Mesencephalic astrocyte-derived neurotrophic factor attenuates inflammatory responses in lipopolysaccharide-induced neural stem cells by regulating NF-κB and phosphorylation of p38-MAPKs pathways

References

• Gage FH. Mammalian neural stem cells. Science 2000;287:1433–1438.
   PubMed Web of Science ®Google Scholar
• Uchida N, Buck DW, He D, et al. Direct isolation of human central nervous system stem cells. Proc Natl Acad Sci 2000;97:14720–14725.
   PubMed Web of Science ®Google Scholar
• Mathews DJ, Sugarman J, Bok H, et al. Cell-based interventions for neurologic conditions: ethical challenges for early human trials. Neurology 2008;71:288–293.
   PubMed Web of Science ®Google Scholar
• van Praag H, Schinder AF, Christie BR, et al. Functional neurogenesis in the adult hippocampus. Nature 2002;415:1030–1034.
   PubMed Web of Science ®Google Scholar
• Doetsch F. The glial identity of neural stem cells. Nat Neurosci 2003;6:1127–1134.
   PubMed Web of Science ®Google Scholar
• Taupin P. Adult neurogenesis, neuroinflammation and therapeutic potential of adult neural stem cells. Int J Med Sci 2008;5:127–132.
   PubMedGoogle Scholar
• Anderson KV, Bokla L, Nusslein-Volhard C. Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product. Cell 1985;42:791–798.
   PubMed Web of Science ®Google Scholar
• Nagai Y, Garrett KP, Ohta S, et al. Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. Immunity 2006;24:801–812.
   PubMed Web of Science ®Google Scholar
• Pevsner-Fischer M, Morad V, Cohen-Sfady M, et al. Toll-like receptors and their ligands control mesenchymal stem cell functions. Blood 2007;109:1422–1432.
   PubMed Web of Science ®Google Scholar
• Covacu R, Arvidsson L, Andersson A, et al. TLR activation induces TNF-alpha production from adult neural stem/progenitor cells. J Immunol 2009;182:6889–6895.
   PubMed Web of Science ®Google Scholar
• Miller SI, Ernst RK, Bader MW. LPS, TLR4 and infectious disease diversity. Nat Rev Microbiol 2005;3:36–46.
   PubMed Web of Science ®Google Scholar
• Marsh BJ, Williams-Karnesky RL, Stenzel-Poore MP. Toll-like receptor signaling in endogenous neuroprotection and stroke. Neuroscience 2009;158:1007–1020.
   PubMed Web of Science ®Google Scholar
• Zeuner M, Bieback K, Widera D. Controversial role of Toll-like receptor 4 in adult stem cells. Stem Cell Rev Rep 2015;11:621–634.
   PubMed Web of Science ®Google Scholar
• Voutilainen MH, Back S, Porsti E, et al. Mesencephalic astrocyte-derived neurotrophic factor is neurorestorative in rat model of Parkinson’s disease. J Neurosci 2009;29:9651–9659.
   PubMed Web of Science ®Google Scholar
• Airavaara M, Shen H, Kuo CC, et al. Mesencephalic astrocyte-derived neurotrophic factor reduces ischemic brain injury and promotes behavioral recovery in rats. J Comp Neurol 2009;515:16–124.
   Web of Science ®Google Scholar
• Yang S, Huang SS, Gaertig MA, et al. Age-dependent decrease in chaperone activity impairs MANF expression, leading to Purkinje cell degeneration in inducible SCA17 mice. Neuron 2014;81:349–365.
   PubMed Web of Science ®Google Scholar
• Chen YC, Sundvik M, Rozov S, et al. MANF regulates dopaminergic neuron development in larval zebrafish. Dev Biol 2012;370:237–249.
   PubMed Web of Science ®Google Scholar
• Palgi M, Lindström R, Peränen J, et al. Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons. Proc Natl Acad Sci USA 2009;106:2429–2434.
   PubMed Web of Science ®Google Scholar
• Lindahl M, Danilova T, Palm E, et al. MANF is indispensable for the proliferation and survival of pancreatic β cells. Cell Rep 2014;7:366–375.
   PubMed Web of Science ®Google Scholar
• Lindholm P, Peränen J, Andressoo JO, et al. MANF is widely expressed in mammalian tissues and differently regulated after ischemic and epileptic insults in rodent brain. Mol Cell Neurosci 2008;39:356–371.
