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Original Article

Diabetes Prone BB Rats are Severely Deficient in Natural Killer T Cells

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Pages 1-14 | Received 09 Apr 1999, Published online: 07 Jul 2009

References

  • Mordes J. P., Greiner D. L., Rossini A. A. Animal models of autoimmune diabetes mellitus. Diabetes Mellitus. A Fundamental ami Clinical Text, D. LeRoith, S. I. Taylor, J. M. Olefsky. Lippineotl-Raven, Philadelphia 1996; 349–360
  • Guberski D. L. Diabetes-prone and diabetes-resistant BB rats: Animal models of spontaneous and virally induced diabetes mellitus. lymphocytic thyroiditis, and collagen-induced arthritis. ILAR News 1994; 35: 29–37
  • áCris L., Mordes J. P., Rossini A. A. Autoimmune diabetes mellitus in the BB rat. Diabetes! Metab. Rev 1992; 8: 9–37
  • Bortell R., Kanaitsuka T., Stevens L. A., Moss J., Mordes J. P., Rossini A. A., et al. The RT6 (Art2) family of ADP-ribosyltransferases in rat and mouse. Mol. Cell. Biochem 1999; 193: 61–68
  • Mordes J. P., Bortell R., Doukas J., Rigby M. R., Whalen B. J., Zipris D., et al. The BB/Wor rat and the balance hypothesis of autoimmunity. Diabetes! Metab. Rex 1996; 2: 103–109
  • Iwakoshi N. N., Goldschneider I., Tausche F., Mordes J. P., Rossini A. A., Greiner D. L. High frequency apoptosis of recent thymic emigrants in the liver of lymphopenic diabetes prone BioBreeding rats. J. Immunol 1998; 160: 5838–5850
  • Wonigeit K., Dinkel A., Fangmann J., Thude H. Expression of the ectoenzyme RT6 is not restricted to resting peripheral T cells and is differently regulated in normal peripheral T cells, intestinal 1EL, and NK cells. Adv. Exp. Med. Biol 1997; 419: 229–240
  • Bendelac A., Rivera M. N., Park S. H., Roark J. H. Mouse CDI-specific NK1 T cells: Development, specificity, and function. Ann. Rev. Immunol 1997; 15: 535–562
  • Vtcariand A. P., Zlotnik A. Mouse NKl.l+ T cells: A new family of T cells. Immunol, Today 1996; 17: 71–76
  • Baxter A. G., Kinder S. J., Hammond K. J.L., Scollay R., Godfrey D. L. Association between αβTCR+ CD4- CD8 T-cell deficiency and IDDM in NOD/Lt mice. Diabetes 1997; 46: 572–582
  • Chen H., Paul W. E. Cultured NK11+ CD4 T cells produce large amounts of IL-4 and IFN-gamma upon activation by anti-CD3 or CDl. J. Immunol 1997; 159: 2240–2249
  • Cui J., Shin T., Kawano T., Sato H., Kondo E., Toura I., et al. Requirement for Valphal4 NKT cells in IL-12-mediated rejection of tumors. Science 1997; 278: 1623–1626
  • Gombert J. M., Herbelin A., Tancrede-Bohin E., Dy M., Carnaud C., Bach J. F. Early quantitative and functional deficiency of NKI 1+ -like thymocytes in the NOD mouse. Eur. J. Immunol 1996; 26: 2989–2998
  • Takeda K., Denncrt G. The development of autoimmunity in C57BL/Ipr mice correlates with the disappearance of natural killer type 1-positive cells: Evidence for their suppressive action on bone marrow stem cell proliferation. B cell immunoglobulin secretion, and autoimmune symptoms. J. Exp. Med 1993; 177: 155–164
  • Mieza M. A., Itoh T., Cui J. Q., Makino Y., Kawano T., Tsuchida K., et al. Selective reduction of V alpha 14+ NKT cells associated with disease development in autoimmune-prone mice. J. Immunol 1996; 156: 4035–4040
  • Hammond K. J.L., Poulton L. D., Palmisano L. J., Silveira P. A., Godfrey D. L, Baxter A. G. alpha/beta-T cell receptor (TCR)'CD4 CD8- (NKT) thymocytes prevent insulin-dependent diabetes mellitus in nonobese diabetic (NOD)/Lt mice by the influence of interleukin (lL)-4 and/or IL-10. J. Exp. Med 1998; 187: 1047–1056
  • Zeng D., Dick M., Cheng L., Amano M., Dejbakhsh-Jones S., Huie P., et al. Subsets of transgenic T cells that recognize CDl induce or prevent murine lupus: Role of cytokines. J. Exp. Med 1998; 187: 525–536
  • Prussin C., Foster B. TCR Valpha24 and Vbetall co-expression defines a human NKT cell analog containing a unique ThO subpopulation. J. Immunol 1997; 159: 5862–5870
  • Wilson S. B., Kent S. C., Patton K. T., Orban T., Jackson R. A., Exley M., et al. Extreme Thl bias of invariant Valpha24JalphaQ T cells in type 1 diabetes. Nature 1998; 391: 177–181
  • Brisselte-Storkus C., Kaufman C. L., Pasewicz L., Worsey H. M., Lakomy R., Ildstad S. T., et al. Characterization and function of the NKR-Pldim/T cell receptor-alpha beta + subset of rat T cells. J. Immunol 1994; 152: 388–396
  • Badovinac V., Boggiano C., Trajkovic V., Frey A. B., Vujanovic N. L., Gold D. P., et al. Rat NKR-P1+ CD3+ T cells: Selective proliferation in interleukin-2, diverse T-cell-receptor-V/i repertoire and polarized interferon-gamma expression. Immunology 1998; 95: U7–125
