The deviated balance between regulatory T cell and Th17 in autoimmunity

References

• Murphy, K.M., Reiner, S.L. The lineage decisions of helper T cells. Nat Rev Immunol 2002, 2, 933–944.
   PubMed Web of Science ®Google Scholar
• Abbas, A.K., Murphy, K.M., Sher, A. Functional diversity of helper T lymphocytes. Nature 1996, 383, 787–793.
   PubMed Web of Science ®Google Scholar
• Gershon, R.K., Kondo, K. Cell interactions in the induction of tolerance: the role of thymic lymphocytes. Immunology 1970, 18, 723–737.
   PubMed Web of Science ®Google Scholar
• Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M., Toda, M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995, 155, 1151–1164.
   PubMed Web of Science ®Google Scholar
• Jonuleit, H., Schmitt, E. The regulatory T cell family: distinct subsets and their interrelations. J Immunol 2003, 171, 6323–6327.
   PubMed Web of Science ®Google Scholar
• Vignali, D.A., Collison, L.W., Workman, C.J. How regulatory T cells work. Nat Rev Immunol 2008, 8, 523–532.
   PubMed Web of Science ®Google Scholar
• Vignali, D. How many mechanisms do regulatory T cells need? Eur J Immunol 2008, 38, 908–911.
   PubMed Web of Science ®Google Scholar
• Chen, Z., O’Shea, J.J. Th17 cells: a new fate for differentiating helper T cells. Immunol Res 2008, 41, 87–102.
   PubMed Web of Science ®Google Scholar
• Jäger, A., Kuchroo, V.K. Effector and regulatory T-cell subsets in autoimmunity and tissue inflammation. Scand J Immunol 2010, 72, 173–184.
   PubMed Web of Science ®Google Scholar
• Nowak, E.C., Noelle, R.J. Interleukin-9 and T cell subsets. Cell Cycle 2009, 8, 3798–3799.
   PubMed Web of Science ®Google Scholar
• Okada, R., Kondo, T., Matsuki, F., Takata, H., Takiguchi, M. Phenotypic classification of human CD4+ T cell subsets and their differentiation. Int Immunol 2008, 20, 1189–1199.
   PubMedGoogle Scholar
• Rolf, J., Fairfax, K., Turner, M. Signaling pathways in T follicular helper cells. J Immunol 2010, 184, 6563–6568.
   Google Scholar
• Laurent, C., Fazilleau, N., Brousset, P. A novel subset of T-helper cells: follicular T-helper cells and their markers. Haematologica 2010, 95, 356–358.
   PubMedGoogle Scholar
• Long, M., Park, S.G., Strickland, I., Hayden, M.S., Ghosh, S. Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor. Immunity 2009, 31, 921–931.
   PubMed Web of Science ®Google Scholar
• Hori, S.. c-Rel: a pioneer in directing regulatory T cell lineage commitment? Eur J Immunol 2010,40, 664–667.
   PubMedGoogle Scholar
• Zheng, Y., Josefowicz, S., Chaudhry, A., Peng, X.P., Forbush, K., Rudensky, A.Y. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 2010, 463, 808–812.
   PubMed Web of Science ®Google Scholar
• Fontenot, J.D., Gavin, M.A., Rudensky, A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003, 4, 330–336.
   PubMed Web of Science ®Google Scholar
• Gavin, M.A., Rasmussen, J.P., Fontenot, J.D., Vasta, V., Manganiello, V.C., Beavo, J.A., Rudensky, A.Y. Foxp3-dependent programme of regulatory T-cell differentiation. Nature 2007, 445, 771–775.
   PubMed Web of Science ®Google Scholar
• Roncarolo, M.G., Gregori, S. Is FOXP3 a bona fide marker for human regulatory T cells? Eur J Immunol 2008, 38, 925–927.
   PubMed Web of Science ®Google Scholar
• Liu, W., Putnam, A.L., Xu-Yu, Z., Szot, G.L., Lee, M.R., Zhu, S., Gottlieb, P.A., Kapranov, P., Gingeras, T.R., Fazekas de St Groth, B., Clayberger, C., Soper, D.M., Ziegler, S.F., Bluestone, J.A. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 2006, 203, 1701–1711.
