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Original Article

NKT Cell Cytokine Imbalance in Murine Diabetes Mellitus

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Pages 201-214 | Received 18 Apr 1998, Published online: 07 Jul 2009

References

  • Bach J.-F. Insulin-dependent diabetes mellitus as an autoimmune disease. Endocrine Rev 1994; 15: 516
  • Delovitch T., Singh B. The Nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD. Immunity 1998; 7: 727
  • Worrell B.-B., Starkebaum G., Greenbaum C., Palmer J. Peripheral blood mononuclear cells of insulin-dependent diabetic patients respond to multiple islet cell proteins. J. Immunol. 1996; 157: 5668
  • Charlton B., Laffcrty K. The Thl/Th2 balance in autoimmunity. Cur. Opin. Immunol. 1995; 7: 793
  • Rabinovich A. Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM: Therapeutic intervention by immunostimulation. Diabetes 1994; 43: 613
  • Sadick M., Heinzcl F., Holaday B., Pu R., Dawkins R., Locksley R. Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon-γ-independent mechanism. J. Exp. Med. 1990; 171: 115
  • Romani L., Mencacci A., Grohmann U., Mocci S., Mosci P., Pucetti P., Bistoni F. Neutralizing antibody to interleukin 4 induces systemic protection and T helper type 1 -associated immunity in murine candidiasis. J. Exp. Med. 1992; 176: 19
  • Chalelain R., Varkila K., Coffman R. IL-4 induces a Th2 response in Leishmania major-infected mice. J. Immunol. 1992; 148: 1182
  • Backkeskov S., Aanstoot H., Christgau S., Reetz A., Soiimena M., Cascalho M., Folli F., Olesen H., Camilli P. D. Identification of the 64 K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nat 1990; 347: 151
  • Muir A, Peck A., Salzler M., Song Y.-H., Cornelius J., Luchetta R., Krischcr J., Maclaren N. Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet inter-feron-γ transcription. J. Clin. Invest. 1995; 95: 628
  • Roep B., Kalian A., Hazenbos W., Bruining G., Bailyes E., Arden S., Hutton J., Vrics R. D. T-cell reactivity to 38 kD insulin-secretory-granule protein in patients with recent-onset type 1 diabetes. Lancet 1991; 337: 1439
  • Tisch R., Yang X., Singer S., Liblau R., Fuggcr L., McDevitt H. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nat 1993; 366: 72
  • Katz J., Wang B., Haskins K., Bcnoist C., Mathis D. Following a diabetogenic T cell from genesis through pathogenesis. Cell 1993; 74: 1089
  • Katz J., Benoist C., Mathis D. T helper cell subsets in insulin-dependent diabetes. Sci 1995; 268: 1185
  • Cambell I., Kay T, Oxbrow L, Harrison L. Essential role for lFN-g and IL-6 in autoimmune insulin-dependent diabetes in NOD/WEH1 mice. J. Clin. Invest. 1991; 87: 739
  • Rapoport M. J., Jaramillo A., Zipris D., Lazarus A. H., Serreze D. V., Leiter E. H., Cyopick P., Danska J. S., Delovitch T. L. Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. J. Exp. Med. 1993; 178: 87
  • Campbell I., Oxbrow L., Koulmanda M., Harrison L. IFN-g induces islet cell MHC antigens and enhances autoimmune streptozotocin-induccd diabetes in the mouse. J. Immunol. 1988; 140: 1111
  • Cockfield S., Ramassar V., Urmson J., Halloran P. Multiple low dose streptozotocin induces systemic MHC expression in mice by triggering T cells to release IFN-7. J. Immunol. 1989; 142: 1120