   PubMed Web of Science ®Google Scholar
• Wang H, Ke Z, Alimov A, et al. Spatiotemporal expression of MANF in the developing rat brain. PLoS One 2014;9:e90433.
   PubMed Web of Science ®Google Scholar
• Lindholm P, Saarma M. Novel CDNF/MANF family of neurotrophic factors. Dev Neurobiol 2010;70:360–371.
   PubMed Web of Science ®Google Scholar
• Nadella R, Voutilainen MH, Saarma M, et al. Transient transfection of human CDNF gene reduces the 6-hydroxydopamine-induced neuroinflammation in the rat substantia nigra. J Neuroinflamm 2014;11:209–227.
   PubMed Web of Science ®Google Scholar
• Cordero-Llana O, Houghton BC, Rinaldi F, et al. Enhanced efficacy of the CDNF/MANF family by combined intranigral overexpression in the 6-OHDA rat model of Parkinson’s disease. Mol Ther 2015;23:244–254.
   PubMed Web of Science ®Google Scholar
• Voutilainen MH, Arumäe U, Airavaara M, Saarma M. Therapeutic potential of the endoplasmic reticulum located and secreted CDNF/MANF family of neurotrophic factors in Parkinson’s disease. FEBS Lett 2015;589:3739–3748.
   PubMed Web of Science ®Google Scholar
• Einstein O, Karussis D, Grigoriadis N, et al. Intraventricular transplantation of neural precursor cell spheres attenuates acute experimental allergic encephalomyelitis. Mol Cell Neurosci 2003;24:1074–1082.
   PubMed Web of Science ®Google Scholar
• Imitola J, Comabella M, Chandraker AK, et al. Neural stem/progenitor cells express co-stimulatory molecules that are differentially regulated by inflammatory and apoptotic stimuli. Am J Pathol 2004;164:1615–1625.
   PubMed Web of Science ®Google Scholar
• Reynolds BA, Weiss S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 1992;255:1707–1710.
   PubMed Web of Science ®Google Scholar
• Mitome M, Low HP, van den Pol A, et al. Towards the reconstruction of central nervous system white matter using neural precursor cells. Brain 2001;124:2147–2161.
   PubMed Web of Science ®Google Scholar
• Moriya T, Horie N, Mitome M, Shinohara K. Melatonin influences the proliferative and differentiative activity of neural stem cells. J Pineal Res 2007;42:411–418.
   PubMed Web of Science ®Google Scholar
• Widera D, Mikenberg I, Elvers M, et al. Tumor necrosis factor alpha triggers proliferation of adult neural stem cells via IKK/NF-κB signaling. BMC Neurosci 2006;7:64.
   PubMed Web of Science ®Google Scholar
• Tiwari SK, Agarwal S, Seth B, et al. Inhibitory effects of Bisphenol-A on neural stem cells proliferation and differentiation in the rat brain are dependent on Wnt/β-Catenin pathway. Mol Neurobiol 2015;52:1735–1757.
   PubMed Web of Science ®Google Scholar
• Foret A, Quertainmont R, Botman O, et al. Stem cells in the adult rat spinal cord: plasticity after injury and treadmill training exercise. J Neurochem 2010;112:762–772.
   PubMed Web of Science ®Google Scholar
• Ivanov VN, Hei TK. Radiation-induced glioblastoma signaling cascade regulates viability, apoptosis and differentiation of neural stem cells (NSC). Apoptosis 2014;19:1736–1754.
   PubMed Web of Science ®Google Scholar
• Yari S, Parivar K, Nabiuni M, Keramatipour M. Effect of embryonic cerebrospinal fluid on proliferation and differentiation of neuroprogenitor cells. Cell J 2013;15:29–36.
   PubMed Web of Science ®Google Scholar
• Reekmans K, Praet J, Daans J, et al. Current challenges for the advancement of neural stem cell biology and transplantation research. Stem Cell Rev 2012;8:262–278.
   PubMed Web of Science ®Google Scholar
• Madhavan L, Collier TJ. A synergistic approach for neural repair: cell transplantation and induction of endogenous precursor cell activity. Neuropharmacology 2010;58:835–844.