   PubMed Web of Science ®Google Scholar
• Sakaguchi, S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 2005, 6, 345–352.
   PubMed Web of Science ®Google Scholar
• Sakaguchi, S., Miyara, M., Costantino, C.M., Hafler, D.A. FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol 2010, 10, 490–500.
   PubMed Web of Science ®Google Scholar
• Shevach, E.M. CD4+ CD25+ suppressor T cells: more questions than answers. Nat Rev Immunol 2002, 2, 389–400.
   PubMed Web of Science ®Google Scholar
• Feger, U., Tolosa, E., Huang, Y.H., Waschbisch, A., Biedermann, T., Melms, A., Wiendl, H. HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation. Blood 2007, 110, 568–577.
   PubMed Web of Science ®Google Scholar
• Wiendl, H., Feger, U., Mittelbronn, M., Jack, C., Schreiner, B., Stadelmann, C., Antel, J., Brueck, W., Meyermann, R., Bar-Or, A., Kieseier, B.C., Weller, M. Expression of the immune-tolerogenic major histocompatibility molecule HLA-G in multiple sclerosis: implications for CNS immunity. Brain 2005, 128, 2689–2704.
   PubMed Web of Science ®Google Scholar
• Bacchetta, R., Sartirana, C., Levings, M.K., Bordignon, C., Narula, S., Roncarolo, M.G. Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines. Eur J Immunol 2002, 32, 2237–2245.
   PubMed Web of Science ®Google Scholar
• Roncarolo, M.G., Gregori, S., Battaglia, M., Bacchetta, R., Fleischhauer, K., Levings, M.K. Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Immunol Rev 2006, 212, 28–50.
   PubMed Web of Science ®Google Scholar
• Roncarolo, M.G., Bacchetta, R., Bordignon, C., Narula, S., Levings, M.K. Type 1 T regulatory cells. Immunol Rev 2001, 182, 68–79.
   PubMed Web of Science ®Google Scholar
• Levings, M.K., Sangregorio, R., Galbiati, F., Squadrone, S., de Waal Malefyt, R., Roncarolo, M.G. IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells. J Immunol 2001, 166, 5530–5539.
   PubMed Web of Science ®Google Scholar
• Weiner, H.L. Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells. Immunol Rev 2001, 182, 207–214.
   PubMed Web of Science ®Google Scholar
• Fukaura, H., Kent, S.C., Pietrusewicz, M.J., Khoury, S.J., Weiner, H.L., Hafler, D.A. Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients. J Clin Invest 1996, 98, 70–77.
   PubMed Web of Science ®Google Scholar
• Faria, A.M., Weiner, H.L. Oral tolerance. Immunol Rev 2005, 206, 232–259.
   PubMed Web of Science ®Google Scholar
• Takahashi, T., Tagami, T., Yamazaki, S., Uede, T., Shimizu, J., Sakaguchi, N., Mak, T.W., Sakaguchi, S. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med 2000, 192, 303–310.
   PubMed Web of Science ®Google Scholar
• Carrier, Y., Yuan, J., Kuchroo, V.K., Weiner, H.L. Th3 cells in peripheral tolerance. I. Induction of Foxp3-positive regulatory T cells by Th3 cells derived from TGF-beta T cell-transgenic mice. J Immunol 2007, 178, 179–185.
   PubMed Web of Science ®Google Scholar
• Filaci, G., Fenoglio, D., Fravega, M., Ansaldo, G., Borgonovo, G., Traverso, P., Villaggio, B., Ferrera, A., Kunkl, A., Rizzi, M., Ferrera, F., Balestra, P., Ghio, M., Contini, P., Setti, M., Olive, D., Azzarone, B., Carmignani, G., Ravetti, J.L., Torre, G., Indiveri, F. CD8+ CD28- T regulatory lymphocytes inhibiting T cell proliferative and cytotoxic functions infiltrate human cancers. J Immunol 2007, 179, 4323–4334.
