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Original Article

Cytokines in the Evolution of Graves' Ophthalmopathy

, &
Pages 129-136 | Received 15 Nov 1996, Accepted 12 Mar 1997, Published online: 07 Jul 2009

References

  • Bahn R. S., Heufelder A. E. Mechanisms of disease: pathogenesis of Graves' ophthalmopathy. N Engl J Med 1993; 329: 1468–1475
  • Bahn R. S. Assessment and management of the patient with Graves' ophthalmopathy. Endo Practice 1995; 1: 172–178
  • Campbell R. J. Pathology of Graves' ophthalmopathy. The eye and orbit in thyroid disease, C. A. Gorman, R. A. Walle, J. A. Dyer. Raven Press, New York 1984; 25–31
  • Weetman A. P., Cohen S., Gatter K. C, Fells P., Shine B. lmmunohistochemical analysis of the retrobulbar tissues in Graves' ophthalmopathy. Clin Exp Immunol 1989; 75: 222–227
  • Heufelder A. E., Bahn R. S. Detection and localization of cytokine immunoreactivity in retro-ocular connective tissue in Graves' ophthalmopathy. Eur J Clin Invest 1993; 23: 10–17
  • De Carli M, DˆElios M. M., Mariotti S., Marcocci C, Pinchera A., Ricci M., Romagnani S., Del Prete G. Cytolytic T cells with Th-1-like cytokine profile predominate in retroorbital lymphocytic infiltrates of Graves' ophthalmopathy. J Clin Endocrinol Metab 1993; 77: 1120–1124
  • McLachlan S. M., Prummel M. F., Rapoport B. Cell-mediated or humoral immunity in Graves' ophthalmopathy? Profiles of T cell cytokines amplified by polymerase chain reaction. J Clin Endocrinol Metab 1994; 78: 1070–1074
  • Grubeck-Loebenstein B., Trieb K., Sztankay A., Hol-Ter W., Andert H., Wick G. Retrobulbar T cells from patients with Graves' ophthalmopathy are CD8+ and specifically recognize autologous fibroblasts. J Clin Invest 1994; 93: 2738–2743
  • Smith T. J., Bahn R. S., Gorman C. A. Connective tissue, glycosaminoglycans and diseases of the thyroid. EndocrRev 1989; 10: 366–391
  • Smith T. J., Bahn R. S., Gorman C. A., Cheav-Ens M. Stimulation of glycosaminoglycan accumulation by interferon-gamma in cultured human retroocular fibroblasts. J Clin Endocrinol Metab 1991; 72: 1169–1171
  • Korducki J. M., Loftus S. J., Bahn R. S. Stimulation of glycosaminoglycan production in cultured human retroocular fibroblasts. Invest Ophthalmol Vis Sci 1992; 33: 2037–2042
  • Sisson J. C. Stimulation of glucose utilization and glycosaminoglycan production in cultured human retroocular fibroblasts. Exp Eye Res 1971; 12: 285–292
  • Heufelder A. E., Bahn R. S. Modulation of Graves' orbital fibroblast proliferation by cytokines and glucocorticoid receptor agonists. Invest Ophthalmol Vis Sci 1994; 35: 120–126
  • Benacerraf B. Role of MHC gene products in immune regulation. Science 1981; 212: 1229
  • Davies T. F., Piccinini L. A. Intrathyroidal MHC class 2 expression and thyroid autoimmunity. Endocrinol Metab Clin North Am 1987; 16: 247
  • Heufelder A. E., Smith T. J., Gorman C. A., Bahn R. S. Increased induction of HLA-DR interferon-/ in cultured fibroblasts derived from patients with Graves' ophthalmopathy and pretibial dermopathy. J Clin Endocrinol Metab 1991; 73: 307–313
  • Razi-Wolf Z., Freeman G. J., Galvin F., Benacerraf B., Nadler L., Reiser H. Expression and function of the murine B7 antigen, the major co-stimulatory molecule expressed by peritoneal exudate cells. Proc Natl Acad Sci USA 1992; 89: 4210–4214
  • Albelda S. M. Buck CA: Integnns and other cell adhesion molecules. FASEB J 1990; 4: 2868–2880
  • Warwryk S. O., Novotny J. R., Wicks I. P., Wilkinson D., Maher D., Salvaris E., Welch K., Fecondo J., Boyd A. W. The role of the LFA-1/ICAM-1 interaction in human leukocytes homing and adhesion. ImmumolRev 1989; 108: 135–161
  • Heufelder A. E., Bahn R. S. Elevated expression in situ of selectin and immunoglobulin superfam-ily type adhesion molecules in retroocular connective tissues from patients with Graves' ophthalmopathy. Clin Exp Immunol 1993; 91: 381–389
  • Heufelder A. E., Bahn R. S. Graves' immunoglobulins and cytokines stimulate the expression of intercellular adhesion molecule-1 (ICAM-1) in cultured Graves' orbital fibroblasts. Eur J Clin Invest 1992; 22: 529–537
  • Chiang H-L., Terlecky S. R., Plant C. L. P., Dice J. F. A role for a 70 kilodalton heat shock protein in lysosomal degradation of intracellular proteins. Science 1989; 246: 382–385
  • Vanbuskirk A, Crump B. L., Margoliash E., Pierce S. K. A peptide binding protein having a role in antigen presentation is a member of the HSP 70 heat shock family. J Exp Med 1989; 170: 1799–1809
  • Heufelder A. E., Wenzel B. E., Bahn R. S. Cell surface localization of a 72 kilodalton heat shock protein in retroocular fibroblasts from patients with Graves' ophthalmopathy. J Clin Endocrinol Metab 1992; 74: 732–736
  • Heufelder A. E., Wenzel B. E., Gorman C. A., Bahn R. S. Detection, cellular localization, and modulation of heat shock proteins in cultured fibroblasts from patients with extrathyroidal manifestations of Graves' disease. J Clin Endocrinol Metab 1991; 73: 739–745
  • Lamb J. R., Bal V., Mendez-Sampiero P., et al. Stress proteins may provide a link between the immune response to infection and autoimmunity. Internal Immunol 1989; 1: 191–196
  • Tan G. H., Dutton C. M., Bahn R. S. Inter-leukin-1 receptor antagonist and soluble interleukin-1 receptor inhibit interleukin-1-induced glycosaminoglycan production in cultured human orbital fibroblasts from patients with Graves' ophthalmopathy. J Clin Endocrinol Metab 1995; 81: 449–452
  • Dinarello C., Wolf S. The role of interleukin-1 in disease. N Engl J Med 1993; 328: 106–113
  • Makarov S. S., Olsen J. C, Johnston W. N., Anderle S. K., Brown R. R., Baldwin A. S., Haskill J. S., Schwab J. H. Suppression of experimental arthritis by gene transfer of interleukin-1 receptor antagonist cDNA. Proc Natl Acad Sci 1991; 93: 402–406
  • Bahn R. S., Heufelder A. E. Retroocular fibroblasts: important effector cells in Graves' ophthalmopathy. Thyroid 1992; 2: 89–94

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