Titin Antibodies in Patients with Late Onset Myasthenia Gravis: Clinical Correlations

References

• Lindstrom J. Immunobiology of myasthenia gravis, experimental autoimmune myasthenia gravis, and Lambert-Eaton syndrome. Ann. Rev. Immunol. 1985; 3: 109–131
   PubMed Web of Science ®Google Scholar
• Lindstrom J. M., Seybold M. E., Lcnnon V. A., Whittingham S., Duane D. D. Antibody to acetylcholine receptor in myasthenia gravis. Prevalence, clinical correlates and diagostic value. Neurology 1976; 26: 1054–1059
   PubMed Web of Science ®Google Scholar
• Lefvert A. K., Bergstram K., Matell G., Osterman P. O., Pirskanen R. Determination f acetylcholine receptor antibody in myasthenia gravis: clinical usefulness and pathogenetic implications. J. Neurol. Neurosurg. Psychiat. 1978; 41: 394–403
   PubMed Web of Science ®Google Scholar
• Oosterhuis H. J.G.H., Limburg P. C., Hummel-Tappel E. Anti-acctylcholine receptor antibodies in myasthenia gravis. Part 2. Clinical and serological follow-up of individual patients. J. Neurol. Sci. 1983; 58: 371–785
   PubMed Web of Science ®Google Scholar
• Oosterhuis H. J.G.H. Myasthenia gravis. Clinical Neurology and Neurosurgery Monographs. Churchill Livingstone, New York 1984
   Google Scholar
• Pescarmona E., Rosati S., Pisacane A., Rendina E. A., Vcnuta F., Baroni C. D. Microscopic thymoma: histological evidence of multifocal cortical and medullary origin. Histopathology 1992; 20: 263–266
   PubMed Web of Science ®Google Scholar
• Compston D. A.S., Vincent A., Newsom-Davis J., Batchclor J. R. Clinical, pathological, HLA antigen and immunological evidence for disease heterogeneity in myasthenia gravis. Brain 1980; 103: 579–601
   PubMed Web of Science ®Google Scholar
• Williams C. L., Lennon V. A. Thymic B-lymphocyte clones from patients with myasthenia gravis secrete monoclonal striational autoantibodies reacting with myosin, a-actinin or actin. J. Exp. Med. 1986; 164: 1043–1059
   PubMed Web of Science ®Google Scholar
• Aarli J. A., Stefansson K., Marton L. S.G., Wollman R. L. Patients with myasthenia gravis and thymoma have in their sera IgG autoantibodies against titin. Clin. Exp. Immunol. 1990; 82: 284–288
   PubMed Web of Science ®Google Scholar
• Ohta M., Ohta K., Itoh N., et al. Anti-skeletal muscle antibodies in the sera from myasthenic patients with thymoma: identification of anti-myosin, actomyosin, actin and a-actinin antibodies by a solid-phase radioimmunoassay and a Western blotting analysis. Clin. Chim. Acta. 1990; 187: 255–264
   PubMed Web of Science ®Google Scholar
• Mygland A., Tysnes O. B., Aarli J. A., Flood P. R., Gilhus N. E. Myasthenia gravis patients with a thymoma have antibodies against a high molecular weight protein in sarcoplasmatic reticulum. J. Neuroimmunol. 1992; 37: 1–7
   PubMed Web of Science ®Google Scholar
• Mygland A, Tysnes O. B., Matre R., Volpe P., Aarli J. A., Gilhus N. E. Ryanodine receptor autoantibodies in myasthenia gravis patients with a thymoma. Ann. Neurol. 1992; 32: 589–591
   PubMed Web of Science ®Google Scholar
• Trinick J., Knight P., Whiting A. Purification and properties of native titin. J. Mol. Biol. 1984; 180: 331–356
   PubMed Web of Science ®Google Scholar
• Kurzban G. P., Wang K. Giant polypeptides of skeletal muscle titin: sedimentation equilibrium in guanidine hydrochloride. Biochem. Biophys. Res. Comm. 1988; 150: 1155–1161
   PubMed Web of Science ®Google Scholar
• Wang K. Cytoskelctal matrix in striational muscle: The role of titin, ncbulin and intermediate filaments. Adv. Exp. Med. Biol. 1984; 170: 285–305
   PubMedGoogle Scholar
