Ig H and L Chain Variable Region Gene Sequence Analyses of Twelve Synovial Tissue-Derived B Cell Lines Producing IgA, IgG, and IgM Rheumatoid Factors Structure/Function Comparisons of Antigenic Specificity, V Gene Sequence, and IG Isotype

References

• Good R. A., Rotstein J., Mazzitello W. F. The simultaneous occurrence of rheumatoid arthritis and agammaglobulinemia. J. Lab. Clin. Med. 1957; 49: 343
   PubMed Web of Science ®Google Scholar
• Rawson A. J., Hollander J. L., Quismorio F. P., Abelson N. M. Experimental arthritis in man and rabbit depends upon serum antiimmunoglobulin factors. Ann. NY Acad. Sci. 1969; 168: 188
   Google Scholar
• Harris E. D.J. Rheumatoid arthritis. N. Engl. J. Med. 1990; 322: 1277–1289
   PubMed Web of Science ®Google Scholar
• Egeland T., Lea T., Saari G., Mellbye O. J., Natvig J. B. Quantitation of cells secreting rheumatoid factor of IgG, IgA, and IgM class after elution from rheumatoid synovial tissue. Arthritis Rheum. 1982; 25: 1445–1450
   PubMedGoogle Scholar
• Panush R. S., Bianco N. E., Schur P. H. Serum and synovial fluid IgG, IgA and IgM antigamma globulins in rheumatoid arthritis. Arthritis Rheum. 1971; 14: 737–747
   PubMedGoogle Scholar
• Robbins D. L., Feigal D. W., Leek J. C. Relationship with serum IgG rheumatoid factor to IgM rheumatoid factor and disease activity in rheumatoid arthritis. J. Rheumatol 1986; 13: 259–262
   PubMed Web of Science ®Google Scholar
• Teitsson I., Withrington D. W., Seifert M. H., Valdimarsson H. Prospective study of early rheumatoid arthritis. I. Prognostic value of IgA rheumatoid factor. Ann. Rheum. Dis. 1988; 43: 673–678
   Google Scholar
• Eberhardt K. B., Truedsson L., Pettersson H., Svensson B., Stigsson L., Eberhardt J. L., et al. Disease activity and joint damage progression in early rheumatoid arthritis: Relation to IgG, IgA, and IgM rheumatoid factor. Ann. Rheum. Dis. 1990; 49: 906–909
   PubMed Web of Science ®Google Scholar
• Kaplan S., Hyman K., Brooks R., Wakai M., Hashimoto S., Furie R., Chiorazzi N. Monoclonal IgM, IgG, and IgA human rheumatoid factors produced by synovial tissue-derived, EBV-transformed B cell lines. Clin. Immunol. Immunopathol 1993; 66: 18–25
   PubMedGoogle Scholar
• Larrick J. W., Danielsson L., Brenner C. A., Wallace E. F., Abrahamson M., Fry K. E., et al. Polymerase chain reaction using mixed primers: cloning of human monoclonal antibody variable genes from single hybridoma cells. Biotechnology 1989; 7: 934–938
   Web of Science ®Google Scholar
• Tomlinson I. M., Williams S. C., Corbett S. J., Cox J. P.L., Winter G. V Base sequence directory. MRC Centre for Protein Engineering, CambridgeUK 1995
   Google Scholar
• Jukes T. H., King J. L. Evolutionary nucleotide replacements in DNA. Nature (Lond.) 1979; 281: 605–606
   Google Scholar
• Shlomchik M., Marshak-Rothstein A., Wolfowicz C. B., Rothstein T. L., Weigert M. G. The role of clonal selection and somatic mutation in autoimmunity. Nature 1987; 328: 805–811
   PubMed Web of Science ®Google Scholar
• Yamada M., Wasserman R., Reichard B. A., Shane S., Caton A. J., Rovera G. Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes. J. Exp. Med. 1991; 173: 395–407
   PubMed Web of Science ®Google Scholar
• Martin T., Duffy S. F., Carson D. A., Kipps T. J. Evidence for somatic selection of natural autoantibodies. J. Exp. Med. 1992; 175: 983–991
   PubMed Web of Science ®Google Scholar