   PubMed Web of Science ®Google Scholar
• Kiniwa, Y., Miyahara, Y., Wang, H.Y., Peng, W., Peng, G., Wheeler, T.M., Thompson, T.C., Old, L.J., Wang, R.F. CD8+ Foxp3+ regulatory T cells mediate immunosuppression in prostate cancer. Clin Cancer Res 2007, 13, 6947–6958.
   PubMed Web of Science ®Google Scholar
• Cosmi, L., Liotta, F., Lazzeri, E., Francalanci, M., Angeli, R., Mazzinghi, B., Santarlasci, V., Manetti, R., Vanini, V., Romagnani, P., Maggi, E., Romagnani, S., Annunziato, F. Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes. Blood 2003, 102, 4107–4114.
   PubMed Web of Science ®Google Scholar
• Smith, T.R., Kumar, V. Revival of CD8+ Treg-mediated suppression. Trends Immunol 2008, 29, 337–342.
   PubMed Web of Science ®Google Scholar
• Xystrakis, E., Dejean, A.S., Bernard, I., Druet, P., Liblau, R., Gonzalez-Dunia, D., Saoudi, A. Identification of a novel natural regulatory CD8 T-cell subset and analysis of its mechanism of regulation. Blood 2004, 104, 3294–3301.
   PubMed Web of Science ®Google Scholar
• Bettelli, E., Korn, T., Kuchroo, V.K. Th17: the third member of the effector T cell trilogy. Curr Opin Immunol 2007, 19, 652–657.
   PubMed Web of Science ®Google Scholar
• Weaver, C.T., Harrington, L.E., Mangan, P.R., Gavrieli, M., Murphy, K.M. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 2006, 24, 677–688.
   PubMed Web of Science ®Google Scholar
• Kawaguchi, M., Adachi, M., Oda, N., Kokubu, F., Huang, S.K. IL-17 cytokine family. J Allergy Clin Immunol 2004, 114, 1265–73; quiz 1274.
   Google Scholar
• Kolls, J.K., Lindén, A. Interleukin-17 family members and inflammation. Immunity 2004, 21, 467–476.
   PubMed Web of Science ®Google Scholar
• Jadidi-Niaragh, F., Mirshafiey, A. Th17 cell, the new player of neuroinflammatory process in multiple sclerosis. Scand J Immunol 2011, 74, 1–13.
   PubMed Web of Science ®Google Scholar
• Acosta-Rodriguez, E.V., Rivino, L., Geginat, J., Jarrossay, D., Gattorno, M., Lanzavecchia, A., Sallusto, F., Napolitani, G. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat Immunol 2007, 8, 639–646.
   PubMed Web of Science ®Google Scholar
• Annunziato, F., Cosmi, L., Santarlasci, V., Maggi, L., Liotta, F., Mazzinghi, B., Parente, E., Filì, L., Ferri, S., Frosali, F., Giudici, F., Romagnani, P., Parronchi, P., Tonelli, F., Maggi, E., Romagnani, S. Phenotypic and functional features of human Th17 cells. J Exp Med 2007, 204, 1849–1861.
   PubMed Web of Science ®Google Scholar
• Annunziato, F., Cosmi, L., Liotta, F., Maggi, E., Romagnani, S. The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation. Int Immunol 2008, 20, 1361–1368.
   PubMed Web of Science ®Google Scholar
• Das, J., Ren, G., Zhang, L., Roberts, A.I., Zhao, X., Bothwell, A.L., Van Kaer, L., Shi, Y., Das, G. Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation. J Exp Med 2009, 206, 2407–2416.
   PubMed Web of Science ®Google Scholar
• Ghoreschi, K., Laurence, A., Yang, X.P., Tato, C.M., McGeachy, M.J., Konkel, J.E., Ramos, H.L., Wei, L., Davidson, T.S., Bouladoux, N., Grainger, J.R., Chen, Q., Kanno, Y., Watford, W.T., Sun, H.W., Eberl, G., Shevach, E.M., Belkaid, Y., Cua, D.J., Chen, W., O’Shea, J.J. Generation of pathogenic T(H)17 cells in the absence of TGF-ß signalling. Nature 2010, 467, 967–971.
   PubMed Web of Science ®Google Scholar
• Korn, T., Bettelli, E., Gao, W., Awasthi, A., Jäger, A., Strom, T.B., Oukka, M., Kuchroo, V.K. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 2007, 448, 484–487.
