Increased Activation and Altered Ratio of Interferon-Gamma: Interleukin-4 Secreting Cells in MRL-lpr/lpr Mice

References

• Morse H. C., Davidson W. F., Yetter R. A., Murhpy E. D., Roths J. B., Coffman R. L. Abnormalities induced by the mutant gene lpr: expansion of a unique lymphocyte subset. J. Immunol. 1982; 129: 2612–2615
   PubMed Web of Science ®Google Scholar
• Murphy E. D. Lymphoproliferation (lpr) and other single locus models for murine lupus. Immunologic Defects in Laboratory Animals, E. M. Gershwin, B. Merchant. Plennum Press, New York 1981; Volume II: 143–173
   Google Scholar
• Roth J. B., Murphy E. D., Eicher E. M. A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice. J. Exp. Med. 1984; 159: 1–9
   Google Scholar
• Bielschowsky M., Helyer B. J., Howie J. B. Spontaneous anemia in mice of the NZB/BL strain. Proc. Univ. Otago. Med. Sch. 1959; 37: 9–25
   Google Scholar
• Cohen P. L., Eisenberg R. A. Lpr and gld: Single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol. 1991; 9: 243–269
   PubMed Web of Science ®Google Scholar
• Watanabe-Fukunaga R., Brannan C. I., Copeland N. G., Jenkins N. A., Nagata S. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 1992; 356: 314–317
   PubMed Web of Science ®Google Scholar
• Parronchi P., DcCarli M., Manetti R., et al. IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by TH1 or TH2 human T cell clones. J. Immunol. 1992; 149: 2977–2983
   PubMed Web of Science ®Google Scholar
• Tanaka T., Hu-Li J., Seder R. A., Fazekas de St. Groth B., Paul W. E. IL-4 suppresses IL-2 and IFNYamma production by naive T cells stimualted by accessory cell- dependent receptor engagement. Proc. Natl Acad. Sci. USA 1993; 90: 5914–5918
   Google Scholar
• Paul W. E. Pleiotropy and redundancy: T cell-derived lymphokines in the immune response. Cell 1989; 57: 521–524
   PubMed Web of Science ®Google Scholar
• Balkwill F. R., Burke F. The cytokine network. Immunol. Today 1989; 10: 299–304
   PubMedGoogle Scholar
• Jacob C. O. TNF and IFN-gamma: relevance for immune regulation and genetic predisposition to autoimmune disease. Semin. Immunol. 1992; 3: 147–154
   Google Scholar
• Snapper C. M., Paul W. E. Interferon gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 1987; 236: 944–947
   PubMed Web of Science ®Google Scholar
• Finkleman F. D., Katona I. M., Mosmann T. R., Coffman R. C. Interferon gamma regulates the isotype of Ig secreting during in vivo humoral responses. J. Immunol. 1988; 140: 1022–1030
   Google Scholar
• Seder R. A., Paul W. E., Mark M. D., Fazelas de St. Groth B. The presence of IL-4 during in vitro proming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. J. Exp. Med. 1992; 176: 1091–1098
   PubMed Web of Science ®Google Scholar
• Mosmann T. R., Cherwinski H., Bond M. W., Giedlin M. A., Coffman R. L. Two types of murine helper T cell clones. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 1986; 136: 2348–2357
   PubMed Web of Science ®Google Scholar
• Croft M., Swain S. L. B cell response to fresh and effector T chelper cells: role of cognate T-B interaction and the cytokines IL-2, IL-4 and IL-6. J. Immunol. 1991; 146: 4055–4064
   PubMedGoogle Scholar
• Moore K. W., Vieira P., Fiorentino D. R., Trounstine M. L., Dhan T., Mosmann T. R. Homology of cytokine synthesis inhibitory factor (IL-10) to the EBV gene BCRFI. Science 1990; 248: 1230–1234
   PubMed Web of Science ®Google Scholar
• Pearce E. J., Caspar P., Grzych J. M., Lewis F. A., Sher A. Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni. J. Exp. Med. 1991; 173: 159–168
   PubMed Web of Science ®Google Scholar
• Heinzel F. P., Sadick M. D., Mutha S. S., Locksley R. M. Production of IFN gamma, IL-2, IL-4 and IL-10 by CD4 +lymphocytes in vivo during healing and progressive murine leishmaniasis. Proc. Natl Acad. Sci. 1991; 88: 7011–7015
   PubMed Web of Science ®Google Scholar
• Tanaka Y., Kazuyoshi S., Shirakawa F., et al. Production of B-cell stimulatory factors by B cells in patients with SLE. J. Immunol. 1988; 141: 3043–3050
   PubMed Web of Science ®Google Scholar
• Yokoyama H., Takabatake T., Takceda M., Wada T. Up-regulated MHC-class II expression and gamma-IFN and soluble IL-2R in lupus nephritis. Kidney Int. 1992; 42: 755–763
   Google Scholar
