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Original Article

Effect of Oral and Intravenous Diltiazem on Whole Blood Platelet Aggregability

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Pages 533-539 | Received 10 May 1993, Accepted 12 Apr 1994, Published online: 09 Jul 2009

References

  • Prentice C. RM. Myocardial infarction. Thrombosis: Clinics in Haematology 1981; 10: 521–541
  • Born G. VR. Platelets in atherogenesis and thrombogenesis. Biology and Pathology of the Vessel Wall, N. Woolf. Praeger Scientific, Eastbourne 1983; 71–80
  • Ikeda Y., Kikuchi M., Toyama K., Watanabe K., Ando Y. Inhibition of human platelet function by verapamil. Thromb Haemost. 1981; 45: 158–161
  • Shinjo A., Sasaki Y., Inamasu M., Morita T. In vitro effect of the coronary vasodilator diltiazem on human and rabbit platelets. Thromb Res. 1978; 13: 941–955
  • Mehta P., Mehta J., Ostrowski N., Brigmon L. Inhibitory effects of diltiazem on platelet activation caused by ionophore A23187 plus ADP or epinephrine in subthreshold concentrations. J Lab Clin Med. 1983; 102: 332–339
  • Kiyomoto A., Sasaki Y., Odawara A., Morita T. Inhibition of platelet aggregation by diltiazem. Circ Rex 1983; 52(suppl 1)115–119
  • Altman R., Scazziota A., Dujovne C. Diltiazem potentiates the inhibitory effect of aspirin on platelet aggregation. Clin Pharmacol Ther. 1988; 44: 320–325
  • Schachter M. Do calcium antagonists affect platelets?. Eur Heart J. 1987; 8: 75–82
  • Strano A., Davi G., Novo S., Custro N., Mattina A., Gallo V. Effects of verapamil on platelet aggregation and serum thromboxane synthesis in vitro and in vivo. Inter Angio. 1985; 4: 379–382
  • Ring M., Corrigan J., Fenster P. Effects of oral diltiazem on platelet function: alone and in combination with low dose aspirin. Thromb Res. 1986; 44: 391–400
  • Yamauchi K., Furui H., Taniguchi N., Sotobata I. Effects of diltiazem hydrochloride on cardiovascular response, platelet aggregation and coagulating activity during exercise testing in systemic hypertension. Am J Cardiol. 1986; 57: 609–612
  • Cremer K., Pieper J., Joyal M., Mehta J. Effects of diltiazem, dipyridamole, and their combination on hemostasis. Clin Pharmacol Ther. 1984; 36: 641–644
  • Johnson H. Effects by nifedipine on platelet function in vitro and in vivo. Thromb Rex 1981; 21: 523–528
  • Dale J., Landmark K., Myhre E. The effects of nifedipine, a calcium antagonist, on platelet function. AmHeartJ. 1983; 105: 103–105
  • Hiroki T., Inoue T., Yoshida T., Arakawa K. Effect of calcium antagonistic agent nifedipine on platelet aggregation response to exercise in patients with angina pectoris. Arzneim Forsch. 1982; 32: 1572–1574
  • Sebekova K., Raucinova M., Sedlakova K., Dzurik R. Serotonin metabolism and platelet aggregation under antihypertensive treatment with nitrendipine. J Cardiovasc Pharmacol. 1988; 12(Suppl 4)S161–S163
  • Francis J. L., Roath O. S., Challenor V. T., Waller D. G. The effect of nisodipine on whole blood platelet aggregation in patients with Raynaud's phenomenon. Br J Pharmac. 1988; 25: 751–754
  • Ring M. E., Martin G. V., Fenster P. E. Clinically significant antiplatelet effects of calcium-channel blockers. J Clin Pharmacol. 1986; 26: 719–720
  • Rostagno C., Prisco D., Paniccia R., Costanzo G., Poggesi L., Boddi M. Effects of calcium channel blockers on platelet aggregation and thromboxane A2 formation: an in vivo double blind randomized study. Thromb Res. 1990; 59: 531–539
  • Hermann P. H., Rodger S. D., Remones G., Thenot J. P., London D. R., Morselli P. L. Pharmacokinetics of diltiazem after intravenous and oral administration. Eur J Pharmacol. 1983; 24: 349–352
  • Smith M., Verghese C. P., Shand D. G., Pritchett E. LC. Pharmacokinetic and pharmacodynamic effects of diltiazem. Am J Cardiol. 1983; 51: 1369–1374
  • Mitchell L. B., Jutzy K. R., Lewis S. J., Schroeder I. S., Mason J. W. Intracardiac electrophysiologic study of intravenous diltiazem and combined diltiazem-digoxin in patients. Am Heart J. 1982; 103: 57–65
  • Ingerman-Wojenski C. M., Silver M. I. A quick method for screening platelet dysfunctions using the whole blood lumi-aggregometer. Thromb Haemost. 1984; 51: 154–156
  • Zhao H., Chow M. SS. Analysis of diltiazem and desacetyldiltiazem in plasma using modified high-performance liquid chromatography: improved sensitivity and reproducibility. Pharmaceutical Research 1989; 6: 428–430
  • Riess H., Braun G., Brehm G., Hiller E. Critical evaluation of platelet aggregation in whole human blood. Am J Clin Pathol. 1986; 85: 50–56
  • Jeremy J. Y., Barradas M. A., Mikhailidis D. P., Dandona P. An investigation into the effects of nifedipine and nimodipine on platelet function and vascular prostacyclin synthesis. Drugs Exptl Clin Res. 1985; 11: 645–651
  • Tartaglione T., Pepine C., Pieper J. Diltiazem: a review of its clinical efficacy and use. Drug Intelligence and Clinical Pharmacy 1982; 16: 371–379
  • Kinney E. L., Moskowitz R. M., Zelis R. The pharmacokinetics and pharmacology of oral diltiazem in normal volunteers. J Clin Pharmacol. 1981; 21: 337–342
  • Zelis R. F. Calcium entry blockers in cardiologic therapy. Hosp Pract. 1981; 16: 52
  • Onoda J. M., Sloane B. F., Honn K. F. Antithrombogenic effects of calcium channel blockers: synergism with prostacyclin and thromboxane synthase inhibitors. Thromb Res. 1984; 34: 367–378
  • Greer I. A., Walker J. J., Calder A. A., Forbes C. D. Aspirin with an adrenergic or a calcium-channel blocking agent as a new combination therapy for arterial thrombosis. Lancet 1985; 1: 351–352

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