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Original Article

Analysis of the VKI Family: Germline Genes from an SLE Patient and Expressed Autoantibodies

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Pages 259-265 | Received 04 Apr 1995, Published online: 07 Jul 2009

References

  • Davidson A., Manheimer‐Lory A., Aranow C., Peterson R., Hannigan N., Diamond B. Molecular characterization of a somatically mutated anti‐DNA antibody bearing two systemic lupus erythematosus‐related idiotypes. J. Clin. Invest. 1990; 85: 1401
  • Manheimer‐Lory A., Katz J. B., Pillinger M., Ghossein C., Smith A., Diamond B. Molecular characteristics of antibodies bearing an anti‐DNA‐associated idiotype. J. Exp. Med. 1991; 174: 1639
  • Andris J. S., Ehrlich P. H., Ostberg L., Capra J. D. Probing the human antibody repertoire to exogenous antigens. Characterization of the H and L chain V region gene segments from anti‐Hepatitis B Virus antibodies. J. Immunol. 1992; 149: 4053
  • Scott M. G., Crimmins D. L., McCourt D. W., Chung G., Schäble K. F., Thiebe R., Quenzel E. M., Zachau H. G., Nahm M. H. Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide. IV. The less frequently expressed VL are heterogenous. J. Immunol. 1991; 147: 4007
  • Fernández de Cossió M. E., Ohlin M., Llano M., Selander B., Cruz S., del Valle J., Borrebaeck C. A. K. Human monoclonal antibodies against an epitope on the class 5C outer membrane protein common to many pathogenic strains of Neisseria meningitidis. J. Infect. Dis. 1992; 166: 1322
  • Bentley D. L., Rabbitts T. H. Human immunoglobulin variable region genes: DNA sequences of two V K genes and a pseudogene. Nature (Lond.). 1980; 288: 730
  • Pech M., Zachau H. G. Immunoglobulin genes of different subgroups are interdigitated within the V K locus. Nucleic Acids Res. 1984; 12: 9229
  • Pohlenz H ‐D., Straubinger B., Thiebe R., Pech M., Zimmer F ‐J., Zachau H. G. The Human V K locus. Characterization of extended immunoglobulin gene regions by cosmid cloning. J. Mol. Biol. 1987; 193: 241
  • Straubinger B., Huber E., Lorenz W., Osterholzer E., Pargent W., Pech M., Pohlenz H ‐D., Zimmer F ‐J., Zachau H. G. The human VK locus. Characterization of a duplicated region encoding 28 different immunoglobulin genes. J. Mol. Biol. 1988; 199: 23
  • Pargent W., Schäble K. F., Zachau H. G. Polymorphisms and haplotypes in the human K locus. Eur. J. Immunol. 1991; 21: 1829
  • Lautner‐Rieske A., Huber C., Meindl A., Pargent W., Schäble K ‐F., Thiebe R., Zocher I., Zachau H. G. The human immunoglobulin K locus. Characterization of the duplicated A regions. Eur. J. Immunol. 1992; 22: 1023
  • Pargent W., Meindl A., Thiebe R., Metzel S., Zachau H. G. The human immunoglobulin K locus. Characterization of the duplicated 0 regions. Eur. J. Immunol. 1991; 21: 1821
  • Kurth J. H., Mountain J. L., Cavalli‐Sforza L. L. Subclustering of human immunoglobulin kappa light chain variable region genes. Genomics. 1993; 16: 69
  • Pech M., Jaenichen H. R., Pohlenz H ‐D., Neumaier P. S., Klobeck H. G., Zachau H. G. Organization and evolution of a gene cluster for human immunoglobulin variable regions of the kappa type. J. Mol. Biol. 1984; 176: 189
  • Klobeck H ‐G., Meindl A., Cambriato G., Solomon A., Zachau H. G. Human immunoglobulin kappa light chain genes of subgroups II and III. Nucleic Acids Res. 1985; 13: 6499
