555
Views
17
CrossRef citations to date
0
Altmetric
Review Article

Siglec-8 and Siglec-F, the new therapeutic targets in asthma

, &
Pages 721-726 | Received 16 May 2011, Accepted 16 May 2011, Published online: 11 Feb 2012

References

  • Gorska, K., Krenke, R., Domagala-Kulawik, J., Korczynski, P., Nejman-Gryz, P., Kosciuch, J., Hildebrand, K., Chazan, R. Comparison of cellular and biochemical markers of airway inflammation in patients with mild-to-moderate asthma and chronic obstructive pulmonary disease: an induced sputum and bronchoalveolar lavage fluid study. J Physiol Pharmacol 2008, 59 Suppl 6, 271–283.
  • Douwes, J., Gibson, P., Pekkanen, J., Pearce, N. Non-eosinophilic asthma: importance and possible mechanisms. Thorax 2002, 57, 643–648.
  • Rothenberg, M.E. Eosinophilia. N Engl J Med 1998, 338, 1592–1600.
  • Kankaanranta, H., Moilanen, E., Zhang, X. Pharmacological regulation of human eosinophil apoptosis. Curr Drug Targets Inflamm Allergy 2005, 4, 433–445.
  • Leckie, M.J., ten Brinke, A., Khan, J., Diamant, Z., O’Connor, B.J., Walls, C.M., Mathur, A.K., Cowley, H.C., Chung, K.F., Djukanovic, R., Hansel, T.T., Holgate, S.T., Sterk, P.J., Barnes, P.J. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 2000, 356, 2144–2148.
  • Green, R.H., Brightling, C.E., Woltmann, G., Parker, D., Wardlaw, A.J., Pavord, I.D. Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax 2002, 57, 875–879.
  • Barthel, S.R., Jarjour, N.N., Mosher, D.F., Johansson, M.W. Dissection of the hyperadhesive phenotype of airway eosinophils in asthma. Am J Respir Cell Mol Biol 2006, 35, 378–386.
  • Powell, L.D., Varki, A. I-type lectins. J Biol Chem 1995, 270, 14243–14246.
  • Crocker, P.R., Clark, E.A., Filbin, M., Gordon, S., Jones, Y., Kehrl, J.H., Kelm, S., Le Douarin, N., Powell, L., Roder, J., Schnaar, R.L., Sgroi, D.C., Stamenkovic, K., Schauer, R., Schachner, M., van den Berg, T.K., van der Merwe, P.A., Watt, S.M., Varki, A. Siglecs: a family of sialic-acid binding lectins. Glycobiology 1998, 8, v.
  • Stamenkovic, I., Seed, B. The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion. Nature 1990, 345, 74–77.
  • von Gunten, S., Bochner, B.S. Basic and clinical immunology of Siglecs. Ann N Y Acad Sci 2008, 1143, 61–82.
  • Crocker, P.R., Varki, A. Siglecs in the immune system. Immunology 2001, 103, 137–145.
  • O’Reilly, M.K., Paulson, J.C. Siglecs as targets for therapy in immune-cell-mediated disease. Trends Pharmacol Sci 2009, 30, 240–248.
  • Crocker, P.R. Siglecs in innate immunity. Curr Opin Pharmacol 2005, 5, 431–437.
  • Zhang, M., Angata, T., Cho, J.Y., Miller, M., Broide, D.H., Varki, A. Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils. Blood 2007, 109, 4280–4287.
  • Bochner, B.S., Alvarez, R.A., Mehta, P., Bovin, N.V., Blixt, O., White, J.R., Schnaar, R.L. Glycan array screening reveals a candidate ligand for Siglec-8. J Biol Chem 2005, 280, 4307–4312.
  • Crocker, P.R. Siglecs: sialic-acid-binding immunoglobulin-like lectins in cell-cell interactions and signalling. Curr Opin Struct Biol 2002, 12, 609–615.
  • Crocker, P.R., Varki, A. Siglecs, sialic acids and innate immunity. Trends Immunol 2001, 22, 337–342.
