Modulation of humoral immune responses and inhibition of proinflammatory cytokines and nitric oxide production by 10-methoxycanthin-6-one

References

• Gokhale, A.B., Damre, A.S., Saraf, M.N. Investigations into the immunomodulatory activity of Argyreia speciosa. J Ethnopharmacol 2003, 84, 109–114.
   PubMed Web of Science ®Google Scholar
• Boscá, L., Zeini, M., Través, P.G., Hortelano, S. Nitric oxide and cell viability in inflammatory cells: a role for NO in macrophage function and fate. Toxicology 2005, 208, 249–258.
   PubMed Web of Science ®Google Scholar
• Schimmer, B.P., Parker, K.L. Adrenocorticotropic hormone; adrenocortical steroids and their synthetic analogs; inhibitors of the synthesis and actions of adrenocortical hormones. In: Hardman, J.G., Limbird, L.E., Goodman, G.A., editors. The Pharmacological Basis of Therapeutics, 10th edition. New York: McGraw-Hill, 2001, pp. 1649–1677.
   Google Scholar
• Jung, H.W., Seo, U.K., Kim, J.H., Leem, K.H., Park, Y.K. Flower extract of Panax notoginseng attenuates lipopolysaccharide-induced inflammatory response via blocking of NF-kappaB signaling pathway in murine macrophages. J Ethnopharmacol 2009, 122, 313–319.
   PubMed Web of Science ®Google Scholar
• Cragg, G.M., Newman, D.J. Antineoplastic agents from natural sources: achievements and future directions. Expert Opin Investig Drugs 2000, 9, 2783–2797.
   PubMed Web of Science ®Google Scholar
• Ammirante, M., Di Giacomo, R., De Martino, L., Rosati, A., Festa, M., Gentilella, A., Pascale, M.C., Belisario, M.A., Leone, A., Turco, M.C., De Feo, V. 1-Methoxy-canthin-6-one induces c-Jun NH2-terminal kinase-dependent apoptosis and synergizes with tumor necrosis factor-related apoptosis-inducing ligand activity in human neoplastic cells of hematopoietic or endodermal origin. Cancer Res 2006, 66, 4385–4393.
   PubMed Web of Science ®Google Scholar
• Siveen, K.S., Kuttan, G. Immunomodulatory and antitumor activity of Aerva lanata ethanolic extract. Immunopharmacol Immunotoxicol 2010.
   PubMed Web of Science ®Google Scholar
• Zapesochnaya, G., Kurkin, V., Okhanov, V., Miroshnikov, A. Canthin-6-one and beta-carboline alkaloids from Aerva lanata. Planta Med 1992, 58, 192–196.
   PubMed Web of Science ®Google Scholar
• King, J. The phosphatases. In: Van Nostrand, D., editor. Practical Clinical Enzymology. London: Nostrand Company Limited, 1965, pp. 91–208.
   Google Scholar
• Bergmeyer, H., Bernt, E. Colorimetric method for aspartate aniline aminotransferases. In: Varley, H., Gowenlock, A., Bell, M., editors. Practical Clinical Biochemistry, 5th edition. London: William Heine-mann Medical Books Ltd., 1980, pp. 741–742.
   Google Scholar
• Toro, G., Ackermann, P. Practical Clinical Chemistry. Boston: Little Brown & Co., 1975, p. 154.
   Google Scholar
• Murray, R. Nonprotein compounds. In: Kaplan, L., Pesce, A., editors. Clinical Chemistry: Theory, Analysis and Co-relation. Toranto: Mosby C.V., 1984, pp. 1230–1268.
   Google Scholar
• Sredni, B., Albeck, M., Kazimirsky, G., Shalit, F. The immunomodulator AS101 administered orally as a chemoprotective and radioprotective agent. Int J Immunopharmacol 1992, 14, 613–619.
   PubMed Web of Science ®Google Scholar
• Bancroft, J.D., Cook, H.C. Manual of Histological Techniques. London: Churchill Livingstone, 1984, p. 274.
   Google Scholar
• Manu, K.A., Kuttan, G. Immunomodulatory activities of punarnavine, an alkaloid from Boerhaavia diffusa. Immunopharmacol Immunotoxicol 2009, 31, 377–387.
   PubMed Web of Science ®Google Scholar
• Hamsa, T.P., Kuttan, G. Ipomoea obscura (L.) enhances the functions of immunological effector cells, inhibits proinflammatory cytokines and nitric oxide production by LPS induced macrophages. Immunopharmacol Immunotoxicol 2009, 31, 222–229.
