References
- Corpas, E., Harman, S.M., Blackman, M.R. Human growth hormone and human aging. Endocr. Rev. 1993, 14, 20–39.
- Ho, K.K., Hoffman, D.M. Aging and growth hormone. Horm. Res. 1993, 40, 80–86.
- Harman, S.M., Blackman, M.R. Use of growth hormone for prevention or treatment of effects of aging. J. Gerontol. A Biol. Sci. Med. Sci. 2004, 59, 652–658.
- Rudman, D., Kutner, M.H., Rogers, C.M., Lubin, M.F., Fleming, G.A., Bain, R.P. Impaired growth hormone secretion in the adult population: relation to age and adiposity. J. Clin. Invest. 1981, 67, 1361–1369.
- Zadik, Z., Chalew, S.A., McCarter, R.J. Jr, Meistas, M., Kowarski, A.A. The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals. J. Clin. Endocrinol. Metab. 1985, 60, 513–516.
- Prinz, P.N., Weitzman, E.D., Cunningham, G.R., Karacan, I. Plasma growth hormone during sleep in young and aged men. J. Gerontol. 1983, 38, 519–524.
- Muggeo, M., Fedele, D., Tiengo, A., Molinari, M., Crepaldi, G. Human growth hormone and cortisol response to insulin stimulation in aging. J. Gerontol. 1975, 30, 546–551.
- Monteleone, P., Iovino, M., Orio, F., Steardo, L. Impaired growth hormone response to sodium valproate in normal aging. Psychopharmacology (Berl.) 1987, 91, 10–13.
- Iovino, M., Monteleone, P., Steardo, L. Repetitive growth hormone-releasing hormone administration restores the attenuated growth hormone (GH) response to GH-releasing hormone testing in normal aging. J. Clin. Endocrinol. Metab. 1989, 69, 910–913.
- Giustina, A., Veldhuis, J.D. Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocr. Rev. 1998, 19, 717–797.
- Ceda, G.P., Valenti, G., Butturini, U., Hoffman, A.R. Diminished pituitary responsiveness to growth hormone-releasing factor in aging male rats. Endocrinology 1986, 118, 2109–2114.
- Arvat, E., Giordano, R., Gianotti, L., Broglio, F., Camanni, F., Ghigo, E. Neuroendocrinology of the human growth hormone-insulin-like growth factor I axis during ageing. Growth Horm. IGF Res. 1999, 9 Suppl A, 111–115.
- Müller, E.E., Cella, S.G., Parenti, M., Deghenghi, R., Locatelli, V., De Gennaro Colonna, V., Torsello, A., Cocchi, D. Somatotropic dysregulation in old mammals. Horm. Res. 1995, 43, 39–45.
- Ghigo, E., Goffi, S., Nicolosi, M., Arvat, E., Valente, F., Mazza, E., Ghigo, M.C., Camanni, F. Growth hormone (GH) responsiveness to combined administration of arginine and GH-releasing hormone does not vary with age in man. J. Clin. Endocrinol. Metab. 1990, 71, 1481–1485.
- Veldhuis, J.D., Liem, A.Y., South, S., Weltman, A., Weltman, J., Clemmons, D.A., Abbott, R., Mulligan, T., Johnson, M.L., Pincus, S. Differential impact of age, sex steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay. J. Clin. Endocrinol. Metab. 1995, 80, 3209–3222.
- Thissen, J.P., Ketelslegers, J.M., Underwood, L.E. Nutritional regulation of the insulin-like growth factors. Endocr. Rev. 1994, 15, 80–101.
- Giagulli, V.A., Carbone, D. Hormonal control of inhibin B in men. J. Endocrinol. Invest. 2006, 29, 706–713.
- Locatelli V, Arimura A, Torsello A, Cella SG, Muller EE. Somatostatin antiserum antagonizes the impaired ability of hpGRS-40 to stimulate GH-release in old unanesthesized male rats. Neuroendocrinol Lett 1984, 6, 261–266.
- Soule, S.G., Macfarlane, P., Levitt, N.S., Millar, R.P. Contribution of growth hormone-releasing hormone and somatostatin to decreased growth hormone secretion in elderly men. S. Afr. Med. J. 2001, 91, 254–260.
- Veldhuis, J.D., Patrie, J.T., Frick, K., Weltman, J.Y., Weltman, A. Sustained growth hormone (GH) and insulin-like growth factor I responses to prolonged high-dose twice-daily GH-releasing hormone stimulation in middle-aged and older men. J. Clin. Endocrinol. Metab. 2004, 89, 6325–6330.
- Zhan, X., Giorgianni, F., Desiderio, D.M. Proteomics analysis of growth hormone isoforms in the human pituitary. Proteomics 2005, 5, 1228–1241.
- Kanashiro-Takeuchi, R.M., Tziomalos, K., Takeuchi, L.M., Treuer, A.V., Lamirault, G., Dulce, R., Hurtado, M., Song, Y., Block, N.L., Rick, F., Klukovits, A., Hu, Q., Varga, J.L., Schally, A.V., Hare, J.M. Cardioprotective effects of growth hormone-releasing hormone agonist after myocardial infarction. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 2604–2609.
- Lin-Su, K., Wajnrajch, M.P. Growth Hormone Releasing Hormone (GHRH) and the GHRH Receptor. Rev. Endocr. Metab. Disord. 2002, 3, 313–323.
- Kiaris, H., Schally, A.V., Kalofoutis, A. Extrapituitary effects of the growth hormone-releasing hormone. Vitam. Horm. 2005, 70, 1–24.
- Siriwardana, G., Bradford, A., Coy, D., Zeitler, P. Autocrine/paracrine regulation of breast cancer cell proliferation by growth hormone releasing hormone via Ras, Raf, and mitogen-activated protein kinase. Mol. Endocrinol. 2006, 20, 2010–2019.
- Schally, A.V., Varga, J.L., Engel, J.B. Antagonists of growth-hormone-releasing hormone: an emerging new therapy for cancer. Nat. Clin. Pract. Endocrinol. Metab. 2008, 4, 33–43.
- Bellyei, S., Schally, A.V., Zarandi, M., Varga, J.L., Vidaurre, I., Pozsgai, E. GHRH antagonists reduce the invasive and metastatic potential of human cancer cell lines in vitro. Cancer Lett. 2010, 293, 31–40.
- Barabutis, N., Siejka, A., Schally, A.V. Effects of growth hormone-releasing hormone and its agonistic and antagonistic analogs in cancer and non-cancerous cell lines. Int. J. Oncol. 2010, 36, 1285–1289.
- Guo, J., Schally, A.V., Zarandi, M., Varga, J., Leung, P.C. Antiproliferative effect of growth hormone-releasing hormone (GHRH) antagonist on ovarian cancer cells through the EGFR-Akt pathway. Reprod. Biol. Endocrinol. 2010, 8, 54.
- Bartke, A. Is growth hormone deficiency a beneficial adaptation to aging? Evidence from experimental animals. Trends Endocrinol. Metab. 2003, 14, 340–344.