• Ikematsu H., Kasaian M. T., Shettino E. W., Casali P. Structural analysis of the VH-D-JH segments of human polyreactive IgG mAb. J. Immunol. 1993; 151: 3604–3616
   PubMed Web of Science ®Google Scholar
• Kabat E., Wu T. T., Reid-Miller M., Perry H. M. Gottesmann Sequences of Proteins of Immunological Interest. U.S. Department of Health and Human Services, National Institutes of Health, Bethesda, MD 1987
   Google Scholar
• Randen I., Thompson K. M., Pascual V., Victor K., Beale D., Coadwell J., et al. Rheumatoid factor V genes from patients with rheumatoid arthritis are diverse and show evidence of an antigen-driven response. Immunol. Rev. 1992; 128: 49–71
   PubMed Web of Science ®Google Scholar
• Schroeder H. W., Hillson J. L., Perlmutter R. M. Early restriction of the human antibody repertoire. Science 1987; 238: 791–793
   PubMed Web of Science ®Google Scholar
• Schroeder H. W., Jr., Wang J. Y. Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life. Proc. Natl Acad. USA 1990; 87: 6146–6150
   PubMed Web of Science ®Google Scholar
• Dersimonian H., Schwartz R. S., Barrett K. J., Stollar B. D. Relationship of human variable region heavy chain germline genes to genes encoding anti-DNA autoantibodies. J Immunol 1987; 139: 2496–2501
   PubMed Web of Science ®Google Scholar
• Chen P. P., Liu M. F., Sinha S., Carson D. A. A 16/6 idiotype positive anti-DNA antibody is encoded by a conserved VH gene with no somatic mutation. Arthritis Rheum. 1988; 31: 1429–1431
   PubMed Web of Science ®Google Scholar
• Sanz I., Dang H., Takei M., Talal N. and Capra J.D. VH sequence of a human anti-Sm autoantibody: evidence that autoantibodies can be unmutated copies of germ-line genes. J. Immunol. 1989; 142: 883–887
   PubMed Web of Science ®Google Scholar
• Van Es J. H., Aanstoot H., Gmelig-Meyling F. H.J., Derksen R. H.W.M., Logtenberg T. A human systemic erythematosus-related anti-cardiolipin/single-stranded DNA autoantibody is encoded by a somatically mutated variant of the developmentally restricted 51pl VH gene. J. Immunol. 1992; 149: 2234–2240
   PubMed Web of Science ®Google Scholar
• Willems van Dijk K., Sasso E. H., Milner E. C.B. Polymorphism of the human Ig VH4 gene family. J. Immunol. 1991; 146: 3646–3651
   Google Scholar
• Radoux V., Chen P. P., Sorge J. A., Carson D. A. A conserved human germline VK gene directly encodes rheumatoid factor light chains. J. Exp. Med. 1986; 164: 2119–2124
   PubMed Web of Science ®Google Scholar
• Lee S. K., Bridges S. L., Koopman W. J., Schroeder H. W. The immunoglobulin kappa light chain repertoire expressed in the synovium of a patient with rheumatoid arthritis. Arthritis Rheum. 1992; 35: 905–913
   PubMed Web of Science ®Google Scholar
• Harindranath N., Goldfarb I. S., Ikematsu H., Burastero S. E., Wilder R. L., Noktins A. L., Casali P. Complete sequence of genes encoding the VH and VL regions of low-and high-affinity monoclonal IgM and IgA1 rheumatoid factors produced by CD5+ B cells from a rheumatoid arthritis patient. Int. Immunol. 1991; 3: 865–875
   PubMed Web of Science ®Google Scholar
• Ermel R. W., Kenny T. P., Wong A., Solomon A., Chen P. P., Robbins D. L. Preferential utilization of a novel Vλ3 gene in monoclonal rheumatoid factor derived from the synovial cells of rheumatoid arthritis patients. Arthritis Rheum. 1994; 37: 860–868
   PubMedGoogle Scholar
