Immunoregulation of Encephalitogenic MBP-NAc1-11-Reactive T Cells by CD4+ TCR-Specific T Cells Involves IL-4, IL-10 and IFN-γ

References

• Putcrson, P.Y. Experimental allergic encephalomyelitis and autoimmune disease. Adv. Immunol. 1986: 5: 131.
   Google Scholar
• Pcttinelli, C.B. and McFarlin. D.E. Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein: requirement for Lyt-1.2+ T lymphocytes. J. Immunol. 1981; 127: 1420.
   Google Scholar
• Miller, S.D. and Karpus, W.J. The immunopathogenesis and regulation of T-ccll-mcdiated dcmyelinating diseases. Immunol. Today 1994; 15: 356–361.
   PubMedGoogle Scholar
• Sclmaj. K.W. and Raine, C.S. Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro. Ann. Neurol. 1988; 23: 339–346.
   Google Scholar
• Karpus, W.J. and Swanborg, R.H. CD4+ suppressor cells inhibit the function of effector cells of EAE through a mechanism involving transforming growth factor-beta. J. Immunol. 1991; 146: 1163–1168.
   PubMed Web of Science ®Google Scholar
• Cua, D.J., Hinton, D.R. and Stohlman. S.A. Self-antigen-induced Th2 responses in experimental allergic encephalomyelitis (EAE)-rcsistant mice. Th2-mediated suppression of autoimmune disease. J. Immunol. 1995: 155: 4052.
   Google Scholar
• Kuchroo, V.K., Das, M.P., Brown, J.A. Ranger. A.M., Zamvil, S.S., Sobel, R.A. et al. B7-1 and B7-2 costimula-tory molecules activate differentially the Thl/Th2 developmental pathways: application to autoimmune disease therapy. Cell 1995; 80: 707.
   Google Scholar
• Shaw, M.K., Lorens, J.B., Dhawan, A. DalCanto. R. Tsc, H.Y., Tran. A.B. et al. Local delivery of intcrleukin 4 by rctrovirus-transduccd T lymphocytes ameliorates experimental autoimmune encephalomyelitis. J. .y/j. Med. 1997; 185: 1711.
   Google Scholar
• Burns, F.R., Li, X., Shcn. N. Offner. H. Chou. Y. Vandcnbark, A.A. et al. Both rat and mouse T cell receptors specific for the cnccphalitogenic determinant of myelin basic protein use similar V and V/9 chain genes even though the major histocompatibility complex and cnccphalitogenic determinants being recognized are different. J. Exp. Med. 1989; 169: 27 39.
   Google Scholar
• Vandcnbark, A.A., Hashim, G. and Offner. H. Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis. Nature 1989; 341: 541 544.
   Google Scholar
• Offner. H.. Hashim. G.A. and Vandcnbark. A.A. T cell receptor peptide therapy triggers autoregulation of experimental encephalomyelitis. Science 1991; 251: 430 432.
   Google Scholar
• Howell. M.D., Winters. ST.. Olee. T., Powell. H.C.. Carlo. D.J. and Brostoff. S.W. Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides. Science (Wash. DC) 1989; 246: 668–670.
   PubMed Web of Science ®Google Scholar
• Offncr. H.. Adlard. K.. Bebo Jr. B.F., Schuster. J., Burrows. G.G., Bucnafc. A.C. el al. Vaccination with BV8S2 protein amplifies TCR specific regulation and protection against experimental autoimmune encephalomyelitis in TCR BV8S2 transgenic mice. J. Immunol. 1998: 161: 2178–2186.
   Google Scholar
• Vandenbark. A.A.. Hashim. G.A. and Offner. H. T cell receptor peptides in treatment of autoimmune disease: rationale and potential.J. New-osci. Res. 1996:43: 391–402.
   PubMed Web of Science ®Google Scholar
• Weinberg. A.D.. Celnik, B., Vainicne. M.. Bucnafc. A.C. Vandenbark. A.A. and Offner. H. The effect of TCR V/38 peptide therapy on T cell populations isolated from the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis. J. Newoiinmunol. 1994:49: 161.
   Google Scholar
• Kumar, V. and Sercarz. E.E. The involvement of T cell receptor peptidc-specific regulatory CD4+ T cells in recovery from antigen-induced autoimmune disease. J. Exp. Med. 1993: 178: 909–916.
   Google Scholar
• Kumar. V.. Tabibiazar, R., Gcysen, H.M. and Sercarz. E. Immunodominant framework region 3 peptide from TCR V/38.2 chain controls murine experimental autoimmune encephalomyelitis. J. Immunol. 1995; 154: 1941–1950.
