The Frequency of Homozygous Deletion of a Developmentally Regulated Vh Gene (Humhv3005) is Increased in Patients with Chronic Idiopathic Thrombocytopenic Purpura

References

• George J. N., El-Harake M. A., Aster R. H. Thromb-ocytopenia due to enhanced platelet destruction by immunologic mechanisms. Williams Hematology, fifth Edition, E. Beutler, M. A. Lichtman, B. S. Coller, T. J. Kipps. McGraw-Hill, Inc., New York 1995; 1315–1342
   Google Scholar
• McMillan R., Imbach P. A. Immune thrombocytopenic purpura. Thrombosis and Hemorrhage, J. Loscalzo, A. I. Schager. Blackwell Scientific Publications, Inc., Boston 1994; 575–595
   Google Scholar
• Helmerhost F. M., Nijenhuis L. E., de Lange G. G., van den Berg-Loonen P. M., Jansen M. F., von dem Borne A. E., et al. HLA antigens in idiopathic thromb-ocytopenic purpura. Tissue Antigens 1982; 20: 372–379
   Google Scholar
• Gratama J. W., D'Amaro J., de Koning J., den Ottolander G. J. The HLA-system in immune thrombocytopenic purpura: its relation to the outcome of therapy. Br. J. Haematol. 1984; 56: 287–293
   PubMed Web of Science ®Google Scholar
• Porges A., Bussel J., Kimberly R., Schulman I., Pollack M., Pandey J., et al. Elevation of platelet associated antibody levels in patients with chronic idiopathic thrombocytopenic purpura expressing the B8 and/or DK3 allotypes. Tissue Antigens 1985; 26: 132–137
   PubMedGoogle Scholar
• Conley C. L. Idiopathic thrombocytopenic purpura. Arch. Intern. Med. 1986; 146: 1244–1247
   PubMedGoogle Scholar
• El-Khateeb M. S., Awidi A. S., Tarawneh M. S., Abu-Khalaf M. HLA antigens, blood groups and immunoglobulin levels in idiopathic thrombocytopenic purpura. Acta. haemat. 1986; 16: 110–114
   Google Scholar
• Gaiger A., Neumeister A., Heinzl H., Pabinger I., Panzer S. HLA class-I and II antigens in chronic idiopathic autoimmune thrombocytopenia. Ann. Hematol. 1994; 68: 299–302
   PubMed Web of Science ®Google Scholar
• Norris A. D. C. Hiopathic thrombocytopenic purpura in identical twins. Br. J. Clin. Pract. 1973; 27: 95–97
   Google Scholar
• Laster A. J., Conley C. L., Kickler T. S., Dorsch C. A., Bias W. B. Chronic immune thrombocytopenic purpura in monozygotic twins. N. Engl. J. Med 1982; 397: 1495–1498
   Google Scholar
• Bias W. B., Reveille J. D., Beaty T. H., Meyers D. A., Arnett F. C. Evidence that autoimmunity in man is a Mendelian dominant trait. Am. J. Hum. Genet. 1986; 39: 584–602
   PubMed Web of Science ®Google Scholar
• Yang P-M., Olsen N. J., Siminovitch K. A., Olec T., Korin F., Carson D. A., et al. Possible deletion of a developmentally regulated Vh gene in autoimmune disease. Proc Natl. Acad. Sci. USA 1990; 87: 7907–7911
   PubMed Web of Science ®Google Scholar
• Olee T., Yang P-M., Siminovith K. A., Olsen N. J., Hillson J., Wu J., et al. Molecular basis of an autoantibody-associated restriction fragment length polymorphism that confers susceptibility to autoimmune diseases. J. Clin. Invest. 1991; 88: 193–203
   PubMed Web of Science ®Google Scholar
• Huang D-F., Siminovitch K. A., Liu X. Y., Olee T., Olsen N. J., Berry C., et al. Population and family studies of three disease-related polymorphic genes in systemic lupus erythematosus. J. Clin. Invest. 1995; 95: 1766–1772
   Google Scholar
• Dwyer J. M. Manipulating the immune system with immune globulin. N. Engl. J. Med. 1992; 326: 107–116
   PubMed Web of Science ®Google Scholar
• Berchtold P., Wenger M. Autoantibodies against platelet glycoproteins in autoimmune thrombocytopenic purpura: Their clinical significance and response to treatment. Blood 1993; 81: 1246–1250
   PubMed Web of Science ®Google Scholar
• Berchtold P., Dale G. L., Tani P., McMillan K. Inhibition of autoantibody binding to platelet glycoprotein IIb/IIIa by anti-idioptic antibodies in intravenous gammaglobulin. Blood 1989; 74: 2414
   PubMed Web of Science ®Google Scholar
• Kossi F., Kazatchkintyp M. D. Antiidiatypes against autoantibodies in pooled normal human polyspecific Ig. J. Immunol. 1989; 143: 4104–4109
   Google Scholar
• Rossi F., Dietrich G., Kazatchkine M. D. Anti-idiotypes against autoantibodies in normal immunoglobulins: Evidence for network regulation of human autoimmune responses. Immunol. Rev. 1989; 110: 136–149
