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Original Article

GAD65 and Insulin B Chain Peptide (9-23) are not Primary Autoantigens in the Type 1 Diabetes Syndrome of the BB Rat

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Pages 15-24 | Received 04 Jun 1999, Published online: 07 Jul 2009

References

  • Leiter E. H., Gill R. G. Prevention of autoimmune diabetes in the BB rat by intrathymic islet transplantation at birth. J. Endocrinol. Invest 1994; 17: 595–599
  • Charlton B., Taylor C. E.-, Tisch R., Fathtman C. G. Prevention of diabetes and insulitis by neonatal intrathymic islet administration in NOD mice. J. Autoimmunity 1994; 7: 549–560
  • Bach J. F. Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr. Rev 1994; 15: 516–542
  • Sernmark R. Immune surveillance: Paraneoplastic or environmental triggers of autoimmunity. Crit. Rev. Immunol 1997; 17: 437–447
  • Ramiya V. K., Lan M. S., Wasserfall C. H., Notkins A. L., Maclaren N. K. Immunization therapies in the prevention of diabetes. J. Autoimmunity 1997; 10: 287–292
  • Xie H., Zhang B. W., Matsumoto Y., Li Q., Notkins A. L., Lan M. S. Autoantibodies to IA-2 and IA-2 beta in insulin-dependent diabetes mellitus recognize conformational epitopes - Location of the 37- and 40-kDa fragments determined. J. Immunol 1997; 159: 3662–3667
  • Aanstoot H. J., Rang S. M., Kim J., Lindsay L. A., Roll U., Knip M., et al. Identification and characterization of glima 38, a glycosylated islet cell membrane antigen, which together with GAD(65) and IA2 marks the early phases of autoimmune response in type 1 diabetes. J. Clin. Invest 1996; 97: 2772–2783
  • Aguilar-Diosdado M., Parkinson D., Corbett J., Kwon G., Marshall C. A., Gingerich R. L., et al. Potential autoantigens in IDDM. Expression of carboxypeptidase-H and insulin but not glutamate decarboxylase on the beta-cell surface. Diabetes 1994; 43: 418–425
  • Bergman B., Haskins K. Islet-specific T-cell clones from the NOD mouse respond to beta-granule antigen. Diabetes 1994; 43: 197–203
  • Petersen J. S., Karlsen A. E., Markholst H., Worsaae A., Dyrberg T., Michelsen B. Neonatal tolerization with glutamic acid decarboxylase but not with bovine serum albumin delays the onset of diabetes in NOD mice. Diabetes 1994; 43: 1478–1484
  • Tisch R., Liblau R. S., Yang X. D., Liblau P., McDevitt H. O. Induction of GAD65-specific regulatory T-cells inhibits ongoing autoimmune diabetes in nonobese diabetic mice. Diabetes 1998; 47: 894–899
  • Daniel D., Wegmann D. R. Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B (9–23). PNAS USA 1996; 93: 956–960
  • Mordes J. P., Schirf B., Roipko D., Greiner D. L., Weiner H., Nelson P., et al. Oral insulin does not prevent insulin-dependent diabetes mellitus in BB rats. Ann. N. Y. Acad. Sei 1996; 418–421, 778
  • Petersen J. S., Mackay P., Plesner A., Karlsen A., Gotfredsen C., Verland S., et al. Treatment with GAD65 or BSA does not protect against diabetes in BB rats. Autoimmunity 1997; 25: 129–138
  • Gottlieb P. A., Handler E. S., Appel M. C., Greiner D. L., Mordes J. P., Rossini A. A. Insulin treatment prevents diabetes mellitus but not thyroiditis in RT6-depIeted diabetes resistant BB/Wor rats. Diabeto/ogia 1991; 34: 296–300
  • Bieg S., Moller C., Olsson T., Sernmark R. The lymphopenia (lyp) gene controls the intrathymic cytokine ratio in congenic BioBreeding rats. Diabetologia 1997; 40: 786–792
  • Hegewald M. J., Schoenfeld S. L., McCulloch D. K., Greenbaum C. J., Klaff L. J., Palmer J. P. Increased specificity and sensitivity of insulin antibody measurements in autoimmune thyroid disease and type 1 diabetes. J. Immunol. Meth 1992; 154: 61–68
  • McCulloch D. K., Klaff L. J., Kahn S. E., Schoenfeld S. L., Greenbaum C. J., Mauseth R. S, et al. Nonprogression of subclinical beta-cell dysfunction among first-degree relatives of IDDM patients. 5-yr follow-up of the Seattle Family Study. Diabetes 1990; 39: 549–556
