Isradipine Inhibits PMN Leukocyte Function. A Possible Interference with the Adenosine System

References

• Malech H. L., Gallin J. I. Neutrophils in human diseases. N. Engl. J. Med. 1987; 317: 687
   PubMed Web of Science ®Google Scholar
• Lehrer R. I., Ganz T., Selsted M. E., Babior B. M., Curnutte J. T. Neutrophils and host defense. Ann. Intern. Med. 1988; 109: 127
   PubMed Web of Science ®Google Scholar
• Weiss S. J. Tissue destruction by neutrophils. N. Engl. J. Med. 1989; 320: 365
   PubMed Web of Science ®Google Scholar
• Henson P. M., Johnston R. B., Jr. Tissue injury in inflammation: oxidants, proteinases and cationic proteins. J. Clin. Invest. 1987; 79: 669
   PubMed Web of Science ®Google Scholar
• Cross C. E., Halliwell B., Boush E. T. Human radicals and human diseases. Ann. Intern. Med. 1987; 107: 526
   PubMed Web of Science ®Google Scholar
• Mehta J., Dinerman J., Mehta P., Saldeen T., Lawson D., Donnelly W. H., Wallin R. Neutrophil functions in ischemic heart disease. Circulation 1989; 79: 549
   PubMed Web of Science ®Google Scholar
• Mehta J., Nichols W., Mehta P. Neutrophils as potential participants in acute myocardial ischemia. Relevance to reperfusion. J. Am. Coll. Cardiol. 1988; 11: 1309
   PubMed Web of Science ®Google Scholar
• Engler R. L., Dahlgren M. D., Morris D. D., Peterson M. A., Schmidt-Schömbein G. W. Role of leukocytes in the response to acute myocardial ischemia and restflow in dogs. Am. J. Physiol. 1986; 251: H314
   PubMed Web of Science ®Google Scholar
• Friedman G. D., Klatsky A. L., Siegelamb A. B. The leukocyte count as a predictor of myocardial infarction. N. Engl. J. Med. 1974; 290: 1275
   PubMed Web of Science ®Google Scholar
• Lowe G. D., Machado S. G., Krol W. F., Barton B. A., Forbes C. D. White blood cell count and hematocrit as predictors of coronary recurrence after myocardial infarction. Thromb. Haemost. 1985; 54: 700
   PubMedGoogle Scholar
• Maisel A. S., Gilfrin E. A., Le Winter M., Henning H., Ross J., Jr, Engler R. Initial leukocyte count during acute myocardial infarction independently predicts early ventricular fibrillation. Circulation 1985; 72: III–414, (suppl. III)
   Google Scholar
• Kosatis J. B., Turkevich D., Sharp J. Association between leukocyte count and the presence and extent of coronary atherosclerosis as determined by coronary arteriography. Am. J. Cardiol. 1984; 53: 997
   PubMedGoogle Scholar
• Di Perri T., Laghi Pasini F., Pasqui A. L., Ceccatelli L., Orrico A., Capecchi P. L. Evidence of polymorphonuclear leukocyte (PMN) activation during spontaneous or provoked ischemia in man. III International Congress of Inflammation, Paris, September 3–7, 1984
   Google Scholar
• Di Perri T., Guerrini M., Laghi Pasini F., Acciavatti A., Pieragalli D., Galigani C., Capecchi P. L., Orrico A., Franchi M., Blardi P. Hemorheological factors in the pathophyiology of acute and chronic cerebrovascular disease. Caphalalgia 1985; 2: 71
   Google Scholar
• Pozzan T., Lew D. P., Wollheim C. B., Tsien R. T. Is cytosolic free calcium regulating neutrophil activation. J. Cell. Biol. 1982; 94: 629
   Google Scholar
• Korchak H. M., Vienne K., Rutherford L. E., Weissman G. Neutrophil stimulation: receptor, membrane and metabolic events. Fed. Proc. 1984; 43: 2749
   PubMedGoogle Scholar
• De Togni P., Cabrini G., Di Virgilio F. Cyclic AMP inhibition of f-Met-Let-Phe dependent metabolic responses in human neutrophils is not due to its effect on cytosolic Ca++. Biochem. J. 1984; 224: 629
