Influence of the Light Chain Repertoire on Immunoglobulin Genes Encoding Thyroid Autoantibody Fab from Combinatorial Libraries

References

• Burton D. R., Barbas C. F., III. Human antibodies from combinatorial libraries. Advances in Immunology 1994; 57: 191–281
   PubMed Web of Science ®Google Scholar
• Winter G., Griffiths A. D., Hawkins R. E., Hoogenboom H. R. Making antibodies by phage display technology. Ann. Rev. Immunol. 1994; 12: 433–455
   PubMed Web of Science ®Google Scholar
• Rapoport B., Portolano S., McLachlan S. M. Combinatorial immunoglobulin gene libraries: new insights into human organ-specific autoantibodies. Immunol. Today 1995; 16: 43–49
   PubMedGoogle Scholar
• Portolano S., Seto P., Chazenbalk G. D., Nagayama Y., McLachlan S., Rapoport B. A human Fab fragment specific for thyroid peroxidase generated by cloning thyroid lymphocyte-derived immunoglobulin genes in a bacteriophage lambda library. Biochem. Biophys. Res. Comm. 1991; 179: 372–379
   PubMed Web of Science ®Google Scholar
• Portolano S., Chazenbalk G. D., Seto P., Hutchison J. S., Rapoport B., McLachlan S. M. Recognition by recombinant autoimmune thyroid disease-derived Fab fragments of a dominant conformational epitope on human thyroid peroxidase. J. Clin. Invest. 1992; 90: 720–726
   PubMed Web of Science ®Google Scholar
• Portolano S., Chazenbalk G. D., Hutchison J. S., McLachlan S. M., Rapoport B. Lack of promiscuity in autoantigen-specific H and L chain combinations as revealed by human H and L chain “roulette”. J. Immunol. 1993; 150: 880–887
   PubMedGoogle Scholar
• Chazenbalk G. D., Portolano S., Russo D., Hutchison J. S., Rapoport B., McLachlan S. M. Human organ-specific autoimmune disease: molecular cloning and expression of an autoantibody gene repertoire for a major autoantigen reveals an antigenic dominant region and restricted immunoglobulin gene usage in the target organ. J. Clin. Invest. 1993; 92: 62–74
   PubMed Web of Science ®Google Scholar
• Portolano S., McLachlan S. M., Rapoport B. High affinity, thyroid-specific human autoantibodies displayed on the surface of filamentous phage use V genes similar to other autoantibodies. J. Immunol. 1993; 151: 2839–2851
   PubMed Web of Science ®Google Scholar
• Hexham J. M., Partridge L. J., Furmaniak J., Petersen V. B., Colls J. C. J., Peg C. R., Rees Smith B., Burton D. R. Cloning and characterisation of TPO autoantibodies using combinatorial phage display libraries. Autoimmunity 1994; 17: 167–179
   PubMedGoogle Scholar
• Prummel M. F., Portolano S., Costante G., Rapoport B., McLachlan S. Isolation and characterization of a monoclonal human thyroid peroxidase autoantibody of lambda light chain type. Molec. Cell. Endocrinol. 1994; 102: 161–166
   Google Scholar
• Portolano S., Prummel M. F., Rapoport B., McLachlan S. M. Molecular cloning and characterization of human thyroid peroxidase autoantibodies of lambda light chain type. Molec. Immunol. 1995; 32: 1157–1169
   PubMedGoogle Scholar
• McLachlan S. M., Rapoport B. Genetic and epitopic analysis of thyroid peroxidase (TPO) autoantibodies: markers of the human thyroid autoimmune response. Clin. Exp. Immunol. 1995; 101: 200–206
   PubMed Web of Science ®Google Scholar
• Nishikawa T., Costante G., Prummel M. F., McLachlan S. M., Rapoport B. Recombinant thyroid peroxidase autoantibodies can be used for epitopic “fingerprinting” of thyroid peroxidase autoantibodies in the sera of individual patients. J. Clin. Endocrinol. Metab. 1994; 78: 944–949
   PubMedGoogle Scholar
• Jaume J. C., Costante G., Nishikawa T., Phillips D. I. W., Rapoport B., McLachlan S. M. Thyroid peroxidase autoantibody fingerprints in hypothyroid and euthyroid individuals. I. Cross-sectional study in elderly women. J. Clin. Endocrinol. Metab. 1995; 80: 994–999