  • Falorni A., Örtqvist E., Persson B., Sernmark R. Radioimmunoassays for glutamic acid decarboxylase (GAD65) and GAD65 autoantibodies using l3S or 3H recombinant human ligands. J. Immunol. Meth 1995; 186: 89–99
  • Grubin C. E., Daniels T., Toivola B., Landin-Olsson M., Hagopian W. A., Li L., et al. A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM. Diabetologia 1994; 37: 344–350
  • Karlsen A. E., Hagopian W. A., Grubin C. E., Dube S. C, Disteche M., Adler D. A., Bärmeier H., Mathewes S., Grant F. J., Foster D., Sernmark R. Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10. PNAS USA 1991; 88: 8337–8341
  • Michelsen B. K., Petersen J. S., Boel E., Moldrup A., Dyrberg T., Madsen O. D. Cloning, characterization, and autoimmune recognition of rat islet glutamic acid decarboxylase in insulin-dependent mellitus. PNAS USA 1991; 88: 8754–8758
  • Falorni A., Ackefors M., Carlberg C., Daniels T., Persson B., Robertson J., et al. Diagnostic sensitivity of immunodominant epitopes of glutamic acid decarboxylase (GAD65) autoantibodies in childhood IDDM. Diabetologia 1996; 39: 1091–1098
  • Cetkovic-Cvrlje M., Gerling I. C., Muir A., Elliot M. A., Leiter E. H. Retardation or acceleration of diabetes in NOD/Lt mice mediated by intrathymic administration of candidate beta cell antigens. Diabetes 1997; 46: 1975–1982
  • Ziegler M., Schlosser M., Hamann J., Vieregge P., Luhder F., Kloting I., et al. Autoantibodies to glutamate decarboxylase detected in diabetes-prone BB/OK rats do not distinguish onset of diabetes. Exp. Clin. Endoerinol 1994; 102: 98–103
  • Elder M. E., Maclaren N. K. Identification of profound peripheral T lymphocyte immunodeficiencies in the spontaneously diabetic BB rat. J. Immunol 1983; 130: 1723–1731
  • Cataldo D. M., Van Nast G. A. The adjuvant MF59 increases the immunogenicity and protective efficacy of subunit influenza vaccine in mice. Vaccine 1997; 15: 1710–1715
  • Granoff D. M., McHugh Y E, Raff H. V., Mokatnn A. S., Van Nest G. A. MF59 adjuvant enhances antibody responses of infant baboons immunized with Haemophilus influenzae type b and Neisseria meningitidis group C oligosaccharide ∼CRM 197 conjugate vaccine. Infect, Im-mun 1997; 65: 1710–1715
  • Higgins D. A., Carlson J. R., Van Nest G. A. MF59 adjuvant enhances the immunogenicity of influenza vaccine in both young and old mice. Vaccine 1996; 14: 478–484
  • Kim J., Namchuck M., Bugawan T., Fu Q., Jaffe M., Shi Y., et al. Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish Stiff-Man Syndrome from insulin-dependent diabetes mellitus. J. Exp. Med 1994; 180: 595–606
  • Dunnovic B. I., Hummel M., Ziegler A. G. Cellular immune response to diverse islet cell antigens in IDDM. Diabetes 1996; 45: 795–800
  • Harrison L. C., Honeyman M. C., DeAizpurua H. J., Schmidli R. S., Colman P. G., Tait B. D., et al. Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes. Lancet 1993; 341: 1365–1369
  • Honeyman M. C., Stone N., DeAizpurua H. J., Rowley M. J., Harrison L. C. High T cell responses to the glutamic acid decarboxylase (GAD) isoform 67 reflect a hyperimmune state that precedes the onset of insulin-dependent diabetes. J. Autoimmunity 1997; 10: 165–173
  • Hummel M., Durinovic-Bello I., Ziegler A. G. Relation between cellular and humoral immunity to islet cell antigens in type 1 diabetes. J. Autoimmunity 1996; 9: 427–430
  • Bieg S., Bailyes E. M., Yassin N., Amann J., Herberg L., McGregor A. M., et al. A multiplicity of protein antigens in subcellular fractions of rat insulinoma tissue are able to stimulate T cells obtained from non-obese diabetic mice. Diabetologia 1993; 36: 385–390
  • Brooks-Worrell B. M., Starkebaum G. A., Greenbaum C., Palmer J. P. Peripheral blood mononuclear cells of insulin-dependent diabetic patients respond to multiple islet cell proteins. J. Immunol 1996; 157: 5668–5674

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