  • Tedder, T.F., Poe, J.C., Haas, K.M. CD22: a multifunctional receptor that regulates B lymphocyte survival and signal transduction. Adv Immunol 2005, 88, 1–50.
  • Bochner, B.S. Siglec-8 on human eosinophils and mast cells, and Siglec-F on murine eosinophils, are functionally related inhibitory receptors. Clin Exp Allergy 2009, 39, 317–324.
  • Patel, N., Brinkman-Van der Linden, E.C., Altmann, S.W., Gish, K., Balasubramanian, S., Timans, J.C., Peterson, D., Bell, M.P., Bazan, J.F., Varki, A., Kastelein, R.A. OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily. J Biol Chem 1999, 274, 22729–22738.
  • Falco, M., Biassoni, R., Bottino, C., Vitale, M., Sivori, S., Augugliaro, R., Moretta, L., Moretta, A. Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells. J Exp Med 1999, 190, 793–802.
  • Munday, J., Kerr, S., Ni, J., Cornish, A.L., Zhang, J.Q., Nicoll, G., Floyd, H., Mattei, M.G., Moore, P., Liu, D., Crocker, P.R. Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor. Biochem J 2001, 355, 489–497.
  • Whitney, G., Wang, S., Chang, H., Cheng, K.Y., Lu, P., Zhou, X.D., Yang, W.P., McKinnon, M., Longphre, M. A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33. Eur J Biochem 2001, 268, 6083–6096.
  • Aizawa, H., Zimmermann, N., Carrigan, P.E., Lee, J.J., Rothenberg, M.E., Bochner, B.S. Molecular analysis of human Siglec-8 orthologs relevant to mouse eosinophils: identification of mouse orthologs of Siglec-5 (mSiglec-F) and Siglec-10 (mSiglec-G). Genomics 2003, 82, 521–530.
  • Ravetch, J.V., Lanier, L.L. Immune inhibitory receptors. Science 2000, 290, 84–89.
  • Crocker, P.R., Paulson, J.C., Varki, A. Siglecs and their roles in the immune system. Nat Rev Immunol 2007, 7, 255–266.
  • Crocker, P.R., Redelinghuys, P. Siglecs as positive and negative regulators of the immune system. Biochem Soc Trans 2008, 36, 1467–1471.
  • Balaian, L., Zhong, R.K., Ball, E.D. The inhibitory effect of anti-CD33 monoclonal antibodies on AML cell growth correlates with Syk and/or ZAP-70 expression. Exp Hematol 2003, 31, 363–371.
  • Hudson, S.A., Bovin, N.V., Schnaar, R.L., Crocker, P.R., Bochner, B.S. Eosinophil-selective binding and proapoptotic effect in vitro of a synthetic Siglec-8 ligand, polymeric 6′-sulfated sialyl Lewis x. J Pharmacol Exp Ther 2009, 330, 608–612.
  • Lock, K., Zhang, J., Lu, J., Lee, S.H., Crocker, P.R. Expression of CD33-related siglecs on human mononuclear phagocytes, monocyte-derived dendritic cells and plasmacytoid dendritic cells. Immunobiology 2004, 209, 199–207.
  • Zhang, J.Q., Biedermann, B., Nitschke, L., Crocker, P.R. The murine inhibitory receptor mSiglec-E is expressed broadly on cells of the innate immune system whereas mSiglec-F is restricted to eosinophils. Eur J Immunol 2004, 34, 1175–1184.
  • Brinkman-Van der Linden, E.C., Hurtado-Ziola, N., Hayakawa, T., Wiggleton, L., Benirschke, K., Varki, A., Varki, N. Human-specific expression of Siglec-6 in the placenta. Glycobiology 2007, 17, 922–931.
  • Blixt, O., Collins, B.E., van den Nieuwenhof, I.M., Crocker, P.R., Paulson, J.C. Sialoside specificity of the siglec family assessed using novel multivalent probes: identification of potent inhibitors of myelin-associated glycoprotein. J Biol Chem 2003, 278, 31007–31019.
