18
Views
7
CrossRef citations to date
0
Altmetric
Original Article

Reversal of Immunodominance Aong Autoantigenic T-cell Epitopes

Pages 209-221 | Received 07 Sep 1998, Published online: 13 Mar 2012

References

  • D.R. Madden. The three-dimensional structure of peptide-MHC complexes. Amili. Rev. Immunol. 1995, 13: 587 622.
  • E.Y. Jones. MHC class I and class II structures. Cur. Opin. Immunol. 1997,9: 75 79.
  • P.J. Fairchild. Presentation of antigenic peptides by products of the major histocompatibility complex. J. Peptide Sci. 1998, 4: 182 194.
  • J.B. Rothbard and W.R. Taylor. A sequence pattern common to T cell epitopes. EM BO J. 1988. 7: 93 100.
  • A. Setle, S. Buus. E. Appella, J.A. Smith, R. Chesnut. C. Miles, S.M. Colon and H.M. Grey. Prediction of major histocompatibility complex binding regions of protein antigens by sequence pattern analysis. Proc. Null. Acati. Sci. USA 1989,86: 3296 3300.
  • J. Hammer, E. Bono, F. Gallazzi, C. Belunis, Z. Nagy and F. Sinigaglia. Precise prediction of major histocompatibility complex class 11-peptide interaction based on peptide side chain scanning. J. Exp. Med. 1994. 180: 2353–2358.
  • D.L. Perkins. G. Berriz, T. Kamradt, J.A. Smith and M.L. Gefter. Immunodominance: intramolecular competition between T cell epitopes. J. Immunol. 1991. 146: 2137–2144.
  • S.J. Landry. Local protein instability predictive of helper T-cell epitopes. Immunol. Today 1997. 18: 527 532.
  • E.G. Pamer, J.T. Harty and M.J. Bevan. Precise prediction of a dominant class 1 MHC-restricted epitope of Listeria monocytogenes. Nature 1991. 353: 852–855.
  • W.-F.'Li. M.-D. Fan, C.-B. Pan and M.-Z. Lai. T cell epitope selection: dominance may be determined by both affinity for MHC and stoichiometry of epitope. Eur. J. Immunol. 1992. 22: 943–949.
  • L. Adorini. E. Appella, G. Doria and Z.A. Nagy. Mechanisms influencing the immunodominance of T cell determinants. J. Exp. Med. 1988. 168: 2091–2104.
  • E.E. Sercarz, P.V. Lehmann, A. Ametani, G. Benichou, A. Miller and K. Moudgil. Dominance and crypticity of T cell antigenic determinants. Anmt. Rev. Immunol. 1993. 11: 729–766.
  • G. Benichou. P.A. Takizawa, P.T. Ho, C.C. Killion. C.A. Olson. M. McMillan and E.E. Sercarz. Immunogeni-city and tolerogenicity of self-MHC peptides. J. Exp. Med. 1990. 172: 134–1346.
  • C. Watts and A. Lanzavecchia. Suppressive effect of antibody on processing of T cell epitopes. J. Exp. Med. 1993, 178: 1459–1463.
  • P.D. Simitsek. D.G. Campbell, A. Lanzavecchia, N. Fairweather and C. Watts. Modulation of antigen processing by bound antibodies can boost or suppress class II major histocompatibility complex presentation of different T cell determinants. J. Exp. Med. 1995, 181: 1957 1963.
  • X. Dong, K.J. Hamilton, M. Satoh, J. Wang and W.H. Reeves. Initiation of autoimmunity to the p53 tumor suppressor protein by complexes of p53 and SV40 large T antigen. J. Exp. Med. 1994, 179: 1243–1252.
  • S. Salemi, A.P. Caporossi, L. Boffa, M.G. Longobardi and V. Barnaba. HIVgpl20 activates autoreactive CD4-specific T cell responses by unveiling of hidden CD4 peptides during processing. J. Exp. Med. 1995, 181: 2253 2257.
  • A. Lanzavecchia. How can cryptic epitopes trigger autoimmunity?/ Exp. Med. 1995. 181: 1945 1948.
  • N. Shastri, A. Miller and E.E. Sercarz. Amino acid residues distinct from the determinant region can profoundly affect activation of T cell clones by related antigens. J. Immunol. 1986, 136: 371–376.
