In Vitro Stimulation by Islet Antigen Facilitates the Detectability of Beta-cell Reactive Cells in Diabetes-prone BB/OK Rats

References

• G.S. Eisenbarth. Type 1 diabetes mellitus: a chronic autoimmune disease. N. Engl. J. Med. 1986: 314: 1360–1368.
   PubMedGoogle Scholar
• P.J. Bingley. M.R. Christie. R. Bonifacio, M. Shattock, M.T. Foute. G.F. Bottazzo and E.A. Gale. Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody positive relatives. Diabetes 1994: 43: 1304 1310.
   Google Scholar
• CF. Verge. R. Gianani, E. Kawasaki, L. Yu, M. Pietropaolo. R.A. Jackson, H.P. Chase and G.S. Eisenbarth. Prediction of type I diabetes in first degree relatives using a combination of insulin GAD and 1CA12-bde 1A-2 autoantibodies. Diabetes 1996; 45: 926–933.
   PubMedGoogle Scholar
• J. Nerup and C. Binder. Thyroid, gastric and adrenal autoimmunity in diabetes mellitus. Acta Endocrinol. 1973; 72: 279 286.
   Google Scholar
• A.N. Gorsuch, K.M. Spencer, J. Lister, J.M. McNally, B.M. Dean, G.F. Bottazzo and A.G. Cudworth. Evidence for a long prediabetic period in type 1 (insulin dependent) diabetes mellitus. Lancei 1981; ii: 1363 1365.
   Google Scholar
• D.R. Martin and J. Logothetopoulos. Complement-fixing islet cell antibodies in the spontaneously diabetic BB rat. Diabetes 1984; 33: 93–96.
   PubMedGoogle Scholar
• E. Kahler, S. Knospe, I. Rjasanovvski and D. Michaelis. Effect of lymphocytes and serum from probands before and after manifestation of type 1 (insulin dependent) diabetes on rat islets in vitro. Exp. Clin. Endocrinol. 1988; 92: 182–188.
   PubMedGoogle Scholar
• K.M. Spencer, A. Tarn, B.M. Dean, J. Lister and G.F. Bottazzo. Fluctuating islet cell autoimmunity in unaffected relatives of patients with insulin dependent diabetes. Lancet 1984: i: 764 766.
   Google Scholar
• A.J. Tingle, G. Lim, V.J. Wright, J.E. Dimmick and J. A. Hunt. Transplacental passage of islet cell antibodies in infants of diabetic mothers. Peclialr. Res. 1979: 13: 1323–1325.
   Google Scholar
• G. Papadopoulos, C. Petersen, V. Andersen, A. Lernmark, B. Marner, J. Nerup and C. Binder. Spontaneous in vitro immunoglobulin secretion at the diagnosis of insulin-dependent diabetes. Acta Endocrinol. 1984; 105: 521 527.
   Google Scholar
• A.K. Foulis, M. McGill and M.A. Farquarson. lnsulitis in type 1 (insulin dependent) diabetes mellitus in man -macrophages, lymphocytes and interferon-gamma containing cells. J. Pathol. 1991; 165: 97 103.
   Google Scholar
• W. Gepts. Pathological anatomy of the pancreas of juvenile diabetes mellitus. Diabetes 1986; 14: 619–633.
   Google Scholar
• B.M. Dean, R. Walker, A.J. Bare, J.D. Baird and A. Cook. Prediabetes in the spontaneously diabetic BB E rat: lymphocyte subpopulations in the pancreatic infiltrate and expression of MHC class 11 molecules in endocrine cells. Diabetologia 1985; 28: 464–469.
   PubMedGoogle Scholar
• S. Lucke, T. Diamantstein and H.J. Halm. Different lymphocyte subset distribution within insulitis islets of normo-glycaemic and prediabetic BB/OK rats of similar age. Exp. Clin. Endocrinol. 1990; 95: 57–63.
   PubMedGoogle Scholar
• A.A. Like, E. Kislauskis, R.M. Williams and A.A. Rossini. Neonatal thymectomy prevents spontaneous diabetes mellitus in the BB/W rat. Science 1982: 216: 644–646.
   PubMedGoogle Scholar
• A.A. Like, C.A. Biron, E.J. Weringer, K. Byman. E. Stroczinski and D.L. Guberski. Prevention of diabetes in BioBreeding/Worcester rats with monoclonal antibodies that recognize T lymphocytes or natural killer cells. J. Exp. Med. 1986; 164: 1145–1159.
   PubMedGoogle Scholar
• H.J. Halm, J. Gerdes, S. Lucke. L. Liepe, C. Kauert, H.D. Volk, H.H. Wacker, S. Brocke, H. Stein and T. Diamantstein. Phenotypical characterization of the cells invading pancreatic islets of diabetic BB OK rats: effect of interleukin 2 receptor-target immunotherapy. Eur. J. Immunol. 1988: 18: 2037–2042.
   PubMedGoogle Scholar
• S.B. Koevary, A. Rossini, W. Stoller, W.L. Chick and R.M. Williams. Passive transfer of diabetes in the BB W rat. Science 1983: 220: 727–728.
   PubMedGoogle Scholar
• S.B. Koevary, D.E. Williams, R.M. Williams and W.L. Chick. Passive transfer of diabetes from BB W to Wistar Furth rats. J. Clin. Inven. 1985; 75: 1904 1907.
