Safety of subcutaneous immunotherapy with inhalant allergen extracts: a single-center 30-year experience from Turkey

References

• Noon L. Prophylactic inoculation against hay fever. Lancet 1911;1:1572–1574
   Google Scholar
• Freeman J. Further observations on the treatment of hay fever by hypodermic inoculation of pollen vaccine. Lancet 1911;2:814–817
   Google Scholar
• Moreno C, Cuesta-Herranz J, Fernandez-Tavora L, Alvarez-Cuesta E. Immunotherapy safety: a prospective multi-centric monitoring study of biologically standardized therapeutic vaccines for allergic diseases. Clin Exp Allergy 2004;34:527–531
   PubMed Web of Science ®Google Scholar
• More DR, Hagan LL. Factors affecting compliance with allergen immunotherapy at a military medical center. Ann Allergy Asthma Immunol 2002;88:391–394
   PubMed Web of Science ®Google Scholar
• Mellerup MT, Hahn GW, Poulsen LK, Malling HJ. Safety of allergen-specific immunotherapy: relation between dosage regimen, allergen extract, disease and systemic side-effects during induction treatment. Clin Exp Allergy 2000;30:1423–1429
   PubMed Web of Science ®Google Scholar
• Luigi A, Senna G, Mezzalani P, Pappalardo G. Safety of specific immunotherapy: a retrospective study. J Invest Allergol Clin Immunol 1994;4:250–254
   PubMed Web of Science ®Google Scholar
• Winther L, Arnved J, Malling HJ, et al. Side-effects of allergen-specific immunotherapy: a prospective multi-centre study. Clin Exp Allergy 2006;36:254–260
   PubMed Web of Science ®Google Scholar
• Roy SR, Sigmon JR, Olivier J, et al. Increased frequency of large local reactions among systemic reactors during subcutaneous allergen immunotherapy. Ann Allergy Asthma Immunol 2007;99:82–86
   PubMed Web of Science ®Google Scholar
• Cox L, Nelson H, Lockey R, et al. Allergen immunotherapy: a practice parameter third update. J Allergy Clin Immunol 2011;127:S1–S55
   PubMed Web of Science ®Google Scholar
• Cox L, Larenas-Linnemann D, Lockey RF, Passalacqua G. Speaking the same language: the world allergy organization subcutaneous immunotherapy systemic reaction grading system. J Allergy Clin Immunol 2010;125:569–574
   PubMed Web of Science ®Google Scholar
• DaVeiga SP, Liu X, Caruso K, et al. Systemic reactions associated with subcutaneous allergen immunotherapy: timing and risk assessment. Ann Allergy Asthma Immunol 2011;106:533–537
   PubMed Web of Science ®Google Scholar
• Webber CM, Calabria CW. Assessing the safety of subcutaneous immunotherapy dose adjustments. Ann Allergy Asthma Immunol 2010;105:369–375
   Google Scholar
• Rogala B, Markiewicz-Bendkowska IB, Brzoza Z, et al. Side-effects of injective allergen immunotherapy administered to intermittent or persistent allergic rhinitis patients. Rhinology 2007;45:134–139
   PubMed Web of Science ®Google Scholar
• Santos N, Pereira AM, Silva R, et al. Characterisation of systemic reactions to subcutaneous immunotherapy with airborne allergens and classification according to WAO 2010. Allergol Immunopathol (Madr) 2015;43:25–31
   Google Scholar
• Rank MA, Oslie CL, Krogman JL, et al. Allergen immunotherapy safety: characterizing systemic reactions and identifying risk factors. Allergy Asthma Proc 2008;29:400–405
   PubMed Web of Science ®Google Scholar
• Ragusa VF, Massolo A. Non fatal systemic reactions to subcutaneous immunotherapy: a 20 year experience of two 10-year periods. Allergie Immunol 2004;36:52–55
   Google Scholar
• Akçakaya N, Hassanzadeh A, Camcioğlu Y, Cokuğraş H. Local and systemic reactions during immunotherapy with adsorbed extracts of house dust mite in children. Ann Allergy Asthma Immunol 2000;85:317–321
   PubMedGoogle Scholar
• Lockey RF, Nicoara-Kasti GL, Theodoropoulos DS, Bukantz SC. Systemic reactions and fatalities associated with allergen immunotherapy. Ann Allergy Asthma Immunol 2001;87:47–55
   PubMed Web of Science ®Google Scholar
• Bernstein DI, Wanner M, Borish L, Liss GM. Twelve-year survey of fatal reactions to allergen injections and skin testing: 1990–2001. J Allergy Clin Immunol 2004;113:1129–1136
   PubMed Web of Science ®Google Scholar
• Bousquet J, Hejjaoui A, Dhivert H, et al. Immunotherapy with a standardized Dermatophagoides pteronyssinus extract: systemic reactions during the rush protocol in patients suffering from asthma. J Allergy Clin Immunol 1989;83:797–802
   PubMed Web of Science ®Google Scholar
• Dursun AB, Sin BA, Oner F, Misirligil Z. The safety of allergen immunotherapy (IT) in Turkey. J Investig Allergol Clin Immunol 2006;16:123–128
   PubMedGoogle Scholar
• Tinkelman DG, Cole WQ, Tunno J. Immunotherapy: a one-year prospective study to evaluate risk factors of systemic reactions. J Allergy Clin Immunol 1995;95:8–14