   PubMed Web of Science ®Google Scholar
• Jerne, N.K., Nordin, A.A. Plaque formation in agar by single antibody-producing cells. Science 1963, 140, 405.
   Web of Science ®Google Scholar
• Stuehr, D.J., Nathan, C.F. Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J Exp Med 1989, 169, 1543–1555.
   PubMed Web of Science ®Google Scholar
• Alexeeff, G.V., Broadwin, R., Liaw, J., Dawson, S.V. Characterization of the LOAEL-to-NOAEL uncertainty factor for mild adverse effects from acute inhalation exposures. Regul Toxicol Pharmacol 2002, 36, 96–105.
   PubMed Web of Science ®Google Scholar
• Pratheeshkumar, P., Kuttan, G. Modulation of immune response by Vernonia cinerea L. inhibits the proinflammatory cytokine profile, iNOS, and COX-2 expression in LPS-stimulated macrophages. Immunopharmacol Immunotoxicol 2010, 1–11.
   Web of Science ®Google Scholar
• Guruvayoorappan, C., Kuttan, G. Immunomodulatory and antitumor activity of Biophytum sensitivum extract. Asian Pac J Cancer Prev 2007, 8, 27–32.
   PubMed Web of Science ®Google Scholar
• Davis, L., Kuttan, G. Immunomodulatory activity of Withania somnifera. J Ethnopharmacol 2000, 71, 193–200.
   PubMed Web of Science ®Google Scholar
• Mathew, S., Kuttan, G. Antioxidant activity of Tinospora cordifolia and its usefulness in the amelioration of cyclophosphamide induced toxicity. J Exp Clin Cancer Res 1997, 16, 407–411.
   PubMed Web of Science ®Google Scholar
• Sunila, E.S., Kuttan, G. Immunomodulatory and antitumor activity of Piper longum Linn. and piperine. J Ethnopharmacol 2004, 90, 339–346.
   PubMed Web of Science ®Google Scholar
• Raphael, T.J., Kuttan, G. Immunomodulatory activity of naturally occurring monoterpenes carvone, limonene, and perillic acid. Immunopharmacol Immunotoxicol 2003, 25, 285–294.
   PubMed Web of Science ®Google Scholar
• Thejass, P., Kuttan, G. Immunomodulatory activity of sulforaphane, a naturally occurring isothiocyanate from broccoli (Brassica oleracea). Phytomedicine 2007, 14, 538–545.
   PubMed Web of Science ®Google Scholar
• Manesh, C., Kuttan, G. Effect of naturally occurring isothiocyanates on the immune system. Immunopharmacol Immunotoxicol 2003, 25, 451–459.
   PubMed Web of Science ®Google Scholar
• Andreakos, E., Foxwell, B., Feldmann, M. Is targeting Toll-like receptors and their signaling pathway a useful therapeutic approach to modulating cytokine-driven inflammation? Immunol Rev 2004, 202, 250–265.
   PubMed Web of Science ®Google Scholar
• Bondeson, J. The mechanisms of action of disease-modifying antirheumatic drugs: a review with emphasis on macrophage signal transduction and the induction of proinflammatory cytokines. Gen Pharmacol 1997, 29, 127–150.
   PubMedGoogle Scholar
• Dinarello, C.A. Biology of interleukin 1. FASEB J 1988, 2, 108–115.
   PubMed Web of Science ®Google Scholar
• Hirano, T. Interleukin-6 and its relation to inflammation and disease. Clin Immunol Immunopathol 1992, 62, S60–S65.
   PubMedGoogle Scholar
• Moncada, S. Nitric oxide: discovery and impact on clinical medicine. J R Soc Med 1999, 92, 164–169.
   PubMed Web of Science ®Google Scholar
• Nathan, C. Nitric oxide as a secretory product of mammalian cells. FASEB J 1992, 6, 3051–3064.
   PubMed Web of Science ®Google Scholar
• Rocca, B., FitzGerald, G.A. Cyclooxygenases and prostaglandins: shaping up the immune response. Int Immunopharmacol 2002, 2, 603–630.
   PubMed Web of Science ®Google Scholar
• Turini, M.E., DuBois, R.N. Cyclooxygenase-2: a therapeutic target. Annu Rev Med 2002, 53, 35–57.
   PubMed Web of Science ®Google Scholar