Chlorphentermine Suppresses the Phosphatidylinositol Pathway in Concanavalin A-Activated Mouse Splenic Lymphocytes

References

• Reasor M. J. Drug-induced lipidosis and the alveolar macrophage. Toxicology 1981; 20: 1
   PubMed Web of Science ®Google Scholar
• Lullmann H., Lullmann-Rauch R. Tamoxifen-induced generalized lipidosis in rats subchronically treated with high doses. Toxicol. Applied Pharmacol. 1981; 61: 138
   PubMed Web of Science ®Google Scholar
• Lullmann-Rauch R., Reil G. H. Fenfluramine induced ultrastructural alterations in tissues of rats and guinea pigs, Naunyn-Schmeideberg's. Arch. Pharmacol. 1974; 285: 175
   Web of Science ®Google Scholar
• Dake M. D., Madison J. M., Montgomery C. K., Shellito J. E., Bainton D. F. Electron microscopic demonstration of lysosomal inclusion bodies in lung, liver, lymph nodes, and blood leukocytes of patients with amiodarone pulmonary toxicity. Amer. J. Med. 1985; 78: 506
   PubMed Web of Science ®Google Scholar
• Matsuzawa Y., Hostetler K. Y. Studies on drug-induced lipidosis: subcellular localization of phospholipid and cholesterol in the livers of rats treated with chloroquine and 4,4′-bis (diethylaminoethoxy),-diethyldiphenylethane. J. Lipid Res. 1980; 21: 202
   PubMed Web of Science ®Google Scholar
• Hostetler K. Y. Molecular studies of the induction of cellular phospholipidosis by cationic amphiphilic drugs. Federation Proc. 1984; 43: 2582
   PubMedGoogle Scholar
• Sauers L. J., Wierda D., Walker E. R., Reasor M. J. Morphological and functional changes in mouse splenic lymphocytes following in vivo and in vitro exposure to chlorphentermine. J. Immunopharmacol. 1986; 8: 611
   PubMedGoogle Scholar
• Lullmann-Rauch R., Pietschmann N. Lipidosis like cellular alterations in lymphatic tissues of chlorphentermine treated animals. Virchows Arch. Abt. B Zellpath. 1974; 15: 295
   Web of Science ®Google Scholar
• Sauers L. J., Wierda D., Walker E. R., Reasor M. J. Chlorphentermine-induced alterations in the response of human lymphocytes to mitogens. Biochem. Pharmacol. 1986; 35: 3651
   PubMed Web of Science ®Google Scholar
• Quastel M. B., Kaplan J. G. Early stimulation of potassium uptake in lymphocytes stimulated with PHA. Exp. Cell Res. 1970; 63: 230
   PubMed Web of Science ®Google Scholar
• Coffey R. G., Hadden E. M., Hadden J. W. Evidence for cyclic GMP and calcium mediation of lymphocyte activation by mitogens. J. Immunol. 1977; 119: 1387
   PubMed Web of Science ®Google Scholar
• Waxdal M. J. Membrane methylation and other early biochemical reactions in the mitogenic action of lymphocytes. Advances in Immunopharmacology, J. W. Hadden. Pergamon Press, Oxford 1983; 75
   Google Scholar
• Abdel-Latif A. Calcium-mobilizing receptors, phosphoinositides and the generation of second messengers. Pharmacol. Rev. 1974; 38: 227
   Google Scholar
• Tsein R. Y., Pozzan T., Rink T. J. T cell mitogens cause early changes in cytoplasmic free calcium and membrane potential in lymphocytes. Nature 1982; 295: 68
   PubMed Web of Science ®Google Scholar
• Sugiura T., Waku K. Enhanced turnover of arachidonic acid-containing species of phosphatidyl inositol and phosphatidic acid of Concanvalin A stimulated lymphocytes. Biochim. Biophys. Acta 1984; 796: 190
   PubMed Web of Science ®Google Scholar
• Maino V. C., Hayman M. J., Crumpton M. J. Relationship between enhanced turnover of phosphatidyl inositol and lymphocyte activation by mitogens. Biochem. J. 1975; 146: 247
   PubMed Web of Science ®Google Scholar
• Hui D. Y., Harmony J. A. Phosphatidylinositol turnover in mitogen-activated lymphocytes. Biochem. J. 1980; 192: 91
   PubMed Web of Science ®Google Scholar
• Hasegawa-Sasaki H., Sasaki T. Phytomitogen-induced stimulation of synthesis de novo of phosphatidylinositol, phosphatidic acid and diacylglycerol in rat and human lymphocytes. Biochim. Biophys. Acta 1981; 666: 252
   PubMed Web of Science ®Google Scholar
• Abdel-Latif A. A., Smith J. P., Akhtar R. A. Studies on the mechanism of alteration by propranolol and mepacrine of the metabolism of phosphoinositides and other glycerolipids in the rabbit iris muscle. Biochem. Pharmacol. 1983; 32: 38156
   Web of Science ®Google Scholar
• Allan D., Michell R. H. Phosphatidylinositol cleavage by the soluble fraction from lymphocytes. Biochem. J. 1974; 142: 591
   PubMedGoogle Scholar
• Bijsterbosch M. K., Klaus G. G. Cyclosporin does not inhibit mitogen-induced inositol phospholipid degradation in mouse lymphocytes. Immunology 1985; 56: 435