   PubMed Web of Science ®Google Scholar
• Rolls A, Shechter R, London A, et al. Toll-like receptors modulate adult hippocampal neurogenesis. Nat Cell Biol 2007;9:1081–1088.
   PubMed Web of Science ®Google Scholar
• Dooley D, Vidal P, Hendrix S. Immunopharmacological intervention for successful neural stem cell therapy: new perspectives in CNS neurogenesis and repair. Pharmacol Therap 2014;141:21–31.
   PubMed Web of Science ®Google Scholar
• Johnson GB, Brunn GJ, Platt JL. Activation of mammalian Toll-like receptors by endogenous agonists. Crit Rev Immunol 2003;23:15–44.
   PubMed Web of Science ®Google Scholar
• Schuster A, Klotz M, Schwab T, et al. Maintenance of the enteric stem cell niche by bacterial lipopolysaccharides? Evidence and perspectives. J Cell Mol Med 2014;18:1429–1443.
   PubMed Web of Science ®Google Scholar
• Lu P, Jones LL, Snyder EY, Tuszynski MH. Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury. Exp Neurol 2003;181:115–129.
   PubMed Web of Science ®Google Scholar
• Zhu JM, Zhao YY, Chen SD, et al. Functional recovery after transplantation of neural stem cells modified by brain-derived neurotrophic factor in rats with cerebral ischaemia. J Int Med Res 2011;39:488–498.
   PubMed Web of Science ®Google Scholar
• Yoneyama M, Shiba T, Hasebe S. Adult neurogenesis is regulated by endogenous factors produced during neurodegeneration. J Pharmacol Sci 2011;115:425–432.
   PubMed Web of Science ®Google Scholar
• Carletti B, Piemonte F, Rossi F. Neuroprotection: the emerging concept of restorative neural stem cell biology for the treatment of neurodegenerative diseases. Curr Neuropharmacol 2011;9:313–317.
   PubMed Web of Science ®Google Scholar
• Whitney NP, Eidem TM, Peng H. Inflammation mediates varying effects in neurogenesis: relevance to the pathogenesis of brain injury and neurodegenerative disorders. J Neurochem 2009;108:1343–1359.
   PubMed Web of Science ®Google Scholar
• Wang X, Fu S, Wang Y, et al. Interleukin-1beta mediates proliferation and differentiation of multipotent neural precursor cells through the activation of SAPK/JNK pathway. Mol Cell Neurosci 2007;36:343–354.
   PubMed Web of Science ®Google Scholar
• Song J, Kang SM, Lee KM, Eun Lee JE. The protective effect of melatonin on neural stem cell against LPS-induced inflammation. Biomed Res Int 2015;2015:854359.
   PubMedGoogle Scholar
• Apostolou A, Shen Y, Liang Y, et al. Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death. Exp Cell Res 2008;314:2454–2467.
   PubMed Web of Science ®Google Scholar
• Glembotski CC, Thuerauf DJ, Huang C, et al. Mesencephalic astrocyte-derived neurotrophic factor protects the heart from ischemic damage and is selectively secreted upon sarco/endoplasmic reticulum calcium depletion. J Biol Chem 2012;287:25893–25904.
   PubMed Web of Science ®Google Scholar
• Zhao H, Cheng L, Liu Y, et al. Mechanisms of anti-inflammatory property of conserved dopamine neurotrophic factor: inhibition of JNK signaling in lipopolysaccharide-induced microglia. J Mol Neurosci 2014;52:186–192.
   PubMed Web of Science ®Google Scholar
• Islam O, Loo TX, Heese K. Brain-derived neurotrophic factor (BDNF) has proliferative effects on neural stem cells through the truncated TRK-B receptor, MAP kinase, AKT, and STAT-3 signaling pathways. Curr Neurovasc Res 2009;6:42–53.
   PubMed Web of Science ®Google Scholar
• Barnabe-Heider F, Miller FD. Endogenously produced neurotrophins regulate survival and differentiation of cortical progenitors via distinct signaling pathways. J Neurosci 2003;23:5149–5160.
   PubMed Web of Science ®Google Scholar
• Lowenthal J, Sugarman J. Ethics and policy issues for stem cell research and pulmonary medicine. Chest 2015;147:824–834.
   PubMed Web of Science ®Google Scholar