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Original Article

Gad65 is recognized by t-cells, but not by antibodies from nod-mice

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Pages 189-194 | Received 04 Jan 1994, Published online: 07 Jul 2009

References

  • Eisenbarth GS. Type 1 Diabetes Mellitus: A chronic autoimmune disease. NEnglJMed 1986; 314: 1360–1368
  • Roep BO, DeVries RRP. T lymphocytes and the pathogenesis of type 1 (insulin-dependent) diabetes mellitus. J, Clin. Invest. 1992; 22: 1–15
  • Roep BO, Kalian AA, Hazenbos WL, Bruining GJ, Baileys EM, Arden SD. T-cell reactivity to 38kD insulin secretory granule protein in patients with recent-onset type 1 diabetes. Lancet 1991; 337: 1439–1441
  • Baekkeskov S, Aanstoot AJ, Christgau S, Reetz A, Solimena M, Cascalho F. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthezising enzyme glutamic acid decarboxylase. Nature 1990; 347: 151–156
  • Seissler J, Amann J, Mauch L, Haubruck H, Wolfahrt S, Bieg S. Prevalence of autoantibodies to the 65- and 67-kDa isoforms of glutamate decarboxylase in insulin-dependent diabetes mellitus. J Clin Invest. 1993; 92: 1394–1399
  • Solimena M, De Camilli P. Autoimmunity to glutamic acid decarboxylase (GAD) in Stiff Man Syndrome and insulin dependent diabetes mellitus. Trends in Neurosciences 1991; 14(10)452–457
  • Solimena M, Folli F, Aparisis R, Pozza G, DeCamilli P. Autoantibodies to GABA-ergic neurons and pancreatic beta cells in Stiff Man Syndrome. Engl J Med 1991; 322(22)1555–1560
  • Christgau S, Aanstoot HJ, Schierbeck H, Bcgley K, Tullin S, Hejnaes K. Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic (3-cells by palmitoyla-tion in the NH2-terminal domain. J Cell Biol 1992; 118: 309–320
  • Atkinson M A, Kaufman DL, Campbell L, Gibbs KA, Shah SC, Bu D. Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes. Lancet 1992; 339: 458–459
  • Honeyman MC, Cram DS, Harrison LC. XY1Glutamic acid decarboxylase 67-reactivc T-cells: a marker of insulin-dependent diabetes. J Exp Med 1993; 77: 535–540
  • Diaz JL, Ways J, Hammonds P. T-lymphocyte lines specific for glutamic acid decarboxylase (GAD), the 65K P-cell antigen of IDDM. Diabetes 1992; 41: 118–121
  • Ohneda A, Kobayashi T, Nihei J, Tochino Y, Kanaya H, Makino S. Insulin and glucagon in spontaneously diabetic non-obese mice. Diabetologia 1984; 27: 460–463
  • Leiter EH, Prochazka M, Coleman DL. Animal model of human disease – the non-obese diabetic mouse. Am J Path 1987; 28: 380–383
  • Atkinson MA, Maclaren NK. Autoantibodies in non obese diabetic mice immunoprccipitate 64,000-Mr islet antigen. Diabetes 1988; 37: 1587–1590
  • Velloso LA, Kampe O, Eizirik DL, Hallberg A, Andcrsson A, Karlsson FA. Human autoantibodies react with glutamic acid decarboxylase antigen in human and rat but not in mouse pancreatic islets. Diabetologia 1993; 36: 39–46
  • Mauch L, Seissler J, Haubruck H, Cook NJ, Abncy CC, Berthold H. Baculovirus mediated expression of human 65 kDa and 67 kDa glutamic acid decarboxylase in SF9 cells and their relevance in diagnosis of insulin-dependent diabetes mellitus. J Biochem 1993; 113: 699–704
  • Miller LP, Martin DL, Mazumder A, Walters JR. Studies on the regulation of GABA synthesis: substrate promoted dissociation of pyridoxial-5'-phosphate from GAD. J. Neuro-chem. 1978; 30: 361–369
  • Bieg S, Bailycs EM, Yassin N, Amann J, Herberg L, McGregor AM. A multiplicity of protein antigens in subcellular fractions of rat insulinoma tissue are able to stimulate T-cells obtained from non-obese diabetic mice. Diabetologia 1993; 36: 385–390
  • Seissler J, Hering B, Richter W, Gluck M, Yassin N, Bretzel RG. Antibodies to the MR 64.000 (64K) protein in islet cell antibody positive non-diabetic individuals indicate high risk for impaired beta-cell function. Diabetologia 1992; 35: 550–554
  • Christie MR, Brown TJ, Cassidy D. Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia 1992; 35: 380–384
  • Peters PJ, Neefjes JJ, Oorschot V, Ploegh HL, Geuze HJ. Segregation of MHC class II from molecules HC class I molecules in the Golgi complex for transport to lysosomal compartments. Nature 1992; 349: 669–676
  • Lie W, Myers NB, Gorka J, Rubocki RJ, Connolly JM, Hansen TH. Peptide ligand-induced conformation and surface expression of the Ld class I MHC molecule. Nature 1990; 344: 439–441
  • Hackett CJ. Later for the rendezvous: antigen presentation. Nature 1991; 349: 655–656
  • Alzari PM, Lascombe MB, Poljak RJ. Three dimensional structure of antibodies. Ann Rev Immunol. 1988; 6: 555–580
  • Jennings PA, Boyle DB, Andrew ME. Class I MHC restricted cytotoxic T-cells efficiently recognize haemagglutinin that is defective in protein folding and cell surface expression. Molecular Immunology 1988; 25(2)1371–1376

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