142
Views
7
CrossRef citations to date
0
Altmetric
NEW METHODOLOGIES

Development of a New Biomechanically Defined Single Impact Rabbit Cartilage Trauma Model for In Vivo-Studies

, , , , , , & show all
Pages 235-241 | Received 14 Jun 2011, Accepted 04 Oct 2011, Published online: 09 May 2012

REFERENCES

  • Furman BD, Olson SA, Guilak F. The development of posttraumatic arthritis after articular fracture. J Orthop Trauma 2006;20:719–725.
  • Lotz MK, Kraus VB. New developments in osteoarthritis: posttraumatic osteoarthritis—pathogenesis and pharmacological treatment options. Arthritis Res Ther. 2010;12:211.
  • Brown TD, Johnston RC, Saltzman CL, Posttraumatic osteoarthritis: a first estimate of incidence, prevalence, and burden of disease. J Orthop Trauma 2006;20:739–744.
  • Roos H, Adalberth T, Dahlberg L, Osteoarthritis of the knee after injury to the anterior cruciate ligament or meniscus: the influence of time and age. Osteoarthritis Cartilage 1995;3:261–267.
  • Lai EW, Toledo-Pereyra LH, Walsh J, The role of MAP kinases in trauma and ischemia-reperfusion. J Invest Surg. 2004;17:45–53.
  • Huser CAM, Peacock M, Davies ME. Inhibition of caspase-9 reduces chondrocyte apoptosis and proteoglycan loss following mechanical trauma. Osteoarthritis Cartilage 2006;14:1002–1010.
  • Jeffrey JE, Aspden RM. Cyclooxygenase inhibition lowers prostaglandin E2 release from articular cartilage and reduces apoptosis but not proteoglycan degradation following an impact load in vitro. Arthritis Res Ther. 2007;9: R129.
  • Ding L, Heying E, Nicholson N, Mechanical impact induces cartilage degradation via mitogen activated protein kinases. Osteoarthritis Cartilage 2010;18:1509–1517.
  • Joos H, Hogrefe C, Rieger L, Single impact trauma in human early-stage osteoarthritic cartilage: implication of prostaglandin D2 but no additive effect of IL-1beta on cell survival. Int J Mol Med. 2011;28:271–277.
  • Martin JA, McCabe D, Walter M, N-acetylcysteine inhibits post-impact chondrocyte death in osteochondral explants. J Bone Joint Surg Am. 2009;91:1890–1897.
  • Borrelli J, Burns ME, Ricci WM, A method for delivering variable impact stresses to the articular cartilage of rabbit knees. J Orthop Trauma 2002;16:182–188.
  • Milentijevic D, Rubel IF, Liew ASL, An in vivo rabbit model for cartilage trauma: a preliminary study of the influence of impact stress magnitude on chondrocyte death and matrix damage. J Orthop Trauma 2005;19:466–473.
  • Newberry WN, Zukosky DK, Haut RC. Subfracture insult to a knee joint causes alterations in the bone and in the functional stiffness of overlying cartilage. J Orthop Res. 1997;15:450–455.
  • Vrahas MS, Smith GA, Rosler DM, Method to impact in vivo rabbit femoral cartilage with blows of quantifiable stress. J Orthop Res. 1997;15:314–317.
  • Goodman SB, Lee J, Smith RL, Mechanical overload of a single compartment induces early degenerative changes in the rabbit knee: a preliminary study. J Invest Surg. 1991;4:161–170.
  • Borrelli J, Silva MJ, Zaegel MA, Single high-energy impact load causes posttraumatic OA in young rabbits via a decrease in cellular metabolism. J Orthop Res. 2009;27:347–352.
  • Isaac DI, Meyer EG, Haut RC. Chondrocyte damage and contact pressures following impact on the rabbit tibiofemoral joint. J Biomech Eng. 2008;130:041018.
  • Jansen NWD, Roosendaal G, Bijlsma JWJ, Exposure of human cartilage tissue to low concentrations of blood for a short period of time leads to prolonged cartilage damage: an in vitro study. Arthritis Rheum. 56:2007;199–207.
  • Khan WS, Johnson DS, Hardingham TE. The potential of stem cells in the treatment of knee cartilage defects. Knee 2010;17:369–374.
  • Singer NG, Caplan AI. Mesenchymal stem cells: mechanisms of inflammation. Annu Rev Pathol. 2011;6:457–478.
  • Wei X, Gao J, Messner K. Maturation-dependent repair of untreated osteochondral defects in the rabbit knee joint. J Biomed Mater Res. 1997;34:63–72.
  • Zhang H, Vrahas MS, Baratta RV, Damage to rabbit femoral articular cartilage following direct impacts of uniform stresses: an in vitro study. Clin Biomech. (Bristol, Avon) 1999;14:543–548.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.