478
Views
70
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

VEGF Promotes Angiogenesis and Functional Recovery in Stroke Rats

, &
Pages 149-155 | Received 10 Jun 2009, Accepted 03 Aug 2009, Published online: 30 Jun 2010

REFERENCES

  • Beck H, Acker T, Wiessner C, Expression of angiopoietin-1, angiopoietin-2, and tie receptors after middle cerebral artery occlusion in the rat. Am J Pathol. 2000;157:1473–1483.
  • Hayashi T, Noshita N, Sugawara T, Temporal profile of angiogenesis and expression of related genes in the brain after ischemia. J Cereb Blood Flow Metab. 2003;23:166–180.
  • Marti HJ, Bernaudin M, Bellail A, Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia. Am J Pathol. 2000;156:965–976.
  • Petrova TV, Makinen T, Alitalo K. Signaling via vascular endothelial growth factor receptors. Exp Cell Res. 1999;253:117–130.
  • Raab S, Plate KH. Different networks, common growth factors: shared growth factors and receptors of the vascular and the nervous system. Acta Neuropathol. 2007;113:607–626.
  • Yang JP, Liu XF, Liu HJ, Extracellular signal-regulated kinase involved in NGF/VEGF-induced neuroprotective effect. Neurosci Lett. 2008;434:212–217.
  • Yang JP, Liu HJ, Li Y. Effect of endoplasmic reticulum stress in VEGF-induced neuroprotection. J Invest Surg. 2009;22:29–34.
  • Thorne RG, Pronk GJ, Padmanabhan V, Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience. 2004;127:481–496.
  • Liu XF, Fawcett JR, Thorne RG, Intranasal administration of insulin-like growth factor-I bypasses the blood-brain barrier and protects against focal cerebral ischemic damage. J Neurol Sci. 2001;187:91–97.
  • Thorne RG, Frey WH. 2nd. Delivery of neurotrophic factors to the central nervous system: pharmacokinetic considerations. Clin Pharmacokinet. 2001;40:907–946.
  • Yang JP, Liu HJ, Cheng SM, Direct transport of VEGF from the nasal cavity to brain. Neurosci Lett. 2009;449:108–111
  • Longa EZ, Weinstein PR, Carlson S, Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 1989;20:84–91.
  • Yang JP, Liu HJ, Wang ZL, The dose-effectiveness of intranasal VEGF in treatment of experimental stroke. Neurosci Lett. 2009;461:212–216.
  • Chen J, Sanberg PR, Li Y, Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke. 2001;32:2682–2688.
  • Swanson RA, Morton MT, Tsao-Wu G, A semiautomated method for measuring brain infarct volume. J Cereb Blood Flow Metab. 1990;10:290–293.
  • Barros LF, Belfort R Jr. The effects of the subconjunctival injection of bevacizumab (Avastin) on angiogenesis in the rat cornea. An Acad Bras Cienc. 2007;79:389–394.
  • Blatt RJ, Clark AN, Courtney J, Automated quantitative analysis of angiogenesis in the rat aorta model using Image-Pro Plus 4.1. Comput Methods Programs Biomed. 2004;75:75–79.
  • Beck H, Plate KH. Angiogenesis after cerebral ischemia. Acta Neuropathol. 2009;117:481–496.
  • Leventhal C, Rafii S, Rafii D, Endothelial trophic support of neuronal production and recruitment from the adult mammalian subependyma. Mol Cell Neurosci. 1999;13:450–464.
  • Yamashita T, Ninomiya M, Hernández Acosta P, Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum. J Neurosci. 2006;26:6627–6636.
  • Krupinski J, Kaluza J, Kumar P, Role of angiogenesis in patients with cerebral ischemic stroke. Stroke. 1994;25:1794–1798.
  • Hayashi T, Abe K, Suzuki H, Rapid induction of vascular endothelial growth factor gene expression after transient middle cerebral artery occlusion in rats. Stroke. 1997;28:2039–2044.
  • Plate KH, Beck H, Danner S, Cell type specific upregulation of vascular endothelial growth factor in an MCA-occlusion model of cerebral infarct. J Neuropathol Exp Neurol. 1999;58:654–666.
  • Kovács Z, Ikezaki K, Samoto K, VEGF and flt. Expression time kinetics in rat brain infarct. Stroke. 1996;27:1865–1872.
  • Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol. 2005;23:1011–1027.
  • Lennmyr F, Ata KA, Funa K, Expression of vascular endothelial growth factor (VEGF) and its receptors (Flt-1 and Flk-1) following permanent and transient occlusion of the middle cerebral artery in the rat. J Neuropathol Exp Neurol. 1998;57:874–882.
  • Ogunshola OO, Stewart WB, Mihalcik V, Neuronal VEGF expression correlates with angiogenesis in postnatal developing rat brain. Brain Res Dev Brain Res. 2000;119:139–153.
  • Zhang ZG, Zhang L, Tsang W, Correlation of VEGF and angiopoietin expression with disruption of blood-brain barrier and angiogenesis after focal cerebral ischemia. J Cereb Blood Flow Metab. 2002;22:379–392.
  • Rosenstein JM, Mani N, Silverman WF, Patterns of brain angiogenesis after vascular endothelial growth factor administration in vitro and in vivo. Proc Nat Acad Sci U S A. 1998;95:7086–7091.
  • Krum JM, Mani N, Rosenstein JM. Angiogenic and astroglial responses to vascular endothelial growth factor administration in adult rat brain. Neuroscience. 2002;110:589–604.
  • Zhang ZG, Zhang L, Jiang Q, VEGF enhances angiogenesis and promotes blood–brain barrier leakage in the ischemic brain. J Clin Invest. 2000;106:829–838.
  • Sun Y, Jin K, Xie L, VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J Clin Invest. 2003;111:1843–1851.
  • Astrup J, Siesjo BK, Symon L. Thresholds in cerebral ischemia: the ischemic penumbra. Stroke. 1981;12:723–725.
  • Dirnagl U, Iadecola C, Moskowitz MA. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. 1999;22:391–397.
  • Chen HH, Chien CH, Liu M. Correlation between angiogenesis and basic fibroblast growth factor expression in experimental brain infarct. Stroke. 1994;25:1651–1657.
  • Krupinski J, Kumar P, Kumar S, Increased expression of TGF-beta 1 in brain tissue after ischemic stroke in humans. Stroke. 1996;27:852–857.
  • Okada Y, Copeland BR, Hamann GF, Integrin alphavbeta3 is expressed in selected microvessels after focal cerebral ischemia. Am J Pathol. 1996;149:37–44.
  • van Bruggen N, Thibodeaux H, Palmer JT, VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain. J Clin Invest. 1999;104:1613–1620.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.