Glutamate Decarboxylase Antibodies in Non-Diabetic Pregnancy Precedes Insulin-Dependent Diabetes in the Mother but not Necessarily in the Offspring

References

• Baekkeskov S., Landin-Olsson M., Kristensen J. K., Sri-Kanta S., Bruining G. J., Mandrup-Poulsen T., De Beaufort C, Soeldner J. S., Eisenbarth G., Lindgren F. Antibodies to a Mr 64,000 human islet cell antigen precede the clinical onset of insulin-dependent diabetes. J Clin Invest 1987; 79: 926–934
   PubMed Web of Science ®Google Scholar
• Zimmet P. Z., Tuomi T., Mackay I. R., Rowley M. J., Knowles W., Cohen M., Lang D. A. Latent autoimmune diabetes mellitus in adults (LADA): The role of antibodies to glutamic acid decarboxylase in diagnosis and prediction of insulin dependency. Diabetic Med. 1994; 11: 299–303
   PubMed Web of Science ®Google Scholar
• Bingley P. J., Christie M. R., Bonifacio E., Bonifanti R., Shattock M., Fonte M. T., Bottazzo G. F., Gale E. A. Combined analysis of autoantibodies improves prediction of 1DDM in islet cell antibody-positive relatives. Diabetes 1994; 43: 1304–1310
   PubMed Web of Science ®Google Scholar
• Gorsuch A. N., Spencer K. M., Lister J., McNally J. M., Dean B. M, Bottazzo G. F., Cudworth A. G. Evidence for a long prediabetic period in Type 1 (insulin-dependent) diabetes mellitus. Lancet 1981; 2: 1363–1365
   PubMed Web of Science ®Google Scholar
• Tuomilehto J., Zimmet P., Mackay 1. R., Koskela P., Vid-Gren G., Tolvanen L., Tuomilehto-Wolf E., Kohtamaki K., Stengard J., Rowley M. J. Antibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus before clinical onset of disease. Lancet 1994; 343: 1383–1385
   PubMed Web of Science ®Google Scholar
• Landin-Olsson M., Palmer J. P., Lernmark Å., Blom L., Sundkvist G., Nystrom L., Dahlquist G. Predictive value of islet cell and insulin autoantibodies for type 1 (insulin-dependent) diabetes mellitus in a population-based study of newly-diagnosed diabetic and matched control children. Diabetologia 1992; 35: 1068–1073
   PubMed Web of Science ®Google Scholar
• Hagopian W. A., Sanjeevi C. B., Kockum 1., Landin-Olsson M., Karlsen A. E., Sundkvist G., Dahlquist G., Palmer J., Lernmark Å. Glutamate decarboxylase-, insulin-and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children. J. Clin. Invest. 1995; 95: 1505–1511
   PubMed Web of Science ®Google Scholar
• Dahlquist G., Blom L., Tuvemo T., Nyström L., Sandström A, Wall S. The Swedish Childhood Diabetes Study –results from a nine year case register and one year case-referent study indicating that type 1 (insulin-dependent) diabetes mellitus is associated with both type 2 (non-insulin-dependent) diabetes mellitus and autoimmune disorders. Diabetologia 1989; 32: 2–6
   PubMed Web of Science ®Google Scholar
• Warram J. H., Krolewski A. S., Gottlieb M. S., Kahn C. R. Differences in risk of insulin-dependent diabetes in offspring of diabetic mothers and diabetic fathers. N. Engl. J. Med 1984; 311: 149–152
   PubMed Web of Science ®Google Scholar
• Yu L., Chase H. P., Falorni A., Rewers M, Lernmark A., Eisenbarth G. S. Sexual dimorphism in transmission to offspring of expression of islet autoantibodies. Diabetologia 1995; 38: 1353–1357
   PubMedGoogle Scholar
• Ahlfors K., Ivarsson S-A., Johnsson I., Svanberg I. Primary and secondary maternal cytomegalovirus infections and their relation to congenital infection. Acta Paediatr. Scand 1982; 71: 109–113
   PubMed Web of Science ®Google Scholar
• Falorni A., Ortqvist E., Persson B., Lernmark A. Radioimmunoassays for glutamic acid decarboxylase (GAD65) and GAD65 autoantibodies using 33S or 3H recombinant human ligands. J. Immunol. Meth. 1995; 186: 89–99
   PubMed Web of Science ®Google Scholar
• Grubin C. E., Daniels T., Toivola B., Landin-Olsson M., Hagopian W. A., Li L., Karlsen A. E., Boel E., Michel-Sen B., Lernmark A. A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM. Diabetologia 1994; 37: 344–350
   PubMed Web of Science ®Google Scholar