  • Varki, A., Angata, T. Siglecs–the major subfamily of I-type lectins. Glycobiology 2006, 16, 1R–27R.
  • Sonnenburg, J.L., Altheide, T.K., Varki, A. A uniquely human consequence of domain-specific functional adaptation in a sialic acid-binding receptor. Glycobiology 2004, 14, 339–346.
  • Biedermann, B., Gil, D., Bowen, D.T., Crocker, P.R. Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors. Leuk Res 2007, 31, 211–220.
  • Castillo, J., Winer, E., Quesenberry, P. Newer monoclonal antibodies for hematological malignancies. Exp Hematol 2008, 36, 755–768.
  • Kikly, K.K., Bochner, B.S., Freeman, S.D., Tan, K.B., Gallagher, K.T., D’alessio, K.J., Holmes, S.D., Abrahamson, J.A., Erickson-Miller, C.L., Murdock, P.R., Tachimoto, H., Schleimer, R.P., White, J.R. Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils. J Allergy Clin Immunol 2000, 105, 1093–1100.
  • Kumar, V., McNerney, M.E. A new self: MHC-class-I-independent natural-killer-cell self-tolerance. Nat Rev Immunol 2005, 5, 363–374.
  • Zimmermann, N., McBride, M.L., Yamada, Y., Hudson, S.A., Jones, C., Cromie, K.D., Crocker, P.R., Rothenberg, M.E., Bochner, B.S. Siglec-F antibody administration to mice selectively reduces blood and tissue eosinophils. Allergy 2008, 63, 1156–1163.
  • Nutku, E., Aizawa, H., Hudson, S.A., Bochner, B.S. Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis. Blood 2003, 101, 5014–5020.
  • Park, Y.M., Bochner, B.S. Eosinophil survival and apoptosis in health and disease. Allergy Asthma Immunol Res 2010, 2, 87–101.
  • Yokoi, H., Choi, O.H., Hubbard, W., Lee, H.S., Canning, B.J., Lee, H.H., Ryu, S.D., von Gunten, S., Bickel, C.A., Hudson, S.A., Macglashan, D.W. Jr, Bochner, B.S. Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement. J Allergy Clin Immunol 2008, 121, 499–505.e1.
  • Nutku, E., Hudson, S.A., Bochner, B.S. Mechanism of Siglec-8-induced human eosinophil apoptosis: role of caspases and mitochondrial injury. Biochem Biophys Res Commun 2005, 336, 918–924.
  • Rothenberg, M.E., Hogan, S.P. The eosinophil. Annu Rev Immunol 2006, 24, 147–174.
  • Denburg, J.A., Sehmi, R., Saito, H., Pil-Seob, J., Inman, M.D., O’Byrne, P.M. Systemic aspects of allergic disease: bone marrow responses. J Allergy Clin Immunol 2000, 106, S242–S246.
  • Flood-Page, P., Swenson, C., Faiferman, I., Matthews, J., Williams, M., Brannick, L., Robinson, D., Wenzel, S., Busse, W., Hansel, T.T., Barnes, N.C.; International Mepolizumab Study Group. A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma. Am J Respir Crit Care Med 2007, 176, 1062–1071.
  • Flood-Page, P.T., Menzies-Gow, A.N., Kay, A.B., Robinson, D.S. Eosinophil’s role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway. Am J Respir Crit Care Med 2003, 167, 199–204.
  • Simon, H.U. Molecules involved in the regulation of eosinophil apoptosis. Chem Immunol Allergy 2006, 91, 49–58.
  • Zangrilli, J., Robertson, N., Shetty, A., Wu, J., Hastie, A., Fish, J.E., Litwack, G., Peters, S.P. Effect of IL-5, glucocorticoid, and Fas ligation on Bcl-2 homologue expression and caspase activation in circulating human eosinophils. Clin Exp Immunol 2000, 120, 12–21.
