28
Views
4
CrossRef citations to date
0
Altmetric
Original Article

Anti-Neutrophil Cytoplasm Autoantibodies (ANCA). The Need for Specific and Sensitive Assays

&
Pages 231-238 | Received 11 Aug 1997, Published online: 07 Jul 2009

References

  • Kallenberg C. G.M, Brouwer E., Weening J. J., Tervaert J. W. C. Anti-neutrophil cytoplasmic antibodies: Current diagnostic and pathophysiological potential. Kidney Int 1994; 46: 1–15
  • Goldschmeding R., van der Schoot C. E., ten Bokkel Huinink D., et al. Wegener's granulomatosis autoantibodies identify a novel diisopropylfiuorophosphate-binding protein in the lysosomes of normal human neutrophils. J Clin Invest 1989; 84: 1577–1587
  • Jenne D., Tschopp J., Ludemann J., Utecht B., Gross W. Wegener's autoantigen decoded. Nature 1990; 346: 520
  • Niles J. L., McCluskey R. T., Ahmad M. F., Arnaout M. A. Wegener's granulomatosis autoantigen is a novel neutrophil serine proteinase. Blood 1989; 74: 1888–1893
  • Wiik A., Rasmussen N., Wieslander J. Methods to detect autoantibodies to neutrophilic granulocytes. Manual of biological markers of disease, W. J. Van Venrooij, R. N. Maini. Kluwer Academic Publishers, Dordrecht 1993; A9: 1–A914
  • Hagen E. C, Andrassy K., Chernok E., et al. The value of indirect immunofluorescence and solid phase techniques for ANCA detection. A report on the first phase of an international cooperative study on the standardization of ANCA assays. EEC/BCR Group for ANCA Assay Standardization. J Immunol Methods 1993; 159: 1–16
  • Goldschmeding R. Target antigens of antineutrophil cytoplasmic antibodies. Amsterdam 1992, Thesis
  • Braun M. G., Csernok E., Gross W. L., Muller Herme-link H. K. Proteinase 3, the target antigen of anticy-toplasmic antibodies circulating in Wegener's granulomatosis. Immunolocalization in normal and pathologic tissues. Am J Pathol 1991; 139: 831–838
  • Egesten A., Bretongorius J., Guichard J., Gullberg U., Olsson I. The heterogenity of azurophil granules in neutrophil promyelocytes: Immunogold localization of myeloperoxidase, cathepsin, G. elastase, proteinase 3, and bactericidal permeability increasing protein. Blood 1994; 83: 2984–2994
  • Rao N. V., Wehner N. G., Marshall B. C, Gray W. R., Gray B. H., Hoidal J. R. Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties. J Biol Chem 1991; 266: 9540–9548
  • Dalpe G., Beliveau A., Menard H. A. Cross-Reactivity of an Anti-Proteinase 3 Antibody to Elastase. Autoimmunity 1993; 16: 311–313
  • Nassberger L., Hansson A. L., Mårtensson U. Lack of cross-reactivity of c-ANCA to elastase and cathepsin G. Autoimmunity 1993; 14: 259
  • Bini P., Gabay J. E., Teitel A., Melchior M., Zhou J. L., Elkon K. B. Antineutrophil cytoplasmic autoantibodies in Wegener's granulomatosis recognize conformational epitope(s) on proteinase 3. J Immunol 1992; 149: 1409–1415
  • Plow E. F. Leukocyte elastase release during blood coagulation. J Clin Invest 1982; 69: 564–572
  • Baslund B., Segelmark M., Wiik A., Szpirt W., Petersen J., Wieslander J. Screening for antineutrophil cytoplasmic antibodies (ANCA): is indirect immunofluorescence the method of choice?. Clin Exp Immunol 1995; 99: 486–492
  • Bergenfeldt M., Axelsson L., Ohlsson K. Release of neutrophil proteinase 4(3) and leukocyte elastase during phagocytosis and their interaction with proteinase inhibitors. Scand J Clin Lab Invest 1992; 52: 823–829
