2
Views
2
CrossRef citations to date
0
Altmetric
Original Article

T Cells from BB-DP Rats Show a Unique Cytokine mRNA Profile Associated with the IDDMI Susceptibility Gene, LYP

, , , , , , & show all
Pages 149-161 | Received 17 Nov 1995, Published online: 07 Jul 2009

References

  • Like A., Kislauskis E., Williams M., Rossini A. Neonatal thymectomy prevents spontaneous diabetes mellitus in the BB/W rat. Science 1982; 216: 644–646
  • Like A., Biron C. A., Weringer E. J., Byman K., Srocynski E., Guberski D. L. Prevention of diabetes in biobreeding/Worcester rats with monoclonal antibodies that recognize T lymphocytes or natural killer cells. J. Exp. Med. 1986; 164: 1145–1159
  • Bellgrau D., Naji A., Silvers W., Markmann J., Barker C. Spontaneous diabetes in BB rats: Evidence for a T cell dependent immune response defect. Diabetologia 1982; 23: 359–364
  • Elder M., Maclaren N. Identification of profound peripheral T lymphocytes immunodeficiencies in the spontaneously diabetic BB rat. J. Immunol. 1983; 130: 1723–1731
  • Georgiou H., Lagarde C., Bellgrau D. T cell dysfunction in the diabetes-prone BB rat: A role for thymic migrants that are not T cell precursors. J. Exp. Med. 1988; 167: 132–149
  • Bellgrau D., Redd J., Sellins K. S. Peculiar T cell signalling does not preclude positive selection in the diabetes prone BB rat. Diabetes 1994; 43: 47–52
  • Greiner D., Handler E., Nakano K., Mordes J., Rossini A. Absence of the RT-6 T cell subset in diabetes-prone BB/W rats. J. Immunol. 1986; 136: 148–151
  • Groen H., Van Der Berk J., Nieuwenhuis P., Kampinga J. Peripheral T cells in diabetes prone (DP) BB rats are CD45R-negative. Thymus 1989; 14: 145–150
  • Bellgrau D., Lagarde A.-C. Cytotoxic T-cell precursors with low-level CD8 in the diabetes-prone biobreeding rat: Implications for generation of an autoimmune T-cell repertoire. Proc. Natl. Acad. Sci. USA 1990; 87: 313–317
  • Plamondon C., Kottis V., Bridau C., Metroz-Dayer M.-D., Poussier P. Abnormal thymocyte maturation in spontaneously diabetic BB rats involves deletions of CD4- CD8 + T cells. J. Immunol. 1990; 144: 923–928
  • Jackson R., Rassi N., Crump T., Haynes B., Eisenbarth G. The BB diabetic rat: profound T-cell lymphocytopenia. Diabetes 1981; 30: 887–889
  • Woda B. A., Like A. A., Padden C., McFadden M. L. Deficiency of phenotypic cytotoxic-suppressor T lymphocytes in the BB/W rat. J. Immunol. 1986; 136: 856–859
  • Markholst H., Eastman S., Wilson D., Andressen B. E., Lernmark A. Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes. J. Exp. Med. 1991; 174: 297–300
  • Jacob H. J., Pettersson A., Wilson D., Mao Y., Lernmark A., Lander E. Genetic dissection of autoimmune type I diabetes in the BB rat. Nature Genetics 1992; 2: 56–60
  • Arthur R. P., Mason D. T cells that help B cell responses to soluble antigen are distinguishable from those producing interleukin 2 on mitogenic or allogeneic stimulation. J. Exp. Med. 1986; 163: 774–786
  • McKnight A. J., Barclay A. N., Mason D. W. Molecular cloning of rat interleukin 4 cDNA and analysis of the cytokine repertoire of subsets of CD4+ T cells. Eur. J. Immunol. 1991; 21: 1187–1194
  • Parfrey N. A., Prud'homme G. J., Colle E., Fuks A., Seemayer T. A., Guttman R. D. Immunologic and genetic studies of diabetes in the BB rat. Critical Reviews Immunology 1989; 9: 45–65
  • Yang C., Bel E. B. Functional maturation of recent thymic emigrants in the periphery: development of alloreactivity correlates with the cyclic expression of CD45RC isoforms. Eur. J. Immunol. 1992; 22: 2261–2269
  • Hosseinzadeh H., Goldschneider I. Recent thymic emigrants in the rat express a unique antigenic phenotype and undergo post-thymic maturation in peripheral lymphoid tissues. J. Immunol. 1993; 150: 1670–1679
  • Sellins K. S., Bellgrau D., Gold D. P. Specificity of rat T cell receptor Vβ chain usage in proliferative responses to staphylococcal enterotoxin B. Eur. J. Immunol. 1992; 22: 1931–1934
  • Hunig T., Wallny H.-J., Hartley J., Lawetzky A., Tiefenthaler G. A monoclonal antibody to a constant determinant of the rat T cell antigen that induces T cell activation. J. Exp. Med. 1989; 169: 73–86
  • Mason D. W., Arthur R. P., Dallman M. J., Green J. R., Spickett G. P., Thomas M. L. Functions of rat T-lymphocyte subsets isolated by means of monoclonal antibodies. Immunogical Rev. 1983; 74: 57–82
  • Paterson D. J., Jefferies W. A., Green J. R., Brandon M. R., Corthesy P., Puklavec M., Williams A. F. Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts. Molec. Immunol. 1987; 24: 1281–1290
  • Paterson D. J., Green J. R., Jefferies W. A., Puklavec M., Williams A. F. The MRC OX-44 antigen marks a functionally relevant subset among rat thymocytes. J. Exp. Med. 1987; 165: 1–13
  • Redd J. R., Sellins K. S., Lagarde A.-C., Bellgrau D. Islet specific cytotoxic cells in diabetes prone and diabetes resistant rats. An identification of potential regulatory cells in diabetes resistant rats. J. of Clinical Biochem. Sup. 1990; 15A: 302
  • Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction. Anal. Biochem. 1987; 162: 156–159
  • Gold D. P., Vainiene M., Celnik B., Wiley S., Gibbs C., Hashim G. R., Vandenbark A. A., Offner H. Characterization of the immune response to a secondary encephalitogenic eptiope of basic protein in Lewis rats. II. Biased T cell receptor Vb expression predominates in spinal cord infiltrating T cells. J. Immunol. 1992; 1: 48–1712, 1717
  • McKnight A. J., Moason D. W., Barclay A. N. Sequence of rat interleukin 2 and anomalous binding of a mouse interleukin 2 cDNA probe to rat MHC class II-associated invariant chain mRNA. Immunogenetics 1989; 30: 145–147
  • Uberla K., LI W., Qin Z., Richter G., Raabe T., Diamanststein T., Blankenstein T. The rat interleukin-5 gene: characterization and expression by retroviral gene transfer and polymerase chain reaction. Cytokine 1991; 3: 72–81
  • Northemann W., Braciak T. A., Hattori L., Lee F., Fey G. H. Structure of the rat interleukin 6 gene and its expression in macrophage-derived cells. J. Biol. Chem. 1989; 264: 16072–16082
  • Dijkema R., van der Meide P. H., Pouwels P. H., Caspers M., Dubbeld M., Schellekens H. Cloning and expression of the chromosomal immune interferon gene of the rat. EMBO Journal 1985; 4: 761–767
  • Morris M., Barclay N. A., Williams A. F. Analysis of T cell receptor β chains in rat thymus, and rat Cα and Cβ sequences. Immunogenetics 1988; 27: 174–179
  • Takatsu K., Tominaga A., Harade N., Mita S., Matsumoto M., Takahashi T., Kikuchi, Yamaguchi N. T cell-replacing factor (TRF)/interleukin 5 (IL5): molecular and functional properties. Immunol. Rev. 1988; 102: 107–135
  • Swain S. L., McKenzie D. T., Dutton R. W., Tonkonogy S. L., English M. The role of IL4 and IL5: characterization of a distinct helper T cell subset that makes IL4 and IL5 (TH2) and requires priming before induction of lymphokine secretion. Immunol. Rev. 1988; 102: 77–105
  • Guberski D. L., Butler L., Kastern W., Like A. A. Genetic studies in inbred BB/Wor rats. Analysis of progeny produced by crossing lymphopenic diabetes prone with non lymphopenic diabetic rats. Diabetes 1989; 38: 887–893
  • Firestein G. S., Roeder W. D., Laxer J. A., Townsend K. S., Weaver C. T., Horn J. T., Linton J., Torbett B. E., Glasebrook A. L. A new murine CD4+ T cell subset with an unrestricted cytokine profile. J. Immunol. 1989; 143: 518–525
  • Mallett S., Fossum S., Barclay A. N. Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes-a molecule related to nerve growth factor receptor. EMBO Journal 1990; 9: 1063–1068
  • Like A. Depletion of RT6.1 + T-lymphocytes alone is insufficient to induce diabetes in diabetes-resistant BB/W rats. Am. J. Pathol. 1990; 136: 565–574
  • McKeever U., Mordes J. P., Greiner D. L., Appel M., Rozing J., Handler E. S., Rossini A. A. Adoptive transfer of autoimmune diabetes and thyroiditis to athymic rats. Proc. Natl. Acad. Sci. USA. 1990; 87: 7618–7622
  • Angelillo M., Greiner D., Morders J., Handler E., Nakamura N., Rossini A. Absence of RT6+ cells in diabetesprone BB/W rats is due to genetic and cell developmental defects. J. Immunol. 1988; 41: 4146–4151
  • Georgiou H. M., Bellgrau D. Thymus transplantation and disease prevention in the diabetes-prone bio-breeding rat. J. Immunol. 1989; 142: 3400–3405
  • Serreze D. V., Leiter E. H., Worthen M., Shultz L. D. NOD marrow stem cells adoptively transfer diabetes to resistant (NOD × NON) F1 mice. Diabetes 1988; 37: 252–255
  • Shores E. W., Van Ewijk W., Singer A. Disorganization and restoration of thymic medullary epithelial cells in T cell receptor-negative scid mice: evidence that receptor-bearing lymphocytes influence maturation of the thymic microenvironment. Eur. J. Immunol. 1991; 21: 1657–1661
  • Rozing J., Coolen G., Tielen F. J., Weegenaar J., Schuurman H.-J., Greiner D. L., Rossini A. A. Defects in thymic epithelial stroma of diabetes prone BB rats. Thymus 1989; 14: 125–135
  • Bendelac A., Schwartz R. H. CD4+ and CD8+ T cells acquire specific lymphokine secretion potentials during thymic maturation. Nature 1991; 353: 68–71
  • Bendelac A., Matzinger P., Seder R. A., Paul W. E., Schwartz R. H. Activation events during thymic selection. J. Exp. Med. 1992; 75: 731–742
  • Hayakawa K., Lin B. T., Hardy R. R. Murine thymic CD4+ T cell subsets: A subset (ThyO) that secretes diverse cytokines and overexpresses the Vβ 8 T cell receptor gene family. J. Exp. Med. 1992; 76: 269–274
  • Kariv I., Hardy R. R., Hayakawa K. Selective enrichment of MHC class II specific autoreactive T cells in the thymic ThyO subset. J. Exp. Med. 1993; 177: 1429–1437
  • Fowell D., Mason D. Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential. J. Exp. Med. 1993; 177: 627–636

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.