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Original Article

Molecular Characterization of Monoclonal IgM Derived from Human B Cell Lines Expressing the 4C9 Rheumatoid Factor Associated Idiotype

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Pages 171-183 | Received 13 Apr 1995, Published online: 07 Jul 2009

References

  • Carson D. A. Rheumatoid factor. Textbook of RheumatologyThird Edition, W. M. Kelley, E. D. Harris, S. Ruddy, C. B. Sledge. WB Saunders, Philadelphia 1989; 198–207
  • Crowley J. J., Goldfien R. D., Schrohenloher R. E., et al. Incidence of three crossreactive idiotypes on human rheumatoid factor paraproteins. J. Immunol. 1988; 140: 3411–3418
  • Carson D. A., Chen P. P., Fox R. I., et al. Rheumatoid factor and immune networks. Ann. Rev. Immunol. 1987; 5: 109–126
  • Chen P. P., Silverman G. J., Liu M. F., Carson D. A. Idiotypic and molecular characterization of human rheumatoid factors. Chem. Immunol 1990; 48: 63–81
  • Schrohenloher R. E., Accavitti M. A., Bhown A. S., Koopman W. J. Monoclonal antibody 6B6.6 defines a cross-reactive kappa light chain idiotype on human monoclonal and polyclonal rheumatoid factors. Arthritis Rheum. 1990; 33: 187–198
  • Koopman W. J., Schrohenloher R. E., Carson D. A. Dissociation of expression of two rheumatoid factor cross-reactive light chain idiotypes in rheumatoid arthritis. J. Immunol. 1990; 144: 3468–3472
  • Youngblood K., Fruchter L., Ding G., et al. Rheumatoid factors from the periperhal blood of two patients with rheumatoid arthritis are genetically heterogeneous and somatically mutated. J. Clin. Invest. 1994; 93: 852–861
  • Sasso E. H. Immunoglobulin V region genes in rheumatoid arthritis. Rheum. Dis. Clin. N. Am. 1992; 18: 809–836
  • Davidson A., Lopez J., Sun D., Prus D. A monoclonal anti-idiotype specific for human polyclonal IgM rheumatoid factor. J. Immunol. 1992; 148: 3873–3878
  • Davidson A., Keiser H. D., del Puente A., et al. Expression of Rheumatoid Factor Idiotypes 17.109, 6B6.6 and 4C9 in the sera of Pima Indians. Autoimmunity 1994; 18: 251–258
  • Manheimer-Lory A., Davidson A., Watkins D. Generation and analysis of clonal IgM and IgG producing human B cell lines expressing an anti-DNA-associated idiotype. J. Clin. Invest 1991; 87: 1519–1525
  • Davidson A., Manheimer-Lory A., Aranow C., et al. Molecular characterization of a somatically mutated anti-DNA antibody bearing two Systemic Lupus Erythematosus-related idiotypes. J. Clin. Invest. 1990; 85: 1401–1409
  • Lee S. K., Bridges S. L., Jr., Koopman W. J., Schroeder H. W., Jr. The immunoglobulin kappa light chain repertoire expressed in the synovium of a patient with rheumatoid arthritis. Arthritis Rheum. 1992; 35: 905–913
  • Irigoyen M., Manheimer-Lory A., Gaynor B., Diamond B. Molecular analysis of the human immunoglobulin V II gene family. J. Clin. Invest. 1994; 94: 532–538
  • Potter K. N., Li Y., Pascual V., et al. Molecular characterization of a cross-reactive idiotope on human immunoglobulins utilizing the VH4–21 gene segment. J. Exp. Med. 1993; 178: 1419–1428
  • Martin T., Duffy S. F., Carson D. A., Kipps T. J. Evidence for somatic selection of natural autoantibodies. J. Exp. Med. 1992; 175: 983–991
  • Lee S. K., Bridges S. L., Jr., Kirkham P. M., et al. Evidence of antigen receptor-influenced oligoclonal B lymphocyte expansion in the synovium of a patient with longstanding Rheumatoid Arthritis. J. Clin. Invest. 1994; 93: 361–370
  • Victor K. D., Randen I., Thompson K., et al. Rheumatoid factors isolated from patients with autoimmune disorders are derived from germline genes distinct from those encoding the Wa, Po and Bla cross-reactive idiotypes. J. Clin. Invest. 1991; 87: 1603–1613
  • Martin T., Blaison G., Levallois H., Pasquali J. L. Molecular analysis of the VkIII-Jk junctional diversity of polyclonal rheumatoid factors durign rheumatoid arthritis frequently reveals N addition. Eur. J. Immunol. 1992; 22: 1773–1779
  • Potter K. N., Li Y. C., Capra J. D. The cross-reactive idiotopes recognized by the monoclonal antibodies 9G4 and LCI are located in framework region 1 of two non-overlapping subsets of human VH4 family encoded antibodies. Scand. J. Immunol. 1994; 40: 43–49
  • Jerne N. K. Towards a network theory of the immune system. Ann. Immunol. (Inst. Pasteur.) 1974; 125C: 373–389
  • Kearney J. F., Battels J., Hamilton A. M., et al. Development of function of the early B cell repertoire. Int. Rev. Immunol. 1992; 8: 247–257
  • Bogen B., Weiss S. Processing and presentation of idiotypes to MHC-restricted T cell. Int. Rev. Immunol. 1993; 10: 337–335
  • Yamamoto H. Idiotype-dependent repertoire generation in the Network System. Critical Reviews in Immunology. 1993; 13: 151–161
  • Olee T., Yang P. M., Siminovitch K. A., et al. Molecular basis of an autoantibody-associated restriction fragment length polymorphism that confers susceptibility to autoimmune diseases. J. Clin. Invest. 1991; 88: 193–203
  • Kuppers R., Fischer U., Rajewsky K., Gause A. Immunoglobulin heavy and light chain gene sequences of a human CD5 positive immunocytoma and sequences of four novel VHIII germline genes. Immunol. Lett. 1992; 34: 57–62
  • Raaphorst F. M., Timmers E., Renter M. J. H., Van Tol M. J. D., Vossen J. M., Schuurman R. K. B. Restricted utilization of germ-line Vh3 elements and short diverse third complementarily-determining regions (CDR3) in human fetal immunoglobulin heavy chain rearrangements. Eur. J. Immunol. 1992; 22: 247–251
  • Pascual V., Capra J. Human immunoglobulin heavy chain variable region genes—organization, polymorphism and expression. Adv. Immunol. 1991; 49: 1–74

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