Regulation of the Effector Stages of Experimental Autoimmune Encephalomyelitis via Neuroantigen-Specific Tolerance Induction. III. A Role for Anergy/Deletion*

References

• Brown A. M., McFarlin D. E. Relapsing experimental allergic encephalomyelitis in the SJL/J mouse. Lab Invest 1981; 45: 278–284
   PubMed Web of Science ®Google Scholar
• Lublin F. D., Maurer P. H., Berry R. G., Tippett D. Delayed, relapsing experimental allergic encephalomyelitis in mice. J Immunol 1981; 126: 819–822
   PubMed Web of Science ®Google Scholar
• Fritz R. B., Chou C. H., McFarlin D. E. Induction of experimental allergic encephalomyelitis in PL/J and (SJL/J × PL/J) Fl mice by myelin basic protein and its peptides: localization of a second encephalitogenic determinant. J Immunol 1983; 130: 191–194
   PubMed Web of Science ®Google Scholar
• Trotter J. L., Clark H. B., Collins K. G., Wegeschiede C. L., Scarpellini J. D. Myelin proteolipid protein induces demyelinating disease in mice. J Neurol Sd 1987; 79: 173–188
   PubMed Web of Science ®Google Scholar
• Pettinelli C. B., McFarlin D. E. Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein: requirement for Lyt 1+2− T lymphocytes. J Immunol 1981; 127: 1420–1423
   PubMed Web of Science ®Google Scholar
• Mokhtarian F., McFarlin D. E., Raine C. S. Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice. Nature 1984; 309: 356–358
   PubMed Web of Science ®Google Scholar
• van der Veen R. C, Trotter J. L., Clark H. B., Kapp J. A. The adoptive transfer of chronic relapsing experimental allergic encephalomyelitis with lymph node cells sensitized to myelin proteolipid protein. J Neuroim-munol 1989; 21: 183–191
   PubMed Web of Science ®Google Scholar
• Lublin F. D. Relapsing experimental allergic encephalomyelitis. An autoimmune model of multiple sclerosis. Springer Semin Immunopathol 1985; 8: 197–208
   PubMed Web of Science ®Google Scholar
• Arnason B. G. Relevance of experimental allergic encephalomyelitis to multiple sclerosis. Neurol Clin 1983; 1: 765–782
   PubMedGoogle Scholar
• Kennedy M. K., Tan L. J., Dal Canto M. C., Miller S. D. Regulation of the effector stages of experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance induction. J Immunol; 1990; 145: 117–126
   PubMed Web of Science ®Google Scholar
• Tan L. J., Kennedy M. K., Miller S. D. Regulation of the effector stages of experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance induction. II. Fine specificity of effector T cell inhibition. J Immunol 1992; 148: 2748–2755
   PubMed Web of Science ®Google Scholar
• Tan L-J., Kennedy M. K., Dal Canto M. C., Miller S. D. Successful treatment of paralytic relapses in adoptive experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance. J Immunol 1991; 147: 1797–1802
   PubMed Web of Science ®Google Scholar
• McRae B. L., Vanderlugt C. L., Dal Canto M. C., Miller S. D. Functional evidence for epitope spreading in the relapsing pathology of EAE in the SJL/J mouse. J Exp Med 1995; 182: 75–85
   PubMed Web of Science ®Google Scholar
• Miller S. D., McRae B. L., Vanderlugt C. L., Nikcevich K. M., Pope J. G., Pope L. Evolution of the T cell repertoire during the course of experimental autoimmune encephalomyelitis. Immunol Rev 1995; 144: 225–244
   PubMed Web of Science ®Google Scholar
• Yu M., Johnson J. M., Tuohy V. K. A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: A basis for peptide-specific therapy after onset of clinical disease. J Exp Med 1996; 183: 1777–1788
   PubMed Web of Science ®Google Scholar
• Kennedy K. J., Smith W. S., Miller S. D., Karpus W. J. Induction of antigen-specific tolerance for the treatment of ongoing relapsing autoimmune encephalomyelitis. A comparison between oral and peripheral tolerance. Eur J Immunol 1997
   PubMedGoogle Scholar
• Miller S. D., Sy M. S., Claman H. N. The induction of hapten-specific T cell tolerance using hapten-modified lymphoid membranes. II. Relative roles of suppressor T cells and clone inhibition in the tolerant state. Eur J Immunol 1977; 7: 165–170
   PubMed Web of Science ®Google Scholar
• Miller S. D., Claman H. N. The induction of hapten-specific T cell tolerance using hapten-modified lymphoid cells. I. Characteristics of tolerance induction. J Immunol 1976; 117: 1519–1526
   PubMed Web of Science ®Google Scholar
