Advanced search
Publication Cover
Immunopharmacology and Immunotoxicology Volume 14, 1992 - Issue 1-2
Submit an article Journal homepage
16
Views
27
CrossRef citations to date
0
Altmetric
Research Article

Antiallergic Effect of Epinastine (WAL 801 CL) on Immediate Hypersensitivity Reactions: (I) Elucidation of the Mechanism for Histamine Release Inhibition

Chiaki Kamei Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, 700, Japan
,
Masaaki Akagi Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, 700, Japan
,
Mitsunobu Mio Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, 700, Japan
,
Kazuhiro Kitazumi Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, 700, Japan
,
Keiji Izushi Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, 700, Japan
,
Shigehiro Masaki Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, 700, Japan
&
Kenji Tasaka Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, 700, Japan
 show all
Pages 191-205 | Published online: 28 Sep 2008

References

  • Fügner A., Bechtel W. D., Kuhn F. J., Mierau J. In vitro and in vivo studies of the non-sedating antihistamine epinastine. Arzneim.-Forsch. 1988; 38: 1446
  • Nemeth A., Röhlich P. Rapid separation of rat peritoneal mast cells with Percoll. European J. Cell Biol. 1980; 20: 272
  • Akagi M., Tasaka K. Lateral diffusion of membrane particles at the early stage in IgE-mediated mast cell degranulation. J. Electron. Micrsc. 1984; 33: 371
  • Siraganian R. P. An automated continous-flow system for the extraction and fluorometric analysis of histamine. Anal. Biochem. 1974; 57: 383
  • Mota I. The mechanism of anaphylaxis. I. Production and biological properties of 'mast cell sensitizing' antibody. Immunology 1964; 7: 681
  • Akagi M., Mio M., Miyoshi K., Tasaka K. Antiallergic effects of terfenadine on immediate type hypersensitivity reactions. Immunopharmacol. immunotoxicol. 1987; 9: 257
  • Tasaka K., Akagi M., Mio M., Miyoshi K., Nakaya N. Inhibitory effects of oxatomide on intracellular Ca mobilization, Ca uptake, and histamine release, using rat peritoneal mast cells. Int. Archs Allergy appl. Immunol. 1987; 83: 348
  • Izushi K., Tasaka K. Histamine release from β-escin-permeabilized rat peritoneal mast cells and its inhibition by intracellular Ca2+ blockers, calmodulin inhibitors and cAMP. Immunopharmacol. 1989; 18: 177
  • Itano T., Itano R., Penniston J. T. Interactions of basic polypeptides and proteins with calmodulin. Biochem. J. 1980; 189: 455
  • Kebabian J. W., Petzold G. L., Greengard P. Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the “Dopamine Receptor”. Proc. Nat. Acad. Sci. USA 1972; 69: 2145
  • Pöch G. Assay of phosphodiesterase with radioactivcly labeled cyclic 3′,5′-AMP as substrate. Naunyn-Schmied. Arch. Pharmak. 1971; 268: 272
  • Akagi M., Mio M., Tasaka K. Histamine release inhibition and prevention of the decrease in membrane fluidity induced by certain anti-allergic drugs: Analysis of the inhibitory mechanism of NCO-650. Agents Actions 1983; 13: 149
  • Akagi M., Mio M., Shibata H., Kurokawa K., Nakaya N., Miyoshi K., Tasaka K. Antiallergic action of fenotcrol and its mechanism. Jpn. Pharmacol. Ther. 1985; 13: 21
  • Ohmori K., Ishii H., Shuto K., Nakamizo N. Pharmacological studies on oxatomide: (4) Effect on the histamine release from rat isolated peritoneal exudate cells (PEC) and lung slices. Folia pharmacol. japon. 1982; 80: 441
  • Tasaka K., Akagi M, Izushi K., Aoki I. Antiallergic effect of epinastine: the elucidation of the mechanism. Pharmacometrics 1990; 39: 365
  • Foreman J. C., Hallet M. B., Mongar J. L. The relationship between histamine secretion and 45Ca uptake by mast cells. J. Physiol. 1977; 271: 193
  • Tasaka K., Mio M., Okamoto M. Intracellular calcium release induced by histamine releasers and its inhibition by some antiallergic drugs. Ann. Allergy 1986; 56: 464

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.