Concanavalin A-induced Hepatitis in Mice is Prevented by Interleukin (IL)-10 and Exacerbated by Endogenous IL-10 Deficiency

References

• Tiegs G., Hentschel J., Wendel A. A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J. Clin. Invest 1992; 90: 196–203
   PubMed Web of Science ®Google Scholar
• Gantner F., Leist M., Lose A. W., German P. G., Tiegs G. ConcanavalinA-induced T-cell-medialed hepatic injury in mice: the role of tumor necrosis factor. Hepatology 1995; 21: 190–198
   PubMed Web of Science ®Google Scholar
• Mizuhara H., O'Neill E., Seki N., Ogawa T., Kusunoki C., Otsuka K., Satoh S., Niwa M., Senoh H., Fujiwara H. T cell activation-associated hepatic injury: mediation by tumor necrosis factor and protection by interlcukin 6. J. Exp. Med 1994; 179: 1529–1537
   PubMed Web of Science ®Google Scholar
• Lohse A. W., Meyer zum Bushenfelde H. K.-. Experimental hepatitis. Autoimmune Disease Models. A Guidebook, I. R. Cohen, A. Miller. Academic Press, San Diego 1994; 191–199
   Google Scholar
• Nicolelti F., Beltrami B., Raschi E., Di Marco R., Grasso S., Bendtzen K., Fiorelli G., Meroni P. L. Protection from concanavalin A (Con A)-induced T cell dependent hepatic lesions and modulation of cytokine release in mice by sodium fusidate. Clin. Exp. Immunol 1997; 110: 479–484
   PubMedGoogle Scholar
• Louis H., Le O., Moine M., Peny O., Quertinmont E., Fokan D., Goldman M., Deviere J. Production and role of interleukin-10 in concanavalin A-induced hepatitis in mice. Hepatology 1997; 25: 1382–1389
   PubMedGoogle Scholar
• Kusters K., Gantner F., Kunstle G., Tiegs G. Interferon-gamma plays a critical role in T-cell dependent liver injury in mice initiated by Concanavalin A. Gastroenterology 1996; 111: 462–471
   PubMed Web of Science ®Google Scholar
• Mizuhara H., Uno M., Seki N., Yamashita M., Yamaoka M., Ogawa T., Kaneda K., Fuji T., Senoh H., Fujiwara H. Critical involvement of interferon-gamma in the pathogenesis of T-cell activation-associated hepatitis and regulatory mechanisms of interleukin-6 for the manifestation of hepatitis. Hepatology 1996; 23: 1608–1615
   PubMed Web of Science ®Google Scholar
• Tagawa Y., Sekikawa K., lwakur Y. Suppression of concanavalin A-induced hepatitis in IFN-gamma (-/-) mice but not in TNF-alpha (-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes. J. Immunol 1997; 159: 1418–1428
   PubMed Web of Science ®Google Scholar
• Toyabe S., Seki S., laii T., Takeda K., Shirai K., Watanabe H., Hiraidc H., Uchiyama M., Abo T. Requirement of IL-4 and liver NK.1+ T cells for concanavalin A-induced hepatic injury in mice. J. Immunol 1997; 159: 1537–1542
   PubMedGoogle Scholar
• Kusters S., Tiegs G., Alexopoulou L., Pasparakis M., Douni E., Kunstle G., Bluethmann H., Wendel A., Pfizenmaier K., Kollias G., Grell M. In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis. Eur. J. Immunol 1997; 27: 2870–2875
   PubMedGoogle Scholar
• Rosenbaum J. T., Angell E. Paradoxical effects of IL-10 in endotoxin-induced uveitis. J. Immunol 1995; 155: 4090–4094
   PubMed Web of Science ®Google Scholar
• Pennline K. J., Roque-Gaffney E., Monaham R. Recombinant human 1L-10 prevents the onset of diabetes in the nonobese diabetic mouse. Clin. Immunol. Immunopathoi 1994; 71: 169–175
   PubMedGoogle Scholar
• Wogensen L., Lee S. M.-, Sarvertnick N. Production of interleukin-10 by islet cells accelerates immune-mediated destruction of β cells in nonobese diabetic mice. J Exp. Med 1994; 179: 1379–1384
   PubMed Web of Science ®Google Scholar
• Klein B., Brailly H. Cytokine-binding proteins: stimulating antagonists. Immunol. Today 1995; 16: 216–220
   PubMedGoogle Scholar
• Kuhna R., Lohler J., Rennick D., Rajewsky K., Muller W. Inlerleukin-10-deficient mice develop chronic enterocolitis. Cell 1993; 75: 263–274
   PubMedGoogle Scholar
• Moosmann T. R., Schumaker J. H., Florentine D. F., Leverah J., Moore K. W., Bond M. W. Isolation of monoclonal antibodies specific for IL-4. 1L-5, IL-6 and a new Th2 specific cytokine (IL-10) cytokine synthesis inhibitory factor, by using a solid phase radioimmunoad-sorbent assay. J. Immunol 1990; 145: 2938–2945