  • Herold K., Vezys V., Sun Q., Viktora D., Seung E., Reiner S., Brown D. Regulation of cytokine production during development of autoimmune diabetes induced with multiple low doses of streptozotocin. J. Immunol. 1996; 156: 3521
  • Fox C., Danska J. IL-4 expression at the onset of islet inflammation predicts nondestructive insulitis in nonobese diabetic mice. J. Immunol. 1997; 158: 2414
  • Hsieh C, Heimberger A., Gold J., O'Garra A., Murphy K. Differential regulation of T helper phenotype by Interleukins 4 and 10 in an a/i T cell receptor transgenic system. Proc. Natl. Acad. Sci. 1992; 89: 6065
  • Seder R., Paul W., Davis M., Groth B. F.D.S. The presence of interleukin 4 during in vitro priming determined the lymphokin-producing potential of CD4 + T cells from T cell receptor transgenic mice. J. Exp. Med. 1992; 176: 1091
  • Gross A., Ben-Sasson S., Paul W. Anti-IL-4 diminishes in vivo priming for antigen-specific IL-4 production by T cells. J. Immunol. 1993; 150: 2112
  • Shehadeh N., LaRosa F., Lafferty K. Altered cytokine activity in adjuvant inhibition of autotimmune diabetes. J. Autoimmunity. 1993; 6: 291
  • Rackc M., Bonomo A., Scott D., Cannclla B., Lcvinc Rainc A., Shevach C. E., Rockcn M. Cylokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J. Exp. Med. 1994; 180, 1961
  • Arase H., Arase N., Nakagawa K., Good R., Onoc K. NK1.1 CD4+ CD8- thymocytes with specific lympho-kinc secretion. Eur. J. Immunol. 1993; 23: 307
  • Seder R., Paul W. Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu. Rev. Immunol. 1994; 12: 635
  • Bendelac A. Mouse NK1.I + cells. Curr. Opin. Immunol. 1995; 7: 367
  • MacDonald H. NK1.1′ T cell receptor-α/β cells: new clues to their origin, specificity and function. J. Exp. Med. 1995; 182: 633
  • Viacari A., Zlotnik A, Mouse N K. 1.1′ T cells: a new family of T cells. Immunol. Today. 1996; 17: 71
  • Tanaka T., Kilamura F., Nagasaka Y., Kuida K., Suwa H., Miyasaka M. Selective long-term elimination of natural killer cells in vivo by an anti-interleukin 2 receptor β chain monoclonal antibody in mice. J. Exp. Med. 1993; 178: 1103
  • Gomberl J.-M., Herbclin A. T., Bohin E., Dy M., Carnaud C., Bach J.-F. Early quantitative and functional deficiency of NK1 -like thymocytes in the NOD mouse. Eur. J. Immunol. 1996; 26: 2989
  • Lantz O., Bendelac A. An invariant T cell receptor a chain is used by a unique subset of major histocompatibility complex class I-speeific CD4 + and CD4- 8-T cells in mice and humans.,/. Exp. Med. 1994; 180: 1097
  • Bendelac A., Lainz O., Quimby M., Yewdell J., Bennink L., Brutkiewicz R. CD1 recognition by mouse NK I + T lymphocytes. Science 1995; 268: 863
  • Zipris D., Lazarus A., Crow A., Hadzija M., Delovitch T. Defective thymic T cell activation by concanavalin A and anti-CD3 in autoimmune nonobese diabetic mice. J Immunol 1991; 146: 3763
  • Wood S., Rao T. D., Frey A. B. Multi-dose strepto-zotoein induction of diabetes in BALB/cBy mice induces a T cell receptor-mediated signaling defect in thymocytes which is reversible by interleukin-4 (submitted). 1998
  • Berman M., Sandborg C, Wang Z., Imfeld K., Zaldivar I'., Dadufalza V., Buckingham B. Decreased IL-4 production in new onset type I insulin-dependent diabetes mcllitus. J. Immunol. 1996; 157: 4690
  • Yoshimolo T, Paul W. CD4Pos NKl.lpos T cells promptly produce Interlcukin 4 in response to vivo challenge with anti-CD3.,J Exp. Med 1994; 179: 1285
