15
Views
8
CrossRef citations to date
0
Altmetric
Original Article

Pancreatic IL-10 Induces Diabetes in NOD. B6 Idd3 Idd10 Mice

, , &
Pages 215-221 | Received 26 Aug 1996, Published online: 07 Jul 2009

References

  • Ding L., Shevach E. M. IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function. J Immunol. 1992; 148: 3133–3139
  • Ding L., Linsley P. S., Huang L-Y. Germain RN, Shevach EM. IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. J Immunol 1993; 151: 1224–1234
  • Lee M-S., Wogensen L., Shizuru J., Oldstone M. B. A., Sarvetnick N. Pancreatic islet production of murine interleukin 10 does not inhibit immune-mediated tissue destruction. /. Clin Invest 1994; 93: 1332–1338
  • Wogensen L., Lee M-S., Sarvetnick N. Production of interleukin 10 by islet cells accelerates immune-mediated destruction of b cells in nonobese diabetic mice. J Exp Med. 1994; 179: 1379–1384
  • Moritani M., Yoshimoto K., Tashiro F., Hashimoto C, Miyazaki J., Ii S., Kudo E., Iwahana H, Hayashi Y., Sano T., Itakura M. Transgenic expression of IL-10 in pancreatic islet A cells accelerates autoimmune insulitis and diabetes in non-obese diabetic mice. Int Immunol 1994; 6: 1927–1936
  • Lee M-S., Mueller R., Wicker L. S., Peterson L. B., Sarvetnick N. IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity. J Exp Med. 1996; 183: 2663–2668
  • Hearne C. M., McAleer M. A., Love J. M., Aitman T. J., Cornall R. J., Ghosh S., Knight A. M., Prins J-B., Todd J. A. Additional microsatellite markers for mouse genome mapping. Mammalian Genome 1991; 1: 273–282
  • Aitman T. J., Hearne C. M., McAleer M. A., Todd J. A. Mononucleotide repeats are an abundant source of length variants in mouse genomic DNA. Mammalian Genome 1991; 1: 273–282
  • Podolin P. L., Pressey A., DeLarato N. H., Fischer P. A., Peterson L. B., Wicker L. S. I-E+ Nonobese Diabetic mice Develop Insulitis and Diabetes. J Exp Med 1993; 178: 793–803
  • Wicker L. S., Tood J. A, Prins J-B., Podolin P L., Ren-Jilian R. J., Peterson L. B. Resistance alleles at two non-major histocompability complex-linked-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes. J Exp Med. 1994; 180: 1705–1713
  • Wogensen L., Huang X., Sarvetnick N. Leukocyte extravasation into the pancreatic tissue in transgenic mice expressing interleukin-10 in the islets of Langerhans. J Exp Med 1993; 175–185
  • Allison J., McClive P., Oxbrow L., Baxter A., Morahan G., Miller J. F. A. P. Genetic requirements for acceleration of diabetes in non-obese diabetic mice expressing interleukin-2 in islet b-cells. Eur J Immunol. 1994; 24: 2535–2541
  • MacNeil I. A., Suda T., Moore K. W., Mosmann T. R., Zlotnik A. IL-10, a novel growth cofactor for mature and immature T cells. J Immunol. 1990; 145: 4167–4173
  • Go N. F., Castle B. E., Barrett R., Kastelein R., Dang W., Mosmann T. R., Moore K. W., Howard M. Interleukin-10, a novel B cell stimulatory factor: Unresponsiveness of X chromosome-linked immunodeficiency B cells. J Exp Med 1990; 172: 1525–1631
  • Jinquan T., Larsen C. G., Gesser B., Matsushima K., Thestrup-Peterson K. Human IL-10 is a chemoat-tractant for CD8+ T lymphocytes and an inhibitor of IL-8-induced CD4+ T lymphocyte migration. J Immunol. 1993; 151: 4545–4551
  • Rousset F., Garcia E., Defrance T., Peronne C, Vez-Zio N., Hsu D-H., Kastelein R., Moore K. W., Banchereau J. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc Natl Acad Sci USA 1992; 89: 1890–1893
  • Defrance T., Vanbervliet B., Briere F., Durand I., Rousset F., Banchereau J. Interleukin 10 and transforming growth factor b cooperate to induce anti-CD40-activated naive human B cells to secret immunoglobulin A. J Exp Med 1992; 175: 671–682
  • Ishida H., Muchamuel T., Sakaguchi S., Andrade S., Menon S., Howard M. Continuous administration of anti-interleukin 10 antibodies delays onset of autoimmunity in NZB/W F1 mice. J Exp Med. 1994; 179: 305–310
  • Llorente L., Richaud-Patin Y., Fior R., Alcocer-Varela J., Wijdenes J., Fourrier B. M., Galanaud P., Emilie D. In vivo production of interleukin-10 by non-T cells in rhematoid arthritis, Sjogren's syndrome, and systemic lupus erythematosus. Arthritis Rheum. 1994; 37: 1647–1655
  • Llorente L., Zou W., Levy Y., Richaud-Patin Y., Wid-Jenes J., Alcocer-Varela J., Morel-Fourrier B., Brouet J-C, Alarcon-Segovia D., Pierre G., Emilie D. Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus. J Exp Med 1995; 181: 839–844
  • Richter G., Kruger-Krasagakes S., Hein G., Huls C, Schmitt E., Diamantstein T., Blankenstein T. Interleukin 10 transfected into Chinese Hamster Ovary cells prevents tumor growth and macrophage infiltration. Cancer Res. 1993; 53: 4134–4137
  • Suzuki T., Tahara H., Narula S., Moore K. W., Robbings P. D., Lotze M. T. Viral interleukin 10 (IL-10), the human herpes virus 4 cellular IL-10 homologue, induces local anergy to allogeneic and syngeneic tumors. J Exp Med 1995; 182: 477–486
  • Giovarelli M., Musiani P., Modesti A., Dellabona P., Casorati G., Allione A., Consalvo M., Cavallo F., di Pierro F., De Giovanni C, Musso T., Forni G. Local release of IL-10 by transfected mouse mammary adenocarcinoma cells does not suppress but enhances antitumor reaction and elicits a strong cytotoxic lymphocyte and antibody-dependent immune memory. J Immunol 1995; 155: 3112–3123

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.