• Horowits R., Kempner E. S., Bisher M. E., Podolsky R. J. A physiological role for titin and nebulin in skeletal muscle. Nature 1986; 323: 160–164
   PubMed Web of Science ®Google Scholar
• Mygland A., Aarli J. A., Matre R., Gilhus N. E. Ryanodine receptor antibodies related to severity of thymomaassociated myasthenia gravis. J. Neurol. Neurosurg. Psychiat. 1994; 57: 843–846
   PubMed Web of Science ®Google Scholar
• Thorlacius S., Aarli J. A., Riise T., Matre R., Johnsen H. J. Associated disorders in myasthenia gravis: autoimmune diseases and their relation to thymectomy. Acta Neurol. Scand. 1989; 80: 290–299
   PubMed Web of Science ®Google Scholar
• Oosterhuis H. J. Observations of the natural history of myasthenia gravis and the effect of thymectomy. Ann. NY. Acad. Sc. 1981; 377: 678–689
   PubMed Web of Science ®Google Scholar
• Engvall E., Perlmann P. Enzyme-linked immunosorbent assay, ELISA. III. Quantitation of specific antibodies by enzyme labelled anti-immunoglobulin in antigen-coated tubes. J. Immunol. 1972; 109: 129–135
   PubMed Web of Science ®Google Scholar
• Gauted M., Lakey A., Barlow P. D., Holmes Z., Scales S., Leonard K., Labeit S., Mygland A., Gilhus N. E., Aarli J. A. Titin antibodies in myasthenia gravis: identification of a major immunogenic region of titin. Neurology 1993; 43: 1581–1585
   PubMed Web of Science ®Google Scholar
• Lanska D. J. Diagnosis of thymoma in myasthenics using anti-striated muscle antibodies: predictive value and gain in diagnostic certainty. Neurology 1991; 41: 520–524
   PubMed Web of Science ®Google Scholar
• Gilhus N. E., Nagvekar N., Newsom-Davis J., Willcox N. Myasthenia gravis; antigen presentation by thymoma cells. J. Neuroimmunol. 1994, in press
   Web of Science ®Google Scholar
• Marx A., Osborn M., Tzartos S., Geuder K. I., Schalke B., Nix W., Kirchner T., Muller-Hermelink H. K. A striational muscle antigen and myasthenia gravis associated thymomas share an acetylcholine-receptor epitope. Dev. Immunol. 1992; 2: 77–84
   PubMedGoogle Scholar
• Marx A., O'Connor R., Geuder K. I., Hoppe F., Schalke B., Tzartos S., Kalies I., Kirchner T., Muller-Hermelink H. K. Characterisation of a protein with an acetylchoSine receptor epitope from myasthenia gravis associated thymomas. Lab. Invest. 1990; 62: 279–86
   PubMed Web of Science ®Google Scholar
• Somnier F. E., Trojaborg W. Neurophysiological evaluation in myasthenia gravis. A comprehensive study of a complete patient population. Electroencephalogr. Clin. Neurophysiol. 1993; 89: 73–87
   PubMedGoogle Scholar
• Gross W. L., Schmitt W. H., Csernok E. ANCA and associated diseases: immunodiagnostic and pathogenetic aspects. Clin. Exp. Immunol. 1993; 91: 1–12
   PubMed Web of Science ®Google Scholar
• Ma J., King N., Chen S. L., Penny R., Breit S. N. Antibody penetration of viable human cells. II. Anti-RNP antibodies binding to RNP antigen expressed on cell surface, which may mediate the antibody internalisation. Clin. Exp. Immunol. 1993; 93: 396–404
   PubMed Web of Science ®Google Scholar
• Emlen W., Holers V. M., Arend W. P., Kotzin B. Regulation of nuclear antigen expression on the cell surface of human monocytes. J. Immunol. 1992; 148: 3042–3048
   PubMed Web of Science ®Google Scholar
• Morgan B. P. Effects of the membrane attack complex of complement on nucleated cells. Current topics in Microbiology and immunology, C. M. Parker. Springer-Verlag, Heidelberg 1992; 178: 115–140
   Google Scholar
• Harrison R. Myasthenia gravis. Clinical Neuroimmunology, J. A. Aarli, W. M.H. Behan, P. O. Behan. Black-well Scientific Publications. 1987; 245–258
   Google Scholar