   Google Scholar
• Kumar. V. and Sercarz. E. Induction or protection from experimental autoimmune encephalomyelitis depends on the cytokine secretion profile of TCR peptide specific regulatory CD4 T cells. J. Immunol. 1998: 161: 6585–6591.
   PubMed Web of Science ®Google Scholar
• Kennedy. M.K. Torrance, D.S., Picha. K.S. and Mohler. K.M. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-I0 mRNA expression correlates with recovery. J. Immunol. 1992: 149: 2496–2505.
   Google Scholar
• Kumar. V.. Stellrecht, K. and Sercarz, E. Inactivation of T cell receptor peptide-specific CD4 regulatory T cells induces chronic experimental autoimmune encephalomyelitis (EAE). J. Exp. Med. 1996; 184: 1609–1617.
   PubMed Web of Science ®Google Scholar
• Siklodi. B.. Jacobs. R.. Burrows, G.G.. Vandenbark. A.A. and Offner. H. Neonatal exposure of TCR BV8S2 transgenic mice to recombinant TCR BV8S2 results in reduced T cell proliferation and elevated antibody response to BV8S2 and increased severity of EAE., /. New-osci. Res. 1998; 52: 750.
   Google Scholar
• Goverman, J., Woods, A., Larson. L., Werner, L.P. and Zallcr. D.M. Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell 1993; 72: 551–560.
   Google Scholar
• Vainicne, M., Burrows, G.G.. Ariail, K., Robey. 1. Vandenbark. A.A. and Offner. H. Neonatal injection of Lewis rats with recombinant V/38.2 induces T cell but not B cell tolerance and increased severity of experimental autoimmune encephalomyelitis. J. Neurosci. Res. 1996: 45: 475–486.
   Google Scholar
• Hashim. G.A.. Day, E.D.. Frcdanc. L., Intintola. P. and Carvalho, E. Biological activity of region 65 to 102 of the myelin basic protein. J. Neurosci. Res. 1986: 16: 467.
   Google Scholar
• Voorthuis. J.A.C.. Uitdehaag. B.M.J.. DcGroot. C.J.A.. Goedc. P.H., VanDcrMeide. P.H. and Dijkstra. CD. Suppression of experimental allergic encephalomyelitis by intraventricular administration of interfcron-gamma in Lewis rats. Clin. Exp. Immunol. 1990; 81: 183. "
   Google Scholar
• Billiau. A., Heremans. H., Vandekerckhove, F.. Dijkmans. R.. Sobis. H.. Meulepas, E. el al. Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma. J. Immunol. 1988: 140: 1506.
   Google Scholar
• Duong, T.T. Finkelman. F.D. Singh. G. and Strcjan. G.H. Effect of anti-interfcron-gamma monoclonal antibody treatment on the development of experimental allergic encephalomyelitis in resistant mouse strains. J. Neuroimmunol. 1994; 53: 101.
   Google Scholar
• O'Garra, A. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 1998: 8: 275.
   PubMed Web of Science ®Google Scholar
• Chou. Y.K.. Weinberg. A.D.. Bucnafc. A.. Bourdette, D.N.. Whitham. R.. Kaleeba, J.A.R. el al. MHC-rcstriction. cytokine profile, and immunorcgulatory effects of human T cells specific for TCR VB CDR2 peptides: comparison with myelin basic protein-specific T cells. J. Neurosci. Res. 1996:45: 838 851.
   Google Scholar
• Vandenbark. A.A.. Chou. Y.K., Whitham. R., Mass. M., Buenafe. A.. Liefcld, D. el al. Treatment of multiple sclerosis with T cell receptor peptides: results of a double-blind pilot trial. Nature Med. 1996; 2: 1109–1115.
   Google Scholar
• Vandenbark. A.A.. Chou. Y.K.. Bourdette. D.N.. Whitham. R. and Offner. H. Therapeutic application of T cell receptor peptides. Drug News Persp. 1997: 10: 341 346.
   Google Scholar
• Kumar. V.. Sercarz. E. and Adorini. L. Regulatory mechanisms in organ-specific autoimmunity. The Immu-no/ogisl 1998; 6: 161–166.
   Google Scholar
• Zhang. J., Mcdacr. R.. Stinisscn, P.. Haflcr. D.A. and Raus. J.CM. MHC-restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination. Science 1993:261: 1451–1454.
   PubMed Web of Science ®Google Scholar
• Lehmann, P.V. Forsthubcr. T. and Sercarz, E.E. Spreading of T-cell autoimmunity to cryptic determinants of an autoanligcn. Nature 1992; 358: 155 157.
   Google Scholar