   PubMed Web of Science ®Google Scholar
• Jaume J. C., Parkes A. B., Lazarus J. H., Hall R., Costante G., McLachlan S. M., Rapoport B. Thyroid peroxidase autoantibody fingerprints II. A longitudinal study in postpartum thyroiditis. J. Clin. Endocrinol. Metab. 1995; 80: 1000–1005
   PubMed Web of Science ®Google Scholar
• Jaume J. C., Burek C. L., Hoffman W. H., Rose N. R., McLachlan S. M., Rapoport B. Thyroid peroxidase autoantibody epitopic “fingerprints” in juvenile Hashimoto's thyroiditis: evidence for conservation over time and in families. Clin. Exp. Immunol. 1996; 104: 115–123
   PubMedGoogle Scholar
• Jaume J. C., Costante G., Portolano S., McLachlan S. M., Rapoport B. Recombinant thyroid peroxidase-specific autoantibodies: I. How diverse is the pool of H and L chain genes in immunoglobulin combinatorial libraries constructed from thyroid tissue-infiltrating plasma cells. Endocrinology 1994; 134: 16–24
   Google Scholar
• Saiki R. K., Gelfand D. N., Stoffel S., Scharf S. J., Higuchi R., Horn G. T., Mullis K. B., Erlich H. A. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 1988; 239: 487–4911
   PubMed Web of Science ®Google Scholar
• Marks J. D., Hoogenboom H. R., Bonnert T. P., McCafferty J., Griffiths A. D., Winter G. By-passing immunization: human antibodies from V-gene libraries displayed on phage. J. Mol. Biol. 1991; 222: 581–597
   PubMed Web of Science ®Google Scholar
• Barbas C. F., III, Kang A. S., Lerner R. A., Benkovic S. J. Assembly of combinatorial antibody libraries on phage surfaces: the gene III site. Proc. Natl Acad. Sci. USA 1991; 88: 7978–7982
   PubMed Web of Science ®Google Scholar
• Barbas C. P., III, Lener R. A. Combinatorial immunoglobulin libraries on the surface of phage (Phabs): Rapid selection of antigen-specific Fabs. Methods Comp. Methods Enzymol. 1991; 2: 119–124
   Google Scholar
• Kaufman K. D., Foti D., Seto P., Rapoport B. Over-expression of an immunologically-intact, secreted form of human thyroid peroxidase in eukaryotic cells. Molec. Cell. Endocrinol. 1991; 78: 107–114
   PubMedGoogle Scholar
• Salacinski P. R. P., McLean C., Sykes J. E. C., Clement-Jones V. V., Lowery P. J. Iodination of proteins, glycoproteins, and peptides using a solid-phase oxidizing agent, 1,3,4,6-tetrachloro-3 alpha, 6 alpha-diphenyl Glycoluril (Iodogen). Anal. Biochem. 1981; 117: 136–146
   PubMed Web of Science ®Google Scholar
• Sanger F., Nicklen S., Coulson A. R. DNA sequencing with chain terminating inhibitors. Proc. Natl Acad. Sci. USA 1977; 14: 5463–5467
   Google Scholar
• Scatchard G. The attractions of proteins for small molecules and ions. Ann. NY Acad. Sci. 1949; 51: 660–672
   Web of Science ®Google Scholar
• Foti D., Kaufman K. D., Chazenbalk G., Repoport B. Generation of a biologically-active, secreted form of human thyroid perosidase by site-directed mutagenesis. Mol. Endocrinol. 1990; 4: 786–791
   PubMedGoogle Scholar
• Nakajima Y., Howells R. D., Peg C., Davies Jones E., Rees Smith B. Structure activity analysis of microsomal antigen/thyroid peroxidase. Mol. Cell. Endocrinol. 1987; 53: 15–23
   PubMed Web of Science ®Google Scholar
• Pargent W., Meindl A., Thiebe R., Mitzel S., Zachau H. G. The human immunoglobulin k locus. Characterization of the duplicated O regions. Eur. J. Immunol. 1991; 21: 1821–1827
   PubMedGoogle Scholar
• Huber C., Schable K. F., Huber E., Klein R., Meindl A., Thiebe R., Lamm R., Zachau H. G. The V kappa genes of the L regions and the repertoire of V kappa gene sequences in the human germ line. Eur. J. Immunol. 1993; 23: 2868–2875
   PubMed Web of Science ®Google Scholar
• Klein R., Jaenichen R., Zachau H. G. Expressed human immunogloblin kappa genes and their hyper-mutation. Eur. J. Immunol. 1993; 23: 3248–3271
   PubMed Web of Science ®Google Scholar
