20
Views
20
CrossRef citations to date
0
Altmetric
Original Article

Association between Antibodies to the MR 67,000 Isoform of Glutamate Decarboxylase (GAD) and Type 1 (Insulin-Dependent) Diabetes Mellitus with Coexisting Autoimmune Polyendocrine Syndrome Type II

, , , , , & show all
Pages 231-238 | Received 01 Sep 1994, Accepted 29 Nov 1994, Published online: 07 Jul 2009

References

  • Bottazzo G. F, Doniach D. Polyendocrine autoimmunity: an extended concept. Autoimmunity and endocrine disease, R. Volpe. Marcel/Dekker Inc., New York 1985; 375–403
  • Bottazzo G. F., Todd I., Mirakian R., Belfiore A., Pujol-Borrell R. Organ-specific autoimmunity. A 1986 overview. Immunol. Rev. 1986; 94: 137–169
  • Muir A., MacLaren N. K. Autoimmune diseases of the adrenal glands, parathyroid glands, gonads, and hypothalamic-pituitary axis. Endorin. Metab. Clin. 1993; 20: 619–643
  • Banga J. P., Barnett P. S., Mahadevan D., McGregor A. M. Immune recognition of antigen and its relevance to autoimmune disease: recent advances on the molecular level. Europ. J. Clin. Invest. 1989; 19: 107–116
  • Tarn A. C., Thomas J. M., Dean B. M., et al. Predicting insulin-dependent diabetes. Lancet 1988; 845–850
  • Riley W. J., MacLaren N. K., Kirscher J., Spillar R. P., Silverstein J. H., Schatz D. A., et al. A prospective study of the development of diabetes in relatives of patients with insulin-dependent diabetes. N. Engl. J. Med. 1990; 323: 1167–1172
  • Genovese S., Bonifacio E., McNally J. M., Dean B. M., Wagner R., Bosi E., et al. Distinct cytoplasmic islet cell antibodies with different risks for type 1 (insulin-dependent) diabetes mellitus. Diabetologia. 1992; 35: 385–388
  • Scherbaum W. A. Cytoplasmic islet cell antibodies (ICA): towards a molecular understanding of the autoantigens. Clin. Endocrin. 1994; 40: 15–18
  • Richter W., Seissler J., Northemann W., Wolfahrt S., Meinck H. M., Scherbaum W. A. Cytoplasmic islet cell antibodies recognize distinct antigens in IDDM but not in Stiff Man Syndrome. Diabetes 1993; 42: 1642–1648
  • Baekkeskov S., Aanstoot A. J., Christgau S., Reetz A., Solimena M., Cascalho M., et al. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 1990; 347: 151–156
  • Karlsen A. E., Hagopian W. A., Grubin C. E., Dube S., Distech C. M., Adler D. A., et al. Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10. Proc. Natl Acad. Sci. 1991; 88: 8337–8341
  • Seissler J., Amann J., Mauch L, Haubruck H., Wolfahrt S., Bieg S., et al. Prevalence of autoantibodies to the 65-and 67-kD isoforms of glutamate decarboxylase in insulin-dependent diabetes mellitus. J. Clin. Invest. 1993; 92: 1394–1399
  • Hagopan W. A., Michelsen B., Karlsen A. E., Larsen F., Moody A., Grubin C. E., et al. Autoantibodies in IDDM primarily recognize the 65,000-Mr rather than the 67,000-Mr isoform of glutamic acid decarboxylase. Diabetes 1993; 42: 631–636
  • Solimena M., Folli F., Aparisi R., Pozza G., de Camilli P. Autoantibodies to GABA-eric neurons and pancreatic beta cells in Stiff-Man Syndrome. N. Engl. J. Med. 1990; 322: 1555–1560
  • Mauch L., Seissler J., Haubruck H., Cook N., Abney C. C., Berthold H., et al. Baculovirus mediated expression of human 65a and 67 KDa glutamic acid decarboxylase in SF9 insect cells and their relevance in diagnosis of insulin-dependent diabetes mellitus. J. Biochem. 1993; 113: 699–704
  • Schmidli R TS, Colman P. G., Bonifacio E., Bottazzo G. F., Harrison L. C. High level of concordance between assays for glutamic acid decarboxylase antibodies. The first interbational glutamic acid decarboxylase antibody workshop. Diabetes 1994; 43: 1005–1009
  • Scherbaum W. A., Mirakian A. R., Pujol-Borrell R., Dean M., Bottazzo G. F. Immunochemistry in the study and diagnosis of organ-specific autoimmune diseases. Immunochemistry. Modern Methods and Applications, J. M. Polak, S. Van Noorden. Wirght, Bistrol 1986; 456–476
  • Betterle C. F., Zanette F., Pedini B., Presotto F., Rapp L. B., Monciotto C. M., et al. Clinical and subclinical organ-specific autoimmune manifestations in Type 1 (insulin-dependent) diabetic patients and their first degree relatives. Diabetologia. 1984; 26: 431–436
  • Bjork E., Velloso L. A., Kampe O., Karlsson F. A. GAD autoantibodies in IDDM. Stiff-Man Syndrome and autoimmune polyendocrine syndrome Type I recognize different epitopes. Diabetes 1993; 43: 161–165
  • Velloso L. A., Winqvist O., Gustafsson J., Kampe O., Karlsson F. A. Autoantibodies against a novel 51 KDa islet antigen and glutamate decarboxylase isoforms in autoimmune polyendocrine syndrome Type 1. Diabetologia. 1994; 37: 61–69
  • Kim J., Richter W., Aanstoot H. J., Beakkeskov S. Differential expression of GAD65 and GAD67 in human, rat, and mouse pancreatic islets. Diabetes 1993; 42: 1799–1808
  • Christie M. R., Brown T. J., Cassidy D. Binding of autoantibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia. 1992; 35: 380–384
  • Ujihara N., Daw K., Gianini R., Boel E., Yu L., Powers A. C. Identification of glutamic acid decarboxylase autoanti-body heterogeneity and epitope regions in Type 1 diabetes. Diabetes 1994; 43: 968–975
  • Kawasaki E., Takino H., Yano M., Uotani S., Matsumoto K., Takao Y., et al. Autoantibodies to glutamic acid decarboxylase in patients with IDDM and autoimmune thyroid disease. Diabetes 1994; 43: 80–86.S.
  • Wagner R., Genovese S., Bosi E., Becker F., Singly P. J., Bonifacio E., et al. Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia. 1994; 37: 365–371
  • Wagner R., McNally J. M., Bonifacio E., Genovese S., Foulis A., McGill M., et al. Lack of immunohistochemical changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-selective GAD-specific islet cell antibodies. Diabetes 1994; 43: 851–856

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.