Inhibition of Mitochondrial Oxidative Phosphorylation Induces Hyper-Expression of Glutamic Acid Decarboxylase in Pancreatic Islet Cells

References

• Maechler P., Kennedy E. D., Pozzan T., Wollheim C. B. Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic β-cells. EMBO J. 1997; 16: 3833–3841
   Google Scholar
• Gerbitz K. D., Van den Ouweland J. M.W., Maassen J. A., Jaksh M. Mitochondrial diabetes mellitus. A review. Biochim. Biophys. Acta 1995; 1271: 253–260
   PubMed Web of Science ®Google Scholar
• Dukes I. D., McIntyre M. S., Mertz R. J., Philipson L. H., Roe M. W., Spencer B., Worley J. F. Dependence on NADH produced during glycolysis for β-cell glucose signaling. J. Bid. Chem. 1994; 269: 10979–10982
   PubMed Web of Science ®Google Scholar
• Gerbitz K. D., Gempel K., Brdiczka D. Mitochondria and diabetes - Genetic, biochemical, and clinical implications of the cellular energy circuit. Diabetes 1996; 45: 113–126
   PubMed Web of Science ®Google Scholar
• Kobayashi T., Oha Y., Falorni A., Kasuga A., Takei I., Nakanishi K., Murase T., Kosaka K., Lernmark A. Association between HLA and islet cell antibodies in diabetic patients with a mitochondrial DNA mutation at base pair 3243. Diabetologia 1996; 39: 1196–1200
   PubMed Web of Science ®Google Scholar
• Matschinsky F. M. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm. Diabetes 1996; 45: 223–241
   PubMed Web of Science ®Google Scholar
• Degli Esposti M., Ngo A., Myers M. A. Inhibition of mitochondrial complex I may account for the insulin-dependent diabetes induced by intoxication with the rodenticide Vacor. Diabetes 1996; 45: 1531–1534
   PubMed Web of Science ®Google Scholar
• Atkinson M. A., Maclaren N. K. Islet cell autoantigens in insulin-dependent diabetes. J. Clin. Invest. 1996; 92: 1608–1616
   Google Scholar
• Degli M., EspostiMackay I. R. The GABA network and the pathogenesis of IDDM. Diabetologia 1997; 40: 352–356
   PubMed Web of Science ®Google Scholar
• Erecinska M., Bryla J., Michalik M., Meglasson M. D., Nelson D. Energy metabolism in islets of Langerhans. Biochim. Biophys. Ada 1992; 1101: 273–295
   PubMed Web of Science ®Google Scholar
• Kampe O., Andersson A., Bjork E., Hallberg A., Karlsson F. A. High glucose stimulation of 64,000-Mw islet cell autoantigen expression. Diabetes 1989; 38: 1326–1328
   PubMed Web of Science ®Google Scholar
• Bjork E., Kampe O., Andersson A., Karlsson F. A. Expression of the 64 kDa/glutamic acid decarboxylase rat islet cell autoantigen is influenced by the rate of insulin secretion. Diabetologia 1992; 32: 490–493
   Web of Science ®Google Scholar
• Velloso L. A., Bjork E., Ballagi A. E., Funa K., Andersson A., Kampe O., Karlsson F. A., Eizirik D. L. Regulation of GAD expression in islet of Langerhans occurs both at the mRNA and protein level. Mol. Cell. Endocrinol. 1994; 102: 31–37
   PubMed Web of Science ®Google Scholar
• Aaen K., Rygaard J., Josefsen K., Petersen H., Brogren C., Horn T., Buschard K. Dependence of antigen expression on functional state of β-cells. Diabetes 1990; 39: 697–701
   PubMed Web of Science ®Google Scholar
• O'Relly L. A., Cooke A. Animal models of insulin dependent diabetes mellitus. The Molecular Biology of Autoimmune Diseases, C. A. Bona, K. A. Siminovitch, M. Zanetti, A. N. Theofilopoulos. Harwood Academic Chur., Switzerland 1993; 619–625
   Google Scholar
• Lernmark A. Glutamic acid decarboxylase - gene to antigen to disease. J. Int. Med. 1996; 240: 259–277
   PubMed Web of Science ®Google Scholar
• Mandel T. E., Hoffman L., Carter W. M. Long-term isografts of cultured foetal mouse pancreatic islets: the oncogenic effects of streptozotocin and the prevention of diabetic renal complications. Am. J. Pathol. 1981; 104: 227–236
   PubMed Web of Science ®Google Scholar
• Georgiou H. M., Mandel T. E. Islet cell subpopulations in cultured mouse foetal pancreas and pancreatic isografis. Transplant Proc. 1984; 16: 1055–1056
