Influence of Deletion of T Cell Receptor V_β Genes on the Theiler's Virus Model of Multiple Sclerosis

References

• Weyand C M, Oppitz U., Hicok K., Goronzy J. J. Selection of T cell receptor V beta elements by HLA-DR determinants predisposing to rheumatoid arthritis. Arthritis Rheum. 1992; 35: 990–998
   PubMedGoogle Scholar
• Pluschke G., Ricken G., Taube H., Kroninger S., Melchers I., Peter H. H., et al. Biased T cell receptor V alpha region repertoire in the synovial fluid of rheumatoid arthritis patients. Eur. J. Immunol. 1991; 21: 2749–2754
   PubMed Web of Science ®Google Scholar
• Maksymowych W. P., Gabriel C. A., Luyrink L., Melinaldana H., Elma M., Giannini E. H., et al. Polymorphism in a T-cell receptor variable gene is associated with susceptibility to a juvenile rheumatoid arthritis subset. Immunogenetics 1992; 35: 257–262
   PubMedGoogle Scholar
• Paliard X., West S. G., Lafferty J. A., Clements J. R., Kappler J. W., Marrack P., et al. Evidence for the effects of a super-antigen in rheumatoid arthritis. Science 1991; 253: 325–329
   PubMed Web of Science ®Google Scholar
• Savill C. M., Delves P. J., Kioussis D., Walker P., Lydyard P. M., Colaco B., et al. A minority of patients with rheumatoid arthritis show a dominant rearrangement of T-cell receptor beta chain genes in synovial lymphocytes. Scand. J. Immunol. 1987; 25: 629–635
   PubMed Web of Science ®Google Scholar
• Gudmundsson S., Ronnelid J., Karlsson Parra A., Lysholm J., Gudbjornsson B., Widenfalk B., et al. T-cell receptor V-gene usage in synovial fluid and synovial tissue from RA patients. Scand. J. Immunol. 1992; 36: 681–688
   PubMed Web of Science ®Google Scholar
• Malhotra U., Concannon P. T cell receptor beta gene polymorphism and rheumatoid arthritis. Autoimmunity 1992; 12: 75–77
   Web of Science ®Google Scholar
• Millward B. A., Welsh K. I., Leslie R. D., Pyke D. A., Demaine A. G. T cell receptor beta chain polymorphisms are associated with insulin-dependent diabetes. Clin. Exp. Immunol. 1987; 70: 152–157
   PubMed Web of Science ®Google Scholar
• Hibberd M. L., Millward B. A., Wong F. S., Demaine A. G. T-cell receptor constant beta chain polymorphisms and susceptibility to type 1 diabetes. Diabet. Med. 1992; 9: 929–933
   PubMedGoogle Scholar
• McMillan S. A., Graham C. A., Hart P. J., Hadden D. R., McNeill T. A. A T cell receptor beta chain polymorphism is associated with patients developing insulin-dependent diabetes after the age of 20 years. Clin. Exp. Immunol. 1990; 82: 538–541
   Google Scholar
• Niven M. J., Caffrey C., Moore R H, Sachs J. A., Mohan V., Festenstein H., et al. T-cell receptor beta-subunit gene polymorphism and autoimmune disease. Hum. Immunol. 1990; 27: 360–367
   Google Scholar
• Sheehy M. J., Meske L. M., Emler C. A., Rowe J. R., Neme de Gimenez M. H., Ingle C. A., et al. Allelic T-cell receptor alpha complexes have little or no influence on susceptibility to type 1 diabetes. Hum. Immunol. 1989; 26: 261–271
   Google Scholar
• Avoustin P., Briant L., de Preval C., Cambon Thomsen A. Polymorphism study of TCR alpha and gamma genes in insulin dependent diabetes mellitus (IDDM) multiplex families. Autoimmunity 1992; 14: 97–100
   Web of Science ®Google Scholar
• Reijonen H., Silvennoinen Kassinen S., Ilonen J., Knip M. Lack of association of T cell receptor beta-chain constant region polymorphism with insulin-dependent diabetes mellitus in Finland. Clin. Exp. Immunol. 1990; 81: 396–399
   Google Scholar
