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Short Communication

Biologically relevant doses of mixed aflatoxins B and G up-regulate MyD88, TLR2, TLR4 and CD14 transcripts in human PBMCs

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Pages 528-532 | Received 09 Mar 2013, Accepted 06 May 2013, Published online: 21 Jun 2013

References

  • Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell 2010;140:805–820
  • Liu Y, Wu F. Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment. Environ Health Perspect 2010;118:818–824
  • Mehrzad J, Klein G, Kamphues J, et al. In vitro effects of very low levels of aflatoxin B on free radicals production and bactericidal activity of bovine blood neutrophils. Vet Immunol Immunopathol 2011;141:16–25
  • Wogan GN, Paglialunga S, Newberne PM. Carcinogenic effects of low dietary levels of aflatoxin B1 in rats. Food Cosmet Toxicol 1974;12:681–685
  • Hardin BD, Robbins CA, Fallah P, Kelman BJ. The concentration of no toxicologic concern (CoNTC) and airborne mycotoxins. J Toxicol Environ Health A 2009;72:585–598
  • Tchana AN, Moundipa PF, Tchouanguep FM. Aflatoxin contamination in food and body fluids in relation to malnutrition and cancer status in Cameroon. Int J Environ Res Public Health 2010;7:178–188
  • Carnaghan RB, Hartley RD, O'Kelly J. Toxicity and fluorescence properties of the aflatoxins. Nature 1963;200:1101
  • Rawal S, Kim JE, Coulombe R Jr. Aflatoxin B1 in poultry: Toxicology, metabolism and prevention. Res Vet Sci 2010;89:325–331
  • Shuaib FM, Ehiri J, Abdullahi A, et al. Reproductive health effects of aflatoxins: a review of the literature. Reprod Toxicol 2010;29:262–270
  • Wang X, Spandidos A, Wang H, Seed B. PrimerBank: A PCR primer database for quantitative gene expression analysis, 2012 update. Nucleic Acids Res 2012;40:D1144–D1149
  • Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 2008;3:1101–1108
  • Mehrzad J, Dosogne H, Vangroenweghe F, Burvenich C. A comparative study of bovine blood and milk neutrophil functions with luminol-dependent chemiluminescence. Luminescence 2001;16:343–356
  • Gursoy-Yuzugullu O, Yuzugullu H, Yilmaz M, Ozturk M. Aflatoxin genotoxicity is associated with a defective DNA damage response bypassing p53 activation. Liver Int 2011;31:561–571
  • Bernabucci U, Colavecchia L, Danieli PP, et al. Aflatoxin B1 and fumonisin B1 affect the oxidative status of bovine peripheral blood mononuclear cells. Toxicol In Vitro 2011;25:684–691
  • Kim HM, Park BS, Kim JI, et al. Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell 2007;130:906–917
  • Ubagai T, Tansho S, Ito T, Ono Y. Influences of aflatoxin B1 on reactive oxygen species generation and chemotaxis of human polymorphonuclear leukocytes. Toxicol In Vitro 2008;22:1115–1120
  • Schutze N, Lehmann I, Bonisch U, et al. Exposure to mycotoxins increases the allergic immune response in a murine asthma model. Am J Respir Crit Care Med 2010;181:1188–1199
  • Meissonnier GM, Pinton P, Laffitte J, et al. Immunotoxicity of aflatoxin B1: impairment of the cell-mediated response to vaccine antigen and modulation of cytokine expression. Toxicol Appl Pharmacol 2008;231:142–149
  • Dunne A, Marshall NA, Mills KH. TLR based therapeutics. Curr Opin Pharmacol 2011;11:404–411
  • Amici M, Cecarini V, Pettinari A, et al. Binding of aflatoxins to the 20S proteasome: effects on enzyme functionality and implications for oxidative stress and apoptosis. Biol Chem 2007;388:107–117
  • Winzler C, Fantinato M, Giordan M, et al. CD4(+) T regulatory cells are more resistant to DNA damage compared to CD4(+) T effector cells as revealed by flow cytometric analysis. Cytometry A 2011;79:903–911
  • Aguilo JI, Iturralde M, Monleon I. Cytotoxicity of quinone drugs on highly proliferative human leukemia T cells: reactive oxygen species generation and inactive shortened SOD1 isoform implications. Chem Biol Interact 2012;198:18–28
  • Pandey AK, Sodhi A. Recombinant YopJ induces apoptotic cell death in macrophages through TLR2. Mol Immunol 2011;48:392–398
  • Bruneau JC, Stack E, O'Kennedy R, Loscher CE. Aflatoxins B(1), B(2) and G(1) modulate cytokine secretion and cell surface marker expression in J774A.1 murine macrophages. Toxicol In Vitro 2012;26:686–693

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