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Journal of Investigative Surgery Volume 4, 1991 - Issue 1
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Original Article

Improved Xenograft Survival with Continuous Infusion Deoxyspergualin and RATG

Richard Demasi Department of Surgery, Division of Transplantation, East Carolina University School of Medicine, Greenville, NC, 27858
,
Dorian Araneda Department of Surgery, Division of Transplantation, East Carolina University School of Medicine, Greenville, NC, 27858
,
Uli Gross Department of Surgery, Division of Transplantation, East Carolina University School of Medicine, Greenville, NC, 27858
,
Hugh Daniel Department of Surgery, Division of Transplantation, East Carolina University School of Medicine, Greenville, NC, 27858
,
Ernest Larkin Department of Pathology, East Carolina University School of Medicine, Greenville, NC, 27858
,
Judith Thomas Department of Surgery, Division of Transplantation, East Carolina University School of Medicine, Greenville, NC, 27858
,
Melvin Swanson Department of Surgery, Division of Transplantation, East Carolina University School of Medicine, Greenville, NC, 27858
,
Wiley Nifong Department of Surgery, Division of Transplantation, East Carolina University School of Medicine, Greenville, NC, 27858
&
Francis Thomas Department of Surgery, Division of Transplantation, East Carolina University School of Medicine, Greenville, NC, 27858
 show all
Pages 59-67 | Published online: 09 Jul 2009

References

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  • Starzl T E. Renal transplantation from baboon to man: experience with six cases. Transplantation. 1964; 2: 752
  • Auchincloss H, Jr. Xenogeneic transplantation: a review. Transplantation. 1988; 46: 1–20
  • Takeuchi Iinuma T. H, Kunimoto S. A new antitumor antibiotic spergualin: isolation and antitumor activity. J Antibiot. 1981; 34: 1619–1621
  • Nishikawa K, Shibasaki C, Takahashi K. Antitumor activity of spergualin: a novel antitumor antibiotic. J Antibiot. 1986; 39: 1461–1466
  • Dickneite H U, Schorlemmer E, Wienman H. 15-Deoxyspergualin: from cytostasis to immunosuppression. Behring Inst Mitt. 1988; 82: 231–239
  • Dickneite G, Schorlemmer U, Sedlacek H H. Decrease of phagocyte cell functions and prolongation of graft survival in experimental transplantation by 15-deoxyspergualin. Int J Immunopharmacol. 1987; 9: 559–565
  • Ono K, Lindsay E S. Improved technique of heart transplantation in rats. J Thorac Cardiovasc Surg. 1969; 57: 225–229
  • Thomas J, Hume D M. A standardized ALG for use in man. Transplant Proc. 1972; 4(4)477–479
  • Iwasawa H, Kondo S, Ikeda D. Synthesis of (-)-15-deoxyspergualin and (-)-spergualin-15-phosphate. J Antibiot. 1982; 35: 1665–1669
  • Walter P, Bernhard U, Seitz G. Xenogeneic heart transplantation with 15-deoxyspergualin. Prolongation of graft survival. Transplant Proc. 1987; 19(5)3993–3994
  • Corry R J, Cutkomp J, Oberholser J. Prolongation of allograft and xenograft survival with 15-deoxyspergualin. Transplant Proc. 1989; 21(1)530–531
  • Saumweber D, Singer T, Hammer K. 15-Deoxyspergualin: a new perspective of immunosuppressive therapy in experimental xenogeneic kidney transplantation. Transplant Proc. 1989; 21(1)542
  • Click R E, Sakakibara N, Aziz S, Wick M R, Jamieson S W. Characterization of cells that reject xenografts. Transplantation Proc. 1989; 21(1)524–526
  • Plowman J, Harrison S D, Trader M W. Preclinical antitumor activity and pharmacologic properties of deoxyspergualin. Cancer Res. 1987; 47: 685–689

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