   PubMed Web of Science ®Google Scholar
• Nurieva, R., Yang, X.O., Martinez, G., Zhang, Y., Panopoulos, A.D., Ma, L., Schluns, K., Tian, Q., Watowich, S.S., Jetten, A.M., Dong, C. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 2007, 448, 480–483.
   PubMed Web of Science ®Google Scholar
• Zhou, L., Ivanov, I.I., Spolski, R., Min, R., Shenderov, K., Egawa, T., Levy, D.E., Leonard, W.J., Littman, D.R. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 2007, 8, 967–974.
   PubMed Web of Science ®Google Scholar
• Wei, L., Laurence, A., Elias, K.M., O’Shea, J.J. IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem 2007, 282, 34605–34610.
   PubMed Web of Science ®Google Scholar
• Unutmas, D.. RORC2: the master of human Th17 cell programming. Eur J Immunol 2009, 39, 1452–1455.
   Google Scholar
• Ivanov, I.I., McKenzie, B.S., Zhou, L., Tadokoro, C.E., Lepelley, A., Lafaille, J.J., Cua, D.J., Littman, D.R. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 2006, 126, 1121–1133.
   PubMed Web of Science ®Google Scholar
• Yang, X.O., Panopoulos, A.D., Nurieva, R., Chang, S.H., Wang, D., Watowich, S.S., Dong, C. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J Biol Chem 2007, 282, 9358–9363.
   PubMed Web of Science ®Google Scholar
• Kimura, A., Naka, T., Nohara, K., Fujii-Kuriyama, Y., Kishimoto, T. Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells. Proc Natl Acad Sci USA 2008, 105, 9721–9726.
   PubMed Web of Science ®Google Scholar
• Brüstle, A., Heink, S., Huber, M., Rosenplänter, C., Stadelmann, C., Yu, P., Arpaia, E., Mak, T.W., Kamradt, T., Lohoff, M. The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Nat Immunol 2007, 8, 958–966.
   PubMed Web of Science ®Google Scholar
• Hirota, K., Martin, B., Veldhoen, M.. Development, regulation and functional capacities of Th17 cells. Semin Immunopathol 2010, 32, 3–16.
   PubMed Web of Science ®Google Scholar
• Li, M.O., Wan, Y.Y., Flavell, R.A. T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity 2007, 26, 579–591.
   PubMed Web of Science ®Google Scholar
• Niu, Q., Huang, Z.C., Cai, B., Wang, L.L., Feng, W.H. [Study on ratio imbalance of peripheral blood Th17/Treg cells in patients with rheumatoid arthritis]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2010, 26, 267–9, 272.
   Google Scholar
• Hofstetter, H., Gold, R., Hartung, H.P. Th17 Cells in MS and Experimental Autoimmune Encephalomyelitis. Int MS J 2009, 16, 12–18.
   PubMedGoogle Scholar
• Brucklacher-Waldert, V., Stuerner, K., Kolster, M., Wolthausen, J., Tolosa, E. Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis. Brain 2009, 132, 3329–3341.
   PubMed Web of Science ®Google Scholar
• O’Connor, R.A., Anderton, S.M. Foxp3+ regulatory T cells in the control of experimental CNS autoimmune disease. J Neuroimmunol 2008, 193, 1–11.
   PubMed Web of Science ®Google Scholar
• Tennakoon, D.K., Mehta, R.S., Ortega, S.B., Bhoj, V., Racke, M.K., Karandikar, N.J. Therapeutic induction of regulatory, cytotoxic CD8+ T cells in multiple sclerosis. J Immunol 2006, 176, 7119–7129.
   PubMed Web of Science ®Google Scholar
• Vandenbark, A.A., Huan, J., Agotsch, M., La Tocha, D., Goelz, S., Offner, H., Lanker, S., Bourdette, D. Interferon-beta-1a treatment increases CD56bright natural killer cells and CD4+CD25+ Foxp3 expression in subjects with multiple sclerosis. J Neuroimmunol 2009, 215, 125–128.
