Short-Term Treatment with COX-2 Inhibitors Does Not Impair Fracture Healing.

REFERENCES

• Vaile JH, Davis P. Topical NSAIDs for musculoskel et al. conditions. A review of the literature. Drugs. 1998;56:783–799.
   PubMed Web of Science ®Google Scholar
• Langford RM, Mehta V. Selective cyclooxygenase inhibition: its role in pain and anaesthesia. Biomed Pharmacother. 2006;60:323–328.
   PubMed Web of Science ®Google Scholar
• Camu F, Shi L, Vanlersberghe C. The role of COX-2 inhibitors in pain modulation. Drugs. 2003;63(Suppl 1):1–7.
   PubMedGoogle Scholar
• Simon A, Manigrasso M, O’Connor J. Cyclo-oxygenase 2 function is essential for bone fracture healing. J Bone Miner Res. 2002;17:963–976.
   PubMed Web of Science ®Google Scholar
• Zhang X, Schwarz EM, Young DA, et al. Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblasts lineage and is critically involved in bone repair. Clin Investig. 2002;109:1405–1415.
   Google Scholar
• Altman RD, Latta LL, Keer R, et al. Effect of nonsteroidal anti-inflammatory drugs on fracture healing: a laboratory study in rats. J Orthop Trauma. 1995;9:392–400.
   PubMed Web of Science ®Google Scholar
• Beck A, Krischak G, Sorg T, et al. Influence of diclofenac (group of nonsteroidal anti-inflammatory drugs) on fracture healing. Arch Orthop Trauma Surg. 2003;123:327–332.
   PubMed Web of Science ®Google Scholar
• Riew KD, Long J, Rhee J, et al. Time-dependent inhibitory effects of indomethacin on spinal fusion. J Bone Joint Surg Am. 2003;85:632–634.
   PubMedGoogle Scholar
• Gerstenfeld LC, Thiede M, Seibert K, et al. Differential inhibition of fracture healing by non-selective and cyclooxygenase-selective non-steroidal anti-inflammatory drugs. J Orthop Res. 2003;21:670–675.
   PubMed Web of Science ®Google Scholar
• Endo K, Sairo K, Komatsubara S, et al. Cyclooxygenase-2 inhibitor inhibits the fracture healing. J Physiol Anthropol. 2002;21:235–238.
   Google Scholar
• Goodman S, Ma T, Trindade M, et al. COX-2 selective NSAIDS decrease bone ingrowth in vivo. J Orthop Res. 2002;20:1164–1169.
   PubMed Web of Science ®Google Scholar
• Brown KM, Saunders MM, Kirsch T, et al. Effect of COX-2-specific inhibition on fracture-healing in the rat femur. J Bone Joint Surg Am. 2004;86:116–123.
   PubMed Web of Science ®Google Scholar
• Ho ML, Chang JK, Wang GJ. Effects of ketorolac on bone repair: a radiographic study in modeled demineralized bone matrix grafted rabbits. Pharmacology 1998;57:148–159.
   PubMed Web of Science ®Google Scholar
• Leonelli SM, Goldberg BA, Safanda J, Effects of a cyclooxygenase-2 inhibitor (rofecoxib) on bone healing. Am J Orthop. 2006;35:79–84.
   PubMedGoogle Scholar
• Gerstenfeld LC, Al-Ghawas M, Alkhiary YM, Selective and nonselective cyclooxygenase-2 inhibitors and experimental fracture healing. Reversibility of effects after short-term treatment. J Bone Joint Surg Am. 2007;89:114–125.
   PubMed Web of Science ®Google Scholar
• Long J, Lewis S, Kuklo T, The effect of cyclooxygenase-2 inhibitors on spinal fusion. J Bone Joint Surg Am. 2002;84: 1763–1768.
   PubMedGoogle Scholar
• Ponthan F, Wickstrøm M, Gleissman H Celecoxib prevents meuroblasoma tumor development and potentiates the effect of chemotherapeutic drugs in vitro and in vivo. Clin Cancer Res. 2007;13:1036–1044.
   PubMed Web of Science ®Google Scholar
• Engesaeter LB, Ekeland A, Langeland N. Methods of testing the mechanical properties of the rat femur. Acta Orthop Scand. 1978;49:512–518.
   PubMed Web of Science ®Google Scholar
• FitzGerald GA, Patrono C. The coxibs, selective inhibitors of cyclooxygenase. N Engl J Med. 2001;345:433–442.
   PubMed Web of Science ®Google Scholar
• Nageswara RR, Meen A, Raghuram AR. An overview of the recent developments in analytical methodologies for determination of COX-2 inhibitors in bulk drugs, pharmaceuticals and biological matrices. J Pharmacol Biomed An. 2005;39:349–363.
   PubMedGoogle Scholar
• Gierse JK, Zhang Y, Hood WF, et al. Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity. J Pharmacol Exp Ther. 2005;312:1206–1212.
   PubMedGoogle Scholar
• Laneuville O, Breuer DK, Dewitt DL, et al. Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. 1994;27:927–934.
   Google Scholar
• Gerstenfeld LC, Einhorn TA. COX inhibitors and their effects on bone healing. Expert Opin Drug Saf. 2004;3:131–136.
   PubMedGoogle Scholar
• Gajraj NM. The effect of cyclooxygenase-2 inhibitors on bone healing. Reg Anesth Pain Med. 2003;28:456–465.
   PubMed Web of Science ®Google Scholar
• Meunier A, Aspenberg P. Parecoxib impairs early metaphyseal bone healing in rats. Arch Orthop Trauma Surg. 2006;126:433–436.
   PubMed Web of Science ®Google Scholar
• Sigurdsen UE, Reikeras O, Utvag SE. External fixation compared to intramedullary nailing of tibial fractures in the rat. Acta Orthop. 2009;1:1–5.
   Google Scholar
• Goodman SB, Ma T Mitsunaga L, et al. Temporal effects of a cox-2-selective NSAID on bone ingrowth. J Biomed Mater Res. 2005;3:279–287.
   Google Scholar
• Akritopoulos P, Papaioannidou P, Hatzokos I, et al. Parecoxib has non-significant long-term effects on bone healing in rats when administered for a short period after fracture. Arch Trauma Surg. 2009;129:1427–1432.
   PubMedGoogle Scholar
• Deguchi M, Rapoff AJ, Zdeblick TA. Posterolateral fusion for isthmic spondylolisthesis in adults: analysis of fusion rate and clinical results. J Spinal Disord. 1998;11:459–464.
   PubMedGoogle Scholar
• Glassman SD, Rose SM, Dimar JR, et al. The effect of postoperative nonsteroidal anti-inflammatory drug administration on spinal fusion. Spine 1998;23:834–838.
   PubMed Web of Science ®Google Scholar
• Reuben SS, Ekman EF. The effect of cyclooxygenase-2 inhibition on analgesia and spinal fusion. J Bone Joint Surg Am. 2005;87:536–542.
   PubMed Web of Science ®Google Scholar
• Giannoudis PV, MacDonald DA, Matthews SJ, et al. Nonunion of the femoral diaphysis. The influence of reaming and non-steroidal anti-inflammatory drugs. J Bone Joint Surg Br. 2000;82:655–658.
   PubMed Web of Science ®Google Scholar
• Bhattacharyya T, Levin R, Vrahas MS, et al. Nonsteroidal antiinflammatory drugs and nonunion of humeral shaft fractures. Arthritis Rheum. 2005;53:364–367.
   PubMed Web of Science ®Google Scholar