Fas is Expressed in Murine Pancreatic Islet Cells and an Insulinoma Cell Line but Does Not Mediate Their Apoptosis in vitro

References

• Christianson S. W., Shultz L. D., Leiter E. H. Adoptive transfer of diabetes into immunodeficient NOD-scid scid mice. Diabetes 1993; 42: 44–55
   PubMed Web of Science ®Google Scholar
• Haskins K., MeDuffie M. Acceleration of diabetes in young NOD mice with a CD4+ islet-specific T cell clone. Science 1990; 249: 1433–6
   PubMed Web of Science ®Google Scholar
• Bradley B. J., Haskins K., La Rosa E. G., Laff'erty K. L. CDS T cells are not required for islet destruction induced bv a CD4+ islet-specific T-cell clone. Diabetes 1992; 41: 1603–8
   PubMed Web of Science ®Google Scholar
• Wang B., Gonzalez A., Benoist C., Mathis D. The role of CD8+ cells in the initiation of insulin-dependent diabetes mellitus. Eur. J Immunol. 1996; 26: 1762–9
   PubMed Web of Science ®Google Scholar
• Signore A., Cooke A., Pozzilli P., Butcher G., Simpson E., Beverley P. C. Class II and 1L-2 receptor positive cells in the pancreas of NOD mice. Diabetologia 1987; 30: 902–5
   PubMed Web of Science ®Google Scholar
• Hanafusa T., Fuhino-Kunihara E L, Miyazaki A., Yamada K., Nakajima H., Miyagawa J., Kono K., Tarui S. Expression of class II MHC antigens on pancreatic β lls in the NOD mouse. Diabelologia 1987; 30: 104–8
   PubMed Web of Science ®Google Scholar
• Wang Y., Pontcsilli O., Gill R. D., La Rosa E. G., Lafferty K. I. The role ofCD4f and CD8 f T cells in the destruction of islet grafts by spontaneously diabetic mice. Proc. Null. Acad. Sci. USA 1991; 88: 527–31
   PubMed Web of Science ®Google Scholar
• Kagi D., Vignaux I., Ledermann B., Burki K., Depraetere V., Nagata S., Hcngartner H., Golstein P. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science 1994; 265: 528–30
   PubMed Web of Science ®Google Scholar
• Mogil R. L, Radvanyi L., Gonzalez-Ouinlial R., Miller R., Mills G., Theofiiopoulos A. N., Green D. R. Eas. (CD95) participates in peripheral T cell deletion and associated apoptosis in vivo. Inl. Immunol. 1995; 7: 1451–8
   PubMed Web of Science ®Google Scholar
• Parijs L. V., Ibraghimov A., Abbas A. K. The role of costimulalion and Fas in T cell apoptosis and peripheral tolerance. Immunity 1996; 4: 321–8
   PubMed Web of Science ®Google Scholar
• Ju S.-T., Cui E E, Panka D. J., Ettinger R., A. M.-R. Participation of target Eas protein in apoptosis pathway induced by CD44 Th I and CD8+ cytotoxic T cells. Proc. Natl. Acad. Sci. USA 1994; 9E: 4185–9
   Google Scholar
• Stalder T., Hahn S., Erb P. Eas antigen is the major target molecule for CD4+ T cell-mediated cytotoxicity. J Immunol 1994; 152: 1127–33
   PubMed Web of Science ®Google Scholar
• Wang R., Rogers A. M., Ratliff T. L., Russell J. H. CD95-dependent bystander lysis caused by CD44- T helper 1 effectors. J. Immunol. 1996; 157: 2961–8
   PubMed Web of Science ®Google Scholar
• Zamvil S. S., Nelson P. A., Mitchell D. J., Knobler R. L., Fritz R. B., Steinman L. Encephalitogenic T cell clones specific for myelin basic protein. An usual bias in antigen recognition. J. Exp. Med. 1985; 162: 2107–24
   PubMed Web of Science ®Google Scholar
• Zamvil S., Nelson P., Protter J., Mitchell D., Knobler R., Eril7 R., Steinman L. T-eell. clones specific for myelin basic protein induce chronic relapsing paralysis and dcmyelination. Nature 1985; 317: 355–8
   PubMed Web of Science ®Google Scholar
• Dowling P., Shang G., Raval S., Menonna J., Cook S., Husar W. Involvement of the CD95 (APO-1/F'as) receptor/Hgand system in multiple scleosis brain. J Exp. Med. 1996; 184: 1513–8
   PubMed Web of Science ®Google Scholar
• Chervonsky A. V., Wang Y., Wong E. S., Visimin L, Elavell R. A., Jancway C. A., Matis L. A. The role of Fas in autoimmune diabetes. Cell 1997; 89: 17–24
   PubMed Web of Science ®Google Scholar
• Itoh N., lmagawa A., Hanafusa T., Waguri M., Yamamoto K., Ivvahashi H., Moriwaki M., Nakajima H., Miyagawa J., Namba M., Makino S., Nagata S., Kono M., Matsuzawa Y. Requirement of Eas for the development of autoimmune diabetes in nonobese diabetic mice. J. Exp. Med. 1997; 186: 613–8
   PubMed Web of Science ®Google Scholar
• Yagi N., Yokono K., Amano K., Nagata M., Tsukamoto K., Hasegawa Y., Yoneda R., Okamoto N., Moriyama H., Miki M., Tominaga Y., Miyazaki I.-I., Yagita H., Oktimura K., Mizoguchi A., Miki A., Ide C, Maeda S., Kasuga M. Expression of intercellular adhesion molecule 1 on pancreatic. β-cells accelerates. (-cell destruction by cytotoxic T-cells in murine autoimmune diabetes. Diabetes 1995; 44: 744–52
   PubMed Web of Science ®Google Scholar