  • Dibbert, B., Daigle, I., Braun, D., Schranz, C., Weber, M., Blaser, K., Zangemeister-Wittke, U., Akbar, A.N., Simon, H.U. Role for Bcl-xL in delayed eosinophil apoptosis mediated by granulocyte-macrophage colony-stimulating factor and interleukin-5. Blood 1998, 92, 778–783.
  • Abbas Abul, K., Lichtman Andrew, H., Pillai Shiv.Cellular and Molecular Immunology. ELSEVIER 2007 6th Edition, p 256.
  • Song, D.J., Cho, J.Y., Miller, M., Strangman, W., Zhang, M., Varki, A., Broide, D.H. Anti-Siglec-F antibody inhibits oral egg allergen induced intestinal eosinophilic inflammation in a mouse model. Clin Immunol 2009, 131, 157–169.
  • Nutku-Bilir, E., Hudson, S.A., Bochner, B.S. Interleukin-5 priming of human eosinophils alters siglec-8 mediated apoptosis pathways. Am J Respir Cell Mol Biol 2008, 38, 121–124.
  • Angata, T., Hingorani, R., Varki, N.M., Varki, A. Cloning and characterization of a novel mouse Siglec, mSiglec-F: differential evolution of the mouse and human (CD33) Siglec-3-related gene clusters. J Biol Chem 2001, 276, 45128–45136.
  • Angata, T., Margulies, E.H., Green, E.D., Varki, A. Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms. Proc Natl Acad Sci USA 2004, 101, 13251–13256.
  • Tateno, H., Crocker, P.R., Paulson, J.C. Mouse Siglec-F and human Siglec-8 are functionally convergent paralogs that are selectively expressed on eosinophils and recognize 6′-sulfo-sialyl Lewis X as a preferred glycan ligand. Glycobiology 2005, 15, 1125–1135.
  • Song, D.J., Cho, J.Y., Lee, S.Y., Miller, M., Rosenthal, P., Soroosh, P., Croft, M., Zhang, M., Varki, A., Broide, D.H. Anti-Siglec-F antibody reduces allergen-induced eosinophilic inflammation and airway remodeling. J Immunol 2009, 183, 5333–5341.
  • Kearley, J., Jones, C., McMillan, S.J., Cromie, K., Crocker, P.R., Lloyd, C.M.. Anti-Siglec-F antibody treatment during allergen-induced airway inflammation reduces eosinophil numbers but has no effect on airway hyperreactivity in vivo. Am J Respir Crit Care Med 2007, 175, A690.
  • Tateno, H., Li, H., Schur, M.J., Bovin, N., Crocker, P.R., Wakarchuk, W.W., Paulson, J.C. Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity. Mol Cell Biol 2007, 27, 5699–5710.
  • Floyd, H., Ni, J., Cornish, A.L., Zeng, Z., Liu, D., Carter, K.C., Steel, J., Crocker, P.R. Siglec-8. A novel eosinophil-specific member of the immunoglobulin superfamily. J Biol Chem 2000, 275, 861–866.
  • Guo, J., Myers, A., Choi, O., Lee, H., Zhu, Z., Hudson, S., Brummet, M., Crocker, P.R., Bochner, B.S.. Ligands for Siglec-8 and Siglec-F: binding characteristics and tissue distribution. J Allergy Clin Immunol 2007, 119, S299.
  • Ishida, A., Ohta, M., Toda, M., Murata, T., Usui, T., Akita, K., Inoue, M., Nakada, H. Mucin-induced apoptosis of monocyte-derived dendritic cells during maturation. Proteomics 2008, 8, 3342–3349.
  • Delmotte, P., Degroote, S., Lafitte, J.J., Lamblin, G., Perini, J.M., Roussel, P. Tumor necrosis factor alpha increases the expression of glycosyltransferases and sulfotransferases responsible for the biosynthesis of sialylated and/or sulfated Lewis × epitopes in the human bronchial mucosa. J Biol Chem 2002, 277, 424–431.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.