• Fang Q., Kannapell C. C., Gaskin F., Solomon A., Koopman W. J., Fu S. M. Human rheumatoid factors with restrictive specificity for rabbit immunoglobulin G: auto-and multi-reactivity, diverse VH gene segment usage and preferential usage of VλIIIb. J. Exp. Med. 1994; 179: 1445–1456
   PubMed Web of Science ®Google Scholar
• Robbins D. L., Kenny T. P., Coloma M. J., Gavilondo-Cowly J. V., Soto-Gil T. W., Chen P. P., Larrick J. W. Serologic and molecular characterization of a human monoclonal rheumatoid factor derived from rheumatoid synovial cells. Arthritis Rheum 1990; 33: 1188–1195
   PubMedGoogle Scholar
• Solomon A., Weiss D. T., Murphy C., Fu S. M., Robbins D. L. Chemical and serologic characterization of human λ VIII light chains. J Immunol 1994; 153: 1658–1664
   Google Scholar
• Borretzen M., Randen I., Natvig J. B., Thompson K M. Structural restriction in the heavy chain CDR3 of human rheumatoid factors. J. Immunol. 1995; 155: 3630–3637
   PubMed Web of Science ®Google Scholar
• Pascual V., Randen I., Thompson K., Sioud M., Førre Ø., Natvig J., Capra J. D. The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein-Barr virus transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis. J. Clin. Invest. 1990; 86: 1320–1328
   PubMed Web of Science ®Google Scholar
• Lu E. W., Deftos M., Tighe H., Carson D. A., Chen P. P. Generation and characterization of two monoclonal self-associating IgG rheumatoid factors from a rheumatoid synovium. Arthritis Rheum. 1992; 35: 101–105
   Google Scholar
• Olee T., Lu E. W., Huang D.-F., Soto-Gil R. W., Deftos M., Kozin F., et al. Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven response. J. Exp. Med. 1992; 175: 831–842
   PubMedGoogle Scholar
• Brown C. S., Longhurst C., Haynes G., Plater-Zyberk C., Malcolm A., Maini R. N. Immunoglobulin heavy chain variable region gene utilization by B cell hybridomas derived from rheumatoid synovial tissue. Clin. Exp. Immunol. 1992; 89: 230–238
   Google Scholar
• Bridges S. L., Lee S. K., Koopman W. J., Schroeder H. W. Analysis of immunoglobulin gamma heavy chain expression in synovial tissue of a patient with rheumatoid arthritis. Arthritis Rheum. 1993; 36: 631–641
   Google Scholar
• Randen I., Pascual V., Victor K., Thompson K. M., Førre Ø., Capra J. D., et al. Synovial IgG rheumatoid factors show evidence of an antigen-driven immune response and a shift in the V gene repertoire compared to IgM rheumatoid factors. Eur. J. Immunol. 1993; 23: 1220–1225
   Google Scholar
• Lu E. W., Deftos M., Olee T., Huang D.-F., Soto-Gil R. W., Carson D. A., et al. Generation and molecular analyses of two rheumatoid synovial fluid-derived IgG rheumatoid factors. Arthritis Rheum. 1993; 36: 927–937
   Google Scholar
• Ermel R. W., Kenny T. P., Chen P. P., Robbins D. L. Molecular analysis of rheumatoid factors derived from rheumatoid synovium suggests an antigen-driven response in inflamed joints. Arthritis Rheum. 1993; 36: 380–388
   PubMedGoogle Scholar
• Deftos M., Olee T., Carson D. A., Chen P. P. Defining the genetic origins of three rheumatoid synovium-derived IgG rheumatoid factors. J. Clin. Invest. 1994; 93: 2545–2553
   Google Scholar
• Lee S. K., Bridges S. L., Koopman W. J., Schroeder H. W. The immunoglobulin kappa light chain repertoire expressed in the synovium of a patient with rheumatoid arthritis. Arthritis Rheum. 1992; 35: 905–913
   PubMed Web of Science ®Google Scholar