   PubMed Web of Science ®Google Scholar
• Olivito, B., Simonini, G., Ciullini, S., Moriondo, M., Betti, L., Gambineri, E., Cantarini, L., De Martino, M., Azzari, C., Cimaz, R. Th17 transcription factor RORC2 is inversely correlated with FOXP3 expression in the joints of children with juvenile idiopathic arthritis. J Rheumatol 2009, 36, 2017–2024.
   PubMed Web of Science ®Google Scholar
• Feger, U., Luther, C., Poeschel, S., Melms, A., Tolosa, E., Wiendl, H. Increased frequency of CD4+ CD25+ regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients. Clin Exp Immunol 2007, 147, 412–418.
   PubMed Web of Science ®Google Scholar
• Haas, J., Hug, A., Viehöver, A., Fritzsching, B., Falk, C.S., Filser, A., Vetter, T., Milkova, L., Korporal, M., Fritz, B., Storch-Hagenlocher, B., Krammer, P.H., Suri-Payer, E., Wildemann, B. Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis. Eur J Immunol 2005, 35, 3343–3352.
   PubMed Web of Science ®Google Scholar
• Saresella, M., Marventano, I., Longhi, R., Lissoni, F., Trabattoni, D., Mendozzi, L., Caputo, D., Clerici, M. CD4+CD25+FoxP3+PD1- regulatory T cells in acute and stable relapsing-remitting multiple sclerosis and their modulation by therapy. FASEB J 2008, 22, 3500–3508.
   PubMed Web of Science ®Google Scholar
• Jadidi-Niaragh, F., Mirshafiey, A. Regulatory T-cell as orchestra leader in immunosuppression process of multiple sclerosis. Immunopharmacol Immunotoxicol 2011, 33, 545–567.
   PubMed Web of Science ®Google Scholar
• Valmori, D., Raffin, C., Raimbaud, I., Ayyoub, M. Human ROR?t+ TH17 cells preferentially differentiate from naive FOXP3+Treg in the presence of lineage-specific polarizing factors. Proc Natl Acad Sci USA 2010, 107, 19402–19407.
   PubMed Web of Science ®Google Scholar
• Tartar, D.M., VanMorlan, A.M., Wan, X., Guloglu, F.B., Jain, R., Haymaker, C.L., Ellis, J.S., Hoeman, C.M., Cascio, J.A., Dhakal, M., Oukka, M., Zaghouani, H. FoxP3+RORgammat+ T helper intermediates display suppressive function against autoimmune diabetes. J Immunol 2010, 184, 3377–3385.
   Google Scholar
• Hatton, R.D., Weaver, C.T. Duality in the Th17-Treg developmental decision. F1000 Biol Rep 2009, 1, 5.
   Google Scholar
• Yang, X.O., Nurieva, R., Martinez, G.J., Kang, H.S., Chung, Y., Pappu, B.P., Shah, B., Chang, S.H., Schluns, K.S., Watowich, S.S., Feng, X.H., Jetten, A.M., Dong, C. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 2008, 29, 44–56.
   PubMed Web of Science ®Google Scholar
• Zhou, L., Lopes, J.E., Chong, M.M., Ivanov, I.I., Min, R., Victora, G.D., Shen, Y., Du, J., Rubtsov, Y.P., Rudensky, A.Y., Ziegler, S.F., Littman, D.R. TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature 2008, 453, 236–240.
   PubMed Web of Science ®Google Scholar
• Chen, Z., Laurence, A., O’Shea, J.J. Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation. Semin Immunol 2007, 19, 400–408.
   PubMed Web of Science ®Google Scholar
• Xu, L., Kitani, A., Fuss, I., Strober, W. Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta. J Immunol 2007, 178, 6725–6729.
   PubMed Web of Science ®Google Scholar
• Dardalhon, V., Awasthi, A., Kwon, H., Galileos, G., Gao, W., Sobel, R.A., Mitsdoerffer, M., Strom, T.B., Elyaman, W., Ho, I.C., Khoury, S., Oukka, M., Kuchroo, V.K. IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol 2008, 9, 1347–1355.