  • Bentley D. L., Rabbitts T. H. Evolution of immunoglobulin V genes: evidence indicating that recently duplicated human V‐kappa sequences have diverged by gene conversion. Cell 1983; 32: 181
  • Cox J. P. L., Tomlinson I. M., Winter G. A directory of human germline V K segments reveals a strong bias in their usage. Eur. J. Immunol. 1994; 24: 827
  • Klein R., Jaenichen R., Zachau H. G. Expressed human immunoglobulin K genes and their hypermutation. Eur. J. Immunol. 1993; 23: 3248
  • Eckert K. A., Kunkel T. A. High fidelity DNA synthesis by the Thermus aquaticus DNA polymerase. Nucleic Acids Res. 1990; 18: 3739
  • Manheimer‐Lory A. J., Davidson A., Watkins D., Hannigan N. R., Diamond B. Generation and analysis of clonal IgM‐and IgG‐producing human B cells line expressing an anti‐DNA‐associated idiotype. J. Clin. Invest. 1990; 87: 1519
  • Steffen D., Bird S., Rowe W. P., Weinberg R. A. Identification of DNA fragments carrying ecotropic proviruses of AKR mice. Proc. Natl. Acad. Sci. USA. 1979; 76: 4554
  • Sanger F., Nicklen S., Coulson A. R. DNA sequencing with chain terminating inhibitors. Proc. Natl. Acad. Sci. USA. 1977; 74: 5463
  • Weng N ‐P., Yu‐Lee L. Y., Sanz I., Pattern B. M., Marcus D. M. Structure and specificities of antiganglioside autoantibodies associated with motor neuropathies. J. Immunol. 1992; 149: 2518
  • Ermel R., Kenny T. P., Chen P. P., Robbins D. Molecular analysis of rheumatoid factors derived from rheumatoid synovium suggests an antigen‐driven response in inflamed joints. Arthritis Rheum. 1993; 36: 380
  • Victor K. D., Pascual V., Williams C. L., Lennon V. A., Capra J. D. Human monoclonal striational autoantibodies isolated from thymic B lymphocytes of patients with myasthenia gravis use VH and VL gene segments associated with the autoimmune repertoire. Eur. J. Immunol. 1992; 22: 2231
  • Irigoyen M., Manheimer‐Lory A., Gaynor B., Diamond B. Molecular analysis of the human immunoglobulin VLdII family. J. Clin. Invest. 1994; 94: 532
  • Gavalchin J., Nicklas J. A., Eastcott J. W., Madaio M. P., Stollar B. D., Schwartz R. S., Datta S. K. Lupus prone (SWR NZB)F1 mice produce potentially nephritogenic autoantibodies inherited from the normal SWR parent. J. Immunol. 1985; 134(2)885
  • Paul E., Livneh A., Manheimer‐Lory A. J., Diamond B. Characterization of the human Ig VLDII gene family and analysis of VLDII and CLD polymorphism in systemic lupus erythematosus. J. Immunol. 1991; 147: 2771
  • Olee T., Yang P. M., Siminovitch K. A., Olsen N. J., Hillson J., Wu J., Kozin F., Carson D. A., Chen P. P. Molecular basis of an autoantibody‐associated restriction fragment length polymorphism that confers susceptibility to autoimmune diseases. J. Clin. Invest. 1991; 88(1)193
  • Diamond B., Scharff M. D. Somatic mutaiton of T15 heavy chain gives rise to an antibody with autoantibody specificity. Proc. Natl. Acad. Sci. USA. 1984; 81: 5841
  • Chang B., Casali P. The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement. Immunol. Today 1994; 15: 367
  • Rogozin I. B., Kolchanov N. A. Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighboring base sequences on mutagenesis. Biochem. et Biophysica. Acta. 1992; 1171: 11
  • Betz A. G., Neuberger M. S., Milstein C. Discriminating intrinsic and antigen‐selected mutational hotspots in immunoglobulin V genes. Immunology Today 1993; 14: 405