• Sherr D. H., Cheung N. K., Heghinian K. M., Benacer-Raf B., Dorf M. E. Immune suppression in vivo with antigen-modified syngeneic cells. II. T cell mediated nonresponsiveness to fowl gamma globulin. J Immunol 1978; 122: 1899–1908
   Web of Science ®Google Scholar
• Tarleton R. L., Beyer A. M. Medium-scale production and purification of monoclonal antibodies in protein-free medium. Bio Techniques 1991; 11: 590–593
   PubMed Web of Science ®Google Scholar
• Miller S. D., Wetzig R. P., Claman H. N. The induction of cell-mediated immunity and tolerance with protein antigens coupled to syngeneic lymphoid cells. J Exp Med 1979; 149: 758–773
   PubMed Web of Science ®Google Scholar
• Armitage P. Statistical Methods in Medical Research. John Wiley, New York 1971
   Google Scholar
• Miller A., Lider O., Roberts A. B., Sporn M. B., Weiner H. L. Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor b after antigen-specific triggering. Proc Natl Acad Sci USA 1992; 89: 421–425
   PubMed Web of Science ®Google Scholar
• Ofosu-Appiah W., Mokhtarian F. Characterization of a T suppressor cell line that downgrades experimental allergic encephalomyelitis in mice. Cell Immunol 1991; 135: 143–153
   PubMed Web of Science ®Google Scholar
• Sehon A. H. Suppressor T cells induced in vivo by tolerogenic conjugates of a given antigen and mono-methoxypolyethylene glycol downregulate antibody formation also to a second antigen, if the latter is presented as a covalent adduct with the former. Advances In Experimental Medicine & Biology 1991; 303: 199–206
   PubMedGoogle Scholar
• Debre P., Waltenbaugh C, Dorf M. E., Benacerraf B. Genetic control of specific suppression. IV. Responsiveness to the random copolymer L-glutamic acid50-L-tyrosine50 induced in BALB/c mice by cyclophosphamide. J Exp Med 1976; 144: 277–290
   PubMed Web of Science ®Google Scholar
• Lando Z., Teitelbaum D., Arnon R. Effect of cyclophosphamide on suppressor cell activity in mice unresponsive to EAE. J Immunol 1979; 123: 2156–2160
   PubMed Web of Science ®Google Scholar
• McKenna R. M., Carter B. G., Sehon A. H. Studies on the mechanism of suppression of experimental allergic encephalomyelitis induced by myelin basic proteirf-cell conjugates. Cell Immunol 1984; 88: 251–259
   PubMed Web of Science ®Google Scholar
• Karpus W. J., Swanborg R. H. CD4+ suppressor cells inhibit the function of effector cells of experimental autoimmune encephalomyelitis through a mechanism involving transforming growth factor-beta. J Immunol 1991; 146: 1163–1168
   PubMed Web of Science ®Google Scholar
• Flynn J. C., Kong Y. M. In vivo evidence for CD4+ and CD8+ suppressor T cells in vaccination-induced suppression of murine experimental autoimmune thyroiditis. Clin Immunol Immunopathol 1991; 60: 484–494
   PubMedGoogle Scholar
• Chen Y., Kuchroo V. K., Inobe J., Hafler D. A., Weiner H. L. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 1994; 265: 1237–1240
   PubMed Web of Science ®Google Scholar
• Beraud E., Varriale S., Farnarier C., Bernard D. Suppressor cells in Lewis rats with experimental allergic encephalomyelitis: prevention of the disease and inhibition of lymphocyte proliferation by the suppressor cells or their products. Eur J Immunol 1982; 12: 926–930
   PubMed Web of Science ®Google Scholar
• Whitacre C. C, Gienapp I. E., Orosz C. G., Bitar D. M. Oral tolerance in experimental autoimmune encephalomyelitis: III. Evidence for clonal anergy. J Immunol 1991; 147: 2155–2163
   PubMed Web of Science ®Google Scholar
• Fallis R. J., Powers M. L., Sy M. S., Weiner H. L. Adoptive transfer of murine chronic-relapsing autoimmune encephalomyelitis. Analysis of basic protein-reactive cells in lymphoid organs and nervous system of donor and recipient animals. J Neuroimmunol 1987; 14: 205–219
   PubMed Web of Science ®Google Scholar
• Cross A. H., Raine C. S. Serial adoptive transfer of murine experimental allergic encephalomyelitis: successful transfer is dependent on active disease in the donor. J Neuroimmunol 1990; 28: 27–37
   PubMed Web of Science ®Google Scholar
• Vandenbark A. A., Vainiene M., Ariail K., Miller S. D., Offner H. Prevention and treatment of relapsing autoimmune encephalomyelitis with myelin peptide-coupled splenocytes. J Neurosci Res 1996; 45: 430–438
   PubMed Web of Science ®Google Scholar
