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Research Article

Enhanced Macrophage Anti-Microbial Activity Following Dimethylnitrosamine Exposure in Vivo is Related to Augmented Production of Reactive Oxygen Metabolites

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Pages 395-411 | Published online: 28 Sep 2008

References

  • Almawi W. Y., Murphy M. G., Ogbaghebriel A., Pope B. L. Cyclic AMP as the second messenger for prostaglandin E in modulating suppressor cell-activation by natural suppressor/cytotoxic cells. Int. J. Immunopharmacol. 1987; 9: 697
  • Badger A. M. Enhanced superoxide production by rat alveolar macrophages stimulated in vitro with biological response modifiers. J. Leuk. Biol. 1986; 40: 725
  • Chouaib S., Welte K., Metelsmann R., Dupont B. Prostaglandin E2 acts at two distinct pathways of T lymphocyte activation: Inhibition of interleukin 2 production and down regulation of transferrin receptor expression. J. Immunol. 1985; 135: 1172
  • Ding A. H., Nathan C. F. Trace levels of bacterial lipopolysaccharide prevent interferon-g or tumor necrosis factor-from enhancing mouse peritoneal macrophage respiratory burst capacity. J. Immunol. 1987; 139: 1971
  • Duke S. S., Schook L. B., Holsapple M. P. Effects of N-nitrosodimethylamine on tumor susceptibility. J. Leuk. Biol. 1985; 37: 383–394
  • Edwards C K, III, Hedegaard H B, Zlotnik A, Gangadharam P RJ, Johnston R B, Jr, Pabst M J. Chronic infection due to Mycobacterium intracellular in mice: association with macrophage release of prostaglandin E, and reversal by injection of indomethacin, muramyl dipeptide or interferon-γ. J. Immunol. 1986; 136: 1820–1827
  • Edwards C K, III, Ghiasuddin S M, Schepper J M, Yunger I M, Kelley K W. A newly defined property of somatotropin: Priming of macrophages for production of superoxide anion. Science 1988; 239: 769–771
  • Farrar W L, Humes J L. The role of arachidonic acid metabolism in the activities of interleukin 1 and 2. J. Immunol. 1985; 135: 1153–1159
  • Flesch I E, Kaufmann S HE. Attempts to. characterize the mechanism involved in mycobacterial growth inhibition by gamma-interferon-activated bone marrow macrophages. Infect. Immun. 1988; 56: 1464–1469
  • Gangadharam P RJ, Edwards C K, III. Release of superoxide anion (O2) from resident and activated mouse peritoneal macrophages infected with Mycobacterium intracellular. Am. Rev. Respir. Dis. 1984; 130: 834–838
  • Handman E, Burgess A W. Stimulation by granulocyte-macrophage colony stimulating factor of Leishmania tropica killing by macrophages. J. Immunol. 1979; 122: 1134–1137
  • Hassan H. Determination of microbial damage caused by oxygen free radicals, and the protective role of superoxide dismutase. Methods in Enzymology, G DiSabato, J. Everse. Academic Press, New York, NY 1984; Vol 105: 404–412
  • Hoffman M, Weenberg J B. Tumor necrosis factor-a induces increased hydrogen peroxide production and Fc receptor, but not increased Ia antigen expression by peritoneal macrophages. J. Leuk. Biol. 1987; 42: 704–707, Holsapple MP, Bick PH, Duke SS (1985) Effects of N-nitrosodimethylamine on cell-mediated immunity. J. Leuk. Biol. 37:367–382
  • Johnston R B, Jr. Oxygen metabolism and the microbial activity of macrophages. FASEB J. 1978; 37: 2759–2764
  • Johnston R B, Jr. Enhancement of phagocytosis-associated oxidative metabolism as a manifestation of macrophage activation. Lymphokines 1981; 3: 33–56
  • Johnston R B, Jr, Godzik C A, Cohn Z A. Increased superoxide anion production by immunologically activated and chemically elicited macrophages. J. Exp. Med. 1978; 148: 115–127
  • Kim B-S, Yang K-H, Haggerty H G, Holsapple M P. Production of DNA single—strand breaks in unstimulated splenocytes by dimethylnitrosamine. Mutation Res. 1989; 213: 185–193
  • Kurland J I, Bockman R S, Broxmeyer H E, Moore M AS. Limitation of excessive myelopoiesis by the intrinsic modulation of macrophage-derived prostaglandin E. Science 1978; 199: 552–555
  • Lepay D A, Steinamn R M, Nathan C F, Murray H W, Cohn Z A. Liver macrophages in murine Listeriosis. Cell-mediated immunity is regulated with an influx of macrophages capable of generating reactive oxygen intermediates. J. Exp. Med. 1985; 161: 1503–1512
  • Lockwood J F, Myers M J, Schook L B. Dimethylnitrosamine (DMN)-induced changes in TNF-a-expression as detected by Northern blot analysis. The Toxicologist 1988; 8: 149