• Schmidli R. S., Colman P. G., Bonifacio E., Bottazzo G. F., Harrison L. C. High level of concordance between assays for glutamic acid decarboxylase antibodies. The First International Glutamic Acid Decarboxylase Antibody Workshop. Diabetes 1994; 43: 1005–1009
   PubMed Web of Science ®Google Scholar
• Schmidli R. S., Colman P. G., Bonifacio E. Disease sensitivity and specificity of 52 assays for glutamic acid decarboxylase antibodies. The Second International GADAb Workshop. Diabetes 1995; 44: 636–640
   PubMed Web of Science ®Google Scholar
• Landin-Olsson M., Sundkvist G., Lernmark Å. Prolonged incubation in the two-colour immunofluorescence test increases the prevalence and titres of islet cell antibodies in type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1987; 30: 327–332
   PubMed Web of Science ®Google Scholar
• Landin-Olsson M. Precision of the islet cell antibody assay depends on the pancreas. J Clin Lab Anal 1990; 4: 289–294
   Google Scholar
• Bonifacio E., Bingley P. J., Shattock M., Dean B. M., Dunger D., Gale E. A. M., Bottazzo G. F. Quantification of islet cell antibodies and prediction of insulin dependent diabetes. Lancet 1990; 335: 147–149
   PubMed Web of Science ®Google Scholar
• Kockum I., Wassmuth R., Holmberg E., Michelsen B., Lernmark A. HLA-DQ primarily confers protection and HLA-DR susceptibility in Type 1 (insulin-dependent) diabetes studied in population-based affected families and controls. Am J Human Gen 1993; 53: 150–167
   PubMed Web of Science ®Google Scholar
• Sanjeevi C. B., Zeidler A., Shaw S., Rotter R., Nepom G. T., Costin G., Raffel L., Eastman S., Kockum I., Wassmuth R. Analysis of HLA-DQA1 and -DQB1 genes in Mexican Americans with insulin-dependent diabetes mellitus. Tissue Antigens 1993; 42: 72–77
   Google Scholar
• Sanjeevi C. B., Lybrand T. P., DeWeese C, Landin-Olsson M., Kockum I., Dahlquist G., Sundkvist G., Stenger D., Lernmark A. Polymorphic amino acid variations in HLA-DQ are associated with systematic physical property changes and occurrence of insulin-dependent diabetes mellitus. Diabetes 1995; 44: 125–131
   Google Scholar
• Kockum I., Sanjeevi C. B., Eastman S., Landin-Olsson M., Dahlquist G., Lernmark A. Population analysis of protection by HLA-DR and DQ genes protection from insulin-dependent diabetes mellitus in Swedish insulin-dependent diabetes children and controls. Eur. J. Immunogenetics 1995; 22: 443–465
   PubMedGoogle Scholar
• Sanjeevi C. B., Landin-Olsson M., Kockum I., Dahlquist G., Lernmark A. Effects of the second HLA-DQ haplotype on the association with childhood insulin dependent diabetes mellitus. Tissue Antigens 1994; 45: 148–152
   Google Scholar
• Atkinson M. A., Maclaren N. K., Scharp D. W., Lacy P. E., Riley W. J. 64: 000 Mr autoantibodies as predictors of insulin-dependent diabetes. Lancet 1990; 335: 1357–1360
   PubMed Web of Science ®Google Scholar
• Vandewalle C. L., Falorni A., Svanholm S., Lernmark A., Pipeleers D. G., Gorus F. K., Registry T. B. D. High diagnostic sensitivity of glutamate decarboxylase autoantibodies in IDDM with clinical onset between age 20 and 40 years. J. Clin. Endocrinol. Metab. 1995; 80: 846–850
   Google Scholar
• Palmer J. P. What is the best way to predict IDDM?. Lancet 1994; 343: 1377–1378
   Google Scholar
• Landin-Olsson M., Karlsson F. A., Lernmark A., Sundkvist G. Islet cell and thyrogastric antibodies in 633 consecutive 15-34 years old patients in the Diabetes Incidence Study in Sweden (DISS). Diabetes 1992; 41: 1022–27
   PubMed Web of Science ®Google Scholar
• Nyström L., Dahlquist G., Östman J., Wall S., Arnqvist H., Blohmé G., Lithner F., Littorin B., Schersten B., Wibell L. Risk of developing insulin-dependent diabetes mellitus (IDDM) before 35 years of age: Indications of climatological determinants for age at onset. Int. J. Epidemiology 1992; 21: 352–358
   PubMedGoogle Scholar
• Hagopian W. A., Karlsen A. E., Gottsater A., Landin-Olsson M., Grubin C. E., Sundvist G., Petersen J. S., Boel E., Dyrberg T., Lernmark A. Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD-64) showed 64K autoantibody posi-tivity at onset predicts diabetes type. J. Clin. Invest. 1993; 91: 368–374