  • Weiss S. J. Tissue destruction by neutrophils. N Engl J Med 1989; 320: 365–376
  • Venge P., Bergstrand H., Håkansson L. Neutrophils and eosinophils. Textbook of Rheumatology, W. N. Kelley, E. D. Harris, S. Ruddy, C. B. Sledge, 1993; 269–285
  • Falk R. J., Jennette J. C. Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and cresentic glomerulonephritis. N Engl J Med 1988; 318: 1651–1657
  • Wieslander J. How are antineutrophil cytoplasmic autoantibodies detected?. Am J Kidney Dis 1991; 18: 154–158
  • Gross W. L., Schmitt W. H., Csernok E. ANCA and associated diseases: immunodiagnostic and pathogenetic aspects. Clin Exp Immunol 1993; 91: 1–12
  • Zhao M. H., Jones S. J., Lockwood C. M. Bactericidal/permeability-increasing protein (BPI) is an important antigen for anti-neutrophil cytoplasmic autoantibodies (ANCA) in vasculitis. Clin Exp Immunol 1995; 99: 49–56
  • Pesce A. J., Michael J. G. Artefacts and limitations of enzyme immunoassay. J Immunol Methods 1992; 150: 111–119
  • Segelmark M., Baslund B., Wieslander J. Some patients with anti-myeloperoxidase autoantibodies have a c-ANCA pattern. Clin Exp Immunol 1994; 96: 458–465
  • van der Woude F. J., Rasmussen N., Lobatto S., et al. Autoantibodies against neutrophils and monocytes: Tool for diagnosis and marker of disease activity in Wegener's granulomatosis. Lancet 1985; 1: 425–429
  • Nolle B., Specks U., Ludemann J., Rohrbach M. S., DeRemee R. A., Gross W. L. Anticytoplasmic autoantibodies: their immunodiagnostic value in Wegener granulomatosis. Ann Intern Med 1989; 111: 28–40
  • Cohen Tervaert J.W., van der Woude F. J., Fauci A. S., et al. Association between active Wegener's granulomatosis and anticytoplasmic antibodies. Arch Intern Med 1989; 149: 2461–2465
  • Ludemann J., Csernok E., Ulmer M., et al. Antineutrophil cytoplasm antibodies in Wegener's granulomatosis: immunodiagnostic value, monoclonal antibodies and characterization of the target antigen. Neth J Med 1990; 36: 157–162
  • Davenport A., Lock R. J., Wallington T. B., Feest T. G. Clinical significance of anti-neutrophil cytoplasm antibodies detected by a standardized indirect immunofluorescence assay. Q J Med 1994; 87: 291–299
  • Rao J. K., Allen N. B., Feussner J. R., Weinberger M. A prospective study of neutrophil cytoplasmic antibody (c-ANCA) and clinical criteria in diagnosing Wegener's granulomatosis. Lancet 1995; 346: 926–931
  • Savage C. O. S., Winnearls C. G., Jones S., Marshall P. D., Lockwood C. M. Prospective study of radioimmunoassay for antibodies against neutrophil cytoplasm in diagnosis of systemic vasculitis. Lancet, i: 1389–1393
  • Savige J. A., Yeung S. P., Gallicchio M., Davies D. J. Two ELISAs to detect anti-neutrophil cytoplasm antibodies (ANCA) in various vasculitides. Pathology 1989; 21: 282–287
  • Rasmussen N., Sjolin C, Isaksson B., Bygren P., Wieslander J. An ELISA for the detection of antineutrophil cytoplasm antibodies (ANCA). J Immunol Methods 1990; 127: 139–145
  • Goldschmeding R., van der Schoot C. E., van der Snoek M. A., Von dem Borne A. E. G. K. A monoclonal antibody against the 29 kD ANCA-antigen: Application as catching antibody in a sandwich-ELlSA for ANCA detection. APMIS 1989; 97(6)47