   PubMed Web of Science ®Google Scholar
• Degli Esposti M., Ghelli A., Ratta M., Cortes D., Estornell E. Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors of mitochondrial NADH dehydrogenase (Complex I). Biochem. J. 1994; 301: 161–167
   PubMed Web of Science ®Google Scholar
• Brandt U., Trumpower B. L. The protonmotive Q cycle in mitochondria and bacteria. CRC Critic. Rev. Biochem. 1992; 29: 165–197
   Google Scholar
• Mowery P. C., Ackrell B. A., Singer T. P. Carboxins: powerful selective inhibitors of succinate oxidation in animal tissues. Biochem. Biophys. Res. Commun. 1976; 71: 354–361
   PubMed Web of Science ®Google Scholar
• Segovia J., Tillakaratne J. K., Tobin A. J., Gale K. Parallel increases in striatal glutamic acid decarboxylase activity and mRNA levels in rats with lesions of the nigrostriatal pathway. Bruin Res. 1990; 529: 345–358
   PubMed Web of Science ®Google Scholar
• Burkhardt C., Kelly J. P., Lim Y., Filley C. M., Parker W. D.J. Neuroleptic medications inhibit complex 1 of the electron transport chain. Ann. Neurol. 1993; 33: 512–517
   PubMed Web of Science ®Google Scholar
• Karam J. H., Lewitt P. A., Young C. W., Nowlain R. E., Frankel B. J., Fujiya H., Freedman Z. R., Grodsky G. M. Insulinopenic diabetes after rotenticide (Vacor) ingestion: a unique model of acquired diabetes in man. Diabetes 1980; 29: 971–978
   PubMed Web of Science ®Google Scholar
• Myers M. A., Rabin D. U., Rowley M. J. Pancreatic islet cell cytoplasmic antibody in diabetes is represented by antibodies to islet cell antigen 512 and glutamic acid decarboxylase. Diabetes 1995; 44: 1290–1295
   PubMed Web of Science ®Google Scholar
• Myers M. A. Direct measurement of cell numbers in microtitre plate cultures using the fluorescent dye SYBR green I. J. Immunol. Methods 1998; 212: 99–103
   PubMed Web of Science ®Google Scholar
• Ziegler B., Schlosser M., Luhder F., Strebelow M., Augstein P., Northemann W., Powers A. C., Ziegler M. Murine monoclonal glutamic acid decarboxylase (GAD) 65 antibodies recognise autoimmune-associated GAD epitope regions targeted in patients with type 1 diabetes mellitus and Stiff-man syndrome. Acta Diabetol. 1996; 33: 225–231
   PubMed Web of Science ®Google Scholar
• Dukes I. D., Philipson L. H. K1 channels: generating excitement in pancreatic β-cells. Diabetes 1996; 45: 845–853
   PubMed Web of Science ®Google Scholar
• Tanigawa K., Kashiwada I., Tamura K., Kawaguchi M., Seino Y., Kato Y. Differential insulin secretory activity in rat pancreatic islet and HIT cells. Diabetes Res. 1994; 26: 1–11
   PubMedGoogle Scholar
• Schmidli R. S., Faulker-Jones E., Harrison L. C., James R. F.L., DeAizpurua H. J. Cytokine regulation of glutamate decarboxylase biosynthesis in isolated rat islets of Langerhans. Biochem. J. 1996; 317: 713–719
   PubMed Web of Science ®Google Scholar
• Bjork E., Kampe O., Grawe J., Hallberg A., Norheim I., Karlsson F. A. Modulation of beta-cell activity and its influence on islet cell antibody (ICA) and islet cell surface antibody (ICSA) reactivity. Autoimmunity 1993; 16: 4181–4188
   Web of Science ®Google Scholar
• Romijn H. J.A., Janszen W. J.W., Van der Bogert C. Permanent increase of immunocytochemical reactivity for γ-aminobutyric acid (GABA), glutamic acid decarboxylase, mitochondrial enzymes, and glial fibrillary acidic protein in rat cerebral cortex damaged by early postnatal hypoxia-ischemia. Acta Neuropathol. 1994; 87: 612–627
   PubMed Web of Science ®Google Scholar
• Shah S. C., Malone J. I., Simpson N. E. A randomized trial of intensive insulin therapy in newly diagnosed insulin-dependent diabetes mellitus. N. Engl. J. Med. 1989; 320: 550–554
   PubMed Web of Science ®Google Scholar
• Homo-Delarche F., Boitard C. Autoimmune diabetes: the role of the islets of Laugerhans. Immunol. Today 1996; 17: 456–460
   PubMedGoogle Scholar