• Matsumoto K., Fukunaga K., Miyazaki I.-I., Shichiri M., Miyamoto E. Ca2+/calmodulin-dependent protein kinase II and synasin 1 -like protein in mouse insulinoma MIN6 cells. Endocrinology 1995; 136: 3784–93
   PubMed Web of Science ®Google Scholar
• Kayagaki N., Yamaguchi N., Nagao F., Matsuo S., Maeda I, Okumura E. K., Yagita H. Polymorphism of murine Eas ligand that affects the biological activity. Proc. Natl. Acad. Sci. USA 1997; 94: 3914–9
   PubMed Web of Science ®Google Scholar
• Lee M.-S., Wogcnsen L., Shizuru J., Oldstone M B.A., Sarvetnick N. Pancreatic islet production of murine interleukin 10 does not inhibit immune-mediated tissue destruction. J. Clin. Invest. 1994; 93: 1332–8
   PubMed Web of Science ®Google Scholar
• Griffith T. S., Brunner T., Fletcher S. M., Green D. R., Ferguson T. A. Eas ligand-induced apoptosis as a mechanism of immune previlege. Science 1995; 270: 1189–92
   PubMed Web of Science ®Google Scholar
• Bellgrau D., Gold D., Seiawry H., Moore J., Franzusoff A., Duke R. C. A role for CD95 ligand in preventing graft rejection. Nature 1995; 377: 6.30–2
   Web of Science ®Google Scholar
• Giordano C., Stassi G., De Maria R., Todaro M., Richiusa P., Papoff G., Ruberti C i., Bagnasco M., Testi R., Gallulzo A. Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis. Science 1997; 275: 960–3
   PubMed Web of Science ®Google Scholar
• Ogasawara J., Suda T., Nagata S. Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody. J Exp. Med. 1995; 181: 485–91
   PubMed Web of Science ®Google Scholar
• Ni R., Tomita Y., Ichihara A., Ishimura K., Ogasawara J., Nagata S. Fas-mediated apoptosis in primary cultured mouse hepatocyte. Exp. Cell Res. 1994; 215: 332–7
   PubMed Web of Science ®Google Scholar
• Elstein K. H., Zucker R. M. Comparison of cellular and nuclear flow cytometric techniques for discriminating apoptoticsubpopulation. Exp. Cell. Res. 1994; 211: 322–31
   PubMed Web of Science ®Google Scholar
• Santamaria P., Utsugi T., Park B.-J., Averill N., Kawazu S., Yoon J.-W. Beta-cell-cytotoxic CD8+ T cells from nonobese diabetic mice use highly homologous T cell receptor o-chain CDR3 sequences. J Immunol 1995; 154: 2494–503
   PubMed Web of Science ®Google Scholar
• Alderson M. R., Tough T. W., Davis-Smith T., Braddy S., Ealk B., Schooley K. A., Goodwin R. G., Smith C. A., Ramsdell E., Lynch D. H. Fas ligand mediates activation-induced cell death in human T lymphocytes. J Exp. Med. 1995; 181: 71–7
   PubMed Web of Science ®Google Scholar
• Yang Y., Merccp M., Ware C. E., Ashwell J. D. las and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: inhibition of Eas ligand expression by retinoic acid and glucocorticoid. J of Exp. Med. 1995; 181: 1673–82
   PubMed Web of Science ®Google Scholar
• Suda T., Okazaki T., Naito Y., Yokota T., Arai N., Ozaki S., Nakao K., Nagata S. Expression of Fas ligand in cells of T cell lineage. J Immunol 1995; 154: 3806–13
   PubMed Web of Science ®Google Scholar
• Watanabe-Fukunaga R., Brynnan C. I., Itoh N., Yonehara S., Copeland N. G., Jenkins N. A., Nagata S. The cDNA structure, expression and chromosomal assignment of the mouse Fas antigen. J. Immunol. 1992; 148: 1274–9
   PubMed Web of Science ®Google Scholar
• Yamada K., Takane-Gyotoku N., Yuan X., Ichikawa F., Nonaka K. Mouse islet cell lysis mediated by interieukin-1-induced Fas. Diahetologia 1996; 39: 1306–12
   PubMed Web of Science ®Google Scholar
• Shima Y., Nishimoto N., Ogata A., Fujii Y., Yoshizaki K., Kishimoto T. Myeloma. cells express Fas antigen, APO-I (CD95) but only some are sensitive to anti-Fas antibody resulting in apoptosis. Blood 1995; 85: 757–64
   PubMed Web of Science ®Google Scholar
• Itoh N., Tsiijimoto Y., Nagata S. Effect of bcl-2 on Fas antigen-mediated cell death. J. Immunol. 1993; 151: 621–7
   PubMed Web of Science ®Google Scholar
• Boise L. H., Thompson C. B. Hicrachial control of lymphocyte survival. Science 1996; 274: 67–8
   PubMed Web of Science ®Google Scholar
• O'Brien B. A., Harmon B. V., Cameron D. P., Allan D. J. Apoptosis is the mode of beta-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse. Diabetes 1997; 46: 750–7
   PubMed Web of Science ®Google Scholar
• Ogasawara J., Watanabe-Fukunaga R., Adachi M., Matsuzawa A., Kasugai T., Kitamura Y., Itoh N., Suda T., Nagata S. Lethal effect of the anti-Fas antibody in mice. Nature 1993; 364: 806–9
   PubMed Web of Science ®Google Scholar
• Bianeonc L., Dc Martino A., Orlandi V., Conaldi P. G., Toniolo A., Camussi G. Development of inflammatory angiogenesis by local stimulation with Fas /'/; vivo. J. Exp. Med. 1997; 186: 147–52
   PubMed Web of Science ®Google Scholar