   PubMed Web of Science ®Google Scholar
• Elyaman, W., Bradshaw, E.M., Uyttenhove, C., Dardalhon, V., Awasthi, A., Imitola, J., Bettelli, E., Oukka, M., van Snick, J., Renauld, J.C., Kuchroo, V.K., Khoury, S.J. IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells. Proc Natl Acad Sci USA 2009, 106, 12885–12890.
   PubMed Web of Science ®Google Scholar
• Locksley, R.M. Nine lives: plasticity among T helper cell subsets. J Exp Med 2009, 206, 1643–1646.
   PubMed Web of Science ®Google Scholar
• Wan, Y.Y., Flavell, R.A. TGF-beta and regulatory T cell in immunity and autoimmunity. J Clin Immunol 2008, 28, 647–659.
   PubMed Web of Science ®Google Scholar
• Mirshafiey, A., Mohsenzadegan, M. TGF-beta as a promising option in the treatment of multiple sclerosis. Neuropharmacology 2009, 56, 929–936.
   PubMed Web of Science ®Google Scholar
• Jadidi-Niaragh, F., Mirshafiey, A. Histamine and histamine receptors in pathogenesis and treatment of multiple sclerosis. Neuropharmacology 2010, 59, 180–189.
   PubMed Web of Science ®Google Scholar
• Lu, L., Wang, J., Zhang, F., Chai, Y., Brand, D., Wang, X., Horwitz, D.A., Shi, W., Zheng, S.G. Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells. J Immunol 2010, 184, 4295–4306.
   PubMed Web of Science ®Google Scholar
• Maitra, U., Davis, S., Reilly, C.M., Li, L. Differential regulation of Foxp3 and IL-17 expression in CD4 T helper cells by IRAK-1. J Immunol 2009, 182, 5763–5769.
   PubMed Web of Science ®Google Scholar
• Mucida, D., Park, Y., Kim, G., Turovskaya, O., Scott, I., Kronenberg, M., Cheroutre, H. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 2007, 317, 256–260.
   PubMed Web of Science ®Google Scholar
• Chen, Z., Tato, C.M., Muul, L., Laurence, A., O’Shea, J.J. Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum 2007, 56, 2936–2946.
   PubMed Web of Science ®Google Scholar
• Aukrust, P., Müller, F., Ueland, T., Svardal, A.M., Berge, R.K., Frøland, S.S. Decreased vitamin A levels in common variable immunodeficiency: vitamin A supplementation in vivo enhances immunoglobulin production and downregulates inflammatory responses. Eur J Clin Invest 2000, 30, 252–259.
   PubMed Web of Science ®Google Scholar
• Kinoshita, K., Yoo, B.S., Nozaki, Y., Sugiyama, M., Ikoma, S., Ohno, M., Funauchi, M., Kanamaru, A. Retinoic acid reduces autoimmune renal injury and increases survival in NZB/W F1 mice. J Immunol 2003, 170, 5793–5798.
   PubMed Web of Science ®Google Scholar
• Bai, A., Lu, N., Guo, Y., Liu, Z., Chen, J., Peng, Z. All-trans retinoic acid down-regulates inflammatory responses by shifting the Treg/Th17 profile in human ulcerative and murine colitis. J Leukoc Biol 2009, 86, 959–969.
   PubMed Web of Science ®Google Scholar
• Klemann, C., Raveney, B.J., Klemann, A.K., Ozawa, T., von Hörsten, S., Shudo, K., Oki, S., Yamamura, T. Synthetic retinoid AM80 inhibits Th17 cells and ameliorates experimental autoimmune encephalomyelitis. Am J Pathol 2009, 174, 2234–2245.
   PubMed Web of Science ®Google Scholar
• Van, Y.H., Lee, W.H., Ortiz, S., Lee, M.H., Qin, H.J., Liu, C.P. All-trans retinoic acid inhibits type 1 diabetes by T regulatory (Treg)-dependent suppression of interferon-gamma-producing T-cells without affecting Th17 cells. Diabetes 2009, 58, 146–155.
   PubMed Web of Science ®Google Scholar
• van den Brandt, J., Fischer, H.J., Walter, L., Hünig, T., Klöting, I., Reichardt, H.M. Type 1 diabetes in BioBreeding rats is critically linked to an imbalance between Th17 and regulatory T cells and an altered TCR repertoire. J Immunol 2010, 185, 2285–2294.
