158
Views
5
CrossRef citations to date
0
Altmetric
Research Article

The human Ku autoantigen shares amino acid sequence homology with fungal, but not bacterial and viral, proteins

, , &
Pages 329-333 | Received 09 Jun 2010, Accepted 20 Jul 2010, Published online: 18 Aug 2010

References

  • Selmi, C., Gershwin, M.E. Bacteria and human autoimmunity: the case of primary biliary cirrhosis. Curr. Opin. Rheumatol. 2004, 16, 406–410.
  • Sospedra, M., Martin, R. Molecular mimicry in multiple sclerosis. Autoimmunity 2006, 39, 3–8.
  • Ebringer, A., Rashid, T. Rheumatoid arthritis is an autoimmune disease triggered by Proteus urinary tract infection. Clin. Dev. Immunol. 2006, 13, 41–48.
  • Reeves, W.H. Antibodies to the p70/p80 (Ku) antigens in systemic lupus erythematosus. Rheum. Dis. Clin. North Am. 1992, 18, 391–414.
  • Mimori, T., Akizuki, M., Yamagata, H., Inada, S., Yoshida, S., Homma, M. Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlap. J. Clin. Invest. 1981, 68, 611–620.
  • Reeves, W.H., Pierani, A., Chou, C.H., Ng, T., Nicastri, C., Roeder, R.G., Sthoeger, Z.M. Epitopes of the p70 and p80 (Ku) lupus autoantigens. J. Immunol. 1991, 146, 2678–2686.
  • Altschul, S.F., Madden, T.L., Schäffer, A.A., Zhang, J., Zhang, Z., Miller, W., Lipman, D.J. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 1997, 25, 3389–3402.
  • McClain, M.T., Heinlen, L.D., Dennis, G.J., Roebuck, J., Harley, J.B., James, J.A. Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry. Nat. Med. 2005, 11, 85–89.
  • Smiley, J.D., Hoffman, W.L. The role of infections in the rheumatic diseases: molecular mimicry between bacterial and human stress proteins? Am. J. Med. Sci. 1991, 301, 138–149.
  • Lunardi, C., Bason, C., Navone, R., Millo, E., Damonte, G., Corrocher, R., Puccetti, A. Systemic sclerosis immunoglobulin G autoantibodies bind the human cytomegalovirus late protein UL94 and induce apoptosis in human endothelial cells. Nat. Med. 2000, 6, 1183–1186.
  • Gregorio, G.V., Choudhuri, K., Ma, Y., Vegnente, A., Mieli-Vergani, G., Vergani, D. Mimicry between the hepatitis B virus DNA polymerase and the antigenic targets of nuclear and smooth muscle antibodies in chronic hepatitis B virus infection. J. Immunol. 1999, 162, 1802–1810.
  • Nieuwenhuizen, W.F., Pieters, R.H., Knippels, L.M., Jansen, M.C., Koppelman, S.J. Is Candida albicans a trigger in the onset of coeliac disease? Lancet 2003, 361, 2152–2154.
  • Schmid-Grendelmeier, P., Flückiger, S., Disch, R., Trautmann, A., Wüthrich, B., Blaser, K., Scheynius, A., Crameri, R. IgE-mediated and T cell-mediated autoimmunity against manganese superoxide dismutase in atopic dermatitis. J. Allergy Clin. Immunol. 2005, 115, 1068–1075.
  • Yordanov, M., Tchorbanov, A., Ivanovska, N. Candida albicans cell-wall fraction exacerbates collagen-induced arthritis in mice. Scand. J. Immunol. 2005, 61, 301–308.
  • Hida, S., Miura, N.N., Adachi, Y., Ohno, N. Cell wall beta-glucan derived from Candida albicans acts as a trigger for autoimmune arthritis in SKG mice. Biol. Pharm. Bull. 2007, 30, 1589–1592.
  • Yoshitomi, H., Sakaguchi, N., Kobayashi, K., Brown, G.D., Tagami, T., Sakihama, T., Hirota, K., Tanaka, S., Nomura, T., Miki, I., Gordon, S., Akira, S., Nakamura, T., Sakaguchi, S. A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice. J. Exp. Med. 2005, 201, 949–960.
  • Singh, V.K., Yamaki, K., Donoso, L.A., Shinohara, T. Molecular mimicry. Yeast histone H3-induced experimental autoimmune uveitis. J. Immunol. 1989, 142, 1512–1517.
  • Vojdani, A., Rahimian, P., Kalhor, H., Mordechai, E. Immunological cross reactivity between Candida albicans and human tissue. J. Clin. Lab. Immunol. 1996, 48, 1–15.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.