IDDM12 (CTLA4) on 2q33 and IDDM13 on 2q34 in Genetic Susceptibility to Type 1 Diabetes (Insulin-dependent)

References

• Pociot F. Insulin-dependent diabetes mellitus - a polygenic disorder. Dan. Med. Bull. (Thesis) 1996; 43: 216–248
   PubMedGoogle Scholar
• Todd J. A., Farrall M. Panning for gold: genome-wide scanning for linkage in type 1 diabetes. Hum. Mol. Genet 1996; 5: 1443–1448
   PubMed Web of Science ®Google Scholar
• Singal D. P., Blajchman A. M. Histocompatibility (HL- A) antigens, lymphocytotoxic antibodies and tissue antibodies in patients with diabetes mellitus. Diabetes 1973; 22: 429–432
   PubMed Web of Science ®Google Scholar
• Nerup J., et al. HLA antigens and diabetes mellitus. Lancet 1974; ii: 864–866
   Google Scholar
• Owerbach D., Nerup J. Restriction fragment length polymorphism of the insulin gene in diabetes mellitus. Diabetes 1982; 31: 275–277
   PubMedGoogle Scholar
• Bell G. I., Horita S., Karam J. H. A polymophic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus. Diabetes 1984; 33: 1504–1509
   Google Scholar
• Julier C., et al. Insulin-IGF2 region on chromosome lip encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility. Nature 1991; 354: 155–159
   PubMedGoogle Scholar
• Bain S. C., et al. Insulin gene region-encoded susceptibility to type 1 diabetes is not restricted to HLA-DR4-positive individuals. Nature Genet 1992; 2: 212–215
   PubMedGoogle Scholar
• Lucassen A. M., et al. Susceptibility to insulin-dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR. Nature Genet 1993; 4: 305–310
   PubMed Web of Science ®Google Scholar
• Bennett S. T., et al. Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisalellite locus. Nature Genet 1995; 9: 284–291
   PubMed Web of Science ®Google Scholar
• McGinnis R. E., Spielman R. S. Insulin gene 5′flanking polymorphism. Length of class I alleles in number of repeat units. Diabetes 1995; 44: 1296–1302
   PubMedGoogle Scholar
• Davies J. L., et al. A genome-wide search for human susceptibility genes. Nature 1994; 371: 130–136
   PubMed Web of Science ®Google Scholar
• Hashimoto L., et al. Genetic mapping of a susceptibility locus for insulin-dependent mellitus on chromosome 11q. Nature 1994; 371: 161–164
   PubMed Web of Science ®Google Scholar
• Concannon P., et al. A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes-mcllitus. Nature Genet 1998; 19: 292–296
   PubMed Web of Science ®Google Scholar
• Mein C., et al. A search for type-1 diabetes susceptibility genes in families from the United Kingdom. Nature Genet 1998; 19: 297–300
   PubMedGoogle Scholar
• Field L. L., Tobias R., Magnus T. A locus on chromosome I5q26 (IDDM3) produces susceptibility to insulin-dependent diabetes mellitus. Nature Genet 1994; 8: 189–194
   PubMedGoogle Scholar
• Luo F. D.-, et al. Affected sib-pair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM8) on chromosome 6q25-q27. Am. J Hum. Genet 1995; 57: 911–919
   PubMedGoogle Scholar
• Copeman J. B., et al. Fine localisation of a type 1 diabetes susceptibility gene (IDDM7) to human chromosome 2q by linkage disequilibrium mapping. Nature Genet 1995; 9: 80–85
   PubMedGoogle Scholar
• Owerbach D., Gabbay K. H. The HOXD8 locus (2q31) is linked to type I diabetes. Interaction with chromosome 6 and 11 disease susceptibility genes. Diabetes 1995; 44: 132–136
   PubMedGoogle Scholar
• Rowe R. E., et al. Linkage and association between insulin-dependent diabetes mellitus (IDDM) susceptibility and markers near the glucokinase gene on chromosome 7. Nature Genet 1995; 10: 240–242
   PubMedGoogle Scholar
• Luo F. D.-, et al. Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: 1DDM4. IDDM5 and IDDMti. Hum. Mai. Genet 1996; 5: 693–698
   PubMedGoogle Scholar
• Field L. L., et al. Susceptibility to insulin-dependent diabetes mellitus maps to a locus (IDDM 11) on human chromosome 14q24.3-q31. Genomics 1996; 33: 1–8
   PubMedGoogle Scholar
• Zamani M., et al. Linkage of type I diabetes to 15q26 (IDDM3) in the Danish population. Hum. Genet 1996; 98: 491–496
   PubMedGoogle Scholar
• Delépine M., et al. Evidence of a non-HLA susceptibility locus in type 1 diabetes linked to HLA on chromosome 6. Am. J. Hum. Genet 1997; 60: 174–187
   PubMedGoogle Scholar
• Nistico L., et al. The ctla-4 gene region of chromosome 2q33 is linked to, and associated with, type-1 diabetes. Hum. Mol. Genet 1996; 5: 1075–1080
   PubMed Web of Science ®Google Scholar
