Polyamine-fas Interactions: Inhibition of Polyamine Biosynthesis in MRL-lpr/lpr Mice is Associated with the Up-regulation of fas mRNA in Thymocytes

References

• Andrews B. S, Eisenberg R. A, Theofilopoulos A. N, Izui C. B, Wilson C. B, McConahey P. J, Murphy E. D, Roths J. B., Dixon F. J. Spontaneous murine lupus-like syndrome: Clinicalimmunopathological manifestations in several strains. J. Exp. Med. 1978; 148: 1198–1207
   PubMed Web of Science ®Google Scholar
• Watanabe-Fukunaga Brannan CI., Copeland N. A., Nagata S. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature (Lond.) 1992; 356: 314–317
   PubMed Web of Science ®Google Scholar
• Adachi M. Watanabe-Fukunaga, Nagata S. Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of Ipr mice. Proc. Natl. Acad Sci. USA 1993; 90: 1756–1760
   PubMed Web of Science ®Google Scholar
• Wu J., Zhou T., He J., Mountz J. D. Autoimmune disease in mice due to integration of an endogenous retrovirus in an apoptotic gene. J. Exp. Med. 1993; 178: 461–468
   PubMed Web of Science ®Google Scholar
• Kobayashi S., Hirano T., Kakinuma M., Uede T. Transcriptional repressiondifferential splicing of Fas mRNA by early transposon (Etn) insertion in autoimmune Ipr mice. Biochem. Biophy. Res. Comm. 1993; 191: 617–624
   PubMed Web of Science ®Google Scholar
• Ju S.-T., Panka D. J, Cui H., El-Kharih, Sherr D. H, Stranger B. Z., Marshak-Rothstein. Fas (CD95)/FasL interactions required for programmed cell death in T cell activation. Nature 1995; 373: 441–448
   PubMed Web of Science ®Google Scholar
• Brünner T., Mogil R. J, LaFace D., Yoo N. J, Mahboubi A., Echeverri F. S, Martin J., Force W. R, Lynch D. H., Ware C. F. Cell-autonomous Fas (CD95)/Fas ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature 1995; 373: 441–443
   PubMed Web of Science ®Google Scholar
• Rathmell J. C, Cooke M. P, Ho W. Y, Grein J., Town-Send S. E., Davis M. M., , Goodnow C. C, et al. CD95(Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ cells. Nature 1995; 376: 181–183
   PubMed Web of Science ®Google Scholar
• Esser M. T, Haverstick D. M, Fuller C. L, Gullo C. A., , Braciale V. L, et al. Ca2+ signaling modulates cytolytic T lymphocyte effector functions. J. Exp. Med. 1998; 187: 1057–1067
   PubMed Web of Science ®Google Scholar
• Crispe I. N. Fatal interactions: Fas-induced apoptosis of mature T cells. Immunity 1994; 1: 347–349
   PubMed Web of Science ®Google Scholar
• Wu J., Zhou T., Zhang J., He J., Gause W. C., , Mountz J. D, et al. Correction of accelerated autoimmune disease by early replacement of the mutated Ipr gene with the normal Fas apoptosis gene in the T cells of transgenic MRL-lpr/lpr mice. Proc. Natl. Acad. Sci. USA 1994; 91: 2344–2348
   PubMed Web of Science ®Google Scholar
• Watson M. L, Rao J. K, Gilkeson G. E, Ruiz P., Eicher D. S, Pisetsky D. S, Matsuzawa A., Rochelle J. M., , Seldin M. F, et al. Genetic analysis of MRL-lpr/lpr mice: relationship of the Fas apoptosis gene to disease manifestationsrenal disease-modifying loci. J. Exp. Med. 1992; 176: 1645–1656
   PubMed Web of Science ®Google Scholar
• Izui S., Kelley V. E, Masuda K., Yoshida H., Roth I. B., , Murphy E. D, et al. Induction of various autoantibodies by mutant gene Ipr in several strains of mice. J. Immunol. 1984; 133: 227–233
   PubMed Web of Science ®Google Scholar
• Kelley V. E., , Roths J. B, et al. Interaction of mutant lpr gene with background strain influences renal disease. Clin. Immunol. Immunopathol. 1985; 37: 220–229
   PubMedGoogle Scholar
• Berger F. G. Assignment of a gene encoding ornithine decarboxylase to the proximal region of chromosome 12 in the mouse. Biochem. Generics 1989; 27: 745–753
   PubMed Web of Science ®Google Scholar
• Gunnia U. B, Amenta P. S, Seibold J. R., , Thomas T. J, et al. Successful treatment of lupus nephritis in MRL-lpr/lpr mice by inhibiting ornithine decarboxylase. Kidney Internat. 1991; 39: 882–890