   PubMed Web of Science ®Google Scholar
• Hallcher L. M., Sherman W. R. The effects of lithium ion and other agents on the activity of myo-inositol-1phosphatase from bovine brain. J. Biol. Chem. 1980; 255: 10896
   PubMed Web of Science ®Google Scholar
• Gomori G. Histochemical demonstration of sites of choline esterase activity. Proc. Soc. Exptl. Biol. Med. 1948; 68: 354
   PubMed Web of Science ®Google Scholar
• Hoffmann S. L., Majerus P. W. Identification and properties of two distinct phosphatidylinositol specific phospholipase C enzymes from sheep seminal vesicular glands. Proc. Natl. Acad. Sci. 1982; 257: 6461
   Google Scholar
• Irvine R. F., Hemington N., Dawson R. M. The hydrolysis of phosphatidyl inositol by lysosomal enzymes of rat liver and brain. Biochem. J. 1978; 176: 475
   PubMed Web of Science ®Google Scholar
• Irvine R. F., Hemington N., Dawson R. M. The calcium dependent phosphatidyl inositol phosphodiesterase of rat liver. Eur. J. Biochem. 1979; 99: 525
   PubMedGoogle Scholar
• Rittenhouse S. E. Human platelets contain phospholipase C that hydrolyzes phosphoinositides. Proc. Natl. Acad. Sci. 1983; 80: 5417
   PubMed Web of Science ®Google Scholar
• Matsuzawa Y., Hostetler K. Y. Properties of phospholipase C isolated from rat liver lysosomes. J. Biol. Chem. 1980; 255: 646
   PubMed Web of Science ®Google Scholar
• SAS Users' Guide: Statistics. SAS Institute, Cary NC 1982; 584
   Google Scholar
• Gunther G. R., Wang J. L., Edelman G. M. Kinetics of colchicine inhibition of mitogenesis in individual lymphocytes. Exp. Cell Res. 1976; 98: 15
   PubMed Web of Science ®Google Scholar
• Wang J. L., Gunther G. R., Edelman G. M. Inhibition by colchicine of the mitogenic stimulation of lymphocytes prior to S phase. J. Cell Biol. 1975; 66: 128
   PubMed Web of Science ®Google Scholar
• Miller J. J. Oncodazole (R 17934) an inhibitor of phosphotidylinositol in concanavalin A induced lymphocytes. Biochem. Pharmacol. 1979; 28: 2967
   PubMed Web of Science ®Google Scholar
• Wolberg G., Stopford C. R., Zimmerman T. P. Antagonism by toxol of effects of microtubule disrupting agents on lymphocyte cell function. Proc. Natl. Acad. Sci. 1981; 81: 3496
   Web of Science ®Google Scholar
• Schellenberg R. R., Gillespie E. Colchicine inhibits phosphatidyl-inositol turnover induced in lymphocytes by Con A. Nature 1977; 265: 741
   PubMed Web of Science ®Google Scholar
• Matsuzawa Y., Hostetler K. Y. Inhibition of lysosomal phospholipase A and phospholipase C by chloroquine and 4,4′-bis (diethylaminoethoxy), diethyldiphenylethane. J. Biol. Chem. 1980; 255: 5190
   PubMed Web of Science ®Google Scholar
• Hostetler K. Y., Matsuzawa Y. Studies on the mechanism of drug induced lipidosis. Cationic amphiphilic drug inhibition of lysosomal phospholipases A and C. Biochem. Pharmacol. 1981; 30: 1121
   PubMed Web of Science ®Google Scholar
• Downes C. P., Michell R. H. The phosphoinositide phosphodiesterase of erythrocyte membranes. Biochem. J. 1981; 198: 133
   PubMed Web of Science ®Google Scholar
• Lullmann H., Plosch H., Ziegler A. Calcium replacement by cationic amphiphilic drugs from lipid monolayers. Biochem. Pharmacol. 1980; 29: 2969
   PubMed Web of Science ®Google Scholar
• Seydel J. K., Wassermann O. NMR studies on the molecular basis of drug-induced phospholipidosis - interaction between chlorphentermine and phosphatidyl choline. Naunyn Schmiedeberg's Arch. Pharmacol. Suppl. 1973; 279: 107
   Web of Science ®Google Scholar
• Seydel J. K., Wassermann O. NMR studies on the molecular basis of drug-induced phospholipidosis: II - interactions between several amphiphilic drugs and phospholipids. Biochem. Pharmacol. 1976; 25: 2357
   PubMed Web of Science ®Google Scholar
• Lullmann H., Wehling M. The binding of drugs to different polar lipids in vitro. Biochem. Pharmacol. 1979; 28: 3409
   PubMed Web of Science ®Google Scholar
• Guy G. R., Gordon B. J., Michell R. H., Brown G. A combination of calcium ionophore and 12–0-tetradeconyl-13-acetate (TPA) stimulates the growth of purified resting B cells. Scad. J. Immunol. 1985; 22: 591
   PubMed Web of Science ®Google Scholar
• Mastro A. M., Smith M. C. Calcium-dependent activation of lymphocytes by ionophore, A23187, and a phorbol ester tumor promoter. J. Cell. Physiol. 1983; 116: 51
   PubMed Web of Science ®Google Scholar
• Truneh A., Albert F., Golstein P., Schmitt-Verhulst A. Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester. Nature 1985; 313: 318
   PubMed Web of Science ®Google Scholar