   Google Scholar
• Lundsgaard, D., Holm, T.L., Hornum, L., Markholst, H. In vivo control of diabetogenic T-cells by regulatory CD4+CD25+ T-cells expressing Foxp3. Diabetes 2005, 54, 1040–1047.
   PubMed Web of Science ®Google Scholar
• Poussier, P., Ning, T., Murphy, T., Dabrowski, D., Ramanathan, S. Impaired post-thymic development of regulatory CD4 + 25+ T cells contributes to diabetes pathogenesis in BB rats. J Immunol 2005, 174, 4081–4089.
   Google Scholar
• Honkanen, J., Nieminen, J.K., Gao, R., Luopajarvi, K., Salo, H.M., Ilonen, J., Knip, M., Otonkoski, T., Vaarala, O. IL-17 immunity in human type 1 diabetes. J Immunol 2010, 185, 1959–1967.
   PubMed Web of Science ®Google Scholar
• Xiao, S., Jin, H., Korn, T., Liu, S.M., Oukka, M., Lim, B., Kuchroo, V.K. Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression. J Immunol 2008, 181, 2277–2284.
   PubMed Web of Science ®Google Scholar
• Elias, K.M., Laurence, A., Davidson, T.S., Stephens, G., Kanno, Y., Shevach, E.M., O’Shea, J.J. Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway. Blood 2008, 111, 1013–1020.
   PubMed Web of Science ®Google Scholar
• Schambach, F., Schupp, M., Lazar, M.A., Reiner, S.L. Activation of retinoic acid receptor-alpha favours regulatory T cell induction at the expense of IL-17-secreting T helper cell differentiation. Eur J Immunol 2007, 37, 2396–2399.
   PubMed Web of Science ®Google Scholar
• Locke, N.R., Patterson, S.J., Hamilton, M.J., Sly, L.M., Krystal, G., Levings, M.K. SHIP regulates the reciprocal development of T regulatory and Th17 cells. J Immunol 2009, 183, 975–983.
   PubMed Web of Science ®Google Scholar
• Chen, H., Qin, J., Wei, P., Zhang, J., Li, Q., Fu, L., Li, S., Ma, C., Cong, B. Effects of leukotriene B4 and prostaglandin E2 on the differentiation of murine Foxp3+ T regulatory cells and Th17 cells. Prostaglandins Leukot Essent Fatty Acids 2009, 80, 195–200.
   PubMed Web of Science ®Google Scholar
• Mirshafiey, A., Jadidi-Niaragh, F. Immunopharmacological role of the leukotriene receptor antagonists and inhibitors of leukotrienes generating enzymes in multiple sclerosis. Immunopharmacol Immunotoxicol 2010, 32, 219–227.
   PubMed Web of Science ®Google Scholar
• Mirshafiey, A., Jadidi-Niaragh, F. Prostaglandins in pathogenesis and treatment of multiple sclerosis. Immunopharmacol Immunotoxicol 2010, 32, 543–554.
   PubMed Web of Science ®Google Scholar
• Li, Q., Wang, Y., Chen, K., Zhou, Q., Wei, W., Wang, Y., Wang, Y. The role of oxidized low-density lipoprotein in breaking peripheral Th17/Treg balance in patients with acute coronary syndrome. Biochem Biophys Res Commun 2010, 394, 836–842.
   PubMedGoogle Scholar
• Reynolds, A.D., Stone, D.K., Hutter, J.A., Benner, E.J., Mosley, R.L., Gendelman, H.E. Regulatory T cells attenuate Th17 cell-mediated nigrostriatal dopaminergic neurodegeneration in a model of Parkinson’s disease. J Immunol 2010, 184, 2261–2271.
   PubMed Web of Science ®Google Scholar
• Fletcher, J.M., Lonergan, R., Costelloe, L., Kinsella, K., Moran, B., O’Farrelly, C., Tubridy, N., Mills, K.H. CD39+Foxp3+ regulatory T Cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis. J Immunol 2009, 183, 7602–7610.