• Chen P. P., Robbins D. L., Jirik F. R., Kipps T. J., Carson D. A. Isolation and characterization of a light chain variable region gene for human rheumatoid factors. J. Exp. Med. 1987; 166: 1900–1905
   PubMed Web of Science ®Google Scholar
• Cox J. P. L., Tomlinson I. M., Winter G. A directory of human germ-line Vk segments reveals a strong bias in their usuage. Eur. J. Immunol. 1994; 24: 827–836
   PubMed Web of Science ®Google Scholar
• Klobeck H. G., Bornkamm G. W., Combriato G., Mociksy R., Pohlenz H. D., Zachau H. G. Subgroup IV of human immunoglobulin K light chains is encoded by a single germline gene. Nucl. Acids Res. 1985; 13: 6515–6529
   PubMedGoogle Scholar
• Shin E. K., Matsuda F., Nagaoka H., Fukita Y., Imai T., Yokoyama K., Soeda E., Honjo T. Physical map of the 3' region of the human immunoglobulin heavy chain locus: clustering of autoantibody-related variable segments in one haplotype. EMBO J. 1991; 10: 3641–3645
   PubMed Web of Science ®Google Scholar
• Matthyssens G., Rabbitts T. H. Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region. Biochem. 1980; 77: 6561–6565
   Google Scholar
• Tomlinson I. M., Walter G., Marks J. D., Llewelyn M. B., Winter G. The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops. J. Mol. Biol. 1992; 227: 116–198
   Google Scholar
• Olee T., Lu E. W., Nuang D. F., Soto-Gil R. W., Deftos M., Kozin F., Carson D. A., Chen P. P. Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven response. J. Exp. Med. 1992; 175: 831–842
   PubMedGoogle Scholar
• Portmann L., Fitch F. W., Havran W., Hamada N., Franklin W. A., DeGroot L. J. Characterization of the thyroid microsomal antigen, and its relationship to thyroid peroxidase, using monoclonal antibodies. J. Clin. Invest. 1988; 81: 1217–1224
   PubMed Web of Science ®Google Scholar
• Williams S. C., Winter G. Cloning and sequencing of human immunoglobulin Vlambda gene segments. Eur. J. Immunol. 1993; 23: 1456–1461
   PubMed Web of Science ®Google Scholar
• Pascual V., Randen I., Thompson K., Sioud M., Forre O., Natvig J., Capra J. D. The complete nucleo-tide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein-Barr virus-transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis. J. Clin. Invest. 1990; 86: 1320–1328
   PubMed Web of Science ®Google Scholar
• Dersimonian H., Schwartz R. S., Barret K. J., Stollar B. D. Relationship of human variable region heavy chain germ-line genes to genes encoding anti-DNA autoantibodies. J. Immuol. 1987; 139: 2496–2501
   PubMed Web of Science ®Google Scholar
• Pascual V., Capra J. D. VH-21, a human VH gene segment overrepresented in the autoimmune repertoire. Arth. Rheum. 1992; 35: 11–18
   PubMed Web of Science ®Google Scholar
• Ikematsu H., Harindranath N., Ueki Y., Notkins A. L., Casali P. Clonal analysis of a human antibody response. II. Sequences of the VH genes of human IgM, IgG, and IgA to rabies virus reveal preferential utilization of VH III segments and somatic hypermutation. J. Immunol. 1993; 150: 1325–1337
   PubMedGoogle Scholar
• Rees Smith B., McLachlan S. M., Furmaniak J. Autoantibodies to the thyrotropin receptor. Endocr. Rev. 1988; 9: 106–121
   PubMed Web of Science ®Google Scholar
• McLachlan S. M., Rapoport B. The molecular biology of thyroid peroxidase: cloning, expression and role as autoantigen in autoimmune thyroid disease. Endocr. Rev. 1992; 13: 192–206
   PubMed Web of Science ®Google Scholar
• De Forteza R., Smith C. U., Amin J., McKenzie J. M., Zakarija M. Visualization of the thyrotropin receptor on the cell surface by potent autoantibodies. J. Clin. Endocrinol. & Metab. 1994; 78: 1211–1273
   Google Scholar
• McLachlan S. M., Rapoport B. Recombinant thyroid autoantigens: the keys to the pathogenesis of autoimmune thyroid disease. J. Int. Med. 1993; 234: 347–359
   PubMedGoogle Scholar