   Google Scholar
• Devereux J., Haeberli P., Smithies O. A comphrensive set of sequence analysis programs for the VAX. Nucleic Acids Rev. 1984; 12: 387–395
   PubMed Web of Science ®Google Scholar
• Sasso E. H., Van Dijk K. W., Bull A., Van der Maarel S. M., Milner E. C. B. VH genes in tandem array comprise a repeated germline motif. J. Immunol. 1992; 149: 1230–1236
   Google Scholar
• Casali P., Notkins A. L. Probing the human B-cell repertoire with EBV: Polyreactive antibodies and CD5+ B lymphocytes. Anm. Rev. Immunol. 1989; 7: 513–535
   PubMed Web of Science ®Google Scholar
• Chen P. P., Olsen N. J., Yang P. M., Soto-Gil K. W., Olee T., Siminovitch K. A., et al. From human autoantibodies to fetal antibody repertoire to B cell malignancy: It's a small world after all. Int. Rev. Immunol. 1990; 5: 239–251
   PubMedGoogle Scholar
• Chen P. P., Carson D. A. New insights on the physiological and pathological rheumatoid factors in humans. Autoimmunity: Physiology and Disease, A. Coutinho, M. D. Kazatchkine. Wiley-Liss, Inc., New York 1994; 247–266
   Google Scholar
• Theofilopoulos A. N. The basis of autoimmunity: Part I. Mechanisms of aberrant self-recognition. Immunol. Today 1995; 16: 90–98
   PubMedGoogle Scholar
• Denomme G. A., Smith J. W., Kelton J. G., Bell D. A. A human monoclonal autoantibody to platelet glyco-protein IIb derived from normal human lymphocytes. Blood 1992; 79: 447–451
   Google Scholar
• Denomme G. A., Kelton J. G., Bell D. A. The production of human monoclonal antiplatelet autoantibodies derived from human lymphocytes of normal origin: Reactivity to DNA, anionic phospholipids and platelet proteins. Br. J. Haematol. 1992; 82: 99–106
   Google Scholar
• Burastero S. E., Casali P., Wilder R. L., Notkins A. L. Monoreactive high affinity and polyreactive low affinity rheumatoid factors are produced by CD5+ B cells from patients with rheumatoid arthritis. J. Exp. Med 1988; 168: 1979–1992
   PubMed Web of Science ®Google Scholar
• Lu E. W., Deftos M., Tighe H., Carson D. A., Chen P. P. Generation and characterization of two monoclonal self-associating IgG rheumatoid factors from a rheumatoid synovium. Arthritis Rheum. 1992; 35: 101–105
   Google Scholar
• Borretzen M., Randen I., Zdársky E., Forre O., Natvig J. B., Thompson K. M. Control of autoantibody affinity by selection against amino acid replacements in the complementarity-determining regions. Proc. Natl. Acad. Sci. USA 1994; 91: 12917–12921
   Google Scholar
• Kasaian M. T., Ikematsu H., Balow J. E., Casali P. Structure of the VH and VL segments of monoreactive and polyreactive IgA autoantibodies to DNA in patients with systemic lupus erythematosus. J. Immunol. 1994; 152: 3137–3151
   PubMed Web of Science ®Google Scholar
• Siminoviteh K. A., Misener V., Kwong P. C., Song Q-L., Chen P. P. A natural autoantibody is encoded by germline heavy and lambda light chain variable region genes without somatic mutation. J. Clin. Invest. 1989; 84: 1675–1678
   Google Scholar
• Schroeder H. W., Jr., Wang J. Y. Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life. Proc. Natl. Acad. Sci. USA 1990; 87: 6146–6150
   PubMed Web of Science ®Google Scholar
• Coutinho A. Beyond clonal selection and network. Immunol. Rev. 1989; 110: 63–87
   PubMed Web of Science ®Google Scholar
• Weill J-C., Reynaud C-A. Early B-cell development in chickens. sheep and rabbits. Curr. Opinion Immunol. 1992; 4: 177–180
   PubMed Web of Science ®Google Scholar
• von Bochmer H. Positive selection of lymphocytes. Cell 1994; 76: 219–228
   Google Scholar
• Pascual V., Randen I., Thompson K., Sioud M., Forre O., Natvig J., et al. The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein-Barr virus-transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis. J. Clin, Invest. 1990; 86: 1320–1328
   PubMed Web of Science ®Google Scholar
• Carson D. A., Chen P. P., Fox K. I., Kipps T. J., Jirik F., Goldfien R. D., et al. Rheumatoid factors and immune networks. Annu. Rev. Immunol. 1987; 5: 109–126
   PubMed Web of Science ®Google Scholar