   PubMed Web of Science ®Google Scholar
• Du, J., Huang, C., Zhou, B., Ziegler, S.F. Isoform-specific inhibition of ROR alpha-mediated transcriptional activation by human FOXP3. J Immunol 2008, 180, 4785–4792.
   PubMed Web of Science ®Google Scholar
• Ayyoub, M., Deknuydt, F., Raimbaud, I., Dousset, C., Leveque, L., Bioley, G., Valmori, D. Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the T(H)17 lineage-specific transcription factor RORgamma t. Proc Natl Acad Sci USA 2009, 106, 8635–8640.
   PubMed Web of Science ®Google Scholar
• Ichiyama, K., Yoshida, H., Wakabayashi, Y., Chinen, T., Saeki, K., Nakaya, M., Takaesu, G., Hori, S., Yoshimura, A., Kobayashi, T. Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat. J Biol Chem 2008, 283, 17003–17008.
   PubMed Web of Science ®Google Scholar
• Osorio, F., LeibundGut-Landmann, S., Lochner, M., Lahl, K., Sparwasser, T., Eberl, G., Reis e Sousa, C. DC activated via dectin-1 convert Treg into IL-17 producers. Eur J Immunol 2008, 38, 3274–3281.
   PubMed Web of Science ®Google Scholar
• Koenen, H.J., Smeets, R.L., Vink, P.M., van Rijssen, E., Boots, A.M., Joosten, I. Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells. Blood 2008, 112, 2340–2352.
   PubMed Web of Science ®Google Scholar
• Floess, S., Freyer, J., Siewert, C., Baron, U., Olek, S., Polansky, J., Schlawe, K., Chang, H.D., Bopp, T., Schmitt, E., Klein-Hessling, S., Serfling, E., Hamann, A., Huehn, J. Epigenetic control of the foxp3 locus in regulatory T cells. PLoS Biol 2007, 5, e38.
   PubMed Web of Science ®Google Scholar
• Janson, P.C., Winerdal, M.E., Marits, P., Thörn, M., Ohlsson, R., Winqvist, O. FOXP3 promoter demethylation reveals the committed Treg population in humans. PLoS ONE 2008, 3, e1612.
   PubMed Web of Science ®Google Scholar
• Afzali, B., Mitchell, P., Lechler, R.I., John, S., Lombardi, G. Translational mini-review series on Th17 cells: induction of interleukin-17 production by regulatory T cells. Clin Exp Immunol 2010, 159, 120–130.
   PubMed Web of Science ®Google Scholar
• Zheng, S.G., Wang, J., Horwitz, D.A. Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6. J Immunol 2008, 180, 7112–7116.
   PubMed Web of Science ®Google Scholar
• Chung, Y., Chang, S.H., Martinez, G.J., Yang, X.O., Nurieva, R., Kang, H.S., Ma, L., Watowich, S.S., Jetten, A.M., Tian, Q., Dong, C. Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity 2009, 30, 576–587.
   PubMed Web of Science ®Google Scholar
• Pène, J., Chevalier, S., Preisser, L., Vénéreau, E., Guilleux, M.H., Ghannam, S., Molès, J.P., Danger, Y., Ravon, E., Lesaux, S., Yssel, H., Gascan, H. Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J Immunol 2008, 180, 7423–7430.
   PubMed Web of Science ®Google Scholar
• Beriou, G., Costantino, C.M., Ashley, C.W., Yang, L., Kuchroo, V.K., Baecher-Allan, C., Hafler, D.A. IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood 2009, 113, 4240–4249.
   PubMed Web of Science ®Google Scholar
• Wright, G.P., Ehrenstein, M.R., Stauss, H.J. Regulatory T-cell adoptive immunotherapy: potential for treatment of autoimmunity. Expert Rev Clin Immunol 2011, 7, 213–225.
   PubMed Web of Science ®Google Scholar
• Hansen, W., Westendorf, A.M., Buer, J. Regulatory T cells as targets for immunotherapy of autoimmunity and inflammation. Inflamm Allergy Drug Targets 2008, 7, 217–223.
   Google Scholar
• Haak, S., Gyülveszi, G., Becher, B. Th17 cells in autoimmune disease: changing the verdict. Immunotherapy 2009, 1, 199–203.
   Google Scholar