210
Views
7
CrossRef citations to date
0
Altmetric
Original Article

Computational allergenicity prediction of transgenic proteins expressed in genetically modified crops

, , , &
Pages 410-422 | Received 04 May 2010, Accepted 24 Jul 2010, Published online: 21 Oct 2010

References

  • Kuiper, H.A., Kleter, G.A., Noteborn, H.P., Kok, E.J. Assessment of the food safety issues related to genetically modified foods. Plant J. 2001, 27, 503–528.
  • FAO/WHO. Codex principles and guidelines on foods derived from biotechnology. FAO, Rome. 2003.
  • Schilter, B., Constable, A. Regulatory control of genetically modified (GM) foods: likely developments. Toxicol. Lett. 2002, 127, 341–349.
  • Ladics, G.S., Bardina, L., Cressman, R.F., Mattsson, J.L., Sampson, H.A. Lack of cross-reactivity between the Bacillus thuringiensis derived protein Cry1F in maize grain and dust mite Der p7 protein with human sera positive for Der p7-IgE. Regul. Toxicol. Pharmacol. 2006, 44, 136–143.
  • Metcalfe, D.D., Astwood, J.D., Townsend, R., Sampson, H.A., Taylor, S.L., Fuchs, R.L. Assessment of the allergenic potential of foods derived from genetically engineered crop plants. Crit. Rev. Food Sci. Nutr. 1996, 36(Suppl.), S165–S186.
  • FAO/WHO. Evaluation of allergenicity of genetically modified foods. Report of a joint FAO/WHO expert consultation on allergenicity of foods derived from biotechnology. (Food and Agriculture Organization of the United Nations (FAO), Rome, 2001.
  • Codex Alimentarius Commission. Alinorm 03/34: Joint FAO/WHO Food Standard Programme, Codex Alimentarius Commission, Twenty-Fifth Session, Rome, 30 June–5 July, 2003. Appendix III, Guideline for the conduct of food safety assessment of foods derived from recombinant-DNA plants and Appendix IV, Annex on the assessment of possible allergenicity, 2003.
  • OECD. Report of the Organization for Economic cooperation and Development Workshop on the Toxicological and Nutritional Testing of Novel Foods, Aussois, France, 5–8 March 1997. France: Organization for Economic cooperation and Development, 1998.
  • Nadler, M.J., Matthews, S.A., Turner, H., Kinet, J.P. Signal transduction by the high-affinity immunoglobulin E receptor Fc epsilon RI: coupling form to function. Adv. Immunol. 2000, 76, 325–355.
  • Metzger, H. The high affinity receptor for IgE on mast cells. Clin. Exp. Allergy 1991, 21, 269–279.
  • Burks, A.W., Shin, D., Cockrell, G., Stanley, J.S., Helm, R.M., Bannon, G.A. Mapping and mutational analysis of the IgE-binding epitopes on Ara h 1, a legume vicilin protein and a major allergen in peanut hypersensitivity. Eur. J. Biochem. 1997, 245, 334–339.
  • Banerjee, B., Greenberger, P.A., Fink, J.N., Kurup, V.P. Conformational and linear B-cell epitopes of Asp f 2, a major allergen of Aspergillus fumigatus, bind differently to immunoglobulin E antibody in the sera of allergic bronchopulmonary aspergillosis patients. Infect. Immun. 1999, 67, 2284–2291.
  • Silvanovich, A., Nemeth, M.A., Song, P., Herman, R., Tagliani, L., Bannon, G.A. The value of short amino acid sequence matches for prediction of protein allergenicity. Toxicol. Sci. 2006, 90, 252–258.
  • Herman, R.A., Song, P., Thirumalaiswamysekhar, A. Value of eight amino-acid matches in predicting the allergenicity status of proteins: an empirical bioinformatic investigation. Clin. Mol. Allergy 2009, 7–9.
  • Stadler, M.B., Stadler, B.M. Allergenicity prediction by protein sequence. FASEB J. 2003, 17, 1141–1143.
  • Hileman, R.E., Silvanovich, A., Goodman, R.E., Rice, E.A., Holleschak, G., Astwood, J.D., Hefle, S.L. Bioinformatic methods for allergenicity assessment using a comprehensive allergen database. Int. Arch. Allergy Immunol. 2002, 128, 280–291.
  • Pearson, W.R. Effective protein sequence comparison. Meth. Enzymol. 1996, 266, 227–258.
  • Saha, S., Raghava, G.P. AlgPred: prediction of allergenic proteins and mapping of IgE epitopes. Nucleic Acids Res. 2006, 34, W202–W209.
  • Björklund, A.K., Soeria-Atmadja, D., Zorzet, A., Hammerling,  U., Gustafsson, M.G. Supervised identification of allergen-representative peptides for in silico detection of potentially allergenic proteins. Bioinformatics 2005, 21, 39–50.
  • Goodman, R., Silvanovich, A., Hileman, R.E., Bannon, G.A., Rice, E.A., Astwood, J.D. Bioinformatic methods for identifying known or potential allergens in the safety assessment of genetically modified crops. Comments Toxicol. 2002, 8, 251–269.
  • Goodman, R.E., Taylor, S.L., Yamamura, J., Kobayashi, T., Kawakami, H., Kruger, C.L., Thompson, G.P. Assessment of the potential allergenicity of a milk basic protein fraction. Food Chem. Toxicol. 2007, 45, 1787–1794.
  • Gendel, S.M. Sequence analysis for assessing potential allergenicity. Ann. N.Y. Acad. Sci. 2002, 964, 87–98.
  • Kleter, G.A., Peijnenburg, A.A. Screening of transgenic proteins expressed in transgenic food crops for the presence of short amino acid sequences identical to potential, IgE-binding linear epitopes of allergens. BMC Struct. Biol. 2002, 2–8.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.