14
Views
13
CrossRef citations to date
0
Altmetric
Original Article

Immunoglobulin Gene Sequence Anlaysis of Anti-Cardiolipin and Anti-Cardiolipin Idiotype (H3) Human Monoglonal Antibodies

, , , &
Pages 49-57 | Received 03 Oct 1995, Published online: 07 Jul 2009

References

  • Harris E N, Gharavi A. E, Hughes G. R. Anti-phospholipid antibodies. Clin. Rheum. Dis. 1985; 11: 591–609
  • McNeil H. P., Chesterman C. N., Krills S. A. Immunology and clinical importance of antiphospholipid antibodies. Adv. Immunol. 1991; 49: 193–280
  • Branch D. W., Dudley D. J., Mitchell M. D., Creighton K. A., Abbott T. M., Hammond E. H., Daynes R. A. Immunoglobulin G fractions from patients with antiphospholipid antibodies cause fetal death in BALB/c mice: a model for autoimmune fetal loss. Am. J. Obstet. Gynecol. 1990; 163: 210–216
  • Hashimoto Y., Kawamura M., Ichikawa K., Suzuki T., Sumida T., Yoshida S., Matsuura E., Ikehara S., Koike T. Anticardiolipin antibodies in NZW × BXSB F1 mice. A model of antiphospholipid syndrome. J. Immunol. 1992; 149: 1063–1068
  • Vianna J. L., Trotter S., Khamashta M. A., Chikte S., Olsen E., Hughes G. R. The heart and antiphospholipid antibodies in MRL-lpr/lpr mice. Lupus. 1992; 1: 357–361
  • Smith H. R., Hansen C. L., Rose R., Canoso R. T. Autoimmune MRL-1 pr/lpr mice are an animal model for the secondary antiphospholipid syndrome. J. Rheumatol. 1990; 17: 911–915
  • Ichikawa K., Suzuki T., Hashimoto Y., Sumida T., Tomioka H., Yoshida S., Koike T. Monoclonal autoantibodies to cardiolipin derived from SLE mice. Lupus. 1992; 1: 239–247
  • Diamond B., Datz J. B., Paul E., Aranow C., Lustgarten D., Scharff M. D. The role of somatic mutation in the pathogenic anti-DNA response. Ann. Rev. Immunol. 1992; 10: 731–757
  • Marion T. N., Tillman D. M., Jou N. T., Hill R. J. Selection of immunoglobulin variable regions in autoimmunity to DNA. immunol. Rev. 1992; 128: 123–149
  • Shefner R., Mayer R., Kaushik A., D'Eustachio P., Bona C., Diamond B. Identification of a new V kappa gene family that is highly expressed in hybridomas from an autoimmune mouse strain [see comments]. J. Immunol. 1990; 145: 1609–1614
  • Hirabayashi Y., Munakata Y., Takai O., Shibata S., Sasaki T., Sano H. Human B-cell clones expressing lupus nephritis-associated anti-DNA idiotypes are preferentially expanded without somatic mutation. Scand. J. Immunol. 1993; 37: 533–540
  • Randen I., Thompson K. M., Pascual V., Victor K., Beale D., Coadwell J., Forre O., Capra J. D., Natvig J. B. Rheumatoid factor V genes from patients with rheumatoid arthritis are diverse and show evidence of an antigen-driven response. Immunol. Rev. 1992; 128: 49–71
  • Chen P. P., Liu M. F., Sinha S., Carson D. A. A 16/6 idiotype-positive anti-DNA antibody is encoded by a conserved VH gene with no somatic mutation. Arthritis Rheum. 1988; 31: 1429–1431
  • Dersimonian H., Schwartz R. S., Barrett Stollar K. J. B.D. Relationship of human variable region heavy chain germline genes to genes encoding anti-DNA autoantibodies. J. Immunol. 1987; 139: 2496–2501
  • Sanz I. Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions. J. Immunol. 1991; 147: 1720–1729
  • Goodnow C., Crosbie J., Jorgensen H., Brink R. A., Basten A. Induction of self tolerance in mature periferal B lymphocytes. Nature 1989; 342: 385–391
  • Erikson J., Radic M. Z., Camper S. A., Hardy R. R., Carmack C., Weigert M. Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice. Nature 1991; 349: 331–334
  • Okamoto M., Murakami M., Shimizu A., Ozaki S., Tsubata T., Kumagai S., Honjo T. A transgenic model of autoimmune hemolytic anemia. J. Exp. Med. 1992; 175: 71–79
  • Iliev A., Spatz L., Ray S., Diamond B. Lack of allelic exclusion permits autoreactive B cells to escape delection. J. Immunol. 1994; 153: 3551–3556
  • Shoenfeld Y., Rauch J., Massicotte H., Datta S. K., Andre Schwartz J., Stollar B. D., Schwartz R. S. Polyspecificity of monoclonal lupus autoantibodies produced by human-human hybridomas. N. Engl. J. Med. 1983; 308: 414–420
