Pentoxifylline modulates p47phox activation and downregulates neutrophil oxidative burst through PKA-dependent and -independent mechanisms

References

• Brown KA, Brain SD, Pearson JD, Edgeworth JD, Lewis SM, Treacher DF. Neutrophils in development of multiple organ failure in sepsis. Lancet 368(9530), 157–69, 2006.
   PubMed Web of Science ®Google Scholar
• Maier RV. Pathogenesis of multiple organ dysfunction syndrome–endotoxin, inflammatory cells, and their mediators: cytokines and reactive oxygen species. Surg Infect (Larchmt) 1(3), 197–204; discussion 204-195, 2000.
   PubMedGoogle Scholar
• Brechard S, Tschirhart EJ. Regulation of superoxide production in neutrophils: role of calcium influx. J Leukoc Biol 84(5), 1223–37, 2008.
   PubMed Web of Science ®Google Scholar
• Jun T, Gjoerup O, Roberts TM. Tangled webs: evidence of cross-talk between c-Raf-1 and Akt. Sci STKE 1999(13), PE1, 1999.
   PubMedGoogle Scholar
• Nick JA, Avdi NJ, Young SK, Knall C, Gerwins P, Johnson GL, et al. Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP. J Clin Invest 99(5), 975–86, 1997.
   PubMed Web of Science ®Google Scholar
• El Benna J, Han J, Park JW, Schmid E, Ulevitch RJ, Babior BM. Activation of p38 in stimulated human neutrophils: phosphorylation of the oxidase component p47phox by p38 and ERK but not by JNK. Arch Biochem Biophys 334(2), 395–400, 1996.
   PubMed Web of Science ®Google Scholar
• Naccache PH, Levasseur S, Lachance G, Chakravarti S, Bourgoin SG, McColl SR. Stimulation of human neutrophils by chemotactic factors is associated with the activation of phosphatidylinositol 3-kinase gamma. J Biol Chem 275(31), 23636–41, 2000.
   PubMed Web of Science ®Google Scholar
• Chen Q, Powell DW, Rane MJ, Singh S, Butt W, Klein JB, et al. Akt phosphorylates p47phox and mediates respiratory burst activity in human neutrophils. J Immunol 170(10), 5302–8, 2003.
   PubMed Web of Science ®Google Scholar
• Babior BM. NADPH oxidase: an update. Blood 93(5), 1464–76, 1999.
   PubMed Web of Science ®Google Scholar
• Coimbra R, Melbostad H, Hoyt DB. Effects of phosphodiesterase inhibition on the inflammatory response after shock: role of pentoxifylline. J Trauma 56(2), 442–9, 2004.
   PubMedGoogle Scholar
• Coimbra R, Porcides RD, Melbostad H, Loomis W, Tobar M, Hoyt DB, et al. Nonspecific phosphodiesterase inhibition attenuates liver injury in acute endotoxemia. Surg Infect (Larchmt) 6(1), 73–85, 2005.
   PubMedGoogle Scholar
• Costantini TW, Loomis WH, Putnam JG, Drusinsky D, Deree J, Choi S, et al. Burn-induced gut barrier injury is attenuated by phosphodiesterase inhibition: effects on tight junction structural proteins. Shock 31(4), 416–22, 2009.
   PubMed Web of Science ®Google Scholar
• Costantini TW, Loomis WH, Putnam JG, Kroll L, Eliceiri BP, Baird A, et al. Pentoxifylline modulates intestinal tight junction signaling after burn injury: effects on myosin light chain kinase. J Trauma., 66(1), 17–24; discussion 24-15, 2009.
   PubMedGoogle Scholar
• Deree J, de Campos T, Shenvi E, Loomis WH, Hoyt DB, Coimbra R. Hypertonic saline and pentoxifylline attenuates gut injury after hemorrhagic shock: the kinder, gentler resuscitation. J Trauma. 62(4), 818–27; discussion 827–818, 2007.
   PubMedGoogle Scholar
• Coimbra R, Loomis W, Melbostad H, Tobar M, Porcides RD, Lall R, et al. Role of hypertonic saline and pentoxifylline on neutrophil activation and tumor necrosis factor-alpha synthesis: a novel resuscitation strategy. J Trauma 59(2), 257–64; discussion 264–265, 2005.
   PubMedGoogle Scholar
• de Campos T, Deree J, Martins JO, Loomis WH, Shenvi E, Putnam JG, et al. Pentoxifylline attenuates pulmonary inflammation and neutrophil activation in experimental acute pancreatitis. Pancreas 37(1), 42–9, 2008.
   PubMed Web of Science ®Google Scholar
• Deree J, Lall R, Melbostad H, Grant M, Hoyt DB, Coimbra R. Neutrophil degranulation and the effects of phosphodiesterase inhibition. J Surg Res 133(1), 22–8, 2006.
   PubMed Web of Science ®Google Scholar
• Deree J, Lall R, Melbostad H, Loomis W, Hoyt DB, Coimbra R. Pentoxifylline attenuates stored blood-induced inflammation: A new perspective on an old problem. Surgery 140(2), 186–91, 2006.
   PubMed Web of Science ®Google Scholar
• Lall RN, Loomis W, Melbostad H, Hoyt DB, Lane T, Coimbra R. Phosphodiesterase inhibition attenuates stored blood-induced neutrophil activation: a novel adjunct to blood transfusion. J Am Coll Surg 202(1), 10–7, 2006.
   PubMed Web of Science ®Google Scholar
• Endres S, Fulle HJ, Sinha B, Stoll D, Dinarello CA, Gerzer R, et al. Cyclic nucleotides differentially regulate the synthesis of tumour necrosis factor-alpha and interleukin-1 beta by human mononuclear cells. Immunology 72(1), 56–60, 1991.