  • Victor K. D., Pascual V., Lefvert A. K., Capra J. D. Human anti‐acetylcholine receptor antibodies use variable region gene segments analogous to those used in autoantibodies of various specificities. Molec. Immunol. 1992; 29: 1501
  • Kunicki T. J., Annis D. S., Gorski J., Nugent D. J. Nucleotide sequence of the human autoantibody 2E7 specific for the platelet integrin IIb heavy chain. J. Autoimmunity 1991; 4: 433
  • Victor K. D., Randen I., Thompson K., Forre O., Natvig J. B., Fu S. M., Capra J. D. Rheumatoid factors isolated from patients with autoimmune disorders are derived from germline genes distinct from those encoding the Wa, Po, and Bla cross‐reactive idiotypes. J. Clin. Invest. 1991; 987: 1603
  • Pascual V., Victor K., Randen I., Thompson K., Steinitz M., Forre O., Fu S. M., Natvig J. B., Capra J. D. Nucleotide sequence analysis of rheumatoid factors and polyreactive antibodies derived from patients with rheumatoid arthritis reveals diverse use of VH and VL gene segments and extensive variability in CDR3. Scand. J. Immunol. 1992; 36: 349
  • Van Es J. H., Aanstoot H., Gmelig‐Meyling F. H. J., Derksen R. H. W. M., Logtenberg T. A human systemic lupus erythematosus‐related anti‐cardiolipin/singleo stranded DNA autoantibody is encoded by a somatically mutated variant of the developmentally restricted 51P1 VH gene. J. Immunol. 1992; 149: 2234
  • Chazenbalk G. D., Portolano S., Russo D., Hutchison J. S., Rapoport B., McLachlan L. Human organ‐specific autoimmune disease. Molecular cloning and expressin of an autoantibody gene repertoire for a major autoantigen reveals an antigenic immunodominant region and restricted immunoglobulin gene usage in the target organ. J. Clin. Invest. 1993; 92: 62
  • Weisbart R. H., Wong A. L., Noritake D., Kacena A., Chan G., Ruland C., Chin E., Chen I. S. Y., Rosenblatt J. D. The RF reactivity of a human IgG monoclonal autoantibody is encoded by a variant V K II L chain. J. Immunol. 1991; 147: 2795
  • Kipps T. J., Tomhave E., Chen P. P., Fox R. I. Molecular characterization of a major autoantibody‐associated cross‐reactive idiotype in Sjögren's syndrome. J. Immunol. 1989; 142: 4261
  • Youngblood K., Fruchter L., Ding G., Lopez J., Bonagura V., Davidson A. Rheumatoid factors from the peripheral blood of two patients with rheumatoid arthritis are genetically heterogeneous and somatically mutated. J. Clin. Invest. 1994; 93: 852
  • Olee T., Lu E. W., Huang D ‐F., Soto‐Gil R. W., Deftos M., Kozin F., Carson D. A., Chen P. P. Genetic analysis of self‐associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen‐driven response. J. Exp. Med. 1992; 175: 831
  • Winkler T. H., Fehr H., Kalden J. R. Analysis of immunoglobulin variable region genes from human IgG anti‐DNA hybridomas. Eur. J. Immunol. 1992; 22: 1719
  • Radoux V., Chen P. P., Sorge J. A., Carson D. A. A conserved human germline V K gene directly encodes rheumatoid factor light chains. J. Exp. Med. 1986; 164: 2119
  • Spatz L., Wong K. K., Williams M., Desai R., Golier J., Berman J. E., Alt F. W., Latov N. Cloning and sequence analysis of the V K and VL regions of an anti‐myelin/DNA antibody from a patient with peripheral neuropathy and chronic lymphocytic leukemia. J. Immunol. 1990; 144: 2821

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