• Martin T., Blaison G., Levallois H., Pasquali J. L. Molecular analysis of the V?III-J? joins of polyclonal rheumatoid factor during RA frequently reveals N addition. Eur. J. Immunol. 1992; 22: 1773–1779
   PubMed Web of Science ®Google Scholar
• Victor K. D., Capra J. D. An apparently common mechanism of generating antibody diversity: length variation of the VL-JL junction. Mol. Immunol. 1994; 31: 39–46
   PubMed Web of Science ®Google Scholar
• Berek G., Milstein C. Mutation drift and repertoire shift in the maturation of the immune response. Immunol. Rev. 1987; 96: 23–41
   PubMed Web of Science ®Google Scholar
• Allen D., Simon T., Sabiltzkey F., Rajewsky K., Cumano A. Antibody engineering for the analysis of affinity maturation of an anti-hapten response. EMBO J 1988; 7: 1995–2001
   PubMed Web of Science ®Google Scholar
• Sharon J., Gefter M. L., Wysocki L. J., Margolies M. N. Recurrent somatic mutations in mouse antibodies to p-azophenylarsonate increase affinity for hapten. J. Immunol. 1989; 142: 596–601
   PubMed Web of Science ®Google Scholar
• Kocks C., Rajewsky K. Stepwise intraclonoal maturation of antibody affinity through somatic hypermutation. Proc. Natl Acad. Sci. USA 1988; 85: 8206–8210
   PubMed Web of Science ®Google Scholar
• Kepler T. B., Perelson A. S. Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation. Immunology Today 1993; 14: 412–415
   PubMedGoogle Scholar
• Jacobson B. A., Sharon J., Shan H., Shlomchik M., Weigert M. G., Marshak-Rothstein A. An isotype switched and somatically mutated rheumatoid factor clone isolated from a MRL-Ipr/Ipr mouse exhibits limited intraclonal affinity maturation. J. Immunol. 1994; 152: 4489–4499
   Google Scholar
• Rickert R. C., Wloch M. K., Hahn R. L., Clarke S. H. Binding analysis of antibodies produced by precursor and branchpoint intermediates of an anti-influenza hemagglutinin B cell clone. J. Immunol. 1995; 154: 2209–2216
   Google Scholar
• Randen I., Brown D., Thompson K. M., Hughes-Jones N., Pascual V., Victor K., et al. Clonally related IgM rheumatoid factors undergo affinity maturation in the rheumatoid synovial tissue. J. Immunol. 1992; 148: 3296–3301
   PubMed Web of Science ®Google Scholar
• Ichiyoshi Y., Casali P. Analysis of the structural correlates for antibody polyreactivity by multiple reassortments of chimeric human immunoglobulin heavy and light chain V segments. J. Exp. Med. 1994; 180: 885–895
   PubMed Web of Science ®Google Scholar
• Pascual V., Victor K., Randen I., Thompson K., Steinitz M., Førre Ø., et al. Nucleotide sequence analysis of rheumatoid factors and polyreactive antibodies derived from patients with rheumatoid arthritis reveals diverse use of VH and VL gene segments and extensive variability in CDR-3. Scand. J. Immunol. 1992; 36: 349–362
   PubMed Web of Science ®Google Scholar
• Riordan J. F., McElvany K. D., Borders C. L., Jr. Arginyl residues: anion recognition sites in enzymes. Science 1977; 195: 884–886
   PubMed Web of Science ®Google Scholar
• Borders C. L., Broadwater J. A., Bekeny P. A., Salmon J. E., Lee A. S., Eldridge A. M., et al. A structural role for arginine in proteins: Multiple hydrogen bonds to backbone carbonyl oxygens. Protein Science 1994; 3: 541–548
   PubMedGoogle Scholar
• Martin T., Crouzier R., Weber J. C., Kipps T. J., Pasquali J. L. Structure-function studies on a polyreactive (natural) autoantibody. J. Immunol. 1994; 152: 5988–5996
   PubMed Web of Science ®Google Scholar