  • G. Niedermann, S. Butz, H.G. Ihlenfeldt, R. Grimm. M. Lucchiari. H. Hoschutzky, G. Jung, B. Maier and K. Eichmann. Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by Major Histocompatibility Complex class I molecules. Immunitv 1995, 2: 289–299.
  • K. Falk, O. Ratzschke and H.-G. Rammensee. Cellular peptide composition governed by major histocompatibility complex class 1 molecules. Nature 1990, 348: 248 251.
  • D.L. Donermeyer and P.M. Allen. Binding to la protects an immunogenic peptide from proteolytic degradation. J. Immunol. 1989, 142: 1063–1068.
  • S. Mouritsen, M. Meldal, O. Werdelin, A.S. Hansen and S. Buus. MHC molecules protect T cell epitopes against proteolytic destruction. J. Immunol. 1992, 149: 1987–1993.
  • H. Deng, R. Apple, M. Clare-Salzler, S. Trembleau, D. Mathis, L. Adorini and E. Sercarz. Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease. J. Exp. Med. 1993. 178: 1675 1680.
  • W. Chen, S. Khilko, J. Fecondo, D.H. Marguiles and J. McCluskey. Determinant selection of major histocompatibility complex class 1-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues. J. Exp. Med. 1994, 180: 1471–1483.
  • K.M. Nikcevich, D. Kopielski and A. Finnegan. Interference with the binding of a naturally processed peptide to class II alters the immunodominance of T cell epitopes in vivo. J. Immunol. 1994, 153: 1015–1026.
  • V. Bhardwaj. V. Kumar, H.M. Geysen and E.E. Sercarz. Subjugation of dominant immunogenic determinants within a chimeric peptide. Eur. J. Immunol. 1992. 22: 2009–2016.
  • F. Ria. B.M.C. Chan, M.T. Scherer. J.A. Smith and M.L. Gefter. Immunological activity of covalently linked T-cell epitopes. Nature 1990, 343: 381 383.
  • S.J. Brett. K.B. Cease and J.A. Berzofsky. Influences of antigen processing on the expression of the T cell repertoire. Evidence for MHC-specific hindering structures on the products of processing. J. Exp. Med. 1988. 168: 357 373.
  • M.S. Vaccliio, J.A. Berzofsky. U. Krzych, J.A. Smith, R.J. Hodes and A. Finnegan. Sequences outside a minimal immunodominant site exert negative effects on recognition by staphylococcal nuclease-specific T cell clones. J. Immunol. 1989, 143: 2814–2819.
  • K..D. Mougdil, E.E. Sercarz and I.S. Grewal. Modulation or the immunogenicity of antigenic determinants by their flanking residues. Immunol. Today 1998, 19: 217–220.
  • I.S. Grewal, K..D. Mougdil and E.E. Sercarz. Hindrance of binding to class 11 major histocompatibility complex molecules by a single amino acid residue contiguous to a determinant leads to crypticity of the determinant as well as lack of response to the protein antigen. Proc. Natl. Acad. Sci. USA 1995, 92: 1779–1783.
  • K..D. Mougdil, I.S. Grewal, P.E. Jensen and E.E. Sercarz. Unresponsiveness to a self-peptide of mouse lysozyme owing to hindrance of T cell receptor-major histocompatibility complex peptide interaction caused by flanking epitopic residues. J. Exp. Med. 1996, 183: 535–546.
  • A.J.T. George, M.A. Ritter and R.l. Lechler. Disease susceptibility, transplantation and the MHC. Immunol. Todav 1995, 16: 209–211.
  • C.A. Nelson, S.J. Petzold and E.R. Unanue. Peptides determine the lifespan of MHC class 11 molecules in the antigen-presenting cell. Nature 1994. 371: 250 252.
  • E.B. Schaeffer. A. Sette, D.L. Johnson, M.C. Bekoff, J.A. Smith, H.M. Grey and S. Buus. Relative contribution of 'determinant selection' and 'holes in the T-cell repertoire' to T cell responses. Proc. Nail. Acad. Sci. USA 1989. 86: 4649–4653.
  • K..D. Mougdil. D. Sekiguchi, S.Y. Kim and E.E. Sercarz. Immunodominance is independent of structural constraints. Each region within hen eggwhite lysozyme is potentially available upon processing of native antigen. ./. Immunol. 1997, 159: 2574–2579.
  • D.L. Perkins. Y. Wang, D. Fruman, J.G. Seidman and I.J. Rimm. Immunodominance is altered in T cell receptor {fi chain) transgenic mice without the generation of a hole in the repertoire. J. Immunol. 1991, 146: 2960 2964.