• Morahan G., et al. Markers on distal chromosome 2q linked to insulin-dependent diabetes mellitus. Science 1996; 272: 1811–1813
   PubMedGoogle Scholar
• Garchon J. H.-, et al. Identification and mapping to chromosome 1 of a susceptibility gene for periinsulitis in non-obese diabetic mice. Nature 1991; 353: 260–262
   PubMedGoogle Scholar
• Cornall R. J., et al. Type 1 diabetes is linked to the intcrleukin-1 receptor and Ishlitvlbcg genes on chromosome 1. Nature 1991; 353: 262–265
   PubMed Web of Science ®Google Scholar
• Marron M. P., et al. Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups. Hum. Mol. Genet 1997; 6: 1275–1282
   PubMed Web of Science ®Google Scholar
• Donner H., et al. CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus. J. Clin. Endocrinol. Metaboi 1997; 82: 143–146
   PubMed Web of Science ®Google Scholar
• Awata T., et al. Association of CTLA-4 gene A-G polymorphism (IDDM12) with acute-onset and insulin-depleted IDDM as well as autoimmune thyroid disease (Graves' disease and Hashimoto's thyroiditis) in the Japanese population. Diabetes 1998; 47: 128–129
   PubMed Web of Science ®Google Scholar
• Fu J., et al. Association of distal chromosome 2q with IDDM in Japanese subjects. Diabetologia 1998; 41: 228–232
   PubMedGoogle Scholar
• Pociot F., et al. A nationwide population-based study of the familial aggregation of insulin-dependent diabetes in Denmark. Diabetologia 1993; 36: 870–875
   PubMed Web of Science ®Google Scholar
• Lorenzen T., et al. Predictors of IDDM recurrence risk in offspring of Danish IDDM patients. Diabetologia 1998; 41: 666–673
   PubMedGoogle Scholar
• Pociot F., et al. A tumour necrosis factor beta gene polymorphism in relation to monokine secretion and insulin-dependent diabetes mellitus. J. Scund. Immunol 1991; 33: 37–49
   PubMed Web of Science ®Google Scholar
• Polymeropoulos M. H., et al. Dinucleotide repeat polymorphism at the human CTLA4 gene. Nucleic Acids Res 1991; 19: 4018
   Google Scholar
• Sandberg-Wollheim M., et al. An evaluation of tumor necrosis factor microsatellite alleles in genetic susceptibility to multiple sclerosis. Multiple Sclerosis 1995; 1: 181–185
   PubMedGoogle Scholar
• Pociot F., et al. Analysis of an interferon-gamma gene (IFNG) polymorphism in Danish and Finnish insulin-dependent diabetes-mellitus (IDDM) patients and control subjects. J. Interferon. Cytokine Res 1997; 17: 87–93
   PubMedGoogle Scholar
• Spielman R. S., McGinnis R. E., Ewens W. J. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am. J. Hum. Genet 1993; 52: 506–516
   PubMed Web of Science ®Google Scholar
• Ewens W. J., Spielman R. S. The transmission disequilibrium test - history, subdivision and admixture. Am. J. Hum. Genet 1995; 57: 455–464
   PubMed Web of Science ®Google Scholar
• Martin E. R., Kaplan N. L., Weir B. S. Test for linkage and association in nuclear families. Am. J. Hum. Genet 1997; 61: 439–448
   PubMedGoogle Scholar
• Merriman T., et al. Evidence by allelic association-dependent methods for a type 1 diabetes polygene (IDDM6) to chromosome 18q12. Hum. Mol. Genet 1997; 6: 1003–1010
   PubMedGoogle Scholar
• van der Auwera B. J., et al. CTLA-4 gene polymorphism confers susceptibility to insulin-dependent diabetes mellitus (IDDM) independently from age and from other genetic or immune disease markers. Clin. Exp. Immunol 1997; 110: 98–103
   PubMedGoogle Scholar
• Barnes R., Grabs R., Polychronakos C. A CTLA-4 polymorphism affects lymphocyte raRNA levels but is not associated with type 1 diabetes in a Canadian dataset. Diabetologia 1997; 40(Suppl. 1)A51
   Google Scholar
• Yanagawa T., et al. Ctla-4 gene polymorphism associated with Graves-disease in a Caucasian population. J. Clin. Endocrinol. Metab 1995; 80: 41–45
   PubMed Web of Science ®Google Scholar
• Seidl C., et al. CTLA4 codon 17 dimorphism in patients with rheumatoid arthritis. Tissue Antigens 1998; 51: 62–66
   PubMedGoogle Scholar
• Rambrand T., et al. Genetic markers for glutamic acid decarboxylase do not predict insulin-dependent diabetes mellitus in pairs of affected siblings. Hum. Genet 1997; 99: 177–185
   Google Scholar
• Kristiansen O. P., et al. Linkage disequilibrium mapping of IDDM7 and GaINAc-T3 in a Danish IDDM multiplex family material. Eur. J. Endocrinol 1997; 136(Suppl. 1)9
   Google Scholar
• Owerbach D., et al. Analysis of candidate genes for susceptibility to type I diabetes. A case-control and family-association study of genes on chromosome 2q31–35. Diabetes 1997; 46: 1069–1074
   PubMedGoogle Scholar