  • Paul E., Iliev A. A., Livneh A., Diamond B. The anti-DNA-associated idiotype 8.12 is encoded by the V lambda II gene family and maps to the vicinity of L chain CDR1. J. Immunol. 1992; 149: 3588–3595
  • Shefner R., Manheimer Lory A., Davidson A., Paul E., Aranow C., Katz J., Diamond B. Idiotypes in systemic lupus erythematosus. Clues for understanding etiology and pathogenicity. Chem. Immunol. 1990; 48: 82–108
  • Muryoi T., Sasaki T., Hatakeyama A., Shibata S., Suzuki M., Seino J., Yoshinage K. Clonotypes of anti-DNA antibodies expressing specific idiotypes in immune complexes of patients with active lupus nephritis. J. Immunol. 1990; 144: 3856–3861
  • Sutjita M., Hohmann A., Comacchio R., Boey M. L., Bradley J. A common anti-cardiolipin antibody idiotype in autoimmune disease: identification using a mouse monoclonal antibody directed against a naturally occurring antiphospholipid antibody. Clin. Exp. Immunol. 1989; 75: 211–216
  • Hohmann A., Comacchio R., Boswarva V., Sutjita M., Bradley J. The H3 anti-phospholipid idiotype is found in patients with systemic lupus erythematosus (SLE) but not in patients with syphilis. Clin. Exp. Immunol. 1991; 86: 207–211
  • Bakimer R., Fishman P., Blank M., Sredni B., Djaldetti M., Shoenfeld Y. Induction of primary antiphospholipid syndrome in mice by immunization with a human monoclonal anticardiolipin antibody (H-3). J. Clin. Invest. 1992; 89: 1558–1563
  • Sutjita M., Hohmann A., Comacchio R., Bradley J. Polyspecific human and murine antibodies to diphtheria and tetanus toxoids and phospholipids. Clin. Exp. Immunol. 1988; 73: 191–197
  • Massicotte H., Harley J. B., Bell D. A. Characterization of human-human hybridoma monoclonal anti-Ro (SS-A) autoantibodies derived from normal tonsil lymphoid cells. J. Autoimmun. 1992; 5: 771–785
  • Vasicek T. J., Leder P. Structure and expression of the human immunoglobulin lambda genes. J. Exp. Med. 1990; 172: 609–620
  • Hieter P. A., Maizel J. V., Jr, Leder P. Evolution of human immunoglobulin kappa J region genes. J. Biol. Chem. 1982; 257: 1516–1522
  • Ravetch J. V., Siebenlist U., Korsmeyer S., Waldmann T., Leder P. Structure of the human immunoglobulin mu locus: characterization of embryonic and rearranged J and D genes. Cell. 1981; 27: 583–591
  • Kabat E. A., Wu T. T. Sequences of proteins of Immunological Interest, 4th Ed. United States Department of Health and Human Services, Washington, DC 1987
  • Daley M. D., Peng H., Misener V., Liu X., Chen P. P., Siminovitch K. A. Molecular analysis of human immunoglobulin VΔ germline genes: subgroups VΔIII and VΔIV. Mol. Immunol. 1992; 29: 1515–1518
  • Berman J. E., Mellis S. J., Pollock R., Smith C. L., Suh H., Heinke B., Bowal C., Surti U., Chess L., Cantor C. R., Alt F. W. Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus. EMBO. J. 1988; 7: 727–738
  • Robbins D. L., Kenny T. P., Coloma M. J., Gavilondo Cowley J. V., Soto Gil R. W., Chen P. P., Larrick J. W. Serologic and molecular characterization of a human monoclonal rheumatoid factor derived from rheumatoid synovial cells. Arthritis. Rheum. 1990; 33: 1188–1195
  • Weng N. P., Yu Lee L. Y., Sanz I., Patten B. M., Marcus D. M. Structure and specificities of anti-ganglioside autoantibodies associated with motor neuropathies. J. Immunol. 1992; 49: 2518–2529
  • Kuppers R., Fischer U., Rajewsky K., Gause A. Immunoglobulin heavy and light chain sequences of a human CD5 positive immunocytoma and sequences of a novel VHIII germline gene Immunol. Lett. 1992; 34: 57–62
  • Kishimoto T., Okajima H., Okumoto T., Taniguchi M. Nucleotide sequences of the cDNAs encoding the V-regions of H-and L-chains of a human monoclonal antibody with broad reactivity to malignant tumor cells. Nucleic. Acids. Res. 1989; 17: 4385
  • van der Maarel S., van Dijk K. W., Alexander C. M., Sasso E H, Bull A., Milner E. C. Chromosomal organization of the human VH4 gene family. Location of individual gene segments. J. Immunol. 1993; 150: 2858–2868