  • A.G. Farr and A. Rudensky. Medullary thymic epithelium: A mosaic of epithelial 'self? J. Exp. Med. 1988, 188: 1–4.
  • L.M. Wheatley, D. Urso, K. Turnas, J. Maltzman, E. Loll and A.l. Levinson. Molecular evidence for the expression of nicotinic acetylcholine receptor o-chain in the mouse thymus. J. Immunol. 1992, 148: 3105–3109.
  • B. Grima, D. Zelenika and B. Pessac. A novel transcript overlapping the myelin basic protein gene. J. Ncurocliem. 1992.59: 2318–2323.
  • T.M. Pribyl, C.W. Campagnoni, K. Kampf. T. Kashima, V.W. Handley. J. McMahon and A.T. Campagnoni. The human myelin basic protein gene is included within a 179-kilobase transcription unit: expression in the immune and central nervous systems. Proc. Nail. Acad. Sci. USA 1993. 90: 10695–10699.
  • V. Heath, A. Saoudi. B.P. Seddon, N.C. Moore. D.J. Fowell and D.W. Mason. The role of the thymus in the control of autoimmunity. J. Auioimnnm. 1996. 9: 241–246.
  • V. Heath. D. Mason, F. Ramirez and B. Seddon. Homeostatic mechanisms in the control of autoimmunity. Seni. Immunol. 1997, 9: 375 380.
  • K. Kojima, M. Reindl. H. Lassmann, H. Wekerle and C. Linington. The thymus and self-tolerance: co-existence of encephalitogenic SlOO/3-specific T cells and their nominal autoantigen in the normal adult rat thymus. Int. Immunol. 1997, 9: 897 904.
  • S.S. Zamvil and L. Steinman. The T lymphocyte in experimental allergic encephalomyelitis. Ann. Rev. Immunol. 1990,8: 579–621.
  • S.S. Zamvil, D.J. Mitchell, A.C. Moore, K. Kitamura, L. Steinman and J.B. Rothbard. T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis. Nature 1986. 324: 258 260.
  • S. Zamvil, P. Nelson, J. Trotter, D. Mitchell, R. Knobler. R. Fritz and L. Steinmen. T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination. Nature 1985, 317: 355–358.
  • P.J. Fairchild, H. Pope and D.C Wraith. The nature of cryptic epitopes within the self-antigen myelin basic protein. Ini. Immunol. 1996,8: 1035–1043.
  • P.J. Fairchild, R. Wildgoose, E. Atherton, S. Webb and D.C. Wraith. An autoantigenic epitope forms unstable complexes with class 11 MHC: a novel route for escape from tolerance induction. Int. Immunol. 1993, 5: 1151–1158.
  • K. Mason and H.M. McConnell. Short-lived complexes between myelin basic protein peptides and IAk. Proc. Natl. Acad. Sci. USA 1994, 91: 12463–12466.
  • K. Mason, D.W. Denney and H.M. McConnell. Myelin basic protein peptide complexes with the class 11 MHC molecules 1-A" and I-Ak form and dissociate rapidly at neutral pH. J. Immunol. 1995, 154: 5216–5227.
  • C. Lee, M.N. Liang, K..M. Tate, J.D. Rabinowitz. C. Beeson, P.P. Jones and H.M. McConnell. Evidence that the autoimmune antigen myelin basic protein (MBP) Acl 9 binds towards one end of the major histocompatibility complex (MHC) cleft. ./. Exp. Med. 1998. 187: 1505–1516.
  • P.J. Fairchild and D.C. Wraith. Lowering the tone: mechanisms of immunodominance among epitopes with low affinity for MHC. Immunol. Today 1996, 17: 80 85.
  • G. Gammon, E.E. Sercarz and G. Benichou. The dominant self and the cryptic self: shaping the autoreactive T cell repertoire. Immunol. Todav 1991. 12: 193–195.
  • G.Y. Liu, P.J. Fairchild, R.M. Smith. J.R. Prowle, D. Kioussis and D.C. Wraith. Low avidity recognition of self-antigen by T cells permits escape from central tolerance. Immunity 1995. 3: 407 415.
  • C.l. Pearson, W. van Ewijk and H.O. McDevitt. Induction of apoptosis and T helper 2 (Th2) responses correlates with peptide affinity for the major histocompatibility complex in self-reactive T cell receptor transgenic mice. J. Exp. Med. 1997, 185: 583–599.