  • Whalen B. J., Rossini A. A., Mordes J. P., Greiner D. L. DR-BB rat thymus contains thymocyte populations predisposed to autoreactivity. Diabetes 1995; 44: 963–967
  • Chambers W. H., Vujanovic N. L., DeLeo A. B., Olszowy M. W., Herberman R. B., Hiserodt J. C. Monoclonal antibody to a triggering structure expressed on rat natural killer cells and adherent lymphokine-acti-vated killer cells. J. Exp. Med 1989; 169: 1373–1389
  • Kuhnlein P., Park J. H., Herrmann T., Elbe A., Hunig T. Identification and characterization of rat gamma/delta T lymphocytes in peripheral lymphoid organs. small intestine, and skin with a monoclonal antibody to a constant determinant of the gamma delta T cell receptor. J. Immunol 1994; 153: 979–986
  • O'Brien P. C., Shampo M. A. Statistical considerations for performing multiple comparisons in a single experiment. 2. Comparisons among multiple therapies. Mayo Clin. Proc 1988; 63: 816–820
  • Woda B. A., Biron C. A. Natural killer cell number and function in the spontaneously diabetic BB/W rat. J. Immunol 1986; 137: 1860–1866
  • Mojcik C. F., Greiner D. L., Medlock E. S., Komschlies K. L., Goldschneider I. Characterization of RT6 bearing rat lymphocytes. I. Ontogeny of the RT6 subset. Cell. Immunol 1988; 114: 336–346
  • Mojcik C. F., Greiner D. L., Goldschneider I. Characterization of RT6-bearinglymphocytes. II. Developmental relationships of RT6 and RT6+ T cells. Develop. Immunol 1991; 1: 191–201
  • Galandrini R., De Maria R., Piccoli M., Frati L., Santoni A. CD44 triggering enhances human NK cell cytotoxic functions. J. Immunol 1994; 153: 4399–4407
  • Sconocchia G., Titus J. A., Segal M. D. CD44 is a cytotoxic triggering molecule in human peripheral blood NK cells. J. Immunol 1994; 153: 5473–5481
  • Groen H., Klatter F. A., Brons N. H.C., Wubbena A. S., Nieuwenhuis P., Kampinga J. High-frequency, but reduced absolute numbers of recent thymic migrants among peripheral blood T lymphocytes in diabetes-prone BB rats. Cell. Immunol 1995; 163: 113–119
  • Plamondon C., Kottis V., Brideau C., Metroz-Dayer D. M.-, Poussier P. Abnormal thymocyte maturation in spontaneously diabetic BB rats involves the deletion of CD4- 8+ cells. J. Immunol 1990; 144: 923–928
  • Zadeh H. H., Greiner D. L., Wu D. Y., Tausche F., Goldschneider I. Abnormalities in the export and fate of recent thymic emigrants in diabetes-prone BB/W rats. Autoimmunity 1996; 24: 35–46
  • Groen H., Matter F. A., Brons N. H.C., Mesander G., Nieuwenhuis P., Kampinga J. Abnormal thymocyte subset distribution and differential reduction of CD4- and CD8+ T cell subsets during peripheral maturation in diabetes-prone BioBreeding rats. J. Immunol 1996; 156: 1269–1275
  • Greiner D. L.l., Mordes P., Handler E. S., Angclillo M., Nakamura N., Rossini A. A. Depletion of RT6.1- T lymphocytes induces diabetes in resistant BioBreeding/ Worcester (BB/W) rats. J. Exp. Med 1987; 166: 461–475
  • Like A. A., Biron C. A., Weringer E. J., Byman K., Sroczynski E., Guberski D. L. Prevention of diabetes in BioBreeding/Worcester rats with monoclonal antibodies that recognize T lymphocytes or natural killer cells. J. Exp. Med 1986; 164: 1145–1159
  • Woda B. A., Handler E. S., Greiner D. L., Reynolds C., Mordes J. P., Rossini A. A. T lymphocyte requirement for diabetes in RT6-depleted diabetes resistant BB rats. Diabetes 1991; 40: 423–428
  • Jacobson J. D., Markmann J. F., Brayman K. L., Barker C. F., Naji A. Prevention of recurrent autoimmune diabetes in BB rats by anti-asialo-GM 1 antibody. Diabetes 1988; 37: 838–841
  • Ellerman K. E., Wrobieski M., Rabinovitch A., Like A. Natural killer cell depletion and diabetes melli-tus in the BB/Wor rat (revisited). Diabetologia 1993; 36: 596–601
  • Fangmann J., Schwinzer R., Wonigeit K. Unusual phenotype of intestinal intraepithelial lymphocytes in the rat: Predominance of T cell receptor α/β/CD2 cells and high expression of the RT6 alloantigen. Eur. J. Immunol 1991; 21: 753–760
  • Waite D. J., Appel M. C., Handler E. S., Mordes J. P., Rossini A. A., Greiner D. L. Ontogeny and immuno-histochemical localization of thymus dependent and thymus independent RT6+ cells in the rat. Am. J. Pathol 1996; 148: 2043–2056
  • Fangmann J., Schwinzer R., Winkler M., Wonigeit K. Expression of RT6 alloantigens and the T-cell receptor on intestinal intraepithelial lymphocytes of the rat. Transplant. Proc 1990; 22: 2543–2544

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