   PubMed Web of Science ®Google Scholar
• Putney J. W. Calcium mobilizing receptors. Trends In Pharmacol. Sci. 1987; 8: 481
   Web of Science ®Google Scholar
• Marasco W. A., Phon S. A., Krutzsch H. Purification and identification of formyl-methionyl-leucyl-phenylalanine as the major peptide neutrophil chemotactic factor produced by Escherichia Coli. J. Biol. Chem. 1984; 258: 5430
   Google Scholar
• Di Perri T., Laghi Pasini F., Pasqui A. L., Ceccatelli L., Capecchi P. L., Orrico A. Polymorphonuclear leukocyte as a model of Ca++ and Mg++-dependent cellular activation. Effect of flunarizine, Micracirc. Endothel, Lymphatics 1984; 1: 415
   PubMedGoogle Scholar
• Di Perri T., Laghi Pasini F., Pasqui A. L., Ceccatelli L., Orrico A., Capecchi P. L. Polymorphonuclear leukocyte as a model of Ca++ and Mg++-dependent cellular activation. Effect of calcium entry blockers, Int. J. Tissue Reac. 1985; 7: 291
   PubMedGoogle Scholar
• Laghi Pasini F., Capecchi P. L., Pasqui A. L., Ceccatelli L., Mazza S., Gistri A., Di Perri T. Adenosine system and cell calcium translocation: interference of calcium channel blockers. Exp. Gerontol. 1990; 25: 383
   PubMedGoogle Scholar
• Merrill G., Young M., Krieger L. Coronary interactions between nifedipine and adenosine in intact dog heart. Eur. J. Pharmacol. 1982; 81: 543
   PubMedGoogle Scholar
• Di Perri T., Laghi Pasini F., Pecchi S., De Franco V., Damiani P., Pasqui A. L., Capecchi P. L., Orrico A., Materazzi M., Domini L., Ralli L., Monaci A., Blardi P., Ceccatelli L. In vivo and in vitro evidence of an adenosine-mediated mechanism of calcium entry blocker activities. Angiology 1989; 40: 190
   PubMedGoogle Scholar
• Di Perri T., Orrico A., Laghi Pasini F., Gaggelli E., Valensin G. Receptors on the neutrophil membrane. I. Flunarizine-adenosine antagonism as detected by 1H-Nuclear Magnetic Resonance Relaxation investigations. Biophys. J. 1987; 52: 729
   PubMedGoogle Scholar
• Gaggelli E., Di Perri T., Orrico A., Capecchi P. L., Laghi Pasini F., Valensin G. Selective 1H-NMR relaxation investigations of membrane-bound drugs in vitro. 3. Calcium entry blockers and adenosine. Biophys. Chem. 1990; 36: 209
   PubMedGoogle Scholar
• Hof R. F., Ruegg U. T. Pharmacology of the new calcium antagonist isradipine and its metabolites. Am. J. Med. 1988; 84: 13
   PubMed Web of Science ®Google Scholar
• Hof R. P., Salzman R., Siegl H. Selective effects of PN 200–110 (isradipine) on the peripheral circulation and the heart. Am. J. Cardiol. 1987; 59: 30B
   Google Scholar
• Wada Y., Satoh K., Taira N. A study on the separation of the coronary vasodilator from cardiac effects of PN 200–110, a new dihydropyridine calcium antagonist in the dog heart. J. Cardiovasc. Pharmacol. 1985; 7: 190
   PubMedGoogle Scholar
• Grynkiewicz G., Poenie M., Tsien R. V. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 1985; 260: 3440
   PubMed Web of Science ®Google Scholar
• Laghi Pasini F., Capecchi P. L., Orrico A., Ceccatelli L., Di Perri T. Adenosine inhibits polymorphonuclear leukocyte in vitro activation: a possible role as an endogenous calcium entry blocker. J. Immunopharmacol. 1985; 7: 203
   PubMedGoogle Scholar
• Laghi Pasini F., Capecchi P. L., Ceccatelli L., Orrico A., Pasqui A. L., Di Perri T. Effect of extracellular Ca++ on in vitro adenosine-dependent inhibition of neutrophil functions. Int. J. Immunother. 1986; 2: 225
   Web of Science ®Google Scholar