   PubMed Web of Science ®Google Scholar
• Rieckenberg MR, Khan RH, Day JH. Physician reported patient response to immunotherapy: a retrospective study of factors affecting the response. Ann Allergy 1990;64:364–367
   Google Scholar
• Reid MJ, Rockey RF, Turkeltaub PC, Platts-Mills TAE. Survey of fatalities from skin testing and immunotherapy 1985–1989. J Allergy Clin Immunol 1993;92:6–15
   PubMed Web of Science ®Google Scholar
• Gastaminza G, Algorta J, Audicana M, et al. Systemic reactions to immunotherapy: influence of composition and manufacturer. Clin Exp Allergy 2003;33:470–474
   PubMed Web of Science ®Google Scholar
• Mellerup MT, Hahn GW, Poulsen LK, Malling H. Safety of allergen-specific immunotherapy. Relation between dosage regimen, allergen extract, disease and systemic side-effects during induction treatment. Clin Exp Allergy 2000;30:1423–1429
   PubMed Web of Science ®Google Scholar
• Phillips JF, Lockey RF, Fox RW, et al. Systemic reactions to subcutaneous allergen immunotherapy and the response to epinephrine. Allergy Asthma Proc 2011;32:288–294
   Google Scholar
• Cadario G, Marengo F, Ranghino E, et al. Higher frequency of early local side effects with aqueous versus depot immunotherapy for hymenoptera venom allergy. J Investig Allergol Clin Immunol 2004;14:127–133
   Google Scholar
• Malling HJ. Immunotherapy as an effective tool in allergy treatment. Allergy 1998;53:461–472
   PubMed Web of Science ®Google Scholar
• Serrano P, Justicia JL, Sánchez C, et al. Systemic tolerability of specific subcutaneous immunotherapy with index-of-reactivity-standardized allergen extracts administered using clustered regimens: a retrospective, observational, multicenter study. Ann Allergy Asthma Immunol 2009;102:247–252
   PubMed Web of Science ®Google Scholar
• Ickovic MR, Relyveld EH, Hénocq E, et al. Calcium phosphate adjuvanted allergens: total and specific IgE levels before and after immunotherapy with house dust and Dermatophagoides pteronyssinus extracts. Ann Immunol (Institut Pasteur) 1983;134 D:345–398
   Google Scholar
• Aggerbeck H, Heron I. Adjuvanticity of aluminium hydroxide and calcium phosphate in diphtheria-tetanus vaccines – I. Vaccine 1995;13:1360–1365
   PubMed Web of Science ®Google Scholar
• Edelman R. Vaccine adjuvants. Rev Infect Dis 1980;2:370–383
   PubMedGoogle Scholar
• Blennow M, Granstrbm M, Strandell A. Adverse reactions after diphtheria-tetanus booster in 10-year-old school children in relation to the type of vaccine given for the primary vaccination. Vaccine 1994;12:427–430
   Google Scholar
• Calabria CW, Stolfi A, Tankersley MS. The REPEAT study: recognizing and evaluating periodic local reactions in allergen immunotherapy and associated systemic reactions. Ann Allergy Asthma Immunol 2011;106:49–53
   PubMedGoogle Scholar
• Tankersley MS, Butler KK, Butler WK, Goetz DW. Local reactions during allergen immunotherapy do not require dose adjustment. J Allergy Clin Immunol 2000;106:840–843
   PubMed Web of Science ®Google Scholar
• Arifhodzic N, Behbehani N, Duwaisan AR, et al. Safety of subcutaneous specific immunotherapy with pollen allergen extracts for respiratory allergy. Int Arch Allergy Immunol 2003;132:258–262
   Google Scholar
• Calabria CW, Coop CA, Tankersley MS. The GILL study: glycerin-induced local reactions in immunotherapy. J Allergy Clin Immunol 2008;121:222–226
   Google Scholar
• Nelson BL, Dupont LA, Reid MJ. Prospective survey of local and systemic reactions to immunotherapy with pollen extracts. Ann Allergy 1986;56:331–334
   PubMedGoogle Scholar
• Prigal SJ. A ten-year study of repository injections of allergens: local reactions and their management. Ann Allergy 1972;30:529–535
   Google Scholar
• Alessandrini AE, Berra D, Rizzini FL, et al. Flexible approaches in the design of subcutaneous immunotherapy protocols for Hymenoptera venom allergy. Ann Allergy Asthma Immunol 2006;97:92–97
   PubMedGoogle Scholar
• Can D, Demir E, Tanaç R, et al. Immediate adverse reactions to immunotherapy. J Investig Allergol Clin Immunol 2003;13:177–180
   PubMed Web of Science ®Google Scholar
• Frost L, Johansen P, Pedersen S, et al. Persistent subcutaneous nodules in children hyposensitized with aluminium-containing allergen extracts. Allergy 1985;40:368–372
   PubMed Web of Science ®Google Scholar
• Wüthrich B, Gumowski PL, Fäh J, et al. Safety and efficacy of specific immunotherapy with standardized allergenic extracts adsorbed on aluminium hydroxide. J Investig Allergol Clin Immunol 2001;11:149–156
   PubMed Web of Science ®Google Scholar