  • Sommarin Y., Rasmussen N., Wieslander J. Characterization of monoclonal antibodies to proteinase 3 and application in the study of epitopes for cANCA. Exp Nephrol 1995; 3: 249–256
  • Savige J. A., Smith C, Change L., Duggan J. C. Anti-neutrophil cytoplasm antibodies (ANCA) in a patient with the vasculitis of myelodysplasia[letter]. Br J Haematol 1991; 78: 583–584
  • Niles J. L. Value of tests for antineutrophil cytoplasmic autoantibodies in the diagnosis and treatment of vasculitis. Curr Opin Rheumatol 1993; 5: 18–24
  • Cohen Tervaert J.W., Huitema M. G., Hene R. J., et al. Prevention of relapses in Wegener's granulomatosis by treatment based on antineutrophil cytoplasmic antibody titre. Lancet 1990; 336: 709–711
  • Kerr G. S., Fleisher T. A., Hallahan C. W., Leavitt R. Y., Fauci A. S., Hoffman G. S. Limited Prognostic Value of Changes in Antineutrophil Cytoplasmic Antibody Titer in Patients with Wegener's Granulomatosis. Arthritis Rheum 1993; 36: 365–371
  • Hoffman G. S., Kerr G. S., Leavitt R. Y., et al. Wegener granulomatosis: an analysis of 158 patients. Ann Intern Med 1992; 116: 488–498
  • Cohen Tervaert J.W., Mulder L., Stegeman C, et al. Occurrence of autoantibodies to human leucocyte elastase in Wegener's granulomatosis and other inflammatory disorders. Ann Rheum Dis 1993; 52: 115–120
  • Fienberg R., Mark E. J., Goodman M., McCluskey R. T., Niles J. L. Correlation of antineutrophil cytoplasmic antibodies with the extrarenal histopathology of Wegener's (pathergic) granulomatosis and related forms of vasculitis. Hum Pathol 1993; 24: 160–168
  • Gaskin G., Savage C. O., Ryan J. J., et al. Antineutrophil cytoplasmic antibodies and disease activity during long-term follow-up of 70 patients with systemic vasculitis. Nephrol Dial Transplant 1991; 6: 689–694
  • Cohen Tervaert J.W., Goldschmeding R., Elema J., et al. Association of autoantibodies to myeloperoxidase with different forms of vasculitis. Arthritis Rheum 1990; 33: 1264–1268
  • Guillevin L., Visser H., Noel L. H., et al. Antineutrophil cytoplasm antibodies in systemic polyarteritis nodosa with and without hepatitis B virus infection and Churg-Strauss syndrome-62 patients. J Rheumatol 1993; 20: 1345–1349
  • Cohen Tervaert J.W., Limburg P. C, Elema J. D., et al. Detection of autoantibodies against myeloid lysosomal enzymes: A useful adjunct to classification of patients with biopsy-proven necrotizing arteritis. Am J Med 1991; 91: 59–66
  • Guillevin L., Lhote F. Distinguishing polyarteritis nodosa from microscopic polyangiitis and implications for treatment. Curr Opin Rheumatol 1995; 7: 20–24
  • Savage C. O., Tizard J., Jayne D., Lockwood C. M., Dillon M. J. Antineutrophil cytoplasm antibodies in Kawasaki disease. Arch Dis Child 1989; 64: 360–363
  • Shaw G., Ronda N., Bevan J. S., Esnault V., Griffiths D. F., Rees A. Antineutrophil cytoplasmic antibodies (ANCA) of IgA class correlate with disease activity in adult Henoch-Schonlein purpura. Nephrol Dial Transplant 1992; 7: 1238–1241
  • O'Donoghue D. J., Nusbaum P., Noel L. H., Halbwachs Mecarelli L., Lesavre P. Antineutrophil cytoplasmic antibodies in IgA nephropathy and Henoch-Schonlein purpura. Nephrol Dial Transplant 1992; 7: 534–538
  • Ronda N., Esnault V. L. M., Layward L., et al. Antineutrophil cytoplasm antibodies (ANCA) of IgA isotype in adult Henoch-Schonlein purpura. Clin Exp Immunol 1994; 95: 49–55