• Ai-Janadi M., Ai-Balla S., Ai-Dalaan A., Raziuddin S. Cytokine profile in SLE, RA and other rheumatic diseases. J. Clin. Invest. 1993; 13: 58–67
   Google Scholar
• Dueymes M., Barrier J., Beseancenot J. F., et al. Relationship of IL-4 to isotypic distribution of anti-DS DNA antibodies in SLE. Int. Arch. Aller. Appl. Immunol. 1993; 101: 408–415
   Google Scholar
• Klinman D. M. IgG1 and IgG2a production by autoimmune B cells treated in vitro with IL-4 and IFN-gamma. J. Immunol. 1990; 144: 2529–2534
   PubMed Web of Science ®Google Scholar
• Davidson W., Calkins C., Hugin A., Giese T., Holmes K. Cytokine Secretion by C3H-lpr and -gld T cells. J. Immunol. 1991; 146: 4138–4148
   PubMed Web of Science ®Google Scholar
• Murray L. J., Lee R., Martens C. In vitro cytokine gene expression in T cell subsets of the autoimmune MRL/Mp-lpr/lpr mouse. Eur. J. Immunol. 1990; 20: 163–170
   PubMed Web of Science ®Google Scholar
• Rosenberg Y. J., Steinberg A. D., Santoro T. J. The basis of autoimmunity in MRL-lpr/lpr mice: a role for self la-reactive T cells. Immunol. Today 1984; 5: 64–67
   PubMedGoogle Scholar
• Budd R., Schumacher J., Winslow G., Mosmann T. Elevated Production of Interferon-Gamma and Interleukin 4 by Mature T Cells form Autoimmune lpr mice Correlates with Pgp-1 (CD44) expression. Eur. J. Immunol. 1991; 21: 1081–1084
   PubMedGoogle Scholar
• Shirai A., Holmes K., Klinman D. M. Detection and quantitation of cells secreting IL-6 under physiological conditions in BALB/c mice. J. Immunol. 1993; 150: 793–799
   PubMedGoogle Scholar
• Shirai A., Sierra V., Kelly C. I., Klinman D. M. Individual cells simultaneously produce both IL-4 and IL-6 under physiologic conditions in vivo. Cytokine 1994; 6: 329–336
   PubMedGoogle Scholar
• Klinman D. M., Nutman T. B. ELIspot assay to detect cytokine-secreting murine and human cells. Current Protocols in Immunology, J. E. Coligan, A. M. Kruisbcek, D. H. Margulies, E. M. Shevach, W. Strober. Greene Publishing Associates, Brooklyn, NY 1994
   Google Scholar
• Mo X. Y., Sarawar S. R., Doherty P. C. Induction of cytokines in mice with parainflucnza pneumonia. J. Virol. 1995; 69: 1288–1291
   PubMed Web of Science ®Google Scholar
• Tanguay S., Killion J. J. Direct comparison of ELIspot and ELISA based assays for detection of individual cytokine-secreting cells. Lymph. Cyto. Res. 1994; 13: 259–263
   PubMedGoogle Scholar
• Muller I., Kropf P., Louis J. A., Milon G. Expansion of gamma interferon-producing CDS + T cells following secondary infection of mice immune to L. major. Infect. and Immun. 1994; 62: 2575–2581
   PubMed Web of Science ®Google Scholar
• Semple J., Allen D., Chang W., Castaldi P., Frcedman J. Rapid separation of CD4 + and CD19 + lymphocyte populations from human peripheral blood by a magnetic activated cell sorter (MACS). Cytometry 1993; 14: 955–960
   PubMedGoogle Scholar
• Sedgwick J. D., Holt P. G. A solid phase immunoenzy-matic technique for the enumeration of specific antibody secreting cells. J. Immunol. Methods 1983; 57: 301–309
   PubMed Web of Science ®Google Scholar
• Mori K., Kobayashi S., Inobe M., et al. In vivo Cytokine Gene Expression in Various T Cell Subsets of the Autoimmune MRL/Mp-lpr/lpr Mouse. Autoimmunity 1994; 17: 49–57
   PubMed Web of Science ®Google Scholar
• Giese T., Davidson W. F. Evidence for early onset, polyclonal activation of T cell subsets in mice homozygous for lpr. J. Immunol. 1992; 149: 156
   Google Scholar
• Tatakoff A. M. Perturbation of vesicular traffic with the carboxylic ionophore monensin. Cell 1983; 32: 1026–1028
   Google Scholar
• Mosmann T. R., Coffman R. L. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 1989; 7: 147–171
   Google Scholar
• Klinman D. M., Eisenberg R. A., Steinberg A. D. Development of the autoimmune B cell repertoire in MRL-lpr/lpr mice. J. Immunol. 1990; 1440: 506–512
   Google Scholar
• Rozzo S. J., Drake C. G., Chiang B. L., Gershwin M. E., Kotzin B. L. Evidence for polyclonal T cell activation in murine models of SLE. J. Immunol. 1994; 153: 1340–1351
   PubMed Web of Science ®Google Scholar
• Herron L. R., Eisenberg R. A., Roper I., Kakkanaiah V. N., Kotzin B. L. Selection of the T cell receptor repertoire in lpr mice. J. Immunol. 1993; 151: 3450–3459
   PubMed Web of Science ®Google Scholar