   PubMedGoogle Scholar
• Ishida H., Hastings R. L. Thompson-Snipes and M. Howard. Modified immunological status of anti-IL-10-treated mice. Cell. Immunol 1993; 148: 371–384
   PubMed Web of Science ®Google Scholar
• Prat M., Gribaudo C., Comoglio P., Cavallo G., Landolfo S. Monoclonal antibodies against murine interferon. Proe. Natl. Acad. Sci. USA 1984; 81: 4515–4519
   PubMed Web of Science ®Google Scholar
• Moore K. W., O'Garra A., de Waal Malcfyt R., Vicira P. T.R. Mosmann. Interleukin-10. Annu. Rev. Immunol 1993; 11: 165–190
   PubMed Web of Science ®Google Scholar
• Ishida H., Muchamuel S., Sakaguchi S., Andradc S., Menon S., Howard M. Continuous administration of anti-interleukin-10 antibodies delays the onset of autoimmunity in NZB/W F) mice. J. Exp. Med 1994; 179: 305–310
   PubMed Web of Science ®Google Scholar
• Mignon-Godefroy K., Rott O., Brazillet M. P., Charreire J. Curative and protective effects of IL-10 in experimental autoimmune thyroiditis (EAT). Evidence for IL-10 enhanced cell death in EAT. J. Immunol 1995; 154: 6634
   PubMedGoogle Scholar
• Joosten L. A.B., Lubberts E., Durez P., Helsen M. A., Jacobs M. J.M., Goldman M., van den Berg W. B. Role of interleukin-4 and interleukin-10 in murine collagen-induced arthritis. Protective effect of inlerleukin-4 and interleukin-10 treatment on cartilage destruction. Arthritis and Rheum 1997; 40: 249–260
   PubMed Web of Science ®Google Scholar
• Gerard C., Bruyns C., Marchant A., Abramowicz D., Vandenabeelc P., Delvaux A., Fiers W., Goldman M., Velu T. Interleukin-10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. J. Exp. Med 1993; 177: 547–550
   PubMed Web of Science ®Google Scholar
• Howard M., Muchamuel T., Andrade S., Menon S. Interleukin-10 protects mice from lethal endotoxemia. J. Exp. Med 1993; 177: 1205–1208
   PubMed Web of Science ®Google Scholar
• Nicoletti F., Mancuso G., Anzani Ciliberti F., Bcninati C., Carbone M., Franco S., Cusumano V. Endotoxin-induced lethality in neonatal mice is counteracted by interleukin-10 (IL-10) and exacerbated by anti-IL-10. Clin. Diagn. Lab. Immunol 1997; 4: 607–610
   PubMedGoogle Scholar
• Arai T., Hiromatsu K., Kobayashi N., Takano M., Ishida H., Nimura Y., Yoshikai Y. IL-10 is involved in the protective effect of dibutyril cyclic adenosine monophosphate on endotoxin-induced inflammatory liver injury. J. Immunol 1995; 155: 5743–5749
   PubMed Web of Science ®Google Scholar
• Xiang M., Zaccone P., Di Marco R., Magro G., Di Mauro M., Beltrami B., Meroni P. L., Nicolelti F. Prevention by rolipram of concanavalin A-induced T-cell dependent hepatitis in mice. Eur. J. Pharmacol 1999; 367: 399–404, (1998)
   PubMedGoogle Scholar
• Gazzinelli R. T., Wysocka M., Hieny S., Scharton-Kersten T., Cheever A., Kuhn R., Muller W., Trinchieri G., Slier A. In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4 + T cells and accompanied by overproduction of IL-12, IFN-γ and TNF-α. J. Immunol 1996; 157: 798–805
   PubMed Web of Science ®Google Scholar
• Louis H., Le O., Moine M., Peny O., Gulbis B., Nisol F., Goldman M., Devierc J. Hcpatoprotective role of interleukin-10 in galactosamine/lipopolysaccharide mouse liver injury. Gastroenterology 1997; 112: 935–942
   PubMedGoogle Scholar
• Le Moine O., Marchant A., De Groote D., Azara C., Goldman M., Deviere J. Role of defective monocyte interleukin-10 release in tumor necrosis factor-alpha overproduction in alcoholic cirrhosis. Hepatology 1995; 22: 1436–1439
   PubMedGoogle Scholar
• Beutler B., Milsark W. l., Cerami A. C. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science (Wash. DC) 1985; 229: 869–872
   PubMed Web of Science ®Google Scholar
• Wysocka M., Rubin M., Vieira L. Q., Ozmen L., Garotta G., Scott P., Trinchieri G. lnterleukin-12 is required for interferon-gamma production and lethality in lipopolysaccharide-induced shock in mice. Eur. J. Immunol 1995; 23: 672–676
   Google Scholar
• Ikeda K., Hirano M., Orita A., Takeuchi M. Chlorpromazine inhibits concanavalin A-induced liver injury independently of cytokine modulation. Immunology Letters 1997; 55: 127–131
   PubMedGoogle Scholar