   PubMed Web of Science ®Google Scholar
• Hsu H.-C., Seibold J. R., Thomas T. J. Regulation of ornithine decarhoxylase in the kidney of autoimmune mice with the lpr gene. Autoimmunity 1994; 19: 253–264
   PubMed Web of Science ®Google Scholar
• Heby O., Persson L. Molecular genetics of polyamine synthesis in eukaryotic cells. Trends in Biochem. Sci. 1990; 15: 153–158
   PubMed Web of Science ®Google Scholar
• McCann P. P., , Pegg A. E, et al. Ornithine decarboxylase as an enzyme target for therapy. Pharmacol. Ther. 1992; 54: 195–215
   PubMed Web of Science ®Google Scholar
• Davis R. H, Morris D. R., Coffino P. Sequestered end productsenzyme regulation: The case of ornithine decarhoxylase. Microbiol. Rev. 1992; 56: 280–290
   PubMedGoogle Scholar
• Tabor C. W., Tabor H. Polyamines. Ann. Rev. Biochem. 1984; 53: 749–790
   PubMed Web of Science ®Google Scholar
• Pegg A. E. Recent advances in the biochemistry of polyamines in eukaryotes. Biochem. J. 1986; 234: 249–262
   PubMed Web of Science ®Google Scholar
• Thomas T. J., , Messner R. P, et al. Structural Specificity of polyamines in left-handed 2-DNA formation. J. Mol. Biol. 1988; 201: 463–467
   PubMed Web of Science ®Google Scholar
• Thomas T., Thomas T. J. Structural specificity of polyamines in modulating the binding of estrogen receptor to potential Z-DNA forming sequences. J. Receptor Res. 1993; 13: 1115–1133
   PubMed Web of Science ®Google Scholar
• Panagiotidis C. A, Artandi S., Calame K., Silver-Stein S. J. Polyamines alter sequence-specific DNA-protein interactions. Nucleic Acids Res. 1995; 23: 1800–1809
   PubMed Web of Science ®Google Scholar
• Tabib A., Bachrach U. Activation of the proto-oncogene c-mycc-fos by c-ras: Involvement of polyamines. Biochem. Biophy. Res. Comm. 1994; 202: 720–727
   PubMed Web of Science ®Google Scholar
• Thomas T., Thomas T. J. Regulation of cyclin BI by estradiolpolyamines in MCF-7 breast cancer cells. Cancer. Res. 1994; 54: 1077–1084
   PubMed Web of Science ®Google Scholar
• Kanamoto M., Utsunomiya K., Kameji T., Hayashi S. Effects of putrescine on synthesisdegradation of ornithine decarboxylase in primary cultured hepatocytes. Eur. J. Biochem. 1986; 154: 539–544
   PubMedGoogle Scholar
• Packham G., Cleveland J. L. Ornithine decarboxylase is a mediator of c-Myc-induced apoptosis. Mol. Cell. Biol. 1994; 14: 5741–5747
   PubMed Web of Science ®Google Scholar
• Thomas T. J, Gunnia U. B., , Thomas T, et al. Reversal of the abnormal development of T cell subpopulations in the thymus of autoimmune MRL-lpr/lpr mice by a polyamine biosynthesis inhibitor. Autoimmunity 1992; 13: 275–283
   PubMed Web of Science ®Google Scholar
• Rouvier E., Luciani M.-F., , Golstein P, et al. Fas involvement in Ca2+-independent T cell mediated cytotoxicity. J. Exp. Med. 1993; 177: 195–200
   PubMed Web of Science ®Google Scholar
• Sabath D. E, Broome H. E., , Prystowsky M. B, et al. Glyceraldehyde-3-phosphate dehydrogenase mRNA is a major interleukin 2-induced transcript in a cloned T-helper lymphocyte. Gene 1990; 91: 181–191
   Web of Science ®Google Scholar
• Chomczynski P. A reagent for the single-step simultaneous isolation of RNA, DNAproteins from celltissue samples. BioTechniques 1993; 15: 532–537
   PubMed Web of Science ®Google Scholar
• Thomas T., Gunnia U. B, Yurkow E. J, Seibold J. R., , Thomas T. J, et al. Inhibition of calcium signaling in murine splenocytes by polyamines: Differential effects on CD4CD8 T cells. Biochem. J. 1993; 291: 375–381
   PubMed Web of Science ®Google Scholar
• Ogasawara J., Watanabe-Fukunaga, Adachi M., Matsuzawa A., Kasugal T., Kitamura Y., Itoh N., Suda T., Nagata S. Lethal effect of the anti-Fas antibody in mice. Nature (Lond.) 1993; 364: 806–809
   PubMed Web of Science ®Google Scholar
• Chu J.-L., Drappa J., Parnassa A., Elkon K. B. The defect in Fas mRNA expression in MRL-lpr/lpr mice is associated with insertion of the retrotransposon, Etn. J. Exp. Med. 1993; 178: 723–730