   PubMed Web of Science ®Google Scholar
• Coimbra R, Loomis W, Melbostad H, Tobar M, Porcides RD, Hoyt DB. LPS-stimulated PMN activation and proinflammatory mediator synthesis is downregulated by phosphodiesterase inhibition: role of pentoxifylline. J Trauma 57(6), 1157–63, 2004.
   PubMedGoogle Scholar
• Deree J, Melbostad H, Loomis WH, Putnam JG, Coimbra R. The effects of a novel resuscitation strategy combining pentoxifylline and hypertonic saline on neutrophil MAPK signaling. Surgery 142(2), 276–83, 2007.
   PubMed Web of Science ®Google Scholar
• Burelout C, Naccache PH, Bourgoin SG. Dissociation between the translocation and the activation of Akt in fMLP-stimulated human neutrophils–effect of prostaglandin E2. J Leukoc Biol 81(6), 1523–34, 2007.
   PubMed Web of Science ®Google Scholar
• Andrews S, Stephens LR, Hawkins PT. PI3K class IB pathway. Sci STKE 2007(407), cm2, 2007.
   Google Scholar
• Brom J, Koller M, Muller-Lange P, Steinau HU, Konig W. GTP-binding proteins in polymorphonuclear granulocytes of severely burned patients. J Leukoc Biol 53(3), 268–72, 1993.
   PubMed Web of Science ®Google Scholar
• Arcaroli J, Yang KY, Yum HK, Kupfner J, Pitts TM, Park JS, et al. Effects of catecholamines on kinase activation in lung neutrophils after hemorrhage or endotoxemia. J Leukoc Biol 72(3), 571–9, 2002.
   PubMed Web of Science ®Google Scholar
• Grinstein S, Furuya W, Butler JR, Tseng J. Receptor-mediated activation of multiple serine/threonine kinases in human leukocytes. J Biol Chem 268(27), 20223–31, 1993.
   PubMed Web of Science ®Google Scholar
• Avdi NJ, Winston BW, Russel M, Young SK, Johnson GL, Worthen GS. Activation of MEKK by formyl-methionyl-leucyl-phenylalanine in human neutrophils. Mapping pathways for mitogen-activated protein kinase activation. J Biol Chem 271(52), 33598–606, 1996.
   PubMed Web of Science ®Google Scholar
• Dang PM, Morel F, Gougerot-Pocidalo MA, El Benna J. Phosphorylation of the NADPH oxidase component p67(PHOX) by ERK2 and P38MAPK: selectivity of phosphorylated sites and existence of an intramolecular regulatory domain in the tetratricopeptide-rich region. Biochemistry 42(15), 4520–6, 2003.
   PubMed Web of Science ®Google Scholar
• Andjelkovic M, Alessi DR, Meier R, Fernandez A, Lamb NJ, Frech M, et al. Role of translocation in the activation and function of protein kinase B. J Biol Chem 272(50), 31515–24, 1997.
   PubMed Web of Science ®Google Scholar
• Lin SL, Chen RH, Chen YM, Chiang WC, Tsai TJ, Hsieh BS. Pentoxifylline inhibits platelet-derived growth factor-stimulated cyclin D1 expression in mesangial cells by blocking Akt membrane translocation. Mol Pharmacol 64(4), 811–22, 2003.
   PubMed Web of Science ®Google Scholar
• Chiou YL, Shieh JJ, Lin CY. Blocking of Akt/NF-kappaB signaling by pentoxifylline inhibits platelet-derived growth factor-stimulated proliferation in Brown Norway rat airway smooth muscle cells. Pediatr Res 60(6), 657–62, 2006.
   PubMed Web of Science ®Google Scholar
• Johnson JL, Park JW, Benna JE, Faust LP, Inanami O, Babior BM. Activation of p47(PHOX), a cytosolic subunit of the leukocyte NADPH oxidase. Phosphorylation of ser-359 or ser-370 precedes phosphorylation at other sites and is required for activity. J Biol Chem 273(52), 35147–52, 1998.
   PubMed Web of Science ®Google Scholar
• Coimbra R, Melbostad H, Loomis W, Porcides RD, Wolf P, Tobar M, Hoyt DB. LPS-induced acute lung injury is attenuated by phosphodiesterase inhibition: effects on proinflammatory mediators, metalloproteinases, NF-kappaB, and ICAM-1 expression. J Trauma 60(1), 115–125, 2006.
   PubMedGoogle Scholar
• Orlic T, Loomis WH, Shreve A, Namiki S, Junger WG. Hypertonicity increases cAMP in PMN and blocks oxidative burst by PKA-dependent and -independent mechanisms. Am J Physiol Cell Physiol 282(6), C1261–9, 2002.
   Web of Science ®Google Scholar
• Shukla A, Hashiguchi N, Chen Y, Coimbra R, Hoyt DB, Junger WG. Osmotic regulation of cell function and possible clinical applications. Shock 21(5), 391–400, 2004.
   PubMed Web of Science ®Google Scholar
• Worthen GS, Avdi N, Buhl AM, Suzuki N, Johnson GL. FMLP activates Ras and Raf in human neutrophils. Potential role in activation of MAP kinase. J Clin Invest 94(2), 815–23, 1994.
   PubMed Web of Science ®Google Scholar
• Houslay MD. A RSK(y) relationship with promiscuous PKA. Sci STKE 2006(349), pe32, 2006.
   PubMedGoogle Scholar
• VanRenterghem B, Browning MD, Maller JL. Regulation of mitogen-activated protein kinase activation by protein kinases A and C in a cell-free system. J Biol Chem 269(40), 24666–72, 1994.
   PubMed Web of Science ®Google Scholar