  • Lowry O H, Rosebrough N J, Farr A L, Randall R J. Protein measurement with the folin-phenol reagent. J. Biol. Chem. 1951; 193: 265–275
  • Luster M I, Boorman G A, Dean J H, Dawson L D, Wilson R E, Lauer L D, Lubke R W, Rader J, Campbell L. Increased resistance to Listeria monocytogenes following subchronic cyclophosphamide exposure: relationship to altered bone-marrow function. Cellular Immunol. 1981; 65: 131–141
  • Metcalf D, Begley C G, Williamson D J, Nice E C, Lamarter J D, Mermond J-J, Thatcher D, Schmidt A. Hemopoietic response of mice injected with purified recombinant GM-CSF. Exp. Hematol. 1987; 15: l–9
  • Murray H W, Cohn Z A. Macrophage oxygen-dependent antimicrobial activity I. Susceptibility of Toxoplasma gondii. J. Exp. Med. 1979; 150: 938–949
  • Murray H W, Cohn Z A. Macrophage oxygen-dependent antimicrobial activity III. Enhanced oxidative metabolism as an expression of macrophage activation. J. Exp. Med. 1980; 152: 1596–1609
  • Murray H W, Spitaling G L, Nathan C F. Activation of mouse peritoneal macrophages in vitro and in vivo by interferon-γ. J. Immunol. 1985; 134: 1619–1622
  • Myers M. J., Schook L. B. Modification of macrophage differentiation: dimethylnitrosamine induced alteration in the responses toward the regulatory signals controlling myelopoiesis. Int. J. Immunopharm. 1987; 9: 817–825
  • Myers M J, Dickens C S, Schook L B. Alteration of macrophage antitumor activity and transferrin receptor expression by exposure to dimethylnitrosamine in vivo. Immunopharmacol. 1987; 13: 195
  • Myers M J, Pullen J K, Schook L B. Alterations of macrophage differentiation into accessory and effector cells from exposure to dimethylnitrosamine (DMN) in vivo. Immunopharmacol 1986; 12: 105
  • Myers M J, Edwards C K, Lockwood J F, Kelley K W, Schook L B. Changes in the production of macrophage reactive oxygen intermediates (ROI) following dimethylnitrosamine (DMN) exposure. The Toxicologist 1989a; 9: 39
  • Myers M J, Hanafin W P, Schook L B. Augmented macrophage PGE2 production following exposure to dimethylnitrosamine in vivo: relevance to suppressed T cell responses. Immunopharm. 1989b; 18: 115–124
  • Myers M J, Witsell A L, Schook L B. Induction of serum colony-stimulating activity (CSA) following dimethylnitrosamine (DMN) exposure: effects on macrophage differentiation. Immunopharm. 1989c; 18: 125–134
  • Nathan C F. Interferon—gamma and macrophage activation in cell-mediated immunity. Mechanisms of host resistance to infectious agents, tumors and allografts, R M Steinman, R J North. Rockefellor Univ. Press, New York, NY 1986; 164–184
  • Pabst M J, Johnston R B, Jr. Increased production of superoxide anion by macrophages exposed in vitro to muramyl dipeptide or lipopolysaccharide. J. Exp. Med. 1980; 151: 101–114
  • Peck R. Gamma interferon induces monocyte killing of listeria monocytogenes by an oxygen-dependent pathway; alpha-or beta-interferon by interferon-independent pathways. J. Leuk. Biol. 1989; 46: 434–440
  • Phillips W A, Hamilton J A. Phorbol ester-stimulated superoxide production by murine bone marrow-derived macrophages requires preexposure to cytokines. J. Immunol. 1989; 142: 2445–2449
  • Pick E, Keisari Y. A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture. J. Immunol. Methods 1980; 38: 161–170
  • Pick E, Mizel D. Rapid microassays for the measurement of superoxide and hydrogen peroxide production by macrophages in cultures using an automatic enzyme immunoassay reader. J. Immunol. Methods 1981; 46: 211–226
  • Schook L. B., Bingham E. L., Gutmann D. H., Niederhuber J. E. Characterization and expression of H-21 region gene products on bone marrow derived macrophages. Eur. J. Immunol. 1982; 12: 991–997
  • Stern A C, Erb P, Gisler R H. Ia-bearing bone marrow-cultured macrophages induced antigen-specific helper T cells for antibody synthesis. J. Immunol. 1979; 123: 612–615
  • Thomas P, Fugmann R, Arany C, Barbera P, Gibbons R, Fenters J. The effect of dimethylnitrosamine on host resistance and immunity. Toxicol. Appl. Pharmacol. 1985; 77: 219–229
  • Wayneforth H B, Magee P N. The effects of N-nitrosos-N-Methylurea and N-dimethylnitrosamine on cell-mediated and humoral immune responses in rats and mice. Br. J. Cancer 1974; 30: 512–523

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