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Autoimmunity Volume 26, 1997 - Issue 4
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Original Article

Cytokines and Autoimmune β Cell Destruction in NOD Mouse Fetal Pancreas Isografts in

J. Kovarik Transplantation Unit, The Walter and Eliza Hall Institute of Medical Research, Parkville, 3050, Australia
,
B. E. Faulkner-Jones Department of Anatomy, University of Melbourne, Melbourne, Australia
,
M. Koulmanda Transplantation Unit, The Walter and Eliza Hall Institute of Medical Research, Parkville, 3050, Australia
&
T. E. Mandel Transplantation Unit, The Walter and Eliza Hall Institute of Medical Research, Parkville, 3050, AustraliaCorrespondence[email protected]
Pages 245-252 | Received 16 Sep 1996, Published online: 07 Jul 2009

References

  • Bach J. F. Insulin-dependent diabetes mellitus as an autoimmune disease. Endocrine Reviews 1994; 15: 516–542
  • Pozzilli P., Signore A., Williams A. J., Beales P. E. NOD mouse colonies around the world-recent facts and figures. Immunol. Today 1993; 14: 193–196
  • Campbell I. L., Kay T. W., Oxbrow L., Harrison L. C. Essential role for interferongamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice. J. 87 1991; 87: 739–742
  • Mandel T. E., Kovarik J., Koulmanda M. A comparison of organ cultured fetal pancreas alio-, iso, and xenografts (pig) in non-immunosuppressed non-obese diabetic mice. Am. J. Pathol. 1995; 147: 834–844
  • Mandel T. E., Hoffman L., Collier S., Carter W. M., Koulmanda M. Organ culture of fetal mouse and fetal human pancreatic islets for allografting. Diabetes 1982; 31: 39–47
  • Faulkner-Jones B. E., Dempsey-Collier M., Mandel T. E., Harrison L. C. Both T(H)1 and T(H)2 cytokine mRNAs are expressed in the NOD mouse pancreas in vivo. Autoimmunity 1996; 23: 99–110
  • Kovarik J., Faulkner-Jones B. E., Koulmanda M., Mandel T. E. Expression of cytokines during rejection of fetal pig islet xenografts in nonobese diabetic mice. Transplant. Proc 1996; 28: 831
  • Hultgren B., Huang X., Dybdal N., Stewart T. A. Genetic absence of y-interferon delays but does not prevent diabetes in NOD mice. Diabetes 1996; 45: 812–815
  • Yang X-D., Tisch R., Singer S. M., Cao Z. A., Liblau R. S., Schreiber R. D. Effect of tumor necrosis factor α in insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process. J. 180 1994; 180: 995–1004
  • Held W., MacDonald H. R., Weissman I. L., Hess M. W., Mueller C. Genes encoding tumor necrosis factor a and granzyme A are expressed during development of autoimmune diabetes. Immunolgy 1990; 87: 2239–2243
  • Rabinovitch A., Sorensen O., Suarez-Pinzon W. L., Power R. F., Rajotte R. V., Bleackley R. C. Analysis of cytokine mRNA expression in syngeneic islet grafts of NOD mice;interleukin 2 and interferon gamma mRNA expression correlate with graft rejection and interleukin 10 with graft survival. Diabetologia 1994; 37: 833–837
  • Rabinovitch A., Suarez-Pinzon W. L., Sorensen O., Bleackley R. C, Power R. F., Rajotte R. V. Combined therapy with interleukin-4 and interleukin-10 inhibits autoimmune diabetes recurrence in syngeneic islet-transplanted nonobese diabetic mice. Transplantation 1995; 60: 368–374
  • Rothe H., Faust A., Schade U., Kleemann R., Bosse G., Hibino T. Cyclophosphamide treatment of female non-obese diabetic mice causes enhanced expression of inducible nitric oxide synthase and interferon-gamma, but not of interleukin-4. Diabetologia 1994; 37: 1154–1158
  • Pilstrom B., Bjork L., Bohme J. Demonstration of a T-H1 cytokine profile in the late phase of NOD insulitis. Cytokine 1995; 7: 806–814
  • Rabinovitch A., Suarez-Pinzon W., El-Sheikh A., Sorensen O., Power R. F. Cytokine gene expression in pancreatic islet-infiltrating leukocytes of BB rats. Expression of Th1 cytokines correlates with β-cell destructive insulitis and IDDM. Diabetes 1996; 45: 749–754
  • Anderson J. T., Cornelius J. G., Jarpe A. J., Winter W. E., Peck A. B. Insulin dependent diabetes in the NOD mouse model. II. /i cell destruction in autoimmune diabetes is a TH2 and not TH1 mediated event. Autoimmunity 1993; 15: 113–122

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