• Concannon P., Wright J. A., Wright L. G., Sylvester D. R., Spielman R. S. T-cell receptor genes and insulin-dependent diabetes mellitus (IDDM): no evidence for linkage from affected sib pairs. Am. J. Hum. Genet. 1990; 47: 45–52
   Google Scholar
• Beall S. S., Biddison W. E., McFarlin D. E., McFarland H. F., Hood L. E. Susceptibility for multiple sclerosis is determined, in part, by inheritance of a 175-kb region of the TcR V beta chain locus and HLA class II genes. J. Neuroimmunol. 1993; 45: 53–60
   Google Scholar
• Beall S. S., Concannon P., Charmley P., McFarland H. F., Gatti R. A., Hood L. E., et al. The germline repertoire of T cell receptor beta-chain genes in patients with chronic progressive multiple sclerosis. J. Neuroimmunol. 1989; 21: 59–66
   PubMed Web of Science ®Google Scholar
• Sherritt M. A., Oksenberg J., de Rosbo N. K., Bernard C. C. Influence of HLA-DR2, HLA-DPw4, and T cell receptor alpha chain genes on the susceptibility to multiple sclerosis. M. Immunol. 1992; 4: 177–181
   Google Scholar
• Oksenberg J. R., Stuart S., Begovich A. B., Bell R. B., Erlich H. A., Steinman L, et al. Limited heterogeneity of rearranged T-cell receptor V alpha transcripts in brains of multiple sclerosis patients. Nature Sep 5, 1991; 353(6339)94, [published erratum appears in Nature 1990; 345: 344–346
   Google Scholar
• Seboun E., Robinson M. A., Doolittle T. H., Ciulla T. A., Kindt T. J., Hauser S. L. A susceptibility locus for multiple sclerosis is linked to the T-cell receptor beta chain complex. Cell 1989; 57: 1095–1100
   PubMed Web of Science ®Google Scholar
• Fugger L., Sandberg Wollheim M., Morling N., Ryder L. P., Svejgaard A. The germline repertoire of T-cell receptor beta chain genes in patients with relapsing/remitting multiple sclerosis or optic neutritis. Immimogenetics 1990; 31: 278–280
   PubMed Web of Science ®Google Scholar
• Lynch S. G., Rose J. W., Petajan J. H., Leppert M. Discordance of the T-cell receptor alpha-chain gene in familial multiple sclerosis. Neurology 1992; 42: 839–844
   Google Scholar
• Hashimoto L. L., Mak T. W., Ebers G. C. T cell receptor alpha chain polymorphisms in multiple sclerosis. J. Neuroimmunol. 1992; 40: 41–48
   Google Scholar
• Hillert J., Leng C., Olerup O. No association with germline Tcell receptor beta-chain gene alleles or haplotypes in Swedish patients with multiple sclerosis. J. Neuroimmunol. 1991; 32: 141–147
   Google Scholar
• Oksenberg J. R., Stuart S., Begovich A. B., Bell R. B., Erlich H. A., Steinman L., et al. Limited heterogeneity of rearranged T-cell receptor V alpha transcripts in brains of multiple sclerosis patients. Nature 1991; 353: 94
   Google Scholar
• Rodriguez M., Oleszak E., Leibowitz J. Theiler's murine encephalomyelitis: a model of demyelination and persistence of virus. Crit. Rev. Immunol. 1987; 7: 325–365
   PubMed Web of Science ®Google Scholar
• Yamada M., Zurbriggen A., Fujinami R. S. Pathogenesis of Theiler's murine encephalomyelitis virus. Adv. Virus. Res. 1991; 39: 291–320
   Google Scholar
• Welsh C. J., Tonks P., Borrow P., Nash A. A. Theiler's virus: an experimental model of virus-induced demyelination. Autoimmunity 1990; 6: 105–112
   Web of Science ®Google Scholar
• Rodriguez M., David C. S. Demyelination induced by Theiler's virus: influence of the H-2 haplotype. J. Immunol. 1985; 135: 2145–2148
   Google Scholar
• Rodriguez M., Leibowitz J., David C. S. Susceptibility to Theiler's virus-induced demyelination. Mapping of the gene within the H-2D region. J. Exp. Med. 1986; 163: 620–631