  • Van Es J. H., Aanstoot H., Gamelig Meyling F. H., Derksen R. H., Logtenberg T. A human systemic lupus erythematosus-related anti-cardiolipin/single-stranded DNA autoantibody is encoded by a somatically mutated variant of the developmentally restricted 51 PI VH gene. J. Immunol. 1992; 149: 2234–40
  • Yamada M., Wasserman R., Reichard B. A., Shane S., Caton A. J., Rovera G. Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes. J. Exp. Med. 1991; 173: 395–407
  • Ichihara Y., Abe M., Yasui H., Matsuoka H., Kurosawa Y. At least five DH genes of human immunoglobulin heavy chains are encoded in 9-kilobase DNA fragments. Eur. J. Immunol. 1988; 18: 649–652
  • Ichihara Y., Matsuoka H., Kurosawa Y. Organization of human immunoglobulin heavy chain diversity gene loci. EMBO. J. 1988; 7: 414–450
  • Sonntag D., Weingartner B., Grutzmann R. A member of a novel human DH gene family: DHFL16. Nucleic. Acids. Res. 1989; 17: 1267
  • Chuchana P., Blancher A., Brockly F., Alexandre D., Lefranc G., Lefranc M. P. Definition of the human immunoglobulin variable lambda (IGLV) gene subgroups. Eur. J. Immunol. 1990; 20: 1317–1325
  • Eulitz M., Murphy C., Weiss D. T., Solomon A. Serologic and chemical differentiation of human lambda III light chain variable regions. J. Immunol. 1991; 146: 3091–3096
  • Frippiat J. P., Lefranc M. P. Genomic organisation of 34 kb of the human immunoglobulin lambda locus (IGLV): restriction map and sequences of new V lambda III genes. Mol-Immunol. 1994; 31: 657–670
  • Marks J. D., Hoogenboom H. R., Bonnert T. P., McCafferty J., Griffiths A. D., Winter G. By-passing immunization. Human antibodies from V-gene libraries displayed on phage. J. Mol. Biol. 1991; 222: 581–597
  • Bye J. M., Carter C., Cui Y., Gorick B. D., Songsivilai S., Winter G., Hughes Jones N. C., Marks J. D. Germline variable region gene segment derivation of human monoclonal anti-Rh(D) antibodies. Evidence for affinity maturation by somatic hypermutation and repertoire shift. J. Clin. Invest. 1992; 90: 2481–2490
  • Fang Q., Kannapell C. C., Gaskin F., Solomon A., Koopman W. J., Fu S. M. Human rheumatoid factors with restrictive specificity for rabbit immunoglobulin G: auto-and multi-reactivity, diverse VH gene segment usage and preferential usage and V lambda IIIb. J. Exp. Med. 1994; 179: 1445–1456
  • Tomlinson I. M., Walter G., Marks J. D., Llewelyn M. B., Winter G. The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops. J. Mol. Biol. 1992; 227: 776–798
  • Wong A., Kenny T., Ermel R., Robbins D. Human monoclonal rheumatoid factor derived from rheumatoid synovial cells monospecific for rabbit IgG. J. Rheumatol. 1993; 20: 623–629
  • Huber C., Scllable K. F., Huber E., Klein R., Meindl A., Thiebe R., Lamm R., Zachau H. G. The V kappa genes of the L regions and the repertoire of V kappa gene sequences in the human germ line. Eur. J. Immunol. 1993; 23: 2868–2875
  • Bensimon C., Chastagner P., Zouali M. Human lupus anti-DNA autoantibodies undergo essentially primary V kappa gene rearrangements. EMBO. J. 1994; 13: 2951–2965
  • Siminovitch K. A., Misener V., Kwong P. C., Song Q. L., Chen P. P. A natural autoantibody is encoded by germline heavy and lambda light chain variable region genes without somatic mutation. J. Clin. Invest. 1989; 84: 1675–1678
  • Siminovitch K. A., Misener V., Kwong P. C., Yang P. M., Laskin C. A., Cairns E., Bell D., Rubbin L. A., Chen P. P. A human anti-cardiolipin autoantibody is encoded by developmentally restricted heavy and light chain variable region genes. Autoimmunity. 1990; 8: 97–105
  • Logtenberg T., Young F. M., van Es J., Gmelig Meyling F. H., Berman J. E., Alt F. W. Frequency of VH-gene utilization in human EBV-transformed B-cell lines: the most JH-proximal VH segment encodes autoantibodies. J. Autoimmun. 1989; 2: 203–213
  • Mariette X., Levy Y., Dubreuil M. L., Intrator L., Danon F., Brouet J. C. Characterization of a human monoclonal autoantibody directed to cardiolipin/beta 2 glycoprotein I produced by chronic lymphocytic leukaemia B cells. Clin. Exp. Immunol. 1993; 94: 385–390
