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Original Article

Function of Rat Pancreatic Islets Exposed to Interleukin-18 In Vitro

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Pages 263-267 | Received 28 Feb 1998, Accepted 31 Aug 1998, Published online: 07 Jul 2009

References

  • Gepts W. Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 1965; 14: 619–633
  • Eisenbarth G. S. Type I diabetes mellitus. A chronic autoimmune disease. N. Engl. J. Med. 1986; 314: 1360–1368
  • Sandier S., Eizirik D. L, Svensson C., Strandell E., Welsh M., Welsh N. Biochemicalmolecular actions of interleukin-l on pancreatic β-cells. Autoimmunity 1991; 10: 241–253
  • Rabinovitch A. Immunoregulatorycytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunostimulation?. Diabetes 1994; 43: 613–621
  • Mandrup-Poulsen T. The role of interleukin-1 in the pathogenesis of IDDM. Diabetologia 1996; 39: 1005–1029
  • Dao T., Ohashi K., Kayano T., Kurimoto M., Okamura H. Interferon-gamma-inducing factor, a novel cytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper I cells. Cell Immunol. 1996; 173: 230–235
  • Ushio S., Namba M., Okura T., Hattori K., Nukada Y., Akita K., et al. Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, studies of the biologic properties of the protein. J. Immunol. 1996; 156: 4274–4279
  • Zhang T., Kawakami K., Qureshi M. H, Okamura H., Kurimoto M., Saito A. Interleukin-12 (IL-12)IL-18 synergistically induce the fungicidal activity of murine peritoneal exudate cells against Cryptococcus neoformans through production of gamma interferon by natural killer cells. Infect. Immun. 1997; 65: 3594–3599
  • Yoshimoto T., Okamura H., Tagawa Y. I, Iwakura Y., Nakanishi K. Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-gamma production from activated B cells. Proc. Natl. Acad. Sci. USA 1997; 94: 3948–3953
  • Rothe H., O'Hard R. M, Martin S., Kolb H. Suppression of cyclophosphamide induced diabetes developmentpancreatic Thl reactivity in NOD mice treated with the interleukin (IL)-12 antagonist IL-12(p40)(2). Diabetologia 1997; 40: 641–646
  • Matsumoto S., Tsuji-Takayama K., Aizawa Y., Koide K., Takeuchi M., Ohta T., et al. Interleukin-18 activates NF-kappa B in murine T helper type 1 cells. Biochem. Biophys. Res. Commun. 1997; 234: 454–457
  • Eizirik D. L, Flodström M., Karisen A. E., Welsh N. The harmony of the spheres: inducible nitric oxide synthaserelated genes in pancreatic beta cells. Diabetologia 1996; 39: 875–890
  • Sandler S., Bendtzen K., Eizirik D. L., Welsh M. Interleukin-6 affects insulin secretionglucose metabolism of rat pancreatic islets in vitro. Endocrinology 1990; 126: 1288–1294
  • Sandler S., Welsh N. Interleukin-10 stimulates rat pancreatic islets in vitro, but fails to protect against interleukin-1. Biochem. Biophys. Res. Commun. 1993; 195: 859–865
  • Sternesjö J., Bendtzen K., Sandler S. Effects of prolonged exposure in vitro to interferon-gammatumour necrosis factor-alpha on nitric oxideinsulin production of rat pancreatic islets. Autoimmunity 1995; 20: 185–190
  • Sandler S., Sternesjö J. Interleukin-4 impairs rat pancreatic islet function in vitro by an action different to that of interleukin-1. Cytokine 1995; 7: 296–300
  • Sandler S., Anderson A., Hellerström C. Inhibitory effects of interleukin-I on insulin secretion, insulin biosynthesis, oxidative metabolism of isolated rat pancreatic islets. Endocrinology 1987; 121: 1424–1431
  • Heding L. G. Determination of total serum insulin (IRI) in insulin-treated diabetic patients. Diabetologia 1972; 8: 260–266
  • Hinegardner R. T. An improved fluorometric assay for DNA. Anal Biochem 1971; 39: 197–201
  • Anderson A., Sandler S. Viability tests of cryopreserved endocrine pancreatic cells. Cryobiology 1983; 20: 161–168
  • Halban P. A, Wollheim C. B, Blondel B., Renold A. E. Long-term exposure of isolated pancreatic islets to mannoheptulose: evidence for insulin degradation in the β-cell. Biochem. Pharmacol. 1980; 29: 2625–2633
  • Tsuji-Takayama K., Matsumoto S., Koide K., Takeuchi M., Ikeda M., Ohta T., et al. Interleukin-18 induces activationassociation of p56(lck)MAPK in a murine TH1 clone. Biochem. Biophys. Res. Commun. 1997; 237: 126–130
  • Puren A. J, Fantuzzi G., Gu Y., Su M. S.-S., Dinarello C. A. Interleukin-18 (IFNγ-inducing factor) induces IL-8IL-1β via TNFα production from non-CD-14+ human blood mononuclear cells. J. Clin. Invest. 1998; 101: 711–721

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