  • Herold K, Vezys V., Sttn Q., Victora D, Seung E, Reiner S., Brown D. Regulation of cytokine production during development of autoimmune diabetes induced with multiple low doses of strcptozotocin. J. Immunol. 1996; 156: 3527
  • Rabinovitch A., Suarez-Pinzon W., Sorensen O., Bleaekley R., Power R. IE'N-γ gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice. J. Immunol. 1995; 154: 4874
  • Matyniak J., Reiner S. T. helper phenotype and genetic susceptibility in experimental Lyme disease. J. Exp. Med. 1995; 181: 1251
  • Pugh C S, Tabatabai L. Variation in Brucella abortus 2308 infection in BALB/c mice induced by prior vaccination with salt-extractable periplasmic proteins form Brucella abortus 19. Infect. Immun. 1996; 64: 548
  • Yoshimoto T., Bendelac A., Li H.-J., Paul W. Defective IgE production by SJL mice is linked to the absence of CD4+, NK1.1 + T cells that promptly produce interleukin 4. Proc. Natl. Acad. Sci. 1995; 92: 11931
  • Buschard K., Rygaard J. Passive transfer of strcptozotocin induced diabetes mcllitus with spleen cells. Acta. Path. Microbiol. Scand. Seel. C. 1977; 85: 469
  • Buschard K., Rygaard J. Is the diabetogenic effect of streptozotocin in part thymus-dependent?. Acta. Path. Microbiol. Scand. Sect. C. 1978; 86: 23
  • Herold K, Montag A., Fitch F. Treatment with anti-lymphocyte antibodies prevents induction of insulitis in mice given multiple doses of streptozotocin. Diabetes 1987; 36: 796
  • Herold K. C., Bloch T. N., Vezys V., Sun Q. Diabetes induced with low doses of streptozotocin is mediated by Vβ 8.2 T-cells. Diabetes 1995; 44: 354
  • Rapoport M. J., Lazarus A. H., Jararmillo A., Speck E., Delovitch T. L. Thymic T cell anergy in autoimmune nonobese diabetic mice is mediated by deficient 1 cell receptor regulation of the the pathway of p21″ activation. J. Exp. Med. 1993; 177: 1221
  • Kishimoto H., Kubo R., Yorifuji H., Nakayama T., Asano Y, Tada T. Physical dissociation of the TCR-CD3 complex accompanies receptor ligation. J. Exp. Med. 1995; 182: 1997
  • Nishimura T., Santa K., Yuhata T., Sato N., Ohla A, Ohmi Y., Sato T., Hozumi K., Habu S. Involvement of IL-4-producing Vβ8.2′ CD4′ CD62L CD45RB T cells in non-MHC gene-controlled predisposition towards skewing into T helper type-2 immunity in BALB c mice. J. Immunol. 1997; 158: 5698
  • Weid T. V.D., Beebe A, Roopcnian D, Coffman R. Early production of IL-4 and induction of Th2 responses in the lymph node originate from an M HO class I-independcnt CD4 | NK1.I- T cell population. J. Immunol. 1966; 157: 4421
  • Brown D., Fowell D., Corry D., Wynn T., Moskowitz N., Cheever A., Locksley R., Reiner S. β2-micro-globulin-dependent NK1.1+ T cells are not essential for T helper cell 2 immune responses. J. Exp. Med. 1996; 184: 1295
  • Smiley S., Kaplan M, Grusby M. Immunoglobulin E production in the absence of I L-4-secreting CD 1-dependent cells. Sci 1997; 275: 977
  • Wogensen I., Lee M, Sarvctnick N. Production of IL-10 by islet cells accelerates immune-mediated destuetion of beta cells in nonobese diabetic mice. J. Exp. Med. 1994; 179: 1379
  • Pennlinc K., Gaffney R.-E., Monahan M. Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse. Clin. Immunol. Imtnunopatltol. 1994; 71: 169

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