  • van Es J. H., Heutink M., Aanstoot H., Logtenberg T. Sequence analysis of members of the human Ig VH4 gene family derived from a single VH locus. Identification of novel germ-line members. J. Immunol. 1992; 149: 492–497
  • Winkler T. H., Fehr H., Kalden J. R. Analysis of immunoglobulin variable region genes from human IgG anti-DNA hybridomas. Eur. J. Immunol. 1992; 22: 1719–28
  • Rassenti L. Z., Kipps T. J. Lack of extensive mutations in the VH5 genes used in common B cell lymphocytic leukemia. J. Exp. Med. 1993; 177: 1039–1046
  • Chastagner P., Demaison C., Theze J., Zouali M. Clonotypic dominance and variable gene elements of pathogenic anti-DNA autoantibodies from a single patient with lupus. Scand. J. Immunol. 1994; 39: 165–178
  • Demaison C., Chastagner P., Theze J., Zouali M. Somatic diversification in the heavy chain variable region genes expressed by human autoantibodies bearing a lupus-associated nephritogenic anti-DNA idiotype. Proc. Natl. Acad. Sci. USA. 1994; 91: 514–518
  • Pascual V., Victor K., Randen I., Thompson K., Steinitz M., Forre O., Fu S. M., Natvig J. B., Capra J. D. Nucleotide sequence analysis of rheumatoid factors and polyreactive antibodies derived from patients with rheumatoid arthritis reveals diverse use of VH and VL gene segments and extensive variability in CDR-3. Scand. J. Immunol. 1992; 36: 349–362
  • David D., Zouali M. Variable region light chain genes encoding human antibodies to HIV-1. Mol. Immunol. 1995; 32: 77–88
  • Radic M. Z., Mascelli M. A., Erikson J., Shan H., Weigert M. Ig H and L chain contributions to autoimmune specificities. J. Immunol. 1991; 146: 176–182
  • Kabat E. A., Wu T. T. Identical V region amino acid sequences and segments of sequences in antibodies of different specificities. Relative contributions of VH and VL genes, minigenes, and complementarity-determining regions to binding of antibody-combining sites. J. Immunol. 1991; 147: 1709–1719
  • Radic M. Z., Weigert M. Genetic and structural evidence for antigen selection of anti-DNA antibodies. Ann. Rev. Immunol. 1994; 12: 487–520
  • Stewart A. K., Huang C., Long A. A., Stollar B. D., Schwartz R. S. VH gene representation in autoantibodies reflects the normal B cell repertoire. Immunol. Rev. 1992; 128: 101
  • Mannheimer Lory A., Katz J. B., Pillinger M., Ghossein C., Smith A., Diamond B. Molecular characteristics of antibodies bearing an anti-DNA-associated idiotype [published erratum appears in. J Exp Med Jul; 1, 1992; 176(1)309, J. Exp. Med. 1991 174 1639 1652
  • Pascual V., Victor K., Spellerberg M., Hamblin T. J., Stevenson F. K., Capra J. D. VH restriction among human cold agglutinins. The VH4–21 gene segment is required to encode anti-I and anti-i specificities. J. Immunol. 1992; 149: 2337–2344
  • Logtenberg T. How unique are pathogenic anti-DNA autoantibody V regions?. Curr. Opin. Immunol., 6: 921–925
  • Harindranath N., Ikematsu H., Notkins A. L., Casali P. Structure of the VH and VL segments of polyreactive and monoreactive human natural antibodies to HIV-1 and Escherichia coli beta-galactosidase. Int. Immunol. 1993; 5: 1523–1533
  • Diamond B., Scharff M. D. Somatic mutation of the T15 heavy chain give rise to an antibody with autoantibody specificity. Proc. Natl. Acad. Sci. USA. 1984; 81: 5841–5844
  • Katz J. B., Limpanasithikul W., Diamond B. Mutational analysis of an autoantibody: differential binding and pathogenicity. J. Exp. Med. 1994; 180: 925–932
  • Chen G., Stenzel Poore M. P., Rittenberg M. B. Natural auto-and polyreactive antibodies differing from antigeninduced antibodies in the H chain CDR3. J. Immunol. 1991; 147: 2359–2367
  • Martin T., Crouzier R., Weber J., Kipps T. J., Pasquali J. Structure function studies on a polyreactive (natural) autoantibody. Polyreactivity is dependent on somatically generated sequenes in th third complementarity-determining region of antibody heavy chain. J. Immunol. 1994; 152: 5988–5996
  • Hoch S., Schwaber J. Identification and sequence of the VH gene elements encoding a human anti-DNA antibody. J. Immunol. 1987; 139: 1689–1693

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.