  • M. Wall, S. Southwood, J. Sidney. C. Oseroff, M.-F. del Guericio, A.G. Lamont. S.M. Colon, T. Arrhenius, F.C.A. Gaeta and A. Sette. High affinity for class II molecules as a necessary but not sufficient characteristic of encephalitogenic determinants. Int. Immunol. 1992,4: 773–777.
  • D.L. Donermeyer. K..W. Beisel. P.M. Allen and S.C. Smith. Myocarditis-inducing epitope of myosin binds constitutively and stably to 1-Ak on antigen-presenting cells in the heart. J. Exp. Med. 1995, 182: 1291 1300.
  • A.T. Kozhich, R.R. Caspi, J.A. Berzofsky and I. Gery. Immunogenicity and immunopathogenicity of an autoimmune epitope are potentiated by increasing MHC binding through residue substitution. J. Immunol. 1997. 158: 4145–4151.
  • I. Joosten, M.H.M. Wauben, M.C. Holewijn. K. Reske, L.F. Pedersen, C.F.P. Roosenboom, E.J. Hensen, W. Van Eden and S. Buus. Direct binding of autoimmune disease related T cell epitopes to purified Lewis rat MHC class 11 molecules. Int. Immunol. 1994. 6: 751–759.
  • P.A. Muraro, M. Vergelli, M. Kalbus, D.E. Banks, J.W. Nagle, L.R.Tranquill,G.T.Nepom,W.E. Biddison.H.F. McFarland and R. Martin. Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111 129) in HLA-DR4 (B*0401) subjects is associated with a restricted T cell receptor repertoire. J. Clin. Invest. 1997,100:339 349.
  • G. Gammon and E. Sercarz. How some T cells escape tolerance induction. Nature 1989, 342: 183 185.
  • R. Cibotti, J.M. Kanellopoulos, J.-P. Cabaniols, O. Halle-Panenko, K. Kosmatopoulos, E. Sercarz and P. Kourilsky. Tolerance to a self-protein involves its immunodominant but does not involve its subdominant determinants. Proc. Natl. Acad. Sci. USA 1992, 89: 416–420.
  • J.-P. Cabaniols, R. Cibotti, P. Kourilsky, K. Kosmatopoulos and J.M. Kanellopoulos. Dose-dependent T cell tolerance to an immunodominant self peptide. Eur. J. Immunol. 1994. 24: 1743 1749.
  • D.R. Milich. A. McLachlan, A.K. Raney, R. Houghten, G.B. Thornton, T. Maruyama, J.L. Hughes and J.E. Jones. Autoantibody production in hepatitis B e antigen transgenic mice elicited with self-T cell peptide and inhibited with nonself peptides. Proc. Natl. Acati. Sci. USA 1991,88: 4348 4352.
  • G. Benichou, E. Fedoseyeva, C.A. Olson, H.M. Geysen, M. McMillan and E.E. Sercarz. Disruption of the determinant hierarchy on a self-MHC peptide: concomitant tolerance induction to the dominant determinant and priming to the cryptic self-determinant. Int. Immunol. 1994,6: 131 138.
  • A. Roach, N. Takahashi, D. Pravtcheva, F. Ruddle and L. Hood. Chromosomal mapping of mouse myelin basic protein gene and structure and transcription of the partially deleted gene in shiverer mutant mice. Cell 1985, 42: 149–155.
  • I. Yoshizawa, R. Bronson, M.E. Dorf and S. Abromson-Leeman. T-cell responses to myelin basic protein in normal and MBP-deficient mice. J. Neuroimmunol. 1998, 84: 131 138.
  • O.S. Targoni and P.V. Lehmann. Endogenous myelin basic protein inactivates the high avidity T cell repertoire. J. Exp. Med. 1998, 187: 2055 2063.
  • D.M. Zaller and V.S. Sloan. Transgenic mouse models of experimental autoimmune encephalomyelitis. Cur. Topics. Microbiol. Immunol. 1996,206: 15 31.
  • C.J. Harrington, A. Paez, T. Hunkapiller, V. Mannikko, T. Brabb, M.E. Ahearn, C. Beeson and J. Goverman. Differential tolerance is induced in T cells recognizing distinct epitopes of myelin basic protein. Immunity 1998, 8: 571 580.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.