   PubMed Web of Science ®Google Scholar
• Tuomi T., Groop L. C, Zimmet P. Z., Rowley M. J., Knowles W., Mackay I. R. Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease. Diabetes 1993; 42: 359–362
   PubMed Web of Science ®Google Scholar
• Groop L. C, Miettinen A., Groop P-H., Meri S., Koski-Mies S., Bottazzo G. F. Organ-specific autoimmunity and HLA-DR antigens as markers for /i-cell destruction in patients with type II diabetes. Diabetes 1988; 37: 99–103
   PubMed Web of Science ®Google Scholar
• Irvine W. J., Sawers J. S. A., Feek C. M., Prescott R. J., Duncanc J. P. The value of islet cell antibody in predicting secondary failure of oral hypoglycemic agent therapy in diabetes mellitus. J Clin Immunol 1979; 2: 23–26
   Google Scholar
• Landin-Olsson M., Nilsson K. O., Lernmark Å, Sundkvist G. Islet cell antibodies and fasting C-peptide predict insulin requirement at diagnosis of diabetes mellitus. Diabetologia 1990; 33: 561–568
   PubMed Web of Science ®Google Scholar
• Gottsäter A., Landin-Olsson M., Lernmark Å., Fernlund P., Sundkvist G., Hagopian W. A. Glutamate decarboxylase antibody levels predict rate of beta-cell decline in adult onset diabetes. Diabetes Res Clin Practice 1995; 27: 133–140
   Google Scholar
• Sundkvist G., Bergqvist A., Weibull H., Bergqvist D., Fait K., Landin-Olsson M., Lernmark Å. Islet cell antibodies react with human fetal islets. Diabetes Res. Clin. Practice 1991; 14: 1–8
   Google Scholar
• Gamlen T. R., Aynsley-Green A., Irvine W. J., Mc-Callum C. J. Immunological studies in the neonate of a mother with Addison's disease and diabetes mellitus. Clin. Exp. Immunol. 1977; 28: 192–195
   Google Scholar
• Roll U., Christie M. R., Standi E., Ziegler A-G. Association of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of Type 1 diabetic patients. Diabetes 1994; 43: 154–160
   PubMed Web of Science ®Google Scholar
• Baisch J. M., Weeks T., Giles R., Hoover M., Stastny P., Capra J. D. Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus. New England Journal of Medicine 1990; 322: 1836–1882
   PubMed Web of Science ®Google Scholar
• Sanjeevi C. B., Kockum I., Lernmark Å. The role of major histocompatibility complex in insulin-dependent diabetes mellitus. Current Science 1995; 2: 3–11
   Google Scholar
• Phelan D., Hadley G., Duffy B., Mohanam S., Moha-Nakumar T. Anti idiotypic antibodies to HLA class I alloantibodies in normal individuals: a mechanism of tolerance to noninherited maternal HLA antigens. Hum Immunol 1991; 31: 1–6
   Google Scholar
• Landor M. Maternal-fetal transfer of immunoglobulins. Ann Allergy Asthma Immunol 1995; 74: 279–83
   Google Scholar
• Kockum I., Wassmuth R., Holmberg E., Michelsen B., Lernmark Å. Inheritance of MHC class II genes in IDDM studied in population-based affected and control families. Diabetologia 1994; 37: 1105–1112
   Google Scholar
• Rubinstein P., Walker M. E., Fedun B., Witt M. E., Cooper L. Z., Ginsburg-Fellner F. The HLA system in congenital rubella patients with and without diabetes. Diabetes 1982; 31: 1088–1091
   PubMed Web of Science ®Google Scholar
• Ginberg-Fellner F., Witt M. E., Yagihashi S., Dobersen M. J., Taub F., Fedun B., McEvoy R. C, Roman S. H., Davies T. F., Cooper L. Z. Congenital rubella syndrome as a model for Type 1 (insulin-dependent) diabetes mellitus: increased prevalence of islet cell surface antibodies. Diabetologia 1984; 27: 87–89
   Google Scholar
• Hyoty H., Hiltunen M., Knip M., Laakkonen M., Vah-Asalo P., Karjalainen J., Koskela P., Roivainen M., Lein-Ikki P., Hovi T. A prospective study of the role of coxsackie B and other enterovirus infections in the pathogenesis of IDDM. Childhood Diabetes in Finland (DiMe) Study. Diabetes 1995; 44: 652–657
   PubMed Web of Science ®Google Scholar
• Dahlquist G., Ivarsson S., Lindberg B., Forsgren M. Maternal enteroviral infection during pregnancy as a risk factor for childhood IDDM. Diabetes 1995; 44: 408–413
   PubMed Web of Science ®Google Scholar