   PubMed Web of Science ®Google Scholar
• Miyawaki T., Ueharam T., Nibu R., Tsuji T., Yachie S., Yonehara S., Taniguchi N. Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulation in human peripheral blood. J. Immunol. 1992; 149: 3753–3758
   PubMed Web of Science ®Google Scholar
• Pegg A. E. Polyamine metabolismits importance in neoplastic growthas a target for chemotherapy. Cancer Res. 1988; 48: 759–774
   PubMed Web of Science ®Google Scholar
• Thomas T. J, Gunnia U. B, Seibold J. R., Thomas T. Defective signal transduction pathways of T cells from autoimmune MRL-lpr/lpr mice are linked to increased polyamines. Biochemical J. 1995; 311: 175–182
   PubMed Web of Science ®Google Scholar
• Steinberg A. D. MRL-lpr/lpr disease: theories meet Fas. Semin. Immunol. 1994; 6: 55–69
   PubMedGoogle Scholar
• Scott D. E, Kisch W. J., , Steinberg A. D, et al. Studies of T cell deletionT cell anergy following in vivo administration of SEB to normallupus-prone mice. J. Immunol. 1993; 150: 664–672
   PubMed Web of Science ®Google Scholar
• Brulet P., Kachad M., Xu Y.-S., Croissant O. M., , Jacob F, et al. Early differential tissue expression of transposon-like repetitive DNA sequences of the mouse. Proc. Natl. Acad. Sci. USA 1983; 80: 5641–5645
   PubMed Web of Science ®Google Scholar
• Brûlet P., Condamine H., Jacob F. Spatial distribution of transcripts of the long repeated ETn sequence during early mouse embryogenesis. Proc. Natl. Acad Sci. USA 1985; 82: 2054–2058
   PubMed Web of Science ®Google Scholar
• Hirose T., Austin S. J., , Jetten A. M, et al. Identification of a tranposon-related RNA down-regulated by retinoic acid in embryonal carcinomaembryonic stem cells. Exp. Cell Res. 1995; 221: 294–300
   PubMed Web of Science ®Google Scholar
• Torent C., Bordet T., Darlix J. L. Analytical study of rat retrotransposon VL30RNA dimerization in vitropacking murine leukemia virus. J. Mol. Biol. 1994; 240: 434–444
   PubMed Web of Science ®Google Scholar
• Kulkarni G. D., Thomas T. J. Role of polyamine interaction with early transposon elements (Etn) in the expression of chimeric Fas/Etn gene in MRL-lpr/lpr mice. Arthritis Rheum 1995; 38: S298, Abstract
   PubMed Web of Science ®Google Scholar
• Celano P., Baylin S. B., , Casero R. A, et al. Polyamines differentially modulate the transcription of growth-associated genes in human colon carcinoma cells. J. Biol. Chem. 1989; 264: 8922–8927
   PubMed Web of Science ®Google Scholar
• Person L., Holm I., Heby O. Regulation of ornithine decarboxylase mRNA translation by polyamines. J. Biol. Chem. 1988; 263: 3528–3533
   PubMed Web of Science ®Google Scholar
• Pegg A. E., , McCann P. P, et al. Ornithine decarboxylase as an enzyme target for therapy. Pharmac. Ther. 1992; 56: 359–377
   PubMed Web of Science ®Google Scholar
• Casero R. A, Mank A. R, Xiao L., Smith J., Bergeron R. J., , Celano P, et al. Steddy-State messenger RNAactivity correlates with sensitivity to N1N1,2-bis(ethyl)sper-mine in human cell lines representing the major forms of lung cancer. Cancer Res. 1992; 52: 5359–5363
   PubMed Web of Science ®Google Scholar
• Flescher E., Bowlin T. L, Ballester A., Houk R., Talal N. J. Increased polyamines may downregulate interleukin 2 production in rheumatoid arthritis. J. Clin. Invest. 1989; 48: 1356–1362
   Google Scholar
• Flescher E., Ledbetter J. A, Schieven G. L, Vela-Roch, Fossum D., Dang H., Ogawa N., Talal N. Longitudinal exposure of human T lymphocytes to weak oxidative stress suppresses transmembranenuclear signal transduction. J. Immunol. 1994; 153: 4880–4889
   PubMed Web of Science ®Google Scholar
• Drappa J., Brot N., Elkon K. B. The Fas protein is expressed at high levels on CD4+ CD8+ thymocytesactivated matured lymphocytes of normal mice, but not in lupus-prone strain, MRL-lpr/lpr. Proc. Natl. Acad. Sci. USA 1994; 90: 10340–10344
   Web of Science ®Google Scholar