• Miller S. D., Karpus W. J. The immunopatho-genesis and regulation of T-cell mediated demyelinating diseases. Immunol Today 1994; 15: 356–361
   PubMedGoogle Scholar
• Peterson J. D., Karpus W. J., Clatch R. J., Miller S. D. Split tolerance of Th1 and Th2 cells in tolerance to Theiler's murine encephalomyelitis virus. Eur J Immunol 1993; 23: 46–55
   PubMed Web of Science ®Google Scholar
• Karpus W. J., Peterson J. D., Miller S. D. Anergy in vivo, Down-regulation of antigen-specific CD4+ Thl but not Th2 cytokine responses. Int Immunol 1994; 6: 721–730
   PubMed Web of Science ®Google Scholar
• Santambrogio L., Crisi G. M., Leu J., Hochwald G. M, Ryan T., Thorbecke G. J. Tolerogenic forms of auto-antigens and cytokines in the induction of resistance to experimental allergic encephalomyelitis. J Neuroimmunol 1995; 58: 211–222
   PubMed Web of Science ®Google Scholar
• Miller S. D., Tan L. J., Pope L., McRae B. L., Karpus W. J. Antigen-specific tolerance as a therapy for experimental autoimmune encephalomyelitis. Int Rev Immunol 1992; 9: 203–222
   PubMedGoogle Scholar
• Kearney E. R., Walunas T. L., Karr R. W., Morton P. A., Loh D. Y., Bluestone J. A. Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4. J Immunol 1995; 155: 1032–1036
   PubMed Web of Science ®Google Scholar
• Kearney E. R., Pape K. A., Loh D. Y., Jenkins M. K. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity 1994; 1: 327–339
   PubMed Web of Science ®Google Scholar
• Yednock T. A., Cannon C, Fritz L. C, Sanchez-Madrid F., Steinman L., Karin N. Prevention of experimental autoimmune encephalomyelitis by antibodies against a4bl integrin. Nature 1992; 356: 63–66
   PubMed Web of Science ®Google Scholar
• Ruddle N. H., Bergman C. M., McGrath K. M., Lingen-Held E. G., Grunnet M. L., Padula S. J. An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis. J Exp Med 1990; 172: 1193–1200
   PubMed Web of Science ®Google Scholar
• Baron J. L., Madri J. A., Ruddle N. H., Hashim G., Janeway C. A. Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma. J Exp Med 1993; 177: 57–68
   PubMed Web of Science ®Google Scholar
• Matsumoto Y., Fujiwara M. Adoptively transferred experimental allergic encephalomyelitis in chimeric rats: identification of transferred cells in the lesions of the central nervous system. Immunol 1988; 65: 23–29
   PubMed Web of Science ®Google Scholar
• Hickey W. F., Hsu B. L., Kimura H. T lymphocyte entry into the central nervous system. J Neurosci Res 1991; 28: 254–260
   PubMed Web of Science ®Google Scholar
• Offner H., Buenafe A. C, Vainiene M., Celnik B., Weinberg A. D., Gold D. P. Where, when, and how to detect biased expression of disease-relevant V beta genes in rats with experimental autoimmune encephalomyelitis. J Immunol 1993; 151: 506–517
   PubMed Web of Science ®Google Scholar
• Koh D. R., Fung-Leung W. P., Ho A., Gray D., Acha-Orbea H., Mak T. W. Less mortality but more relapses in experimental allergic encephalomyelitis in CD8−/- mice. Science 1992; 256: 1210–1213
   PubMed Web of Science ®Google Scholar
• Jiang H., Zhang S. I., Pernis B. Role of CD8+ T cells in murine experimental allergic encephalomyelitis. Science 1992; 256: 1213–1215
   PubMed Web of Science ®Google Scholar
• Kumar V., Sercarz E. E. The involvement of T cell receptor peptide-specific regulatory CD4+ T cells in recovery from antigen-induced autoimmune disease. J Exp Med 1993; 178: 909–916
   PubMed Web of Science ®Google Scholar
• Offner H., Hashim G. A., Vandenbark A. A. T cell receptor peptide therapy triggers autoregulation of experimental encephalomyelitis. Science 1991; 251: 430–432
   PubMed Web of Science ®Google Scholar
• Jenkins M. K., Schwartz R. H. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J Exp Med 1987; 165: 302–319
   PubMed Web of Science ®Google Scholar
• Jenkins M. K., Pardoll D. M., Mizuguchi J., Quill H., Schwartz R. H. T-cell unresponsiveness in vivo and in vitro: fine specificity of induction and molecular characterization of the unresponsive state. Immunol Rev 1987; 95: 113–135
   PubMed Web of Science ®Google Scholar
• Norton S. D., Zuckerman L., Urdahl K. B., Shefner R., Miller J., Jenkins M. K. The CD28 ligand, B7, enhances IL-2 production by providing a costimulatory signal to T cells. J Immunol 1992; 149: 1556–1561
   PubMed Web of Science ®Google Scholar