science ®Google Scholar
• Marks JD, Tristem M, Karpas A, Winter G. Oligonucleotide primers for polymerase chain reaction amplification of human immunoglobulin variable genes and design of family specific primers. Eur J Immunol 1991; 21: 985–991
   PubMed Web of Science ®Google Scholar
• Winkler TH, Fehr H, Kalden JR. Analysis of immunoglobulin variable region genes from human IgG anti-DNA hy-bridomas. Eur J Immunol 1992; 22: 1719–1728
   PubMed Web of Science ®Google Scholar
• Olee T, Lu EW, Huang D, Soto-Gil RW, Deftos M, Kozin F, Carson DA, Chen PP. Genetic analysis of self-associating immunoglobulin G Rheumatoid Factors from two rheumatoid synovia implicates an antigen-driven response. J Exp Med 1992; 175: 831–842
   PubMedGoogle Scholar
• Huang D, Olee T, Masuho Y, Matsumoto Y, Carson DA, Chen PP. Sequence analyses of three immunoglobulin G antivirus antibodies reveal their utilisation of autoantibody related immunoglobulin VH genes but not VlD genes. J Clin Inv 1992; 90: 2197–2208
   PubMed Web of Science ®Google Scholar
• Ikematsu H, Harindranath N, Ueki Y, Notkins AL, Casali P. Clonal analysis of human antibody response. Sequences of the VH genes of human IgM, IgG and IgA to rabies virus reveal preferential utilisation of VHIII segements and somatic hypermutation. J Immunol 1993; 150: 1325–1337
   PubMedGoogle Scholar
• Kang AS, Jones TM, Burton DR. Antibody redesign by chain shuffling from random combinatorial libraries. Proc Natl Acad Sci USA 1991; 88: 11120–11123
   PubMedGoogle Scholar
• Collet TA, Roben P, O'Kennedy R, Barbas CF, Burton DR, Lerner RA. A binary plasmid system for shuffling combinatorial antibody libraries. Proc Natl Acad Sci USA 1992; 98: 10026–10030
   Google Scholar
• Barry MM, Lee JS. Cloning and expression of an autoimmune DNA-binding single chain Fv. Only the heavy chain is required for binding. Mol Immunol 1993; 30: 833–840
   PubMed Web of Science ®Google Scholar
• Chazenbalk GD, Portolano S, Russo D, Hutchison JS, Rapoport B, McLachlan S. Human organ-specific autoimmune disease. Molecular cloning and expression of an autoantibody gene repertoire for a major autoantigen reveals an antigenic immunodominant region and restricted immunoglobulin gene usage in the target organ. J Clin Invest 1993; 92: 62–74
   PubMed Web of Science ®Google Scholar