  • Sinico R. A., Tadros M, Radice M, et al. LAck of IgA antineutrophil cytoplasmic antibodies in Henoch-Schonlein purpura and IgA nephropathy. Clin Immunol Immunopathol 1994; 73: 19–26
  • McHugh N. J., James I. E., Plant G. T. Anticardiolipin and antineutrophil antibodies in giant cell arteritis. J Rheumatol 1990; 17: 916–922
  • Baranger T. A. R., Audrain M. A. P., Castagne A., Barrier J. H., Esnault V. L. M. Absence of antineutrophil cytoplasmic antibodies in giant cell arteritis. J Rheumatol 1994; 21: 871–873
  • Coremans I. E., Hagen E. C, Daha M. R., et al. Antilactoferrin antibodies in patients with rheumatoid arthritis are associated with vasculitis. Arthritis Rheum 1992; 35: 1466–1475
  • Mulder A. H. L., Horst G., van Leeuwen M., Limburg P. C., Kallenberg C. G. M. Anti-neutrophil cytoplasmic antibodies in rheumatoid arthritis: characterization and clinical correlates. Arthritis Rheum 1993; 36: 1054–1060
  • Mulder A. H. L. Anti-neutrophil cytoplasmic antibodies in idiopathic inflammatory disorders. Thesis, 1994, Gronin-gen
  • Cambridge G., Williams M., Leaker B., Corbett M., Smith C. R. Anti-Myeloperoxidase Antibodies in Patients with Rheumatoid Arthritis - Prevalence, Clinical Correlates, and IgG Subclass. Ann Rheum Dis 1994; 53: 24–29
  • Dolman K. M., Gans R. O. B., Vervaat T. J., et al. Vasculitis and Antineutrophil Cytoplasmic Autoantibodies Associated with Propylthiouracil Therapy. Lancet 1993; 342: 651–652
  • Saxon Shanahan A., Landers F., Ganz C. T., Targan S. A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease. J Allergy Clin Immunol 1990; 86: 202–210
  • Mulder A. H. L., Broekroelofs J., Horst G., Limburg P. C, Nelis G. F., Kallenberg C. G. M. Anti-Neutrophil Cytoplasmic Antibodies (Anca) in Inflammatory Bowel Disease - Characterization and Clinical Correlates. Clin Exp Immunol 1994; 95: 490–497
  • Rump J. A., Scholmerich J., Gross V., et al. A new type of perinuclear anti-neutrophil cytoplasmic antibody (p-ANCA) in active ulcerative colitis but not in Crohn's disease. Immunobiology 1990; 181: 406–413
  • Peen E., Aimer S., Bodemar G., et al. Antilactoferrin antibodies and other types of ANCA in ulcerative colitis, primary sclerosing cholangitis, and Crohn's disease. Gut 1993; 34: 56–62
  • Ellerbroek M., Pool M. O., Ridwan B. U., et al. Neutrophil Cytoplasmic Antibodies (P-Anca) in Ulcerative Colitis. J Clin Pathol 1994; 47: 257–262
  • Broekroelofs J., Mulder A. H. L., Nelis G. F., Westerveld B. D., Tervaert J. W. C., Kallenberg C. G. M. Anti-Neutrophil Cytoplasmic Antibodies (ANCA) in Sera from Patients with Inflammatory Bowel Disease (IBD) - Relation to Disease Pattern and Disease Activity. Dig Dis Sci 1994; 39: 545–549
  • Coremans I. E. M., Hagen E. C, Vandervoort E. A. M., Vanderwoude F. J., Daha M. R., Breedveld F. C. Autoantibodies to Neutrophil Cytoplasmic Enzymes in Felty's Syndrome. Clin Exp Rheumatol 1993; 11: 255–262
  • Pauzner R., Urowitz M., Gladman D., Gough J. Antineutrophil cytoplasmic antibodies in systemic lupus erythematosus. J Rheumatol 1994; 21: 1670–1673
  • Schnabel A., Csernok E., Isenberg D. A., Mrowka C., Gross W. Antineutrophil cytoplasmic antibodies in systemic lupus erythematosus. Arthritis Rheum 1995; 38: 633–637

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.