   Google Scholar
• S.B. Koevary. In vitro lysis of islet cells by lymphocytes from diabetic BB Wor rats is not antibody mediated. Diabetes Res. 1990; 13: 133–138.
   PubMedGoogle Scholar
• C. Pukel, H. Baquerizo and A. Rabinovitch. Interleukin 2 activates BB/W diabetic rat lymphocytes cytotoxic to islet cells. Diabetes 1987: 36: 1217 1222.
   Google Scholar
• M. Debray-Sachs, P. Sai, C. Boitard, R. Assan and J. Hamburger. Anti-pancreatic immunity in genetically diabetic mice. Clin. Exp. Immunol. 1983; 51: 1–7.
   PubMedGoogle Scholar
• L. Martignat, B. Feve, B. Charbonell and P. Sai. Splenocytes from non-obese-diabetic mice binding to xenogeneic /3-cells in vitro: an early marker of cell mediated immunity. Diab. Metah. 1993; 19: 566–574.
   PubMedGoogle Scholar
• J.P. Palmer and D.K. McCulloch. Prediction and prevention of 1DDM 1991. Diabetes 1991; 40: 943–947.
   PubMedGoogle Scholar
• R.D.G. Leslie and D.A. Pyke. Escaping insulin dependent diabetes. Characteristic immunological changes don't invariably lead to disease. Br. Med. J. 1991; 302: 1103–1104.
   Google Scholar
• Kicking and L. Vogt. BB/0(ttawa)K(arlsburg) rats: features of a subline of diabetes-prone BB rats. Diabetes Res. 1991; 15: 37–39.
   Google Scholar
• B. Kuttler, H.D. Volk, C. Kauert, T. Diamantstein and H.J. Hahn. Phenotyping of lymphocytes following transplantation of allogeneic rat pancreatic islets into strepto-zotocin-diabetic recipients. Exp. Clin. Endocrinol. 1990: 95: 64 69.
   Google Scholar
• B. Kuttler, C. Kauert, H. Wanka, T. Diamantstein and H.J. Hahn. Temporary anti-CD25/CsA therapy induces a CD4+ T-cell-mediated tolerance in BB/OK rats. J. Autoimmunity 1996; 9: 321 329.
   Google Scholar
• B. Kuttler, M. Lehmann, J. Lacha, J. Brocke and H.J. Hahn. Anti-CD4 therapy induces a donor-specific, organ-unspecific tolerance in allogeneic kidney graft recipients. Transplant. Proc. 1994; 26: 728–729.
   PubMedGoogle Scholar
• B. Hehmke, K.D. Kohnert and R. Odselius. The use of a new dextran gradient medium for rapid isolation of functionally intact neonatal rat pancreatic islets. Diabetes Res. 1986; 3: 13 16.
   Google Scholar
• K.T. Brunner. J. Manel, J.C. Cerottini and B. Chapuis. Quantitative assay of the lytic action of immune lymphoid cells on 51Cr-labelled allogeneic target cells in vitro: inhibition of isoantibody and drugs. Immunology 1968; 14: 181–196.
   PubMedGoogle Scholar
• H.J. Hahn, S. Lucke, B. Kuttler, A. Dunger, H.D. Volk and T. Diamantstein. Investigations of diabetes-prone normoglycaemic BB-rats. In: Frontiers in Diabetes Research. Lessons from Animal Diabetes III. Ed. E. Shafir, Smith-Gordon, 1990; pp. 30–33.
   Google Scholar
• H.J. Hahn, S. Lucke, 1. Kicking and W. Besch. Prospective investigations of long-term normoglycaemic BB/OK-rats: serial determination of glucose tolerance, insulitis, B-cell volume density and pancreatic insulin content. Exp. Clin. Endocrinol. 1991; 98: 185–192.
   Google Scholar
• J. Zhang, S. Markovic Plese, B. Lacet, J. Raus, H.L. Weiner and D.A. Hafler. Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J. Exp. Med. 1994; 179: 973–984.
   PubMedGoogle Scholar
• L. Martignat, B. Feve, M. Ouary, S. Pagu, B. Charbonnel and P. Sai. T-splenocytes from non-obese diabetic mice binding to xenogeneic pancreatic /3-cells in vitro. Implication of the ct//3 T-cell receptor and of major histocompatibility complex class II molecules from target cells. J. Autoimmunity 1993; 6: 753–769.
   Google Scholar
• J.F. Bach. Insulin-dependent diabetes mellitus as an autoimmune disease. Endocrine rev. 1994; 4: 516–542.
   Google Scholar
• M. Schlosser, B. Ziegler, P. Augstein, 1. Kicking and M. Ziegler. Occurrence of islet reactive autoantibodies in diabetes-prone BB/OK rats is not associated with the onset of diabetes - a cross-sectional study of BB rats and their diabetes-resistant congeneic strains. Diab. Res. 1994; 26: 67–77.
   Google Scholar
• M. Ziegler, M. Schlosser, J. Hamann, P. Vieregge, F. Liihder, 1. Kicking and B. Ziegler. Autoantibodies to glutamate decarboxylase detected in diabetes-prone BB/ OK rats do not distinguish onset of diabetes. Exp. Clin. Endocrinol. 1994; 102:98–103.
   Google Scholar