   Google Scholar
• Clatch R. J., Lipton H. L., Miller S. D. Characterization of Theiler's murine encephalomyelitis virus (TMEV)-specific delayed-type hypersensitivity responses in TMEV-induced demyelinating disease: correlation with clinical signs. J. Immunol. 1986; 136: 920–927
   PubMed Web of Science ®Google Scholar
• Patick A. K., Pease L. R., David C. S., Rodriguez M. Major histocompatibility complex-conferred resistance to Theiler's virus-induced demyelinating disease is inherited as a dominant trait in B10 congenic mice. J. Virol. 1990; 64: 5570–5576
   Google Scholar
• Melvold R. W., Jokinen D. M., Knobler R. L., Lipton H. L. Variations in genetic control of susceptibility to Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. I. Differences between susceptible SJL/J and resistant BALB/c strains map near the T cell beta-chain constant gene on chromsome 6. J. Immunol. 1987; 138: 1429–1433
   Google Scholar
• Kappel C. A., Dal Canto M. C., Melvold R. W., Kim B. S. Hierarchy of effects of the MHC and T cell receptor beta-chain genes in susceptibility to Theiler's murine encephalomyelitis virus-induced demyelinating disease. J. Immunol. 1991; 147: 4322–4326
   Google Scholar
• Lipton H. L., Melvold R. Genetic analysis of susceptibility to Theiler's virus-induced demyelinating disease in mice. J. Immunol. 1984; 132: 1821–1825
   Google Scholar
• Bureau J. F., Montagutelli X., Lefebvre S., Guenet J. L., Pla M., Brahic M. The interaction of two groups of murine genes determines the persistence of Theiler's virus in the central nervous system. J. Virol. 1992; 66: 4698–4704
   Google Scholar
• Melvold R. W., Jokinen D. M., Miller S. D., Dal Canto M. C., Lipton H. L. Identification of a locus on mouse chromosome 3 involved in differential susceptibility to Theiler's murine encephalomyelitis virus-induced demyelinating disease. J. Virol. 1990; 64: 686–690
   PubMed Web of Science ®Google Scholar
• Rodriguez M., Patick A. K., Pease L. R., David C. S. Role of T cell receptor V beta genes in Theiler's virus-induced demyelination of mice. J. Immunol. 1992; 148: 921–927
   Google Scholar
• Rodriguez M., Leibowitz J. R., Lampert P. W. Persistent infection of oligodendrocytes in Theiler's virus-induced encephalomyelitis. Ann. Neurol. 1983; 13: 426–433
   PubMed Web of Science ®Google Scholar
• Rodriguez M., Lindsley M. D., Pierce M. L. Role of T cells in resistance to Theiler's virus infection. Microb. Pathog. 1991; 11: 269–281
   Google Scholar
• Rodriguez M., Nickerson C, Patick A. K., David C. S. Expression of human HLA-B27 transgene alters susceptibility to murine Theiler's virus-induced demyelination. J. Immunol. 1991; 146: 2596–2602
   Google Scholar
• Chamorro M., Aubert C., Brahic M. Demyelinating lesions due to Theiler's virus are associated with ongoing central nervous system infection. J. Virol. 1986; 57: 992–997
   Google Scholar
• Rodriguez M., Patick A. K., Pease L. R. Abrogation of resistance to Theiler's virus-induced demyelination in C57BL mice by total body irradiation. J. Neuroimmunol 1990; 26: 189–199
   PubMed Web of Science ®Google Scholar
• Paya C. V., Patick A. K., Leibson P. J., Rodriguez M. Role of natural killer cells as immune effectors in encephalitis and demyelination induced by Theiler's virus. J. Immunol. 1989; 143: 95–102
   PubMed Web of Science ®Google Scholar
• Rodriguez M., Kenny J. J., Thiemann R. L., Woloschak G. E. Theiler's virus-induced demyelination in mice immunosuppressed with anti-IgM and in mice expressing the xid gene. Microb. Pathog. 1990; 8: 23–35
   PubMed Web of Science ®Google Scholar
• Lindsley M. D., Thiemann R., Rodriguez M. Cytotoxic T cells isolated from the central nervous systems of mice infected with Theiler's virus. J. Virol. 1991; 65: 6612–6620
   Google Scholar
• Rodriguez M., Dunkel A. J., Thiemann R. L., Leibowitz J., Zijlstra M., Jaenisch R. Abrogation of resistance to Theiler's virus-induced demyelination in H-2b mice deficient in beta 2-microglobulin. J. Immunol. 1993; 151: 266–276
   Google Scholar
• Fiette L., Aubert C., Brahic M., Rossi C. P. Theiler's virus infection of beta 2-microglobulin-deficient mice. J. Virol. 1993; 67: 589–592
   Google Scholar
• Pullen L. C., Miller S. D., Dal Cant M. C., Kim B. S. Class I-deficient resistant mice intracerebrally inoculated with Theiler's virus show an increased T cell response to viral antigens and susceptibility to demyelination. Eur. J. Immunol. 1993; 23: 2287–2293
   Google Scholar
• Lipton H. L., Canto C. D. Contrasting effects of immuno-suppression on Theiler's virus infection in mice. Infect. Immun. 1977; 15: 903–909
   Google Scholar
• Roos R. P., Firestone S., Wollmann R., Variakojis D., Arnason B. G. The effect of shore-term and chronic immunosuppression on Theiler's virus demyelination. J. Neuroimmunol. 1982; 2: 223–234
   PubMed Web of Science ®Google Scholar
• Rodriguez M., Quddus J. Effect of cyclosporin A, silica quartz dust, and protease inhibitors on virus-induced demyelination. J. Neuroimmunol. 1986; 13: 159–174
   PubMed Web of Science ®Google Scholar
• Rodriguez M., Sriram S. Successful therapy of Theiler's virus-induced demyelination (DA strain) with monoclonal anti-Lyt-2 antibody. J. Immunol. 1988; 140: 2950–2955
   PubMed Web of Science ®Google Scholar
• Welsh C. J., Tonks P., Nash A. A., Blakemore W. F. The effect of L3T4 T cell depletion on the pathogenesis of Theiler's murine encephalomyelitis virus infection in CBA mice. J. Gen. Virol. 1987; 68: 1659–1667
   PubMed Web of Science ®Google Scholar
• Rodriguez M., Lafuse W. P., Leibowitz J., David C. S. Partial suppression of Theiler's virus-induced demyelination in vivo by administration of monoclonal antibodies to immune-response gene products (la antigens). Neurology 1986; 36: 964–970
   PubMed Web of Science ®Google Scholar
• Rodriguez M., Lindsley M. D. Immunosuppression promotes CNS remyelination in chronic virus-induced demyelinating disease. Neurology 1992; 42: 348–357
   PubMedGoogle Scholar
• Gerety S. J., Clatch R. J., Lipton H. L., Goswami R. G., Rundell M. K., Miller S. D. Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus-induced demyelinating disease. IV. Identification of an immunodominant T cell determinant on the N-terminal end of the VP2 capsid protein in susceptible SJL/J mice. J. Immunol. 1991; 146: 2401–2408
   Google Scholar
• Miller S. D., Gerety S. J., Kennedy M. K., Peterson J. D., Trotter J. L., Tuohy V. K., et al. Clas II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. III. Failure of neuroantigen-specific immune tolerance to affect the clinical course of demyelination. J. Neuroimmunol. 1990; 26: 9–23
   PubMed Web of Science ®Google Scholar
• Rosenthal A., Fujinami R. S., Lampert P. W. Mechanism of Theiler's virus-induced demyelination in nude mice. Lab. Invest. 1986; 54: 515–522
   Google Scholar
• Love S. Distribution of Theiler's virus in the CNS of athymic nude mice: effect of varying the route of inoculation. J. Neurol. Sci. 1987; 81: 55–66
   Google Scholar